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Antioxidants
Special Issues
Recent Advances in Redox Biology Research in China
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Recent Advances in Redox Biology Research in China

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 5024

Special Issue Editors

Prof. Dr. Jiankang Liu

E-Mail Website
Guest Editor
1. School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao 266071, China
2. School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China
Interests: aging; age-related diseases; antioxidants; mitochondrial metabolism
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Canhua Huang

E-Mail Website
Guest Editor
1. School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
2. West China School of Basic Medical Sciences and Forensic Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital and Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China
Interests: redox regulation in tumorigenesis; the mechanism of virus-induced tumorigenesis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The 2023 China Redox Biology and Medicine Conference will take place in Xiamen (China) on 10–13 August 2023 (https://meeting.bsc.org.cn/SFRRC2023/). We are looking forward to seeing you at this event. This Special Issue will publish selected papers based on the new discoveries presented during the meeting, and will include insights and perspectives on:

  1. Redox status detection technology;
  2. The identification and discovery of endogenous redox molecules;
  3. The production and metabolism of redox molecules (endogenous redox homeostasis);
  4. The modification and function regulation of biomacromolecules;
  5. Redox regulation in cell fate and quality control;
  6. Redox regulation in aging and age-related diseases;
  7. Precision of redox interventions and translational applications.

We expect that this conference will present new and exciting developments in redox biology. The Scientific Committee cordially welcomes you, and we look forward to your contribution.

Prof. Dr. Jiankang Liu
Prof. Dr. Canhua Huang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • redox biology
  • free radicals
  • reactive oxygen species
  • aging
  • disease

Published Papers (4 papers)

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Review

29 pages, 2362 KiB  
Review
Targeting Metabolic–Redox Nexus to Regulate Drug Resistance: From Mechanism to Tumor Therapy
by Yuke Wang, Jingqiu He, Shan Lian, Yan Zeng, Sheng He, Jue Xu, Li Luo, Wenyong Yang and Jingwen Jiang
Antioxidants 2024, 13(7), 828; https://doi.org/10.3390/antiox13070828 - 10 Jul 2024
Viewed by 289
Abstract
Drug resistance is currently one of the biggest challenges in cancer treatment. With the deepening understanding of drug resistance, various mechanisms have been revealed, including metabolic reprogramming and alterations of redox balance. Notably, metabolic reprogramming mediates the survival of tumor cells in harsh [...] Read more.
Drug resistance is currently one of the biggest challenges in cancer treatment. With the deepening understanding of drug resistance, various mechanisms have been revealed, including metabolic reprogramming and alterations of redox balance. Notably, metabolic reprogramming mediates the survival of tumor cells in harsh environments, thereby promoting the development of drug resistance. In addition, the changes during metabolic pattern shift trigger reactive oxygen species (ROS) production, which in turn regulates cellular metabolism, DNA repair, cell death, and drug metabolism in direct or indirect ways to influence the sensitivity of tumors to therapies. Therefore, the intersection of metabolism and ROS profoundly affects tumor drug resistance, and clarifying the entangled mechanisms may be beneficial for developing drugs and treatment methods to thwart drug resistance. In this review, we will summarize the regulatory mechanism of redox and metabolism on tumor drug resistance and highlight recent therapeutic strategies targeting metabolic–redox circuits, including dietary interventions, novel chemosynthetic drugs, drug combination regimens, and novel drug delivery systems. Full article
(This article belongs to the Special Issue Recent Advances in Redox Biology Research in China)
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42 pages, 4469 KiB  
Review
Redox-Regulated Iron Metabolism and Ferroptosis in Ovarian Cancer: Molecular Insights and Therapeutic Opportunities
by Dan Liu, Zewen Hu, Jinzhi Lu and Cunjian Yi
Antioxidants 2024, 13(7), 791; https://doi.org/10.3390/antiox13070791 - 28 Jun 2024
Viewed by 313
Abstract
Ovarian cancer (OC), known for its lethality and resistance to chemotherapy, is closely associated with iron metabolism and ferroptosis—an iron-dependent cell death process, distinct from both autophagy and apoptosis. Emerging evidence suggests that dysregulation of iron metabolism could play a crucial role in [...] Read more.
Ovarian cancer (OC), known for its lethality and resistance to chemotherapy, is closely associated with iron metabolism and ferroptosis—an iron-dependent cell death process, distinct from both autophagy and apoptosis. Emerging evidence suggests that dysregulation of iron metabolism could play a crucial role in OC by inducing an imbalance in the redox system, which leads to ferroptosis, offering a novel therapeutic approach. This review examines how disruptions in iron metabolism, which affect redox balance, impact OC progression, focusing on its essential cellular functions and potential as a therapeutic target. It highlights the molecular interplay, including the role of non-coding RNAs (ncRNAs), between iron metabolism and ferroptosis, and explores their interactions with key immune cells such as macrophages and T cells, as well as inflammation within the tumor microenvironment. The review also discusses how glycolysis-related iron metabolism influences ferroptosis via reactive oxygen species. Targeting these pathways, especially through agents that modulate iron metabolism and ferroptosis, presents promising therapeutic prospects. The review emphasizes the need for deeper insights into iron metabolism and ferroptosis within the redox-regulated system to enhance OC therapy and advocates for continued research into these mechanisms as potential strategies to combat OC. Full article
(This article belongs to the Special Issue Recent Advances in Redox Biology Research in China)
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Graphical abstract

35 pages, 10592 KiB  
Review
The Cancer Antioxidant Regulation System in Therapeutic Resistance
by Xuanhao Gu, Chunyang Mu, Rujia Zheng, Zhe Zhang, Qi Zhang and Tingbo Liang
Antioxidants 2024, 13(7), 778; https://doi.org/10.3390/antiox13070778 - 27 Jun 2024
Viewed by 384
Abstract
Antioxidants play a pivotal role in neutralizing reactive oxygen species (ROS), which are known to induce oxidative stress. In the context of cancer development, cancer cells adeptly maintain elevated levels of both ROS and antioxidants through a process termed “redox reprogramming”. This balance [...] Read more.
Antioxidants play a pivotal role in neutralizing reactive oxygen species (ROS), which are known to induce oxidative stress. In the context of cancer development, cancer cells adeptly maintain elevated levels of both ROS and antioxidants through a process termed “redox reprogramming”. This balance optimizes the proliferative influence of ROS while simultaneously reducing the potential for ROS to cause damage to the cell. In some cases, the adapted antioxidant machinery can hamper the efficacy of treatments for neoplastic diseases, representing a significant facet of the resistance mechanisms observed in cancer therapy. In this review, we outline the contribution of antioxidant systems to therapeutic resistance. We detail the fundamental constituents of these systems, encompassing the central regulatory mechanisms involving transcription factors (of particular importance is the KEAP1/NRF2 signaling axis), the molecular effectors of antioxidants, and the auxiliary systems responsible for NADPH generation. Furthermore, we present recent clinical trials based on targeted antioxidant systems for the treatment of cancer, assessing the potential as well as challenges of this strategy in cancer therapy. Additionally, we summarize the pressing issues in the field, with the aim of illuminating a path toward the emergence of novel anticancer therapeutic approaches by orchestrating redox signaling. Full article
(This article belongs to the Special Issue Recent Advances in Redox Biology Research in China)
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Graphical abstract

18 pages, 1557 KiB  
Review
Hydrogen: A Rising Star in Gas Medicine as a Mitochondria-Targeting Nutrient via Activating Keap1-Nrf2 Antioxidant System
by Danyu Cheng, Jiangang Long, Lin Zhao and Jiankang Liu
Antioxidants 2023, 12(12), 2062; https://doi.org/10.3390/antiox12122062 - 30 Nov 2023
Cited by 3 | Viewed by 2981
Abstract
The gas molecules O2, NO, H2S, CO, and CH4, have been increasingly used for medical purposes. Other than these gas molecules, H2 is the smallest diatomic molecule in nature and has become a rising star in [...] Read more.
The gas molecules O2, NO, H2S, CO, and CH4, have been increasingly used for medical purposes. Other than these gas molecules, H2 is the smallest diatomic molecule in nature and has become a rising star in gas medicine in the past few decades. As a non-toxic and easily accessible gas, H2 has shown preventive and therapeutic effects on various diseases of the respiratory, cardiovascular, central nervous system, and other systems, but the mechanisms are still unclear and even controversial, especially the mechanism of H2 as a selective radical scavenger. Mitochondria are the main organelles regulating energy metabolism in living organisms as well as the main organelle of reactive oxygen species’ generation and targeting. We propose that the protective role of H2 may be mainly dependent on its unique ability to penetrate every aspect of cells to regulate mitochondrial homeostasis by activating the Keap1-Nrf2 phase II antioxidant system rather than its direct free radical scavenging activity. In this review, we summarize the protective effects and focus on the mechanism of H2 as a mitochondria-targeting nutrient by activating the Keap1-Nrf2 system in different disease models. In addition, we wish to provide a more rational theoretical support for the medical applications of hydrogen. Full article
(This article belongs to the Special Issue Recent Advances in Redox Biology Research in China)
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