Antioxidants as Adjuvants for Inflammatory Bowel Disease Treatment
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 10 February 2025 | Viewed by 607
Special Issue Editors
Interests: inflammatory bowel disease; muocsal immunology; inflammation; nutrition; polyphenols
Interests: biofortification; biotechnology; gut health; plant polyphenols; nutrition
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Inflammatory bowel disease (IBD), including Crohn disease (CD) and ulcerative colitis (UC), is a multifactorial disorder characterized by chronic inflammation and altered gut barrier function. IBD etiopathogenesis is still debated, with several possible triggers converging to similar pathological effects. During the last few decades, numerous discoveries have contributed to elucidating the role of the mucosal immune response, the importance of the gut barrier and the mucus layer integrity and the role of the intestinal microbiota. Despite this progress and the increasing number of pharmacological options, IBD patients still suffer from frequent disease relapse and an important percentage of patients do not respond to treatment, including biological drugs. Increased reactive oxygen species generation (oxidative stress) is a condition associated with IBD pathogenesis and disease relapse. Adjuvant therapies targeting oxidative stress remain limited, despite the numerous reports suggesting their potential beneficial effects in preclinical and clinical research.
The purpose of this Special Issue is to review the current state of the art regarding antioxidant development and clinical/pre-clinical translation in the context of inflammatory bowel disease onset, treatment and remission maintenance. Prevention of IBD-related complication, particularly colon rectal cancer, will also be taken into deep consideration.
Dr. Marcello Chieppa
Dr. Angelo Santino
Guest Editors
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Keywords
- IBD
- antioxidant
- gut barrier
- inflammation
- natural compounds
- microbiome
- colon cancer
- adjuvant
- nutritional bioactive products
- polyphenols
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