Role of Reactive Oxygen Species (ROS) in Tumor Microenvironment Modulation
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: 30 April 2025 | Viewed by 34
Special Issue Editors
Interests: lncRNA-mediated transcriptional regulation; RNA–chromatin interactions; chromatin architecture; transcriptional and epigenetic regulation in cancer
Special Issues, Collections and Topics in MDPI journals
Interests: antioxidant activity; plant phenolics; exercise; functional foods; toxicology; redox nutrition; antioxidant administration
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Accumulating evidence indicates that the activation or suppression of specific genes leads to an alteration of reactive oxygen species (ROS) levels; this can act as a double-edged sword, mediating tumor suppressive or pro-oncogenic functions, depending on the specific biological context. Thus, a better understanding of the mechanisms that control such genes functions and the most appropriate context of their activation or suppression is a prerequisite for the development of effective therapeutic strategies.
This Special Issue focuses on how ROS levels influence the tumor microenvironment and cancer progression. In this respect, we welcome functional genomics studies that utilize spatial transcriptomics, single-cell sequencing and/or bulk deep sequencing to analyze gene expression changes in tumor-associated stromal cells in response to varying levels of ROS, identifying key signaling pathways, antitumor mechanisms, diagnostic/prognostic biomarkers and potential therapeutic targets for modulating oxidative stress in the tumor microenvironment.
Dr. Antonis Giakountis
Prof. Dr. Dimitrios Kouretas
Guest Editors
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Keywords
- reactive oxygen species
- tumor microenvironment
- stroma cells
- functional genomics
- spatial transcriptomics
- single-cell sequencing
- RNA-seq
- cancer
- diagnosis and prognosis
- biomarkers
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