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Journal of Clinical Medicine, Volume 7, Issue 3

2018 March - 23 articles

Cover Story: Readisorb L-GSH has direct antimycobacterial effects on BCG and Erdman strain of M. tb. Readisorb L-GSH also promotes formation of stable granulomas and enhances granulomatous responses against mycobacterial infection by restoring redox homeostasis, cytokine balance and improving phagosome acidification. View the paper here.
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Articles (23)

  • Review
  • Open Access
25 Citations
20,398 Views
21 Pages

Building on the seminal work by Geoffrey Harris in the 1970s, the neuroendocrinology field, having undergone spectacular growth, has endeavored to understand the mechanisms of hormonal connectivity between the brain and the rest of the body. Given th...

  • Article
  • Open Access
14 Citations
5,423 Views
10 Pages

This study investigated associations of perceived environmental factors with leisure-time physical activity (LTPA) and screen time (ST) among older adults. A cross-sectional study was conducted by administering computer-assisted telephone interviews...

  • Article
  • Open Access
17 Citations
4,204 Views
11 Pages

Long-Term Increase of Radiographic Damage and Disability in Patients with RA in Relation to Disease Duration in the Era of Biologics. Results from the SCQM Cohort

  • Katja Heinimann,
  • Johannes Von Kempis,
  • Rafael Sauter,
  • Michael Schiff,
  • Tuulikki Sokka-Isler,
  • Hendrik Schulze-Koops and
  • Rüdiger Müller

Objectives: There is little information on the relation between disease duration, disability and radiographic outcome since the introduction of biologics into the therapy of rheumatoid arthritis (RA). No long -term cohort studies have been conducted...

  • Article
  • Open Access
22 Citations
7,983 Views
10 Pages

This study examined the perceptions of benefits of and barriers to participating in a community-based diabetes program to improve program effectiveness. The Diabetes Prevention and Management (DPM) program was a twenty-two session, 1-year program, mo...

  • Feature Paper
  • Review
  • Open Access
226 Citations
31,125 Views
17 Pages

Islets of Langerhans are islands of endocrine cells scattered throughout the pancreas. A number of new studies have pointed to the potential for conversion of non-β islet cells in to insulin-producing β-cells to replenish β-cell mass as a means to tr...

  • Review
  • Open Access
15 Citations
6,401 Views
11 Pages

Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells and is the second most common hematological cancer. MM frequently occurs in the elderly population with the median age as the middle sixties. Over the last 10 years, the...

  • Review
  • Open Access
10 Citations
5,032 Views
10 Pages

The trans-venous implantable cardioverter defibrillator (TV-ICD) is effective in treating life-threatening ventricular arrhythmia and reduces mortality in high-risk patients. However, there are significant short- and long-term complications that are...

  • Article
  • Open Access
6 Citations
8,457 Views
11 Pages

Background: Jugulotympanic paraganglioma (JTP) are benign, high-vascularized lesions that frequently invade the jugular foramen, temporal bone, the upper neck, and the posterior fossa cavity, resulting in a wide variety of clinical symptoms. Methods:...

  • Article
  • Open Access
1 Citations
3,614 Views
11 Pages

Preoperative socioeconomic status (SES) is associated with outcomes after surgery, although the effect on mortality may vary according to region. This retrospective study evaluated patients who underwent elective surgery at a tertiary hospital from 2...

  • Case Report
  • Open Access
16 Citations
5,987 Views
7 Pages

Objective: The clinical effectiveness of tigecycline depends on appropriate use, and PK/PD (pharmacokinetic/pharmacodynamic) parameters related to dose and dosing interval. Methods: In our 600-bed university-affiliated teaching hospital, we conducted...

  • Article
  • Open Access
15 Citations
8,303 Views
9 Pages

Outcomes for Women with Gestational Diabetes Treated with Metformin: A Retrospective, Case-Control Study

  • Rachel T. McGrath,
  • Sarah J. Glastras,
  • Emma S. Scott,
  • Samantha L. Hocking and
  • Gregory R. Fulcher

Metformin is increasingly being used a therapeutic option for the management of gestational diabetes mellitus (GDM). The aim of this study was to compare the maternal characteristics and perinatal outcomes of women with GDM treated with metformin (wi...

  • Case Report
  • Open Access
8 Citations
5,029 Views
6 Pages

Jugular paragangliomas are slow growing highly vascular tumors arising from jugular paraganglia. The gold standard of treatment is complete surgical resection. Pre-operative embolization of these highly vascular tumors is essential to reduce intra-op...

  • Feature Paper
  • Correction
  • Open Access
2 Citations
3,398 Views
2 Pages

The authors wish to make the following corrections to this paper [1].[...]

  • Feature Paper
  • Article
  • Open Access
6 Citations
4,909 Views
11 Pages

Helicobacter Pylori Serology in Relation to Hepatitis C Virus Infection and IL28B Single Nucleotide Polymorphism

  • Alexander Gutwerk,
  • Thomas Wex,
  • Kerstin Stein,
  • Cosima Langner,
  • Ali Canbay,
  • Peter Malfertheiner and
  • Alexander Link

The aim of the study was to evaluate the serological rate of Helicobacter pylori (H. pylori) infection in patients with chronic hepatitis C virus (HCV) infection and determine any correlations with liver damage and IL28B single-nucleotide polymorphis...

  • Review
  • Open Access
28 Citations
13,460 Views
16 Pages

Organ transplantation is a new issue in medical science. It is an important achievement and a sign of the progression and ability of medical centers around the world. Governments, populations, the medical community and people involved in culture, art...

  • Article
  • Open Access
17 Citations
6,298 Views
13 Pages

Amiloride Promotes Oligodendrocyte Survival and Remyelination after Spinal Cord Injury in Rats

  • Takeshi Imai,
  • Hiroyuki Katoh,
  • Kaori Suyama,
  • Masahiro Kuroiwa,
  • Sho Yanagisawa and
  • Masahiko Watanabe

After spinal cord injury (SCI), secondary injury results in an expanding area of glial cell apoptosis. Oligodendrocyte precursor cells (OPCs) actively proliferate after SCI, but many of these cells undergo apoptosis. One of the factors that exacerbat...

  • Review
  • Open Access
176 Citations
26,726 Views
13 Pages

Objective: Although current evidence supports the use of virtual reality (VR) in the treatment of mental disorders, it is unknown whether VR exercise would be beneficial to mental health. This review synthesized literature concerning the effect of VR...

  • Article
  • Open Access
1 Citations
4,171 Views
8 Pages

Factors Affecting the Success Rate of Percutaneous Nephrolithotomy in Paediatric Patients

  • Hikmat Jabrayilov,
  • Murat Yavuz Koparal,
  • Serhat Gürocak,
  • Bora Küpeli and
  • Mustafa Özgür Tan

In this study, we aimed to determine factors affecting the success rate of percutaneous nephrolithotomy (PNL) in children. The series consisted of 41 consecutive children operated on by the same surgical team for renal calculi with PNL between June 2...

  • Review
  • Open Access
78 Citations
8,050 Views
13 Pages

The ability to create patient derived xenografts (PDXs) has evolved considerably from the breakthrough of the development of immune compromised mice. How researchers in drug discovery have utilized PDX of certain cancer types has also changed from tr...

  • Feature Paper
  • Article
  • Open Access
17 Citations
7,883 Views
24 Pages

Effects of ReadiSorb L-GSH in Altering Granulomatous Responses against Mycobacterium tuberculosis Infection

  • Hicret Islamoglu,
  • Ruoqiong Cao,
  • Garrett Teskey,
  • Karo Gyurjian,
  • Sebastian Lucar,
  • Marcel P. Fraix,
  • Airani Sathananthan,
  • John K. Chan and
  • Vishwanath Venketaraman

Mycobacterium tuberculosis (M. tb), a rod-shaped acid-fast bacterium, is the causative agent of tuberculosis (TB). TB remains one of the leading causes of morbidity and mortality worldwide. Additionally, approximately one-third of the world’s populat...

  • Feature Paper
  • Review
  • Open Access
43 Citations
6,063 Views
8 Pages

26 February 2018

Thyroid follicular cells, as well as adrenocortical cells, are endowed by an intrinsic heterogeneity regarding their growth potential, in response to various stimuli. This heterogeneity appears to constitute the underlying cause for the focal cell hy...

  • Article
  • Open Access
14 Citations
10,210 Views
12 Pages

The Effect of Music on Exercise Intensity among Children with Autism Spectrum Disorder: A Pilot Study

  • Ashley C. Woodman,
  • Emily Breviglia,
  • Yumiko Mori,
  • Rebecca Golden,
  • John Maina and
  • Hannah Wisniewski

26 February 2018

Children with autism spectrum disorder (ASD) are at risk for obesity, commonly have sleep disorders, and exhibit stereotypic behaviors that disrupt their learning. Vigorous levels of exercise have been shown to ameliorate these issues in children wit...

  • Article
  • Open Access
52 Citations
5,969 Views
9 Pages

C-Reactive Protein to Albumin Ratio Predicts 30-Day and 1-Year Mortality in Postoperative Patients after Admission to the Intensive Care Unit

  • Tak Kyu Oh,
  • Eunjeong Ji,
  • Hyo-seok Na,
  • Byunghun Min,
  • Young-Tae Jeon,
  • Sang-Hwan Do,
  • In-Ae Song,
  • Hee-Pyoung Park and
  • Jung-Won Hwang

26 February 2018

C-reactive protein and albumin are associated with poor outcomes in critically ill patients. This study aimed to investigate the significance of the C-reactive protein/albumin (CRP/ALB) ratio as a novel prognostic factor for 30-day or 1-year mortalit...

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J. Clin. Med. - ISSN 2077-0383