Straddling Physiology and Pathology: A Radical Control of Signal Transduction Pathways
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (15 December 2022) | Viewed by 6125
Special Issue Editors
Interests: cancer cell metabolism; redox alterations of cancer cells; mitochondria; apoptosis; tumor viruses; non-coding RNAs
2. Department of Biomedical Sciences, University of Padova, 35122 Padova, Italy
Interests: heart failure; cardiac function; metabolism; pharmacology; oxidative stress; reactive oxygen species; physiology; diabetes; antioxidants; antioxidant activity
Special Issue Information
Dear Colleagues,
The human body constantly gives rise to free radicals. They are standard products of processes involved in energy conservation (mitochondria) and other cell functions; for instance, in the defense against pathogenic mechanisms, modulation of signaling pathways, and cell differentiation and maturation. Moreover, it is now increasingly appreciated that a myriad of redox-based post-translational modifications have a substantial impact on protein structure and, thus, function. When kept at bay by antioxidant systems, both oxygen and nitrogen-free radicals (ROS and RNS, respectively) can modulate channels, transporters, and many other essential cell structures involved in many, if not all, cell processes. On the other hand, when their generation exceeds the cellular-scavenging capacity, both ROS and RNS cease to contribute to the organismal homeostasis and well-being, becoming a source of harm, the extent of which depends on many factors, including the intrinsic toxicity of the generated ROS or RNS species, the time of exposure to them, as well as the status of the local antioxidant weapons.
For the present Special Issue, we have invited expert investigators to share with the scientific community their new acquisitions on the role played by ROS and RNS in cell physiology and pathology.
Prof. Dr. Vincenzo Ciminale
Prof. Dr. Nazareno Paolocci
Guest Editors
Manuscript Submission Information
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