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Antioxidants
Special Issues
Iron, Oxidative Stress, Skin Ageing and Disorders
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Iron, Oxidative Stress, Skin Ageing and Disorders

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (15 February 2022) | Viewed by 22211

Special Issue Editors

Prof. Dr. Charareh Pourzand

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Guest Editor
Department of Pharmacy and Pharmacology, Centre for Therapeutic Innovation, University of Bath, Claverton Down, Bath BA2 7AY, UK
Interests: skin photoprotection; skin ironome; iron chelation therapy; photodynamic therapy of skin disorders; oxidative stress; iron sensors
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Julia Li Zhong

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Guest Editor
National Innovation and Attracting Talents "111" Base, Key Laboratory of Biorheological Science and Technology of Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, China
Interests: skin photoaging; autophagy; dermatology; photobiology; photomedicine
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Mingxing Lei

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Guest Editor
National Innovation and Attracting Talents "111" Base, Key Laboratory of Biorheological Science and Technology of Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, China
Interests: skin organoid formation; stem cells; wound healing; dermatology; hair follicles; regenerative medicine.
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. XingHua Gao

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Guest Editor
Key Laboratory of Immunodermatology, Ministry of Health and Ministry of Education, National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Shenyang, Liaoning, China
Interests: hyperthermia; skin; psoriasis; vitiligo

Special Issue Information

Dear Colleagues,

Skin is constantly exposed to environmental oxidising agents, notably ultraviolet light, and is therefore the target of cumulative oxidative damage leading to photoageing and pathologies. Labile iron (LI) is potentially toxic to cells, as in the presence of reactive oxygen species (ROS) it can catalyse the formation of highly reactive oxygen-derived free radicals via Fenton chemistry, leading to oxidative stress and damage. Intracellular iron and redox homeostasis are tightly regulated to minimise LI and ROS levels, but during the process of ageing or under conditions of oxidative stress and pathologies, these regulations are severely compromised. The excess presence of LI and ROS has been observed in skin disorders such as psoriasis, venous ulceration, atopic eczema, vitiligo, and cancer. High levels of LI accumulation have also been recognised as a hallmark of ageing in the skin, promoting increased susceptibility to sunlight-mediated oxidative damage. This Special issue aims to (i) provide insights into novel mechanisms underlying iron- and ROS-mediated skin ageing/photoageing and disorders including wound healing; and (ii) critically review the recent trends in the use of natural, synthetic and/or bio-inspired antioxidants and iron chelators as medicaments for the topical therapy of skin disorders as well as anti-ageing/anti-photoageing ingredients for skin care and sunscreen formulations.

Prof. Dr. Charareh Pourzand
Prof. Dr. Julia Li Zhong
Prof. Dr. Mingxing Lei
Prof. Dr. XingHua Gao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • iron chelators
  • oxidative stress
  • skin ageing
  • antioxidants
  • skin diseases

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Published Papers (3 papers)

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Research

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14 pages, 2351 KiB  
Article
ALA_PDT Promotes Ferroptosis-Like Death of Mycobacterium abscessus and Antibiotic Sterilization via Oxidative Stress
by Xiaoyu Wang, Meiyin Wan, Lei Zhang, Yongdong Dai, Yang Hai, Chenda Yue, Junqi Xu, Yadan Ding, Mei Wang, Jianping Xie, Xia Lei and Julia-Li Zhong
Antioxidants 2022, 11(3), 546; https://doi.org/10.3390/antiox11030546 - 14 Mar 2022
Cited by 26 | Viewed by 3741
Abstract
Mycobacterium abscessus is one of the common clinical non-tuberculous mycobacteria (NTM) that can cause severe skin infection. 5-Aminolevulinic acid photodynamic therapy (ALA_PDT) is an emerging effective antimicrobial treatment. To explore whether ALA_PDT can be used to treat M. abscessus infections, we conducted a [...] Read more.
Mycobacterium abscessus is one of the common clinical non-tuberculous mycobacteria (NTM) that can cause severe skin infection. 5-Aminolevulinic acid photodynamic therapy (ALA_PDT) is an emerging effective antimicrobial treatment. To explore whether ALA_PDT can be used to treat M. abscessus infections, we conducted a series of experiments in vitro. We found that ALA_PDT can kill M. abscesses. Mechanistically, we found that ALA_PDT promoted ferroptosis-like death of M. abscesses, and the ROS scavenger N-Acetyl-L-cysteine (NAC) and ferroptosis inhibitor Ferrostatin-1 (Fer-1) can mitigate the ALA_PDT-mediated sterilization. Furthermore, ALA_PDT significantly up-regulated the transcription of heme oxygenase MAB_4773, increased the intracellular Fe2+ concentration and altered the transcription of M. abscessus iron metabolism genes. ALA_PDT disrupted the integrity of the cell membrane and enhanced the permeability of the cell membrane, as evidenced by the boosted sterilization effect of antibiotics. In summary, ALA_PDT can kill M. abscesses via promoting the ferroptosis-like death and antibiotic sterilization through oxidative stress by changing iron metabolism. The study provided new mechanistic insights into the clinical efficacy of ALA_PDT against M. abscessus. Full article
(This article belongs to the Special Issue Iron, Oxidative Stress, Skin Ageing and Disorders)
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14 pages, 2677 KiB  
Article
Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure
by Erika Pambianchi, Francesca Ferrara, Alessandra Pecorelli, Mascia Benedusi, Hina Choudhary, Jean-Philippe Therrien and Giuseppe Valacchi
Antioxidants 2021, 10(12), 1928; https://doi.org/10.3390/antiox10121928 - 30 Nov 2021
Cited by 12 | Viewed by 2889
Abstract
Skin is one of the main targets of the outdoor stressors. Considering that pollution levels are rising progressively, it is not surprising that several cutaneous conditions have been associated with its exposure. Among the pollutants, diesel engine exhaust (DEE) represents one of the [...] Read more.
Skin is one of the main targets of the outdoor stressors. Considering that pollution levels are rising progressively, it is not surprising that several cutaneous conditions have been associated with its exposure. Among the pollutants, diesel engine exhaust (DEE) represents one of the most toxic, as it is composed of a mixture of many different noxious chemicals generated during the compression cycle, for ignition rather than an electrical spark as in gasoline engines. The toxic chemicals of most concern in DEE, besides the oxides of nitrogen, sulfur dioxide and various hydrocarbons, are metals that can induce oxidative stress and inflammation. The present study aimed to evaluate the effects of topical application, singularly or in combination, of the iron-chelator deferoxamine and a commercially available formulation, CE Ferulic, in up to 4-day DEE-exposed skin. DEE induced a significant increase in the oxidative marker 4-hydroxy-nonenal (4HNE) and matrix-metallopeptidase-9 (MMP-9), the loss of cutaneous-barrier-associated proteins (filaggrin and involucrin) and a decrease in collagen-1, while the formulations prevented the cutaneous damage in an additive manner. In conclusion, this study suggests that iron plays a key role in DEE-induced skin damage and its chelation could be an adjuvant strategy to reinforce antioxidant topical formulations. Full article
(This article belongs to the Special Issue Iron, Oxidative Stress, Skin Ageing and Disorders)
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Review

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36 pages, 1893 KiB  
Review
Shedding a New Light on Skin Aging, Iron- and Redox-Homeostasis and Emerging Natural Antioxidants
by Charareh Pourzand, Andrea Albieri-Borges and Nico N. Raczek
Antioxidants 2022, 11(3), 471; https://doi.org/10.3390/antiox11030471 - 27 Feb 2022
Cited by 27 | Viewed by 14120
Abstract
Reactive oxygen species (ROS) are necessary for normal cell signaling and the antimicrobial defense of the skin. However excess production of ROS can disrupt the cellular redox balance and overwhelm the cellular antioxidant (AO) capacity, leading to oxidative stress. In the skin, oxidative [...] Read more.
Reactive oxygen species (ROS) are necessary for normal cell signaling and the antimicrobial defense of the skin. However excess production of ROS can disrupt the cellular redox balance and overwhelm the cellular antioxidant (AO) capacity, leading to oxidative stress. In the skin, oxidative stress plays a key role in driving both extrinsic and intrinsic aging. Sunlight exposure has also been a major contributor to extrinsic photoaging of the skin as its oxidising components disrupt both redox- and iron-homeostasis, promoting oxidative damage to skin cells and tissue constituents. Upon oxidative insults, the interplay between excess accumulation of ROS and redox-active labile iron (LI) and its detrimental consequences to the skin are often overlooked. In this review we have revisited the oxidative mechanisms underlying skin damage and aging by focussing on the concerted action of ROS and redox-active LI in the initiation and progression of intrinsic and extrinsic skin aging processes. Based on these, we propose to redefine the selection criteria for skin antiaging and photoprotective ingredients to include natural antioxidants (AOs) exhibiting robust redox–balancing and/or iron-chelating properties. This would promote the concept of natural-based or bio-inspired bifunctional anti-aging and photoprotective ingredients for skincare and sunscreen formulations with both AO and iron-chelating properties. Full article
(This article belongs to the Special Issue Iron, Oxidative Stress, Skin Ageing and Disorders)
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