Oxidative Stress and Nrf2 in Neuroprotection
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 5932
Special Issue Editors
Interests: neuroprotection; garlic; natural compounds; Nrf2 activation; cerebral ischemia; oxidative stress
Interests: Nrf2; keap1; protein-protein inhibitors; ischemic stroke; oxidative stress; neuroprotection
Interests: design, synthesis and biological evaluation of new neuroprotecting agents; theranostics; design, synthesis and evaluation of new drugs against parasitic diseases caused by protozoa, including chagas disease and leishmaniosis; new antitubercular agents; diversity-oriented synthesis for drug discovery; development of new synthetic methodologies for the exploration of chemical and biological space, with the aim of generating bioactive molecules; mechanochemistry
Interests: design, synthesis and biological evaluation of new neuroprotecting agents; theranostics; design, synthesis and evaluation of new drugs against parasitic diseases caused by protozoa, including chagas disease and leishmaniosis; new antitubercular agents; diversity-oriented synthesis for drug discovery; development of new synthetic methodologies for the exploration of chemical and biological space, with the aim of generating bioactive molecules; mechanochemistry
Interests: design, synthesis and biological evaluation of new neuroprotecting agents; theranostics; design, synthesis and evaluation of new drugs against parasitic diseases caused by protozoa, including chagas disease and leishmaniosis; new antitubercular agents; diversity-oriented synthesis for drug discovery; development of new synthetic methodologies for the exploration of chemical and biological space, with the aim of generating bioactive molecules; mechanochemistry
Special Issue Information
Dear Colleagues,
Neurological disorders contribute importantly to the global burden of disease and represent the leading causes of death and disability worldwide. Despite its high heterogeneity, these conditions share some mechanisms of cellular damage. Oxidative stress is an important and common mechanism involved in the pathophysiology of many neurological diseases, and its neutralization decreases brain tissue damage. The nuclear factor erythroid 2-related factor 2 (Nrf2) is recognized as the master regulator of the antioxidant response. Nrf2 modulates the expression of antioxidants and phase II enzymes maintaining cellular redox homeostasis. Additionally, it modulates the expression of genes involved in immune response, metabolism, cellular proliferation, cellular signaling, cell survival and cellular cycle, contributing to cellular homeostasis. Electrophile compounds and protein–protein interaction inhibitors are widely used as Nrf2 activators in preclinical models of neurological diseases, resulting in neuroprotection due to the decrease in oxidative stress. In this Special Issue, entitled “Oxidative Stress and Nrf2 in Neuroprotection”, original reports and reviews are welcome with the aim to elucidate the molecular mechanisms associated with Nrf2 activation and its implication in neuroprotection, as well as the proposition of new molecules with the ability of decreasing oxidative stress through the Nrf2 pathway in neurological disorders.
Dr. Perla Deyanira Maldonado
Dr. Silva-Islas Carlos Alfredo
Dr. José Carlos Menéndez
Dr. Mercedes Villacampa
Dr. Ángel Cores
Guest Editors
Manuscript Submission Information
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Keywords
- Nrf2 factor
- neuroprotection
- oxidative stress
- Nrf2 activators
- neurological diseases