Regulatory Effects of Curcumin, 2nd Edition

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 20 September 2024 | Viewed by 1352

Special Issue Editors


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Guest Editor
Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
Interests: vitamin E; curcumin; signal transduction; gene expression; senescence
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Guest Editor
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 980-8577, Japan
Interests: food function; antioxidant; curcumin; lipid oxidation; oxidative stress
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Guest Editor
New Industry Creation Hatchery Center (NICHe), Tohoku University, Sendai 980-8579, Japan
Interests: curcumin; nanoparticles; redox regulation; surfactant; soft matter
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The first edition of the Special Issue "Regulatory Effects of Curcumin" has been assembled and has shown the ability of curcumin to affect multiple cellular pathways relevant for the prevention of disease in several organisms. At the molecular level, these effects can be explained by antioxidant, prooxidant, and non-antioxidant actions of curcumin and its metabolites, leading to changes in signaling and gene expression. At the cellular level, curcumin affects inflammation, lipid homeostasis, senescence, mitochondrial β-oxidation, the permeability of intestinal epithelial cell layers, and bacterial growth and biofilm formation, amongst other events. At the organism level, these regulatory effects are more difficult to achieve, and a myriad of nano-formulations are being developed with the increased solubility, stability, and bioavailability of curcumin. However, it turns out that nano-formulations do not equally facilitate the action of curcumin as they depend on the route of uptake, the chemical composition, and physical characteristics such as size and charge, and each application may require specific design and optimization.

In this second edition of the journal Antioxidants, we anticipate an expansion on these aforementioned topics and expect more studies assessing how diseases can be prevented by enhancing the bioavailability and bioactivity of curcumin and its metabolites.

Dr. Jean-Marc Zingg
Dr. Kiyotaka Nakagawa
Dr. Taiki Miyazawa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • curcumin
  • antioxidant
  • prooxidant
  • bioavailability
  • bioactivity

Published Papers (1 paper)

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22 pages, 2238 KiB  
Systematic Review
The Role of Curcumin in Oral Health and Diseases: A Systematic Review
by Francesco Inchingolo, Alessio Danilo Inchingolo, Giulia Latini, Irma Trilli, Laura Ferrante, Paola Nardelli, Giuseppina Malcangi, Angelo Michele Inchingolo, Antonio Mancini, Andrea Palermo and Gianna Dipalma
Antioxidants 2024, 13(6), 660; https://doi.org/10.3390/antiox13060660 - 28 May 2024
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Abstract
Curcumin (Curcumin) belongs to the polyphenol family. It is extracted by drying the root of a plant of Asian origin, belonging to the Zingiberaceae family. The best-known species is Curcumincuma Longa. Curcumin has been recognized as having great therapeutic powers since ancient [...] Read more.
Curcumin (Curcumin) belongs to the polyphenol family. It is extracted by drying the root of a plant of Asian origin, belonging to the Zingiberaceae family. The best-known species is Curcumincuma Longa. Curcumin has been recognized as having great therapeutic powers since ancient times. Studies on curcumin have since confirmed its powerful antioxidant properties, preventing both the formation of free radicals and their neutralization, having anti-inflammatory, antibacterial, immunological, and neuroprotective properties, as well as being a regulator of the intestinal microbiota with beneficial effects on the clinical manifestations of metabolic syndrome. Our study aimed to highlight how all these therapeutic aspects could benefit oral health, both preventing and improving the course of pathological processes. The effect of mouthwashes, and curcumin-based gels on the regulation of bacterial plaque and in the control of gingivitis, was largely comparable to that of using 0.20% chlorhexidine, with fewer side effects. Being a highly hydrophobic substance, it has a high permeability to cross the cell membrane. Bioavailability increases when combined with liposoluble substances (e.g., olive oil) and piperine, which improves absorption. Curcumin also has a negligible degree of toxicity, making it an excellent alternative to the use of gold standard products for oral disinfection. Full article
(This article belongs to the Special Issue Regulatory Effects of Curcumin, 2nd Edition)
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