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Nanoscale Materials for Drug Delivery and Tissue Engineering

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Materials Science and Engineering".

Deadline for manuscript submissions: closed (31 May 2020) | Viewed by 102262

Special Issue Editor


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Guest Editor
Department of Chemistry, Fordham University, Bronx, NY 10458, USA
Interests: tissue engineering; biomaterials; scaffolds; drug delivery; tumor cell targeting

Special Issue Information

Dear Colleagues,

Nanoscale materials have revolutionized medicine and treatment methodologies over the past decade. A wide range of nanoscale materials such as carbon nanotubes, peptide nanostructures, liposomes and polymers, to name a few, have been developed. In particular, hybrids containing quantum dots or gold nanoparticles alongside soft materials have allowed for the development of theranostic nanomaterials for simultaneous diagnostic and therapeutic activity. Nanomaterials have been engineered specifically to target malfunctioning cells so that drugs can be released upon stimulus only to those cells, thus potentially lowering the side effects often found in systemic treatment. Research is underway to develop nanomaterials as vaccines to target viruses. Furthermore, researchers are investigating the development of nanoparticle formulations to develop drugs in pill form.

In the realm of tissue engineering, nano and microscale biomaterials are also gaining prominence. Engineered biomaterials that can mimic the extracellular matrix of cells are being developed for bone, cartilage, cardiac, ophthalmic, neural and skin tissue engineering. These scaffold materials can be prepared with precise architectures that promote cell adhesion, proliferation, transmit cell–cell signaling in an accurate manner and promote tissue growth. By understanding how nanoscale biomaterial scaffolds interact with cells and assemble into specific tissues, researchers can construct biomaterials that mimic these processes to repair damaged tissues or develop new tissues for implants.

This Special Issue, "Nanoscale Biomaterials for Drug Delivery and Tissue Engineering" of Applied Sciences will focus on recent advances in the field and the current cutting-edge research ongoing in nanomedicine, particularly with respect to the development of new nano- and microscale biomaterials for tissue regeneration and targeted drug delivery.

Prof. Ipsita Banerjee
Guest Editor

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Keywords

  • nanomedicine
  • drug delivery
  • tissue engineering
  • nanoscale
  • peptides
  • carbon nanotubes
  • growth factors
  • tumor cells

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Published Papers (9 papers)

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Research

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13 pages, 5609 KiB  
Article
A Biomimetic Drug Delivery System Targeting Tumor Hypoxia in Triple-Negative Breast Cancers
by Katyayani Tatiparti, Mohd Ahmar Rauf, Samaresh Sau and Arun K. Iyer
Appl. Sci. 2020, 10(3), 1075; https://doi.org/10.3390/app10031075 - 5 Feb 2020
Cited by 5 | Viewed by 3167
Abstract
Triple-negative breast cancer (TNBC) is amongst the most challenging tumor subtypes because it presents itself without the estrogen, progesterone, and HER2 receptors. Hence, assessing new markers is an essential requirement for enhancing its targeted treatment. The survival of TNBC relies upon the advancement [...] Read more.
Triple-negative breast cancer (TNBC) is amongst the most challenging tumor subtypes because it presents itself without the estrogen, progesterone, and HER2 receptors. Hence, assessing new markers is an essential requirement for enhancing its targeted treatment. The survival of TNBC relies upon the advancement of hypoxia that contributes to treatment resistance, immune response resistance, and tumor stroma arrangement. Here, we explored bovine serum albumin (BSA) nanoparticle encapsulating the anti-cancer drug Paclitaxel (PTX) for cell-killing mediated by tumor hypoxia. For targeting hypoxia, we conjugated Acetazolamide (ATZ) with BSA nanoparticle that encapsulated PTX (referred hereon as BSA-PTX-ATZ) utilizing copper-free click chemistry, specifically the Strain-Promoted Alkyne Azide Cycloaddition (SPAAC). The in-vitro cell killing study uncovered that BSA-PTX-ATZ is more productive contrasted with free PTX. The evaluations of the physio-chemical properties of BSA-PTX-ATZ proves that the shelf-life is approximately two months when stored either at room or freezing temperatures or under refrigerated conditions. There is no leakage of PTX from the formulation during that period, while their nanoparticulate nature remained undisturbed. The BSA-PTX-ATZ nanoparticles indicated altogether higher cell killing in hypoxic conditions contrasted with normoxia proposing the hypoxia-mediated delivery mechanism of the activity of the formulation. Higher cell uptake found with fluorescent-marked BSA-PTX-ATZ shows CA-IX mediated cell uptake, substantiated by the prominent apoptotic cell death contrasted with free PTX. Full article
(This article belongs to the Special Issue Nanoscale Materials for Drug Delivery and Tissue Engineering)
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12 pages, 3655 KiB  
Article
Effect of Plasma Treatment of Titanium Surface on Biocompatibility
by Daiga Ujino, Hiroshi Nishizaki, Shizuo Higuchi, Satoshi Komasa and Joji Okazaki
Appl. Sci. 2019, 9(11), 2257; https://doi.org/10.3390/app9112257 - 31 May 2019
Cited by 28 | Viewed by 4239
Abstract
It was recently reported that implant osseointegration is affected by surface wettability. The relationship between hydrophilicity and cell adhesion was corroborated by numerous in vivo studies. Concentrated alkali improves the biocompatibility of pure titanium. Research was conducted on the mechanism by which this [...] Read more.
It was recently reported that implant osseointegration is affected by surface wettability. The relationship between hydrophilicity and cell adhesion was corroborated by numerous in vivo studies. Concentrated alkali improves the biocompatibility of pure titanium. Research was conducted on the mechanism by which this treatment increases hydrophilicity. In the present study, we used atmospheric pressure plasma processing to enhance the hydrophilicity of the material surface. The aim was to assess its influences on the initial adhesion of the material to rat bone marrow and subsequent differentiation into hard tissue. Superhydrophilicity was induced on a pure titanium surface with a piezobrush, a simple, compact alternative to the conventional atmospheric pressure plasma device. No structural change was confirmed by Scanning electron microscope (SEM) or scanning probe microscopy (SPM) observation. X-ray photoelectron spectroscopy (XPS) analysis presented with hydroxide formation and a reduction in the C peak. A decrease in contact angle was also observed. The treated samples had higher values for in vitro bovine serum albumin (BSA) adsorption, rat bone marrow (RBM) cell initial adhesion, alkaline phosphatase activity (ALP) activity tests, and factors related to bone differentiation than the untreated control. The present study indicated that the induction of superhydrophilicity in titanium via atmospheric pressure plasma treatment with a piezobrush affects RBM cell adhesion and bone differentiation without altering surface properties. Full article
(This article belongs to the Special Issue Nanoscale Materials for Drug Delivery and Tissue Engineering)
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15 pages, 2823 KiB  
Article
Differences among Unique Nanoparticle Protein Corona Constructs: A Case Study Using Data Analytics and Multi-Variant Visualization to Describe Physicochemical Characteristics
by Madison Stewart, Marina R. Mulenos, London R. Steele and Christie M. Sayes
Appl. Sci. 2018, 8(12), 2669; https://doi.org/10.3390/app8122669 - 18 Dec 2018
Cited by 14 | Viewed by 5278
Abstract
Gold nanoparticles (AuNPs) used in pharmaceutical treatments have been shown to effectively deliver a payload, such as an active pharmaceutical ingredient or image contrast agent, to targeted tissues in need of therapy or diagnostics while minimizing exposure, availability, and accumulation to surrounding biological [...] Read more.
Gold nanoparticles (AuNPs) used in pharmaceutical treatments have been shown to effectively deliver a payload, such as an active pharmaceutical ingredient or image contrast agent, to targeted tissues in need of therapy or diagnostics while minimizing exposure, availability, and accumulation to surrounding biological compartments. Data sets collected in this field of study include some toxico- and pharmacodynamic properties (e.g., distribution and metabolism) but many studies lack information about adsorption of biological molecules or absorption into cells. When nanoparticles are suspended in blood serum, a protein corona cloud forms around its surface. The extent of the applications and implications of this formed cloud are unknown. Some researchers have speculated that the successful use of nanoparticles in pharmaceutical treatments relies on a comprehensive understanding of the protein corona composition. The work presented in this paper uses a suite of data analytics and multi-variant visualization techniques to elucidate particle-to-protein interactions at the molecular level. Through mass spectrometry analyses, corona proteins were identified through large and complex datasets. With such high-output analyses, complex datasets pose a challenge when visualizing and communicating nanoparticle-protein interactions. Thus, the creation of a streamlined visualization method is necessary. A series of user-friendly data informatics techniques were used to demonstrate the data flow of protein corona characteristics. Multi-variant heat maps, pie charts, tables, and three-dimensional regression analyses were used to improve results interpretation, facilitate an iterative data transfer process, and emphasize features of the nanoparticle-protein corona system that might be controllable. Data informatics successfully highlights the differences between protein corona compositions and how they relate to nanoparticle surface charge. Full article
(This article belongs to the Special Issue Nanoscale Materials for Drug Delivery and Tissue Engineering)
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Review

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18 pages, 3348 KiB  
Review
Application of Nanotechnology in Stem-Cell-Based Therapy of Neurodegenerative Diseases
by Shima Masoudi Asil, Jyoti Ahlawat, Gileydis Guillama Barroso and Mahesh Narayan
Appl. Sci. 2020, 10(14), 4852; https://doi.org/10.3390/app10144852 - 15 Jul 2020
Cited by 16 | Viewed by 5779
Abstract
In addition to adverse health outcomes, neurological disorders have serious societal and economic impacts on patients, their family and society as a whole. There is no definite treatment for these disorders, and current available drugs only slow down the progression of the disease. [...] Read more.
In addition to adverse health outcomes, neurological disorders have serious societal and economic impacts on patients, their family and society as a whole. There is no definite treatment for these disorders, and current available drugs only slow down the progression of the disease. In recent years, application of stem cells has been widely advanced due to their potential of self-renewal and differentiation to different cell types which make them suitable candidates for cell therapy. In particular, this approach offers great opportunities for the treatment of neurodegenerative disorders. However, some major issues related to stem-cell therapy, including their tumorigenicity, viability, safety, metastases, uncontrolled differentiation and possible immune response have limited their application in clinical scales. To address these challenges, a combination of stem-cell therapy with nanotechnology can be a solution. Nanotechnology has the potential of improvement of stem-cell therapy by providing ideal substrates for large scale proliferation of stem cells. Application of nanomaterial in stem-cell culture will be also beneficial to modulation of stem-cell differentiation using nanomedicines. Nanodelivery of functional compounds can enhance the efficiency of neuron therapy by stem cells and development of nanobased techniques for real-time, accurate and long-lasting imaging of stem-cell cycle processes. However, these novel techniques need to be investigated to optimize their efficiency in treatment of neurologic diseases. Full article
(This article belongs to the Special Issue Nanoscale Materials for Drug Delivery and Tissue Engineering)
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21 pages, 2153 KiB  
Review
Gold Nanoparticles for Drug Delivery and Cancer Therapy
by Sarkar Siddique and James C. L. Chow
Appl. Sci. 2020, 10(11), 3824; https://doi.org/10.3390/app10113824 - 31 May 2020
Cited by 250 | Viewed by 25940
Abstract
Nanomaterials are popularly used in drug delivery, disease diagnosis and therapy. Among a number of functionalized nanomaterials such as carbon nanotubes, peptide nanostructures, liposomes and polymers, gold nanoparticles (Au NPs) make excellent drug and anticancer agent carriers in biomedical and cancer therapy application. [...] Read more.
Nanomaterials are popularly used in drug delivery, disease diagnosis and therapy. Among a number of functionalized nanomaterials such as carbon nanotubes, peptide nanostructures, liposomes and polymers, gold nanoparticles (Au NPs) make excellent drug and anticancer agent carriers in biomedical and cancer therapy application. Recent advances of synthetic technique improved the surface coating of Au NPs with accurate control of particle size, shape and surface chemistry. These make the gold nanomaterials a much easier and safer cancer agent and drug to be applied to the patient’s tumor. Although many studies on Au NPs have been published, more results are in the pipeline due to the rapid development of nanotechnology. The purpose of this review is to assess how the novel nanomaterials fabricated by Au NPs can impact biomedical applications such as drug delivery and cancer therapy. Moreover, this review explores the viability, property and cytotoxicity of various Au NPs. Full article
(This article belongs to the Special Issue Nanoscale Materials for Drug Delivery and Tissue Engineering)
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24 pages, 6103 KiB  
Review
Therapeutic Potential of Polymer-Coated Mesoporous Silica Nanoparticles
by Kuldeep K. Bansal, Deepak K. Mishra, Ari Rosling and Jessica M. Rosenholm
Appl. Sci. 2020, 10(1), 289; https://doi.org/10.3390/app10010289 - 31 Dec 2019
Cited by 26 | Viewed by 9232
Abstract
Mesoporous silica nanoparticles (MSNs) find tremendous applications in drug delivery due to several advantages such as their easy fabrication process, high drug loading, biodegradability, biocompatibility, and so forth. Nevertheless, despite several advantages, the use of this striking drug delivery carrier is restricted due [...] Read more.
Mesoporous silica nanoparticles (MSNs) find tremendous applications in drug delivery due to several advantages such as their easy fabrication process, high drug loading, biodegradability, biocompatibility, and so forth. Nevertheless, despite several advantages, the use of this striking drug delivery carrier is restricted due to premature drug release owing to the porous structure. Coating of the pores using polymers has emerged as a great solution to this problem. Polymer coatings, which act as gatekeepers, avoid the premature release of loaded content from MSNs and offers the opportunity for controlled and targeted drug delivery. Therefore, in this review, we have compiled the polymer-based coating approaches used in recent years for improving the drug delivery capability of MSNs. This manuscript provides an insight into the research about the potential of polymer-coated MSNs, allowing the selection of right polymer for coating purposes according to the desired application. Full article
(This article belongs to the Special Issue Nanoscale Materials for Drug Delivery and Tissue Engineering)
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31 pages, 1813 KiB  
Review
Tablet Scoring: Current Practice, Fundamentals, and Knowledge Gaps
by Emmanuel Reginald Jacques and Paschalis Alexandridis
Appl. Sci. 2019, 9(15), 3066; https://doi.org/10.3390/app9153066 - 29 Jul 2019
Cited by 22 | Viewed by 36981
Abstract
Oral solid dosage formulations and/or tablets have remained the preferred route of administration by both patients and health care practitioners. Oral tablets are easy to administer, they are non-invasive and cause less risk adversity. Because of the lack of commercially available tablet dose [...] Read more.
Oral solid dosage formulations and/or tablets have remained the preferred route of administration by both patients and health care practitioners. Oral tablets are easy to administer, they are non-invasive and cause less risk adversity. Because of the lack of commercially available tablet dose options, tablets are being split or partitioned by users. Tablet scoring refers to the breakage of a tablet to attain a desired efficacy dose and is an emerging concept in the pharmaceutical industry. The primary reason for the tablet scoring practice is to adjust the dose: dose tapering or dose titrating. Other reasons for tablet partitioning are to facilitate dose administration, particularly among the pediatric and the geriatric patient population, and to mitigating the high cost of prescription drugs. The scope of this review is to: (1) evaluate the advantages and inconveniences associated with tablet scoring/portioning, and (2) identify factors in the formulation and the manufacturing of tablets that influence tablet splitting. Whereas tablet partitioning has been a common practice, there is a lack of understanding regarding the fundamentals underpinning the performance of tablets with respect to splitting. Several factors can influence tablet partitioning: tablet size, shape, and thickness. A requirement has recently been set by the European Pharmacopoeia and the U.S. Food and Drug Administration for the uniformity of mass of subdivided tablets. For breaking ease, an in-vivo reference test and a routinely applicable in-vitro test need to be established. Full article
(This article belongs to the Special Issue Nanoscale Materials for Drug Delivery and Tissue Engineering)
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27 pages, 998 KiB  
Review
Chitosan-Based Nanocarriers for Nose to Brain Delivery
by Blessing Atim Aderibigbe and Tobeka Naki
Appl. Sci. 2019, 9(11), 2219; https://doi.org/10.3390/app9112219 - 30 May 2019
Cited by 65 | Viewed by 6880
Abstract
In the treatment of brain diseases, most potent drugs that have been developed exhibit poor therapeutic outcomes resulting from the inability of a therapeutic amount of the drug to reach the brain. These drugs do not exhibit targeted drug delivery mechanisms, resulting in [...] Read more.
In the treatment of brain diseases, most potent drugs that have been developed exhibit poor therapeutic outcomes resulting from the inability of a therapeutic amount of the drug to reach the brain. These drugs do not exhibit targeted drug delivery mechanisms, resulting in a high concentration of the drugs in vital organs leading to drug toxicity. Chitosan (CS) is a natural-based polymer. It has unique properties such as good biodegradability, biocompatibility, mucoadhesive properties, and it has been approved for biomedical applications. It has been used to develop nanocarriers for brain targeting via intranasal administration. Nanocarriers such as nanoparticles, in situ gels, nanoemulsions, and liposomes have been developed. In vitro and in vivo studies revealed that these nanocarriers exhibited enhanced drug uptake to the brain with reduced side effects resulting from the prolonged contact time of the nanocarriers with the nasal mucosa, the surface charge of the nanocarriers, the nano size of the nanocarriers, and their capability to stretch the tight junctions within the nasal mucosa. The aforementioned unique properties make chitosan a potential material for the development of nanocarriers for targeted drug delivery to the brain. This review will focus on chitosan-based carriers for brain targeting. Full article
(This article belongs to the Special Issue Nanoscale Materials for Drug Delivery and Tissue Engineering)
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14 pages, 878 KiB  
Review
Electrospun Nanometer to Micrometer Scale Biomimetic Synthetic Membrane Scaffolds in Drug Delivery and Tissue Engineering: A Review
by Shaleena K. Pazhanimala, Driton Vllasaliu and Bahijja T. Raimi-Abraham
Appl. Sci. 2019, 9(5), 910; https://doi.org/10.3390/app9050910 - 4 Mar 2019
Cited by 9 | Viewed by 3867
Abstract
The scaffold technology research utilizes biomimicry to produce efficient scaffolds that mimic the natural cell growth environment including the basement membrane for tissue engineering. Because the natural basement membrane is composed of fibrillar protein networks of nanoscale diameter, the scaffold produced should efficiently [...] Read more.
The scaffold technology research utilizes biomimicry to produce efficient scaffolds that mimic the natural cell growth environment including the basement membrane for tissue engineering. Because the natural basement membrane is composed of fibrillar protein networks of nanoscale diameter, the scaffold produced should efficiently mimic the nanoscale topography at a low production cost. Electrospinning is a technique that can achieve that. This review discusses the physical and chemical characteristics of the basement membrane and its significance on cell growth and overall focuses on nanoscale biomimetic synthetic membrane scaffolds primarily generated using electrospinning and their application in drug delivery and tissue engineering. Full article
(This article belongs to the Special Issue Nanoscale Materials for Drug Delivery and Tissue Engineering)
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