The Role of Oxidative Stress in Viral Infections
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (20 January 2023) | Viewed by 6110
Special Issue Editor
Interests: development of methods for detection quantification and genotyping of microorganisms of clinical interest for diagnostic purposes and study on the role of oxidative stress in various biological processes, especially in viral infections
Special Issue Information
Dear Colleagues:
The production of reactive oxygen species (ROS) occurs under normal physiological conditions and plays beneficial roles in important signaling pathways required for essential cellular functions. Nevertheless, a redox imbalance is produced when systemic levels of ROS overwhelm the cellular antioxidant capacity, causing oxidative stress. This stress can be triggered by several situations, including viral infections, and causes the alteration of certain cellular mechanisms, such as the activation of endoplasmic reticulum stress and the triggering of the unfolded protein response, as well as the modulation of autophagy and/or apoptosis. These viral-induced responses facilitate viral replication and proliferation, enhancing viral pathogenesis. On the other hand, the innate immune system responds to viral infection by activating macrophage and dendritic cells, which contribute to inflammation. Oxidative stress and inflammation are closely related pathophysiological processes, one of which can be induced by another. Control of the immune-regulatory events is crucial in order to develop a protective immune response and to avoid the triggering of an exacerbated inflammatory response. The study of these oxidative and/or inflammatory pathways is essential in order to understand the cellular mechanisms involved in viral infection and open the possibility of developing drugs that block some of the described processes. In fact, several antioxidants (e.g., melatonin; vitamins A, C, and D; resveratrol) have been proposed as candidates to be part of the arsenal to treat—or at least attenuate—symptoms and sequelae caused by different viral infections.
Contributions to this Special Issue may cover all research aspects related to the implications of oxidative stress in viral pathogenesis and the therapeutic potential of antioxidants.
Dr. José Antonio Boga
Guest Editor
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Keywords
- viral infection
- oxidative stress
- inflammation
- endoplasmic reticulum stress
- unfolded protein response
- autophagy
- apoptosis
- antioxidants
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