Biology and Life Sciences Forum, Volume 7, Issue 1

During the search for new active compounds, at first, the focus is put mainly on the provision of compound activity towards considered targets. However, at the same time, or in the subsequent stages, the compound needs to be adequately profiled in te...

(1) Background: Various Machine Learning (ML) methods are applied for the prediction of individual efficiency of cancer treatment regimens. As features for ML, different multi-omics data may be used. We proposed a next-generation ML approach termed F...

Medium-chain triglycerides (MCT) have demonstrated a wide range of neuroprotective effects, although the mechanisms still remain poorly understood. Animal models are indispensable for such research. Metabolic effects of regular diet supplementation w...

Aberrant crypt foci (ACF) are early lesions in the neoplastic induction found in the rat colon of a carcinogenic model. ACF are one of the first changes in the colon that lead to colorectal cancer (CRC). Probiotics and fermented foods are well known...

Cutaneous melanoma (CM) is a public health issue and a significant challenge for scientists. At the dawn of the “omics era”, we witnessed groundbreaking advances in CM molecular stratification and therapeutic management assisted by genomi...

G-protein-coupled receptors (GPCR) belong to a large family of molecules eliciting different responses to a variety of signaling molecules. These receptors participate in various physiological functions such as metabolism, growth, immune responses, i...

There are numerous computational tools which support the design of new potential ligands. They assist in the evaluation of potential compound activity as well as in the optimization of compound physicochemical and pharmacokinetic properties. Nowadays...

The pharmacologic properties of gold compounds have been known since the end of the 19th century. In the last decade gold complexes have received increased attention due to the variety of their applications. Rhodopsin-like receptors are a family of p...

Objective. To study the effect of biopsychological age indicators on the likelihood and severity of COVID-19 disease in adults in 2020. We have examined 447 people aged 35–70 years using methods for assessing biological and psychological age in...

The metabolic syndrome is a cluster of conditions that occur together, increasing the risk of chronic diseases such as obesity, type II diabetes, or cardiovascular disease. Nutritional interventions improving inflammation, bioenergetics, and oxidativ...

Improvement of treatment outcomes in patients with locally advanced or metastatic urothelial carcinoma represents an important unmet need, since survival remains poor in patients who progress beyond first-line treatment. The purpose of this study was...

Polysaccharide-based carriers have become attractive materials for the delivery of therapeutics targeting the colon. Ferulated arabinoxylans (AX)—polysaccharides with gelling and antioxidant capacities that can be degraded by colonic microbiota...

Our Work focuses on the development of active molecular targeting utilizing novel conjugated specific targeting molecules that differentially target specific organ or diseased area with minimal distribution into normal organs in order to achieve opti...

Personalized cancer medicine holds promise for the future of cancer treatment. One of the keys to success is the knowledge of exact molecular alterations that drive tumorigenesis in a given patient, so that a suitable targeted therapy can be selected...

According to the World Health Organization, neuropsychiatric disorders pose an increasingly greater burden on health, society, and economy of countries. Currently, there are strategies to prevent some of these disorders, and there are treatments or m...

New sustainable ingredients with beneficial properties for health are a main goal for the food industry. In this regard, the cocoa shell (CS) and the coffee pulp (CP), by-products from the coffee and cocoa industry produced worldwide in large amounts...

2-Styrylchromones (2-SC) are a group of oxygen-containing heterocyclic compounds, which are characterized by the attachment of a styryl group to the C-2 position of their chromone core. Over the years, several biological activities have been attribut...

Antibody-drug conjugates (ADCs) are used in anticancer therapy with some limitations due to their molecular properties. An alternative to monoclonal antibodies is the affibody, composed of 58 amino acids, with lower binding affinities, small size, an...

Chronic pain changes brain connectivity, brainwaves, and volume, often resulting in disability, anxiety, and depression. Opioid pain relievers impair function, with risk of addiction. Music analgesia research suggests that music for long-term analges...

Photothermal therapy (PTT) is a novel therapy for cancer treatment which is based on the conversion of photon energy into heat (>43 °C), and photoacoustic imaging (PAI) is a new bioimaging method for diagnosing and monitoring cancer. To enhanc...

Colorectal cancer (CRC) is among the most commonly occurring cancers. The management of CRC includes laparoscopic surgery, radiotherapy, chemotherapies and neoadjuvant treatment. However, conventional chemotherapies have poor impact on combating CRC...

Introducing an innovative drug to the market requires not only large amounts of money, but also time. Therefore, the process of repositioning, i.e., finding new indications for drugs already in use, is becoming more and more frequent. In 2020, chloro...

Wound infection is a serious issue because of multi-drug resistance bacteria, thus developing an advanced therapy is a needed demand. Photothermal therapy (PTT) is a novel noninvasive strategy that utilizes PTT agents to convert near-infrared (NIR) l...

Some studies demonstrate that gallic acid (GA) and myricetin (MYR) isolated from Rhus trilobata provide the therapeutic activity of this plant against cancer. However, few reports demonstrate that both compounds could also have therapeutic potential...