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Open AccessReview
Natural Products as Hepatoprotective Agents—A Comprehensive Review of Clinical Trials
by
Piotr Służały
Piotr Służały 1
,
Paweł Paśko
Paweł Paśko 2
and
Agnieszka Galanty
Agnieszka Galanty 1,*
1
Department of Pharmacognosy, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland
2
Department of Food Chemistry and Nutrition, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland
*
Author to whom correspondence should be addressed.
Plants 2024, 13(14), 1985; https://doi.org/10.3390/plants13141985 (registering DOI)
Submission received: 17 June 2024
/
Revised: 18 July 2024
/
Accepted: 19 July 2024
/
Published: 20 July 2024
Abstract
The hepatoprotective effects of natural products have been a significant focus in recent decades due to the growing demand for the help in the treatment of hepatic impairments. This review specifically delves into the findings of clinical trials involving 13 selected natural products, namely plants and their derived compounds (e.g., artichoke, berberine, and turmeric), algae (e.g., spirulina), probiotics, and other products like phospholipids and vitamin D. A literature search was performed in the Scopus database, PubMed, and Google Scholar, covering all articles found up to June 2024. Artichoke, berberine, chlorella, chicory, green tea, probiotics, phospholipids, schisandra, silymarin, spirulina, and vitamin D caused a decrease in liver enzymes, while for cinnamon and turmeric such an effect was either not observed or not convincing. The presented results indicate that some natural products might satisfactorily improve hepatic outcomes in NAFLD, NASH, and other liver disorders; however, further studies and metanalyses are needed to clearly demonstrate their effectiveness.
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MDPI and ACS Style
Służały, P.; Paśko, P.; Galanty, A.
Natural Products as Hepatoprotective Agents—A Comprehensive Review of Clinical Trials. Plants 2024, 13, 1985.
https://doi.org/10.3390/plants13141985
AMA Style
Służały P, Paśko P, Galanty A.
Natural Products as Hepatoprotective Agents—A Comprehensive Review of Clinical Trials. Plants. 2024; 13(14):1985.
https://doi.org/10.3390/plants13141985
Chicago/Turabian Style
Służały, Piotr, Paweł Paśko, and Agnieszka Galanty.
2024. "Natural Products as Hepatoprotective Agents—A Comprehensive Review of Clinical Trials" Plants 13, no. 14: 1985.
https://doi.org/10.3390/plants13141985
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