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Antioxidants
Special Issues
Role of Oxidative Stress and Inflammation in Maternal-Perinatal Well-Being-2nd Edition
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Role of Oxidative Stress and Inflammation in Maternal-Perinatal Well-Being-2nd Edition

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (30 August 2024) | Viewed by 3374

Special Issue Editors

Dr. Miguel Ortega

E-Mail Website
Guest Editor
Department of Medicine and Medical Specialities, IRYCYS, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, Spain
Interests: vascular diseases; artery; venous disease; venous hypertension; heart; lymph; diabetes; immune system; translational medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Miguel A. Saez

E-Mail Website
Guest Editor
Pathological Anatomy Service, Central University Hospital of Defence-UAH Madrid, 28801 Alcala de Henares, Spain
Interests: placenta; histology; pathology
Special Issues, Collections and Topics in MDPI journals
Dr. Miguel Ángel Alvarez de Mon

E-Mail Website
Guest Editor
Department of Medicine and Medical Specialities, IRYCYS, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, Spain
Interests: personalized medicine; clinical medicine; new therapies; medical–patient relationship
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Prof. Dr. Coral Bravo

E-Mail Website
Guest Editor
1. Department of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain
2. Department of Obstetrics and Gynecology, University Hospital Gregorio Marañón, 28009 Madrid, Spain
3. Health Research Institute Gregorio Marañón, Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28009 Madrid, Spain
4. Maternal and Infant Research Investigation Unit, Alonso Family Foundation (UDIMIFFA), 28009 Madrid, Spain
Interests: pregnancy; maternal–perinatal well-being
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Julia Bujan

E-Mail Website
Guest Editor
Department of Medicine and Medical Specialities, IRYCYS, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, Spain
Interests: artery; histology; vascular medicine
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Juan Antonio De León-Luis

E-Mail Website
Guest Editor
1. Department of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain. 2. Department of Obstetrics and Gynecology, University Hospital Gregorio Marañón, 28009 Madrid, Spain. 3. Health Research Institute Gregorio Marañón, Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28009 Madrid, Spain. 4. Maternal and Infant Research Investigation Unit, Alonso Family Foundation (UDIMIFFA), 28009 Madrid, Spain.
Interests: pregnancy; maternal–perinatal well-being
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Natalio García-Honduvilla

E-Mail Website
Guest Editor
Department of Medicine and Medical Specialities, IRYCYS, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, Spain
Interests: tissue engineering; vascular medicine; targeted therapies; translational medicine
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Prof. Dr. Melchor Álvarez de Mon

E-Mail Website
Guest Editor
1. Department of Medicine and Medical Specialities, IRYCYS, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, Spain
2. Immune System Diseases-Rheumatology and Internal Medicine Service, University Hospital Príncipe de Asturias, (CIBEREHD), 28806 Alcala de Henares, Spain
Interests: immune system; systemic diseases; semiology; cytokines; translational medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Maternal–fetal well-being depends on the proper integration and function of many physiological events and tissue structures during and after pregnancy. The human placenta is a tissue structure that can be affected by many situations throughout pregnancy. In this sense, the human placenta’s multiple mechanisms for adapting to all the different situations that affect maternal–fetal well-being are notable. One of the processes that most significantly affects tissue structures is oxidative stress and inflammation. Therefore, the structures involved in maternal–fetal well-being must be studied in order to have a comprehensive view of the repercussions of the different pathologies and events that can modify maternal–fetal well-being.

Dr. Miguel Ortega
Dr. Miguel A. Saez
Dr. Miguel Ángel Alvarez de Mon
Prof. Dr. Coral Bravo
Prof. Dr. Julia Bujan
Prof. Dr. Juan Antonio De León-Luis
Prof. Dr. Natalio García-Honduvilla
Prof. Dr. Melchor Álvarez de Mon
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • maternal–fetal well-being
  • placenta
  • umbilical cord
  • oxidative stress
  • inflammation
  • immune system
  • psychoneuroendocrinology
  • psychological stress
  • complications in maternal–fetal well-being

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Published Papers (2 papers)

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Research

19 pages, 27780 KiB  
Article
Lysophosphatidylcholine Impairs the Mitochondria Homeostasis Leading to Trophoblast Dysfunction in Gestational Diabetes Mellitus
by Shao-Chi Hung, Te-Fu Chan, Hsiu-Chuan Chan, Chia-Ying Wu, Mei-Lin Chan, Jie-Yang Jhuang, Ji-Qin Tan, Jia-Bin Mei, Shi-Hui Law, Vinoth Kumar Ponnusamy, Hua-Chen Chan and Liang-Yin Ke
Antioxidants 2024, 13(8), 1007; https://doi.org/10.3390/antiox13081007 - 19 Aug 2024
Viewed by 1114
Abstract
Gestational diabetes mellitus (GDM) is a common pregnancy disorder associated with an increased risk of pre-eclampsia and macrosomia. Recent research has shown that the buildup of excess lipids within the placental trophoblast impairs mitochondrial function. However, the exact lipids that impact the placental [...] Read more.
Gestational diabetes mellitus (GDM) is a common pregnancy disorder associated with an increased risk of pre-eclampsia and macrosomia. Recent research has shown that the buildup of excess lipids within the placental trophoblast impairs mitochondrial function. However, the exact lipids that impact the placental trophoblast and the underlying mechanism remain unclear. GDM cases and healthy controls were recruited at Kaohsiung Medical University Hospital. The placenta and cord blood were taken during birth. Confocal and electron microscopy were utilized to examine the morphology of the placenta and mitochondria. We determined the lipid composition using liquid chromatography-mass spectrometry in data-independent analysis mode (LC/MSE). In vitro studies were carried out on choriocarcinoma cells (JEG3) to investigate the mechanism of trophoblast mitochondrial dysfunction. Results showed that the GDM placenta was distinguished by increased syncytial knots, chorangiosis, lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) overexpression, and mitochondrial dysfunction. Lysophosphatidylcholine (LPC) 16:0 was significantly elevated in the cord blood LDL of GDM patients. In vitro, we demonstrated that LPC dose-dependently disrupts mitochondrial function by increasing reactive oxygen species (ROS) levels and HIF-1α signaling. In conclusion, highly elevated LPC in cord blood plays a pivotal role in GDM, contributing to trophoblast impairment and pregnancy complications. Full article
(This article belongs to the Special Issue Role of Oxidative Stress and Inflammation in Maternal-Perinatal Well-Being-2nd Edition)
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17 pages, 5912 KiB  
Article
Oxidative Stress, Lipid Peroxidation and Ferroptosis Are Major Pathophysiological Signatures in the Placental Tissue of Women with Late-Onset Preeclampsia
by Miguel A. Ortega, Luis M. Garcia-Puente, Oscar Fraile-Martinez, Tatiana Pekarek, Cielo García-Montero, Julia Bujan, Leonel Pekarek, Silvestra Barrena-Blázquez, Raquel Gragera, Inmaculada C. Rodríguez-Rojo, Patrocinio Rodríguez-Benitez, Laura López-González, Raul Díaz-Pedrero, Melchor Álvarez-Mon, Natalio García-Honduvilla, Juan A. De León-Luis, Coral Bravo and Miguel A. Saez
Antioxidants 2024, 13(5), 591; https://doi.org/10.3390/antiox13050591 - 11 May 2024
Cited by 6 | Viewed by 1741
Abstract
Preeclampsia, a serious and potentially life-threatening medical complication occurring during pregnancy, is characterized by hypertension and often accompanied by proteinuria and multiorgan dysfunction. It is classified into two subtypes based on the timing of diagnosis: early-onset (EO-PE) and late-onset preeclampsia (LO-PE). Despite being [...] Read more.
Preeclampsia, a serious and potentially life-threatening medical complication occurring during pregnancy, is characterized by hypertension and often accompanied by proteinuria and multiorgan dysfunction. It is classified into two subtypes based on the timing of diagnosis: early-onset (EO-PE) and late-onset preeclampsia (LO-PE). Despite being less severe and exhibiting distinct pathophysiological characteristics, LO-PE is more prevalent than EO-PE, although both conditions have a significant impact on placental health. Previous research indicates that different pathophysiological events within the placenta may contribute to the development of preeclampsia across multiple pathways. In our experimental study, we investigated markers of oxidative stress, ferroptosis, and lipid peroxidation pathways in placental tissue samples obtained from women with LO-PE (n = 68) compared to healthy control pregnant women (HC, n = 43). Through a comprehensive analysis, we observed an upregulation of specific molecules associated with these pathways, including NADPH oxidase 1 (NOX-1), NADPH oxidase 2 (NOX-2), transferrin receptor protein 1 (TFRC), arachidonate 5-lipoxygenase (ALOX-5), acyl-CoA synthetase long-chain family member 4 (ACSL-4), glutathione peroxidase 4 (GPX4) and malondialdehyde (MDA) in women with LO-PE. Furthermore, increased ferric tissue deposition (Fe3+) was observed in placenta samples stained with Perls’ Prussian blue. The assessment involved gene and protein expression analyses conducted through RT-qPCR experiments and immunohistochemistry assays. Our findings underscore the heightened activation of inflammatory pathways in LO-PE compared to HC, highlighting the pathological mechanisms underlying this pregnancy disorder. Full article
(This article belongs to the Special Issue Role of Oxidative Stress and Inflammation in Maternal-Perinatal Well-Being-2nd Edition)
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