The Role of Oxidative Stress in Viral Infections
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (20 January 2023) | Viewed by 6110
Special Issue Editor
Interests: development of methods for detection quantification and genotyping of microorganisms of clinical interest for diagnostic purposes and study on the role of oxidative stress in various biological processes, especially in viral infections
Special Issue Information
Dear Colleagues:
The production of reactive oxygen species (ROS) occurs under normal physiological conditions and plays beneficial roles in important signaling pathways required for essential cellular functions. Nevertheless, a redox imbalance is produced when systemic levels of ROS overwhelm the cellular antioxidant capacity, causing oxidative stress. This stress can be triggered by several situations, including viral infections, and causes the alteration of certain cellular mechanisms, such as the activation of endoplasmic reticulum stress and the triggering of the unfolded protein response, as well as the modulation of autophagy and/or apoptosis. These viral-induced responses facilitate viral replication and proliferation, enhancing viral pathogenesis. On the other hand, the innate immune system responds to viral infection by activating macrophage and dendritic cells, which contribute to inflammation. Oxidative stress and inflammation are closely related pathophysiological processes, one of which can be induced by another. Control of the immune-regulatory events is crucial in order to develop a protective immune response and to avoid the triggering of an exacerbated inflammatory response. The study of these oxidative and/or inflammatory pathways is essential in order to understand the cellular mechanisms involved in viral infection and open the possibility of developing drugs that block some of the described processes. In fact, several antioxidants (e.g., melatonin; vitamins A, C, and D; resveratrol) have been proposed as candidates to be part of the arsenal to treat—or at least attenuate—symptoms and sequelae caused by different viral infections.
Contributions to this Special Issue may cover all research aspects related to the implications of oxidative stress in viral pathogenesis and the therapeutic potential of antioxidants.
Dr. José Antonio Boga
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- viral infection
- oxidative stress
- inflammation
- endoplasmic reticulum stress
- unfolded protein response
- autophagy
- apoptosis
- antioxidants
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
