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Biosensors, Volume 10, Issue 12

2020 December - 25 articles

Cover Story: Gallium-based liquid metal alloys, as metallic fluids at ambient temperature, can be readily processed into nanoparticles of a size ranging from tens to hundreds of nanometers. These nanoparticles acquire many unique but useful properties that are beneficial in biomedical applications. This review seeks to highlight exciting advances in the use of the gallium-based liquid metal nanoparticles for biomedical applications, including cancer therapy, medical imaging, and pathogen treatment. We also offer a foresight to exemplify underexplored knowledge and highlighting the research challenges faced by LMNP science and technology in expanding into applications potentially yielding clinical advances. View this paper.
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Articles (25)

  • Article
  • Open Access
6 Citations
4,808 Views
15 Pages

Rapid Multianalyte Microfluidic Homogeneous Immunoassay on Electrokinetically Driven Beads

  • Pierre-Emmanuel Thiriet,
  • Danashi Medagoda,
  • Gloria Porro and
  • Carlotta Guiducci

21 December 2020

The simplicity of homogeneous immunoassays makes them suitable for diagnostics of acute conditions. Indeed, the absence of washing steps reduces the binding reaction duration and favors a rapid and compact device, a critical asset for patients experi...

  • Article
  • Open Access
14 Citations
4,694 Views
16 Pages

21 December 2020

Protein tyrosine sulfation (PTS), a vital post-translational modification, facilitates protein–protein interactions and regulates many physiological and pathological responses. Monitoring PTS has been difficult owing to the instability of sulfa...

  • Review
  • Open Access
150 Citations
12,680 Views
22 Pages

Review of Integrated Optical Biosensors for Point-of-Care Applications

  • Yung-Tsan Chen,
  • Ya-Chu Lee,
  • Yao-Hsuan Lai,
  • Jin-Chun Lim,
  • Nien-Tsu Huang,
  • Chih-Ting Lin and
  • Jian-Jang Huang

18 December 2020

This article reviews optical biosensors and their integration with microfluidic channels. The integrated biosensors have the advantages of higher accuracy and sensitivity because they can simultaneously monitor two or more parameters. They can furthe...

  • Communication
  • Open Access
15 Citations
4,209 Views
8 Pages

Highly Sensitive Detection of CA 125 Protein with the Use of an n-Type Nanowire Biosensor

  • Kristina A. Malsagova,
  • Tatyana O. Pleshakova,
  • Rafael A. Galiullin,
  • Andrey F. Kozlov,
  • Ivan D. Shumov,
  • Vladimir P. Popov,
  • Fedor V. Tikhonenko,
  • Alexander V. Glukhov,
  • Vadim S. Ziborov and
  • Yuri D. Ivanov
  • + 3 authors

18 December 2020

The detection of CA 125 protein in a solution using a silicon-on-insulator (SOI)-nanowire biosensor with n-type chip has been experimentally demonstrated. The surface of nanowires was modified by covalent immobilization of antibodies against CA 125 i...

  • Article
  • Open Access
30 Citations
4,631 Views
9 Pages

18 December 2020

In this work, a paper device consisted of a patterned paper chip, wicking pads, and a base was fabricated. On the paper chip, DNA–gold nanoparticles (DNA–AuNPs) were deposited and Hg2+ ions could be adsorbed by the DNA–AuNPs. The fo...

  • Communication
  • Open Access
12 Citations
4,122 Views
9 Pages

Development of a Graphene-Based Biosensor for Detecting Recombinant Cyanovirin-N

  • Pedro Rodrigues de Almeida,
  • André Melro Murad,
  • Luciano Paulino Silva,
  • Elibio Leopoldo Rech and
  • Elmo Salomão Alves

16 December 2020

We present a graphene-based biosensor selective to recombinant cyanovirin-N (rCV-N), an antiviral protein that has proven to be an effective microbicide to inhibit HIV replication. We modified the graphene monolayer devices with 1-pyrenebutanoic acid...

  • Article
  • Open Access
13 Citations
4,853 Views
21 Pages

Advances in the Detection of Toxic Algae Using Electrochemical Biosensors

  • Linda K. Medlin,
  • Maria Gamella,
  • Gerardo Mengs,
  • Verónica Serafín,
  • Susana Campuzano and
  • José M. Pingarrón

16 December 2020

Harmful algal blooms (HABs) are more frequent as climate changes and tropical toxic species move northward, especially along the Iberian Peninsula, a rich aquaculture area. Monitoring programs, detecting the presence of toxic algae before they bloom,...

  • Article
  • Open Access
15 Citations
4,692 Views
12 Pages

Interdigitated Sensor Optimization for Blood Sample Analysis

  • Julien Claudel,
  • Thanh-Tuan Ngo,
  • Djilali Kourtiche and
  • Mustapha Nadi

16 December 2020

Interdigitated (ITD) sensors are specially adapted for the bioimpedance analysis (BIA) of low-volume (microliter scale) biological samples. Impedance spectroscopy is a fast method involving simple and easy biological sample preparation. The geometry...

  • Review
  • Open Access
115 Citations
24,131 Views
34 Pages

15 December 2020

Recent advances in lab-on-a-chip technology establish solid foundations for wearable biosensors. These newly emerging wearable biosensors are capable of non-invasive, continuous monitoring by miniaturization of electronics and integration with microf...

  • Article
  • Open Access
11 Citations
4,324 Views
18 Pages

13 December 2020

Half of the global agricultural fresh produce is lost, mainly because of rots that are caused by various pathogenic fungi. In this study, a complementary metal-oxide-semiconductor (CMOS)-based biosensor was developed, which integrates specific DNA st...

  • Article
  • Open Access
49 Citations
6,489 Views
10 Pages

A CRISPR/Cas12a Based Universal Lateral Flow Biosensor for the Sensitive and Specific Detection of African Swine-Fever Viruses in Whole Blood

  • Jinghua Wu,
  • Omar Mukama,
  • Wei Wu,
  • Zhiyuan Li,
  • Jean De Dieu Habimana,
  • Yinghui Zhang,
  • Rong Zeng,
  • Chengrong Nie and
  • Lingwen Zeng

10 December 2020

Cross-border pathogens such as the African swine fever virus (ASFV) still pose a socio-economic threat. Cheaper, faster, and accurate diagnostics are imperative for healthcare and food safety applications. Currently, the discovery of the Clustered Re...

  • Article
  • Open Access
3 Citations
3,607 Views
13 Pages

Development of a Pharmacogenetic Lab-on-Chip Assay Based on the In-Check Technology to Screen for Genetic Variations Associated to Adverse Drug Reactions to Common Chemotherapeutic Agents

  • Rosario Iemmolo,
  • Valentina La Cognata,
  • Giovanna Morello,
  • Maria Guarnaccia,
  • Mariamena Arbitrio,
  • Enrico Alessi and
  • Sebastiano Cavallaro

9 December 2020

Background: Antineoplastic agents represent the most common class of drugs causing Adverse Drug Reactions (ADRs). Mutant alleles of genes coding for drug-metabolizing enzymes are the best studied individual risk factors for these ADRs. Although the c...

  • Article
  • Open Access
31 Citations
8,000 Views
10 Pages

Wearable Laser Doppler Flowmetry Sensor: A Feasibility Study with Smoker and Non-Smoker Volunteers

  • Mou Saha,
  • Viktor Dremin,
  • Ilya Rafailov,
  • Andrey Dunaev,
  • Sergei Sokolovski and
  • Edik Rafailov

7 December 2020

Novel, non-invasive wearable laser Doppler flowmetry (LDF) devices measure real-time blood circulation of the left middle fingertip and the topside of the wrist of the left hand. The LDF signals are simultaneously recorded for fingertip and wrist. Th...

  • Article
  • Open Access
11 Citations
3,470 Views
11 Pages

4 December 2020

Among the physical, chemical and biological hazards that could arise with respect to food safety, bacterial contamination has been one of the main concerns in recent years. Bacterial contamination in low moisture foods (LMFs) was an emerging threat w...

  • Article
  • Open Access
19 Citations
7,515 Views
13 Pages

An Improved HRPE-Based Transcriptional Output Reporter to Detect Hypoxia and Anoxia in Plant Tissue

  • Gabriele Panicucci,
  • Sergio Iacopino,
  • Elisa De Meo,
  • Pierdomenico Perata and
  • Daan A. Weits

3 December 2020

Oxygen levels in plant tissues may vary, depending on metabolism, diffusion barriers, and environmental availability. Current techniques to assess the oxic status of plant cells rely primarily on invasive microoptodes or Clark-type electrodes, which...

  • Article
  • Open Access
17 Citations
4,634 Views
15 Pages

A Comparative Study of Approaches to Improve the Sensitivity of Lateral Flow Immunoassay of the Antibiotic Lincomycin

  • Kseniya V. Serebrennikova,
  • Olga D. Hendrickson,
  • Elena A. Zvereva,
  • Demid S. Popravko,
  • Anatoly V. Zherdev,
  • Chuanlai Xu and
  • Boris B. Dzantiev

3 December 2020

This study provides a comparative assessment of the various nanodispersed markers and related detection techniques used in the immunochromatographic detection of an antibiotic lincomycin (LIN). Improving the sensitivity of the competitive lateral flo...

  • Review
  • Open Access
140 Citations
12,254 Views
24 Pages

Recent Progress in Manufacturing Techniques of Printed and Flexible Sensors: A Review

  • Dinesh Maddipatla,
  • Binu B. Narakathu and
  • Massood Atashbar

3 December 2020

This review provides an outlook on some of the significant research work done on printed and flexible sensors. Printed sensors fabricated on flexible platforms such as paper, plastic and textiles have been implemented for wearable applications in the...

  • Article
  • Open Access
21 Citations
3,581 Views
11 Pages

Label-Free and Sensitive Determination of Cadmium Ions Using a Ti-Modified Co3O4-Based Electrochemical Aptasensor

  • Yang Liu,
  • Dongwei Zhang,
  • Jina Ding,
  • Kashif Hayat,
  • Xijia Yang,
  • Xuejia Zhan,
  • Dan Zhang,
  • Yitong Lu and
  • Pei Zhou

30 November 2020

The current work demonstrates an electrochemical aptasensor for sensitive determination of Cd2+ based on the Ti-modified Co3O4 nanoparticles. In this unlabeled system, Ti-modified Co3O4 nanoparticles act as current signal amplifiers modified on the s...

  • Review
  • Open Access
82 Citations
10,134 Views
21 Pages

Biomedical Applications of Liquid Metal Nanoparticles: A Critical Review

  • Haiyue Li,
  • Ruirui Qiao,
  • Thomas P. Davis and
  • Shi-Yang Tang

30 November 2020

This review is focused on the basic properties, production, functionalization, cytotoxicity, and biomedical applications of liquid metal nanoparticles (LMNPs), with a focus on particles of the size ranging from tens to hundreds of nanometers. Applica...

  • Review
  • Open Access
95 Citations
14,635 Views
27 Pages

29 November 2020

Plant stresses have been monitored using the imaging or spectrometry of plant leaves in the visible (red-green-blue or RGB), near-infrared (NIR), infrared (IR), and ultraviolet (UV) wavebands, often augmented by fluorescence imaging or fluorescence s...

  • Review
  • Open Access
59 Citations
10,354 Views
19 Pages

29 November 2020

Several individuals will experience accidental exposure to an allergen. In this sense, the industry has invested in the processes of removing allergenic compounds in food. However, accidental exposure to allergenic proteins can result from allergenic...

  • Letter
  • Open Access
14 Citations
3,566 Views
11 Pages

Waveguide-Based Fluorescent Immunosensor for the Simultaneous Detection of Carbofuran and 3-Hydroxy-Carbofuran

  • Weiming Sun,
  • Lanhua Liu,
  • Abdul Ghaffar Memon,
  • Xiaohong Zhou and
  • Hongwei Zhao

27 November 2020

Carbofuran (CBF) is an efficient and broad-spectrum insecticide. As testing indicators for water quality and agricultural products, CBF and its metabolite 3-hydroxy-carbofuran (3-OH-CBF) are regulated by many countries. The detection of CBF and 3-OH-...

  • Review
  • Open Access
33 Citations
7,626 Views
19 Pages

27 November 2020

Amyloid formation plays a major role in a number of neurodegenerative diseases, including Alzheimer’s disease. Amyloid-β peptides (Aβ) are one of the primary markers associated with this pathology. Aβ aggregates exhibit a diverse...

  • Article
  • Open Access
13 Citations
5,029 Views
13 Pages

A Multichannel Microfluidic Sensing Cartridge for Bioanalytical Applications of Monolithic Quartz Crystal Microbalance

  • María Calero,
  • Román Fernández,
  • Pablo García,
  • José Vicente García,
  • María García,
  • Esther Gamero-Sandemetrio,
  • Ilya Reviakine,
  • Antonio Arnau and
  • Yolanda Jiménez

24 November 2020

Integrating acoustic wave sensors into lab-on-a-chip (LoC) devices is a well-known challenge. We address this challenge by designing a microfluidic device housing a monolithic array of 24 high-fundamental frequency quartz crystal microbalance with di...

  • Communication
  • Open Access
15 Citations
4,405 Views
8 Pages

A Rapid Colorimetric Assay for On-Site Authentication of Cephalopod Species

  • Giuseppina Tatulli,
  • Paola Cecere,
  • Davide Maggioni,
  • Andrea Galimberti and
  • Pier Paolo Pompa

24 November 2020

A colorimetric assay, exploiting the combination of loop-mediated isothermal amplification (LAMP) with DNA barcoding, was developed to address the authentication of some cephalopod species, a relevant group in the context of seafood traceability, due...

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Biosensors - ISSN 2079-6374