Applications of Antioxidant Nanoparticles, 2nd Edition

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 20 November 2024 | Viewed by 2754

Special Issue Editors


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Guest Editor
Department of Chemical, Pharmaceutical and Agricultural Sciences (DoCPAS), University of Ferrara, I-44121 Ferrara, Italy
Interests: nanomedicine; lipid-based nanosystems; antioxidant molecules; drug delivery; microparticles; biomaterials
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Chemical, Pharmaceutical and Agricultural Sciences (DoCPAS), University of Ferrara, 44121 Ferrara, Italy
Interests: nanotechnology; topical administration; lipid-based delivery systems; vesicular nanosystems; hydrogels; semisolid formulations; encapsulation; physical chemistry; polymeric matrices
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Reactive oxygen species (ROS) play a crucial role in regulating various physiological functions. However, their excessive production is closely linked to the development of numerous diseases. The administration of antioxidants has emerged as an effective therapeutic strategy against oxidative stress. Additionally, in recent decades, the field of nanotechnology has witnessed significant advancements, and nanoparticles have found applications in a wide range of industries, such as pharmaceuticals, cosmetics, and food production. Notably, lipid nanoparticles have garnered considerable attention due to their environmentally friendly attributes, including biodegradability and non-toxicity, making them an ideal carrier for antioxidant molecules. These innovations have led to remarkable progress in the development of antioxidant nanotherapies, offering a multitude of advantages.

Considering the increased interest in this field, we are pleased to announce this new Special Issue, "Applications of Antioxidant Nanoparticles, 2nd Edition", a continuation of the fruitful first edition  (https://www.mdpi.com/journal/antioxidants/special_issues/antioxidant_nanoparticles).

In this edition too, we will continue our efforts to compile the latest breakthroughs in the design, production, characterization, and utilization of antioxidant nanoparticles in biomedical, pharmaceutical, cosmetic, and food sectors. Potential topics include, but not limited to, the following:

  • Polymeric and lipid-based nanoparticles;
  • Inorganic nanoparticles with ROS-scavenging properties;
  • Organic nanoparticles with intrinsic antioxidant capabilities;
  • Drug-loaded antioxidant nanoparticles suitable for various administration routes.

Dr. Rita Cortesi
Dr. Maddalena Sguizzato
Guest Editors

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Published Papers (3 papers)

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Research

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30 pages, 10529 KiB  
Article
Antioxidant, Antitumoral, Antimicrobial, and Prebiotic Activity of Magnetite Nanoparticles Loaded with Bee Pollen/Bee Bread Extracts and 5-Fluorouracil
by Cornelia-Ioana Ilie, Angela Spoiala, Cristina Chircov, Georgiana Dolete, Ovidiu-Cristian Oprea, Bogdan-Stefan Vasile, Simona Adriana Crainiceanu, Adrian-Ionut Nicoara, Ioana Cristina Marinas, Miruna Silvia Stan, Lia-Mara Ditu, Anton Ficai and Eliza Oprea
Antioxidants 2024, 13(8), 895; https://doi.org/10.3390/antiox13080895 - 24 Jul 2024
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Abstract
The gut microbiota dysbiosis that often occurs in cancer therapy requires more efficient treatment options to be developed. In this concern, the present research approach is to develop drug delivery systems based on magnetite nanoparticles (MNPs) as nanocarriers for bioactive compounds. First, MNPs [...] Read more.
The gut microbiota dysbiosis that often occurs in cancer therapy requires more efficient treatment options to be developed. In this concern, the present research approach is to develop drug delivery systems based on magnetite nanoparticles (MNPs) as nanocarriers for bioactive compounds. First, MNPs were synthesized through the spraying-assisted coprecipitation method, followed by loading bee pollen or bee bread extracts and an antitumoral drug (5-fluorouracil/5-FU). The loaded-MNPs were morphologically and structurally characterized through transmission electron microscopy (TEM), selected area electron diffraction (SAED), scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Dynamic Light Scattering (DLS), and thermogravimetric analysis. UV-Vis spectroscopy was applied to establish the release profiles and antioxidant activity. Furthermore, the antibacterial and antitumoral activity of loaded-MNPs was assessed. The results demonstrate that MNPs with antioxidant, antibacterial, antiproliferative, and prebiotic properties are obtained. Moreover, the data highlight the improvement of 5-FU antibacterial activity by loading on the MNPs’ surface and the synergistic effects between the anticancer drug and phenolic compounds (PCs). In addition, the prolonged release behavior of PCs for many hours (70–75 h) after the release of 5-FU from the developed nanocarriers is an advantage, at least from the point of view of the antioxidant activity of PCs. Considering the enhancement of L. rhamnosus MF9 growth and antitumoral activity, this study developed promising drug delivery alternatives for colorectal cancer therapy. Full article
(This article belongs to the Special Issue Applications of Antioxidant Nanoparticles, 2nd Edition)
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16 pages, 8569 KiB  
Article
Rod-Shaped Mesoporous Zinc-Containing Bioactive Glass Nanoparticles: Structural, Physico-Chemical, Antioxidant, and Immuno-Regulation Properties
by Xiuan Zhu, Wenjie Wen, Jingjing Yan, Yuran Wang, Rumeng Wang, Xiang Ma, Dandan Ren, Kai Zheng, Chao Deng and Jue Zhang
Antioxidants 2024, 13(7), 875; https://doi.org/10.3390/antiox13070875 - 21 Jul 2024
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Abstract
Bioactive glass nanoparticles (BGNs) are applied widely in tissue regeneration. Varied micro/nanostructures and components of BGNs have been designed for different applications. In the present study, nanorod-shaped mesoporous zinc-containing bioactive glass nanoparticles (ZnRBGNs) were designed and developed to form the bioactive content of [...] Read more.
Bioactive glass nanoparticles (BGNs) are applied widely in tissue regeneration. Varied micro/nanostructures and components of BGNs have been designed for different applications. In the present study, nanorod-shaped mesoporous zinc-containing bioactive glass nanoparticles (ZnRBGNs) were designed and developed to form the bioactive content of composite materials for hard/soft tissue repair and regeneration. The nanostructure and components of the ZnRBGNs were characterized, as were their cytocompatibility and radical-scavenging activity in the presence/absence of cells and their ability to modulate macrophage polarization. The ZnRBGNs possessed a uniform rod shape (length ≈ 500 nm; width ≈ 150 nm) with a mesoporous structure (diameter ≈ 2.4 nm). The leaching liquid of the nanorods at a concentration below 0.5 mg/mL resulted in no cytotoxicity. More significant improvements in the antioxidant and M1-polarization-inhibiting effects and the promotion of M2 polarization were found when culturing the cells with the ZnRBGNs compared to when culturing them with the RBGNs. The doping of the Zn element in RBGNs may lead to improved antioxidant and anti-inflammatory effects, which may be beneficial in tissue regeneration/repair. Full article
(This article belongs to the Special Issue Applications of Antioxidant Nanoparticles, 2nd Edition)
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28 pages, 2293 KiB  
Review
Nanotechnological Approaches to Enhance the Potential of α-Lipoic Acid for Application in the Clinic
by Chiara Bellini, Fabrizio Mancin, Emanuele Papini and Regina Tavano
Antioxidants 2024, 13(6), 706; https://doi.org/10.3390/antiox13060706 - 9 Jun 2024
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Abstract
α-lipoic acid is a naturally occurring compound with potent antioxidant properties that helps protect cells and tissues from oxidative stress. Its incorporation into nanoplatforms can affect factors like bioavailability, stability, reactivity, and targeted delivery. Nanoformulations of α-lipoic acid can significantly enhance its solubility [...] Read more.
α-lipoic acid is a naturally occurring compound with potent antioxidant properties that helps protect cells and tissues from oxidative stress. Its incorporation into nanoplatforms can affect factors like bioavailability, stability, reactivity, and targeted delivery. Nanoformulations of α-lipoic acid can significantly enhance its solubility and absorption, making it more bioavailable. While α-lipoic acid can be prone to degradation in its free form, encapsulation within nanoparticles ensures its stability over time, and its release in a controlled and sustained manner to the targeted tissues and cells. In addition, α-lipoic acid can be combined with other compounds, such as other antioxidants, drugs, or nanomaterials, to create synergistic effects that enhance their overall therapeutic benefits or hinder their potential cytotoxicity. This review outlines the advantages and drawbacks associated with the use of α-lipoic acid, as well as various nanotechnological approaches employed to enhance its therapeutic effectiveness, whether alone or in combination with other bioactive agents. Furthermore, it describes the engineering of α-lipoic acid to produce poly(α-lipoic acid) nanoparticles, which hold promise as an effective drug delivery system. Full article
(This article belongs to the Special Issue Applications of Antioxidant Nanoparticles, 2nd Edition)
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