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Applied Sciences
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Advances in Orthopedic Diseases Treatment
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Advances in Orthopedic Diseases Treatment

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: 20 July 2025 | Viewed by 3262

Special Issue Editors

Dr. Silvio Caravelli

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Guest Editor
U.O. Ortopedia Bentivoglio, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Interests: foot and ankle; total ankle replacement; foot and ankle trauma; foot and ankle deformities; sports trauma; cartilage; foot and ankle osteoarthritis
Special Issues, Collections and Topics in MDPI journals
Dr. Massimiliano Mosca

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Guest Editor
Orthopaedic Department, IRCCS Istituto Ortopedico Rizzoli, 40010 Bentivoglio, Italy
Interests: foot and ankle; total ankle replacement; trauma; foot and ankle deformities; sports medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Carlo Perisano

E-Mail Website
Guest Editor
Orthopedics and Trauma Surgery Unit, Department of Aging, Orthopedic and Rheumatologic Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy
Interests: trauma surgery; orthopedic; hip fracture; arthroplasty; osteoporosis; bone tumors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Primary and secondary osteoarthritis, post-traumatic and oncological sequelae, articular avascular necrosis, fractures and fixations, infections and osteomyelitis continue to represent challenging management problems for orthopaedic surgeons and traumatologists. Bone tissue loss or the poor quality of these clinical pictures have conditioned the operational choices in favour of more invasive and sometimes disabling interventions. Often, the poor quality or quantity of bone substance do not allow standard prosthetic devices to be implanted, or large amounts of cadaveric or autologous bone grafts are required, with related risks and complications.

Today, thanks to technological improvements and research related to planning and production, novel treatment options are coming to the aid of operators by making available different tools, protocols and strategies.

We are proud to present this fascinating Special Issue of Applied Sciences dedicated to “Advances in Orthopedic Diseases Treatment”.

The aim of this Special Issue is to share the personal experiences of groups and authors currently working on articular and periarticular implantology, traumatology and orthopaedic oncology, their perspectives with regard to the opportunities and limits in this field, and the results obtained and the problems that have arisen. This will be conveyed via the submission of high-impact research articles that are of interest to the orthopaedic community. 

Dr. Silvio Caravelli
Dr. Massimiliano Mosca
Dr. Carlo Perisano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • traumatology
  • osteoarthitis
  • infections
  • oncology
  • orthopaedics

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Published Papers (3 papers)

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Research

10 pages, 1069 KiB  
Article
Proprioception and Balance Control in Ankle Osteoarthritis and after Total Ankle Replacement: A Prospective Assessment
by Silvio Caravelli, Laura Bragonzoni, Emanuele Vocale, Giuseppe Barone, Giulio Vara, Stefano Di Paolo, Raffaele Zinno, Erika Pinelli, Ciro Ivan De Girolamo, Paolo De Blasiis, Maria Grazia Benedetti and Massimiliano Mosca
Appl. Sci. 2024, 14(11), 4781; https://doi.org/10.3390/app14114781 - 31 May 2024
Cited by 1 | Viewed by 653
Abstract
Total Ankle Replacement (TAR) could, in theory, partially restore joint sensation and motion, enhancing motor coordination, functional stability, and proprioception in a joint affected by osteoarthritis. The aim of this study is to evaluate ankle proprioception before and after a Total Ankle Replacement [...] Read more.
Total Ankle Replacement (TAR) could, in theory, partially restore joint sensation and motion, enhancing motor coordination, functional stability, and proprioception in a joint affected by osteoarthritis. The aim of this study is to evaluate ankle proprioception before and after a Total Ankle Replacement via an instrumental objective assessment. The evaluation of proprioceptive stability was carried out using the dedicated Delos Postural Proprioceptive System (DPPS). The clinical evaluation was performed by administering validated questionnaires, namely the American Orthopaedic Foot and Ankle Society (AOFAS) score and Short Form-36 (SF-36). Twenty patients were selected, undergoing a complete procedure with clinical and instrumental pre-operative and post-operative evaluation at the end of the follow-up. AOFAS ankle–hindfoot and SF-36 both showed a statistically significant improvement between the pre-operative and post-operative state. The postural tests performed using the DPPS showed that the affected limb showed results slightly lower than in pre-operative. In conclusion, according to the current data, the TAR does not show an improvement in proprioceptive joint stability, and although the registered mean values do not present a statistical significance, the stabilometry shows data lower than the healthy limb. In this perspective, further studies are recommended to highlight any rehabilitation scheme or protocols, using wider case series. Full article
(This article belongs to the Special Issue Advances in Orthopedic Diseases Treatment)
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9 pages, 1210 KiB  
Article
Re-Evaluating the Long-Term Efficacy of Semi-Rigid Fixation Using a Nitinol Spring Rod in Lumbar Surgery: A Retrospective Study on an Effective Alternative for Reducing Adjacent Segment Disease
by Hyun-Jun Jang, Bong-Ju Moon and Dong-Kyu Chin
Appl. Sci. 2024, 14(11), 4574; https://doi.org/10.3390/app14114574 - 27 May 2024
Cited by 1 | Viewed by 978
Abstract
Adjacent segment disease (ASD) is a prevalent complication following lumbar fusion surgery, representing a significant challenge in spinal surgery. This study aimed to assess the long-term outcomes of Nitinol spring rod semi-rigid fixation, a potential alternative to traditional rigid fixation, in reducing the [...] Read more.
Adjacent segment disease (ASD) is a prevalent complication following lumbar fusion surgery, representing a significant challenge in spinal surgery. This study aimed to assess the long-term outcomes of Nitinol spring rod semi-rigid fixation, a potential alternative to traditional rigid fixation, in reducing the incidence of ASD. This retrospective case study evaluated 89 patients who underwent lumbar or lumbosacral surgeries using a combination of Bioflex® (a Nitinol spring rod dynamic stabilization system) and an interbody cage over 10 years of follow-up. The fusion status, adjacent segment disc height, mechanical complications, and re-operation rates were analyzed. The cohort had a median follow-up duration of 13.0 years. All patients achieved solid fusion at the final follow-up visit. One patient underwent revision surgery for clinical ASD (1.1%), and no patients required revision surgery due to mechanical problems. Radiological evidence of ASD was observed in 16.9% of the patients. This study’s findings suggest that semi-rigid fixation using Bioflex with an interbody cage is a possibly effective treatment strategy to prevent ASD. The technique potentially reduces the risk of ASD by allowing a degree of movement at the surgical site. Full article
(This article belongs to the Special Issue Advances in Orthopedic Diseases Treatment)
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13 pages, 7430 KiB  
Article
Establishment of a Periprosthetic Acetabular Bone Defect in an In Vivo Model
by Frank Sebastian Fröschen, Thomas Martin Randau, El-Mustapha Haddouti, Frank Alexander Schildberg, Jacques Dominik Müller-Broich, Werner Götz, Susanne Reimann, Dieter Christian Wirtz and Sascha Gravius
Appl. Sci. 2024, 14(8), 3375; https://doi.org/10.3390/app14083375 - 17 Apr 2024
Viewed by 758
Abstract
The biological reconstruction of periprosthetic acetabular defects is essential for the success of revision total hip arthroplasty. However, a standardized in vivo defect model with good analogy to the human situation is still lacking, which has significantly limited the research and development of [...] Read more.
The biological reconstruction of periprosthetic acetabular defects is essential for the success of revision total hip arthroplasty. However, a standardized in vivo defect model with good analogy to the human situation is still lacking, which has significantly limited the research and development of this highly important clinical entity. A defined animal defect model might be a possible solution as it offers the possibility to evaluate different biomaterials for periacetabular bone reconstruction in a reproducible setting. In an ovine periacetabular defect model (n = 27), a defined bone defect (1.5 × 1.5 × 1.5 cm/3.375 cm3) in the cranial load-bearing area of the acetabulum was augmented with two different biomaterials as well as autologous cancellous bone in an ovine periprosthetic defect model and bridged with a Ganz reinforcement ring (n = 9 animals per group). Eight months after implantation, radiological and macroscopic examination was performed. The operation with the establishment of a defined periacetabular defect could be performed in all cases. There were no intraoperative complications in the three groups. During the course of the experiment, three sheep had to be excluded due to complications. A macroscopic evaluation after 8 months showed a firm neocapsula surrounding the hip joint with macroscopic consolidation of the bony defect and a stable inlying implant. There were no detectable differences between the three groups in the macroscopic or radiological evaluation. In summary, the presented ovine model might offer the possibility to create a defined bone defect and investigate bone defect reconstruction with different materials. Full article
(This article belongs to the Special Issue Advances in Orthopedic Diseases Treatment)
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