Special Issues

Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Applications of Gene Expression Profiling in Human Disease
edited by
submission deadline 31 Jul 2026 | Viewed by 234 | Submission Open
Keywords: gene expression profile; biomarkers; cancer; complex disease
(This special issue belongs to the Section Genetics and Genomics)
Ferroptosis: Mechanisms and Human Disease
edited by Chan-Yen Kuo
submission deadline 15 Aug 2026 | 5 articles | Viewed by 14776 | Submission Open
Keywords: ferroptosis; systemic diseases; inflammatory response; mitochondrial-dependent redox homeostasis; microenvironment
(This special issue belongs to the Section Cell Biology)
Gut Microbiota in Aquatic Animals Nutrition, Immunity, and Host–Microbe Interactions
edited by Qunlan Zhou
submission deadline 15 Aug 2026 | 3 articles | Viewed by 6713 | Submission Open
Keywords: gut microbiota; aquatic animal health; host– microbe interactions; functional probiotics; immunomodulation; nutrient metabolism; multi-omics integration; microbial ecology; environmental adaptation
(This special issue belongs to the Section Microbiology)
Changing Coral Reef Biodiversity and Function in the Anthropocene
edited by
submission deadline 15 Aug 2026 | 1 articles | Viewed by 1559 | Submission Open
Keywords: anthropogenic stressors; coral reefs; climate change; biodiversity loss; marine conservation; ecological adaptation; ecosystem function; resilience
(This special issue belongs to the Section Marine and Freshwater Biology)
Role of CARD9 in Health and Diseases
edited by Zuberwasim Sayyad and Nikhil Sharma
submission deadline 15 Aug 2026 | Viewed by 294 | Submission Open
Keywords: CARD9; innate immunity; pattern recognition receptors; autophagy; apoptosis; inflammasome; reactive oxygen species; post-translational modifications; gut microbiota; inflammation and cancer
Recent Advances in Angiogenesis and Vascular Development submission deadline 15 Aug 2026 | Viewed by 201 | Submission Open
Keywords: vasculogenesis; angiogenesis; vascular differentiation markers; endothelial-to-mesenchymal transition (EndMT); mechanotransduction; endothelial function; endothelial damage
(This special issue belongs to the Section Cell Biology)
Population Genetics and Conservation of Amphibians and Reptiles
edited by
submission deadline 25 Aug 2026 | Viewed by 324 | Submission Open
Keywords: conservation genetics; local adaptation; genetic diversity; amphibian; reptile; environmental change
(This special issue belongs to the Section Conservation Biology and Biodiversity)
The Role of Autophagy and Macrophages in Modulating Immune Responses in Atherosclerosis
edited by and Aatira Vijay
submission deadline 25 Aug 2026 | Viewed by 316 | Submission Open
Keywords: atherosclerosis; macrophages; autophagy; immune regulation; chronic inflammation; plaque stability; lipid metabolism; efferocytosis; immunometabolism
Animal Models of Arthritis
edited by Nevena Arsenović-Ranin and Biljana Bufan
submission deadline 30 Aug 2026 | 4 articles | Viewed by 14929 | Submission Open
Keywords: animal models; rheumatoid arthritis; osteoarthritis; inflammation; immunopathology; pathological features; joints; treatment; drug screening; traditional medicine
(This special issue belongs to the Section Medical Biology)
Young Researchers in Neuroscience
edited by
submission deadline 31 Aug 2026 | 7 articles | Viewed by 64021 | Submission Open
Keywords: neurobiology; cell biology; molecular mechanisms; neural development; synaptic function; ion channels; neurotransmitter systems; gene expression; neuronal signaling; cellular physiology
(This special issue belongs to the Section Neuroscience)
Bone Cell Biology
edited by Yohei Abe and
submission deadline 31 Aug 2026 | 7 articles | Viewed by 27101 | Submission Open
Keywords: osteoclast; osteoblast; osteocyte; bone density; macrophage; RANK; transcription factor; cell signaling
(This special issue belongs to the Section Cell Biology)
Biology, Ecology and Management of Harmful Algae
edited by Paul V. Zimba and
submission deadline 31 Aug 2026 | 8 articles | Viewed by 15124 | Submission Open
Keywords: harmful algae; toxic algae; harmful algal bloom (HAB); excessive algae growth; microalgae and macroalgae; cyanobacteria; dinoflagellates; toxins; water quality; phytoplankton; water resources
Editorial Board Members’ Collection Series: Pathology of Cancer and Cardiovascular Disease submission deadline 31 Aug 2026 | 3 articles | Viewed by 12865 | Submission Open
Keywords: cancer; cardiovascular disease; biomarkers; gut microbiome; inflammation; health policy; diet and lifestyle
Insecticide Resistance: Molecular Mechanisms and Ecological Implications
edited by Kaikai Mao
submission deadline 31 Aug 2026 | 1 articles | Viewed by 8717 | Submission Open
Keywords: insecticide resistance; molecular mechanism; regulatory network; ecological impact; non-target impact; resistance genes; pest resistance management
(This special issue belongs to the Section Ecology)
Lipid Metabolism in Plant Growth and Development
edited by Xiaohong Yu and Yingqi Cai
submission deadline 31 Aug 2026 | 3 articles | Viewed by 6635 | Submission Open
Keywords: lipid metabolism; lipid engineering; plant growth; plant development; lipid biosynthesis; lipid signaling; lipid transport; membrane structure; energy storage; plant– microbe interactions; stress response; nutrition value; cellular process
(This special issue belongs to the Section Plant Science)
Advances in Cardiac and Vascular Biology: From Mechanisms to Pathophysiology
edited by and
submission deadline 31 Aug 2026 | 4 articles | Viewed by 4427 | Submission Open
Keywords: cardiovascular biology; molecular mechanisms; cellular signaling; epigenomic regulation; vascular remodeling; metabolic reprogramming; cardiac pathophysiology
(This special issue belongs to the Section Physiology)
Advances in Leishmaniasis and Chagas Disease: Biology, Epidemiology, Treatment and Control (2nd Edition) submission deadline 31 Aug 2026 | 1 articles | Viewed by 4342 | Submission Open
Keywords: leishmaniasis; Chagas disease; immunopathogeny; diagnosis; epidemiology; control; vaccine
Bone Mechanics: From Cells to Organs to Function submission deadline 31 Aug 2026 | 5 articles | Viewed by 4030 | Submission Open
Keywords: bone mechanics; bone remodeling; mechanotransduction; structural analysis; functional morphology; bioengineering
(This special issue belongs to the Section Physiology)
Host–Microbiome–Environment Interactions in Domestic and Wild Animals
edited by and Cesar A. Meza-Herrera
submission deadline 31 Aug 2026 | 3 articles | Viewed by 3881 | Submission Open
Keywords: animal microbiome; environmental microbiota; host– microbiota interactions; wildlife microbiology; livestock health and productivity; microbiome and conservation; One Health approach; gut microbiota dynamics; microbial ecology; microbiome and reproduction; habitat– host microbiome linkages; multi-omics integration
(This special issue belongs to the Section Microbiology)
Cellular and Molecular Biology of Liver Diseases
edited by Matthew McMillin
submission deadline 31 Aug 2026 | 2 articles | Viewed by 3693 | Submission Open
Keywords: drug-induced liver injury; cholestasis; hepatitis; metabolic dysfunction-associated steatotic liver disease; alcohol-associated liver disease
(This special issue belongs to the Section Cell Biology)
Mitochondrial Genomics of Arthropods
edited by Renfu Shao
submission deadline 31 Aug 2026 | 4 articles | Viewed by 3182 | Submission Open
Keywords: mitochondrial genome architecture; transcriptional dynamics; translational mechanisms; comparative genomics; molecular evolution; arthropod phylogenetics; systematics; evolutionary biology
(This special issue belongs to the Section Genetics and Genomics)
Regenerative Biology: Regeneration After Spinal Cord and Peripheral Nerve Injury submission deadline 31 Aug 2026 | 1 articles | Viewed by 1943 | Submission Open
Keywords: neuronal regeneration; peripheral nerve repair; spinal cord injury; axonal growth; neuroplasticity; glial cells; molecular signaling pathways; stem cells in nerve regeneration; neuroinflammation; animal models of nerve injury
(This special issue belongs to the Section Neuroscience)
Biological Invasions in Freshwater Ecosystems
edited by Filipe Banha
submission deadline 31 Aug 2026 | 2 articles | Viewed by 1524 | Submission Open
Keywords: invasive species; rivers; lakes; ecology; biology; impacts
(This special issue belongs to the Section Conservation Biology and Biodiversity)
Energy Metabolism, Genetics and Development in Drosophila
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 1103 | Submission Open
Keywords: Drosophila; energy metabolism; development; epigenetics; non-coding RNAs; metabolic disease; growth; signaling pathway
(This special issue belongs to the Section Bioinformatics)
Perception in Noise: From Human Perceptive Abilities to Neural Correlates and Computational Models
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 975 | Submission Open
Keywords: auditory perception; neural networks; communication sounds; auditory system; masking noise; coding in noise; robust representation
(This special issue belongs to the Section Neuroscience)
Fruits and Seeds of Tropical Plants: Conservation of Species, Ecological Importance and Quality Valorization
edited by Edna Ursulino Alves and Silvanda De Melo Silva
submission deadline 31 Aug 2026 | 1 articles | Viewed by 908 | Submission Open
Keywords: climate change; nature conservation; biodiversity; plant propagation; postharvest quality; metabolic profile; orchard management and quality
(This special issue belongs to the Section Conservation Biology and Biodiversity)
Sickle Cell Disease: Molecular Mechanisms, Pathogenesis and Therapies
edited by Chithra Palani
submission deadline 31 Aug 2026 | Viewed by 647 | Submission Open
Keywords: SCD; anemia; erythrocyte development; erythroid progenitors; CD34 cells; vaso-occlusion; pain crisis; hemolysis; oxidative stress; sickling; inflammation; ER stress; fetal hemoglobin; hematopoiesis; ischemia and tissue damage; organ damage; drug development; SCD diagnosis; gene therapy; cell therapy
(This special issue belongs to the Section Medical Biology)
Microbiology and Metabolomics in Reproductive Biology submission deadline 31 Aug 2026 | Viewed by 593 | Submission Open
Keywords: maternal microbiome; metabolome; pregnancy outcomes; fetal development; biomarkers; immune function; metabolic health; disease prediction; therapeutic interventions; maternal and child health
(This special issue belongs to the Section Developmental and Reproductive Biology)
Current Status and Future Perspectives on Lipid Biology and Beyond submission deadline 31 Aug 2026 | Viewed by 383 | Submission Open
Keywords: lipids; fatty acids (FAs); omega-3 (FA); omega-6 (FA); cancer; cell biology; oxylipins; oxidative stress; lipidomics; lipid nanoparticles; personalized lipid-based therapies
(This special issue belongs to the Section Biochemistry and Molecular Biology)
Biophysics of Exposome: Molecular Mechanisms of Action
edited by and Madhavi K. Ganapathiraju
submission deadline 31 Aug 2026 | Viewed by 377 | Submission Open
Keywords: computational biology; systems biology; mass spectrometry; protein– ligand networks; protein– protein interaction networks; metabolomics; proteomics; surface plasmon resonance; protein structure prediction; molecular docking; target fishing; machine learning; artificial intelligence
Novel Mechanisms and Biological Processes in Redox and Inflammatory Signaling
edited by Shengchen Wang and
submission deadline 31 Aug 2026 | Viewed by 318 | Submission Open
Keywords: redox; inflammatory; oxidative stress; antioxidant; anti-inflammatory; signaling pathways
(This special issue belongs to the Section Biochemistry and Molecular Biology)
Research Progress on Metabolic Pathways in Neurodegenerative Diseases
edited by Ali H. Rafati
submission deadline 31 Aug 2026 | Viewed by 288 | Submission Open
Keywords: neurodegeneration; metabolic dysfunction; mitochondrial impairment; oxidative stress; glucose metabolism; lipid metabolism; autophagy; neuroinflammation; biomarkers; therapeutic targets
(This special issue belongs to the Section Neuroscience)
Biogenesis and Function of Centrioles, Centrosomes, and Primary Cilia in Health and Disease submission deadline 31 Aug 2026 | Viewed by 263 | Submission Open
Keywords: centriole; centrosome; cilia
(This special issue belongs to the Section Cell Biology)
Environmental Factors and Freshwater Organism Responses
edited by and Joana L. Santos
submission deadline 31 Aug 2026 | Viewed by 221 | Submission Open
Keywords: freshwater ecosystems; environmental stressors; climate change; pollution; ecotoxicology; adaptation; phenotypic plasticity; biodiversity; conservation; genomics
(This special issue belongs to the Section Ecology)
Uncovering the Role of T Cells in Immune Homeostasis and Immune Tolerance
edited by
submission deadline 31 Aug 2026 | Viewed by 180 | Submission Open
Keywords: regulatory T cells; immune tolerance; FOXP3; cytokine; suppression
(This special issue belongs to the Section Cell Biology)
Biosynthesis of Metabolites from Microorganisms, or Microorganism-Host Interaction? (Volume II) submission deadline 1 Sep 2026 | 8 articles | Viewed by 25885 | Submission Open
Keywords: biosynthesis; biological activity; biosynthesis regulation; microbial metabolites; microbe– host reaction
(This special issue belongs to the Section Microbiology)
Viral Infections in Animals: Pathogenesis and Immunity
edited by
submission deadline 1 Sep 2026 | 1 articles | Viewed by 3214 | Submission Open
Keywords: virus– host interactions; antiviral immunity; mechanisms of viral pathogenesis
(This special issue belongs to the Section Immunology)
Latest Discoveries in Non-Model Organisms and Non-Translational Biology submission deadline 8 Sep 2026 | Viewed by 441 | Submission Open
Keywords: basic biological research; non-translational biology; non-clinical biology; fundamental science; non-model organisms; model organisms; scientific curiosity– driven research; biological diversity; experimental biology; theoretical biology
Feature Papers on Developmental and Reproductive Biology
edited by
submission deadline 15 Sep 2026 | 16 articles | Viewed by 47405 | Submission Open
Keywords: embryo/fetus development; reproductive biology; gametogenesis; differentiation; growth; homeostasis; regeneration; aging; cell cycle regulation; stem cells; organoids
(This special issue belongs to the Section Developmental and Reproductive Biology)
Molecular and Cellular Mechanisms of Neuroinflammation and Chronic Pain
edited by Mario Garcia-Dominguez
submission deadline 15 Sep 2026 | Viewed by 234 | Submission Open
Keywords: neuroinflammation; chronic pain; neuroimmune interactions; glial activation; cytokine signaling; synaptic plasticity; oxidative stress; epigenetic regulation; microglia and astrocytes; therapeutic targets
(This special issue belongs to the Section Neuroscience)
Plant Breeding: From Biology to Biotechnology
edited by Juwu Gong
submission deadline 30 Sep 2026 | 6 articles | Viewed by 12165 | Submission Open
Keywords: plant breeding; biotechnology; molecular marker-assisted selection; genetic engineering; genome editing; tissue culture; phenotype; genetics; omics
(This special issue belongs to the Section Biotechnology)
Signalling Pathways in Cancer and Disease submission deadline 30 Sep 2026 | 6 articles | Viewed by 12061 | Submission Open
Keywords: cancer; signalling; metastasis; tumorigenesis; cancer targeting
(This special issue belongs to the Section Cancer Biology)
Research Advancements in Oral Biology
edited by and Nina Petrović
submission deadline 30 Sep 2026 | 4 articles | Viewed by 10764 | Submission Open
Keywords: oral biology; oral tissue regeneration; artificial intelligence (AI) in dentistry; genomics and proteomics in dentistry; dental research; salivary diagnostics
(This special issue belongs to the Section Medical Biology)
Large Animal Experimental and Epidemiological Models for Diseases submission deadline 30 Sep 2026 | 5 articles | Viewed by 9021 | Submission Open
Keywords: large animal model; dog; pig; ruminants; experimental study; epidemiological study; infectious diseases; non-infectious diseases; treatment; disease control; disease prediction
(This special issue belongs to the Section Medical Biology)
Molecular Basis of Bone Homeostasis and Skeletal Diseases
edited by
submission deadline 30 Sep 2026 | 5 articles | Viewed by 8965 | Submission Open
Keywords: osteoclast; osteoblast; bone; skeletal disease; bone formation; bone resorption; osteoporosis; osteopetrosis; human genetics; mouse genetics
(This special issue belongs to the Section Biochemistry and Molecular Biology)
Experimental Biology, Life Science and One Health: From Basic to Translational Research
edited by
submission deadline 30 Sep 2026 | 4 articles | Viewed by 5187 | Submission Open
Keywords: anatomy; histology; embryology; aquatic environment and ecosystem; biotechnology and bioengineering; cell stress; environment and health; extracellular vesicles; fight against cancer; movement and nutrition science; neuroscience; plant ecology and ecosystem; regenerative biomedicine
Advances in Animal Functional Genomics
edited by Chugang Mei
submission deadline 30 Sep 2026 | 4 articles | Viewed by 4245 | Submission Open
Keywords: functional genomics; gene editing; phenomics; epigenetics; livestock; conservation; CRISPR; host– microbiome interactions
(This special issue belongs to the Section Zoology)
The Role of Innate Immunity in Organ Transplantation
edited by Todd V. Brennan
submission deadline 30 Sep 2026 | 1 articles | Viewed by 3147 | Submission Open
Keywords: innate immunity; allograft rejection; transplantation; immune tolerance
(This special issue belongs to the Section Medical Biology)
Detection of Parasites and Parasitic Diseases in Animals
edited by and Agnieszka Tylkowska
submission deadline 30 Sep 2026 | 1 articles | Viewed by 2297 | Submission Open
Keywords: parasitic infections; parasitic diseases; veterinary diagnostics; molecular techniques; epidemiology; zoonoses; host-parasite interactions; antiparasitic therapies; wildlife health; preventive programs
(This special issue belongs to the Section Zoology)
Gut Microbiome in Health and Disease (3rd Edition)
edited by and
submission deadline 30 Sep 2026 | 2 articles | Viewed by 2262 | Submission Open
Keywords: gut microbiota; ‘ gut– X’ axis; dysbiosis; food nutrition; metabolites; type 2 diabetes mellitus; gut health; immunity
(This special issue belongs to the Section Microbiology)
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