Special Issues

Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cardiovascular Autonomic Function: From Bench to Bedside—2nd Edition
edited by and
submission deadline 31 Dec 2026 | 3 articles | Viewed by 5326 | Submission Open
Keywords: dysautonomia; heart rate variability; autonomic function testing; cardiovascular autonomic function; autonomic neuroscience; syncope; orthostatic hypotension; baroreflex; autonomic molecular mechanisms
Young Researchers in Immunology
edited by and Moses New-Aaron
submission deadline 31 Dec 2026 | 4 articles | Viewed by 4401 | Submission Open
(This special issue belongs to the Section Immunology)
RNA Biology and mRNA in Diseases
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 3637 | Submission Open
Keywords: stress granule; cRISPR/Cas13; vaccine; mRNA drug; antisense oligonucleotides; RNA methylation; microRNA; long non-coding RNA; RNA binding; RNA activation; circular RNA; fluorescent RNA; cell surface RNA; cancer; neurodegenerative disease
(This special issue belongs to the Section Biochemistry and Molecular Biology)
Feature Papers on Toxicology
edited by
submission deadline 31 Dec 2026 | 3 articles | Viewed by 2736 | Submission Open
Keywords: toxicology; cellular toxicity; organ toxicity; biomarkers; molecular mechanisms; in vitro models; in vivo models; risk assessment; environmental exposures; chemical toxicology
(This special issue belongs to the Section Toxicology)
Cellular Senescence in Development, Regeneration, Aging, and Cancer
edited by
submission deadline 31 Dec 2026 | 2 articles | Viewed by 2277 | Submission Open
Keywords: cellular senescence; aging; cancer; obesity; metabolism; geroscience; age-related diseases; SASP; senolytics; biomarkers
Fungal Biodiversity and Ecology: Unraveling Ecological Roles, Interactions, and Environmental Adaptations
edited by Xin Qian, Junzhi Qiu and Yonglong Wang
submission deadline 31 Dec 2026 | 3 articles | Viewed by 2237 | Submission Open
Keywords: fungal biodiversity; fungal ecology; ecosystem functioning; community assembly; fungal interactions; taxonomy and systematics; extreme environments; biogeography; fungal conservation; biotechnology applications
(This special issue belongs to the Section Ecology)
Molecular Insights into Malignant Cutaneous Adnexal Neoplasms
edited by and Rosalynn M. Nazarian
submission deadline 31 Dec 2026 | Viewed by 2228 | Submission Open
Keywords: malignant adnexal neoplasms; sebaceous carcinoma; hidradenocarcinoma; malignant spiradenoma; trichoblastic carcinoma; molecular mechanisms; signal transduction pathways; tumor microenvironment; epigenetics; genomic profiling
(This special issue belongs to the Section Cancer Biology)
Metabolic and Stress Responses in Aquatic Animals (2nd Edition)
edited by , Laura Fernández-Alacid and
submission deadline 31 Dec 2026 | 3 articles | Viewed by 2222 | Submission Open
Keywords: stress; metabolism; animal welfare; aquaculture; cephalopods; fish; molluscs; crustaceans; aquatic animals; animal physiology
(This special issue belongs to the Section Zoology)
Aquatic Economic Animal Breeding and Healthy Farming (2nd Edition)
edited by Yude Wang and Shengwei Luo
submission deadline 31 Dec 2026 | 2 articles | Viewed by 1877 | Submission Open
Keywords: rice– fish; fish; and aquaculture; hybridization and genetic breeding; nutrient additive and requirement; physiology and immune response; disease control; pathogenesis research; probiotic identification and function; transcriptomics; proteomics; metabonomics
(This special issue belongs to the Section Zoology)
15 Years of Biology: The View Ahead
edited by
submission deadline 31 Dec 2026 | 3 articles | Viewed by 1718 | Submission Open
Keywords: behavioral biology; bioinformatics; biophysics; biotechnology; cancer biology; cell biology; conservation biology and biodiversity; developmental and reproductive biology; ecology; evolutionary biology; genetics and genomics; immunology; infection biology; marine and freshwater biology; medical biology; microbiology; neuroscience; physiology; plant science; toxicology; theoretical biology and biomathematics; zoology
Molecular Insights into the Immune Contexture of Tumors
edited by and Guilherme Zweig Rocha
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1656 | Submission Open
Keywords: immunology; immune oncology; cancer; molecular biology; biomarkers; inflammation
(This special issue belongs to the Section Cancer Biology)
New Insights into Mitochondria in Health and Disease
edited by Huiliang Zhang
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1477 | Submission Open
Keywords: mitochondria; cell dysfunction; aging; diseases
(This special issue belongs to the Section Medical Biology)
Pathobiology of Cardiac Arrhythmias and Heart Failure Issues
edited by Mohit Hulsurkar
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1432 | Submission Open
Keywords: cardiac arrhythmias; atrial fibrillation; heart failure; ion channelopathy; cardiac fibrosis; cardiomyopathy
(This special issue belongs to the Section Physiology)
From Cell Division to Systemic Dysregulation: Genetic Mechanisms and Biomarkers in Civilization Diseases submission deadline 31 Dec 2026 | 2 articles | Viewed by 1353 | Submission Open
Keywords: cell cycle regulation; genetic and epigenetic mechanisms; cellular senescence; oxidative stress; inflammation; molecular biomarkers; neurodegeneration; tumor microenvironment; metabolic and cardiovascular diseases
(This special issue belongs to the Section Cell Biology)
Non-Coding RNA Research and Functional Insights submission deadline 31 Dec 2026 | 2 articles | Viewed by 1228 | Submission Open
Keywords: non-coding RNA; microRNA; long non-coding RNA; circular RNA; gene expression regulation; biomarkers; epigenetics
(This special issue belongs to the Section Genetics and Genomics)
Adaptation Mechanisms of Forest Trees to Abiotic Stress (2nd Edition)
edited by
submission deadline 31 Dec 2026 | 2 articles | Viewed by 1172 | Submission Open
Keywords: genetic variation; epigenetic control; plant hormone; nitric oxide; reactive oxygen; species; phenomic; metabolomic; genomic; signal transduction; gene function
(This special issue belongs to the Section Plant Science)
Microbial Drivers of Aquatic Ecosystem Function: From Genomes to Biogeochemical Cycles
edited by and Jinjun Kan
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1042 | Submission Open
Keywords: aquatic microbial ecology; harmful algal blooms; nutrient cycling; trophic interactions; omics technologies; ecosystem resilience; bioremediation; population dynamics in aquatic ecosystems
(This special issue belongs to the Section Marine and Freshwater Biology)
Landscape Ecology and Ecosystem Resilience: Patterns, Processes and Sustainability
edited by and
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1035 | Submission Open
Keywords: landscape patterns; ecological resilience; blue carbon ecosystems; habitat fragmentation; spatiotemporal modeling; landscape connectivity; ecosystem services; land use change
(This special issue belongs to the Section Ecology)
Vegetation Detection and Ecosystem Carbon Modeling submission deadline 31 Dec 2026 | Viewed by 930 | Submission Open
Keywords: vegetation detection; ecosystem carbon modeling  ; biomass estimation  ; carbon dynamics  ; forest and agro-ecosystem monitoring  ; remote sensing  ; allometric modeling  ; machine learning  ; UAV imagery; climate-change mitigation
(This special issue belongs to the Section Ecology)
Advances in Biomechanics in Physiology and Pathology
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 908 | Submission Open
Keywords: biomechanics; mechanics; extracellular matrix; cellular mechanics; tissue remodeling; developmental biomechanics; computational modeling; bioimaging; engineered microenvironments; artificial intelligence; machine learning
(This special issue belongs to the Section Biophysics)
Waterbird Diversity
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 888 | Submission Open
Keywords: waterbird diversity; endangered species; wetlands; habitats; migration patterns; protection gaps; conservation techniques
(This special issue belongs to the Section Conservation Biology and Biodiversity)
Signaling Mechanisms Controlling Cell Fate in Cancer
edited by Wittaya Chaiwangyen and
submission deadline 31 Dec 2026 | 1 articles | Viewed by 873 | Submission Open
Keywords: cell fate; cancer signaling; miRNA; p53; Wnt; apoptosis; proliferation; differentiation; therapy resistance; biomarkers
(This special issue belongs to the Section Cell Biology)
Novel Dynamics and Mechanisms of Stromal–Leukocyte Interactions in Tissue Inflammation, Immunity and Healing
edited by Matthias Friedrich, Pablo Céspedes and Mathilde Pohin
submission deadline 31 Dec 2026 | 1 articles | Viewed by 856 | Submission Open
Keywords: stromal– immune crosstalk; chronic inflammation; tissue repair and regeneration; single-cell omics; immunometabolism; fibrosis; spatial transcriptomics; immune tolerance; cytokine signaling; stromal niche immunology
(This special issue belongs to the Section Physiology)
Adaptation and Protection Mechanisms in Marine Ecosystem Under Climate Change
edited by and Ya-Fan Chan
submission deadline 31 Dec 2026 | Viewed by 695 | Submission Open
Keywords: global climate change; seawater acidification; marine ecosystem; marine biology; marine biogeochemistry TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in Zulu   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate Zulu to Simplified Chinese Never translate Zulu Never translate admin.mdpi.com
(This special issue belongs to the Section Ecology)
Plant Developmental Transition Under Changing Climate
edited by Zeeshan Nasim
submission deadline 31 Dec 2026 | Viewed by 437 | Submission Open
Keywords: plant development; reproductive transition; flowering; climate change; global warming TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Ecology)
Mammalian Oocyte Biology
edited by Jingcai Liu
submission deadline 31 Dec 2026 | Viewed by 367 | Submission Open
Keywords: oocyte; oogenesis; meiosis; oocyte maturation; oocyte quality; activation; oocyte metabolism; aneuploidy
(This special issue belongs to the Section Developmental and Reproductive Biology)
Molecular Mechanisms of Cancer Cell Invasion and Metastasis
edited by and Veena Kumari Vuttaradhi
submission deadline 31 Dec 2026 | Viewed by 265 | Submission Open
Keywords: cancer cell invasion; metastasis; tumor microenvironment; redox and metabolic signaling; EMT and cellular plasticity; extracellular matrix remodeling; oncogenic signaling pathways; metastatic therapeutic targets; tumor– stromal interactions; functional genomics in metastasis
(This special issue belongs to the Section Cancer Biology)
Differential Gene Expression and Coexpression (3rd Edition) submission deadline 31 Dec 2026 | Viewed by 214 | Submission Open
Keywords: biomarkers; differential gene expression; gene coexpression networks; transcriptomics; RNA-seq; microarrays; systems biology; webtools; cancer; disease
(This special issue belongs to the Section Bioinformatics)
Advances in Cellular Immunotherapy for Malignancy
edited by
submission deadline 31 Dec 2026 | Viewed by 192 | Submission Open
Keywords: chimeric antigen receptor; T cell receptor; genetic engineering; cancer; immune cell; T cell; NK cell; monocyte; macrophage; dendritic cell
(This special issue belongs to the Section Cancer Biology)
The Central Role of Glia and Myelin in Neuroimmunity and Injury Repair
edited by
submission deadline 31 Dec 2026 | Viewed by 191 | Submission Open
Keywords: neuroinflammation; CNS; PNS; astrocytes; oligodendrocyte lineage cells; neurovascular unit; myelin repair; model systems
(This special issue belongs to the Section Cell Biology)
Impact of Climate Change on Individual, Population, Community and Ecosystems
edited by and Wensheng Liu
submission deadline 31 Dec 2026 | Viewed by 189 | Submission Open
Keywords: climate change; cross-scale interactions; ecosystem resilience; ecological forecasting; biodiversity shifts
(This special issue belongs to the Section Ecology)
Dysregulated Enzyme Expression and Function in Cancer and Human Disease submission deadline 31 Dec 2026 | Viewed by 186 | Submission Open
Keywords: enzyme dysregulation; enzymatic activity; metabolic reprogramming; oxidative stress; cellular plasticity; cancer biology; drug resistance; enzyme-targeted therapies; cancer angiogenesis
(This special issue belongs to the Section Biochemistry and Molecular Biology)
Systems Biology Approaches to Genetic Data of Human Diseases
edited by Marcio A. A. Almeida
submission deadline 31 Dec 2026 | Viewed by 182 | Submission Open
Keywords: systems biology; multi-omics integration; human genetics; network analysis; disease mechanisms; machine learning; functional genomics; gene– environment interactions
(This special issue belongs to the Section Genetics and Genomics)
Feature Papers in Neuroscience submission deadline 31 Dec 2026 | Viewed by 179 | Submission Open
Keywords: cellular neuroscience; cognitive neuroscience; computational neuroscience; neuroanatomy; neurodevelopment; neuroimaging; neuroimmunology; neuropathology; neurophysiology; molecular neuroscience; systems neuroscience
(This special issue belongs to the Section Neuroscience)
Vagal Nerve Stimulation for Motor and Non-Motor Benefits in Stroke and Traumatic Brain Injury
edited by Deepak Kumbhare and Julie Lynn Schwertfeger
submission deadline 31 Dec 2026 | Viewed by 143 | Submission Open
Keywords: vagus nerve stimulation (VNS); neuromodulation; electrophysiology; neural circuits; biomarkers; EEG; local field potentials (LFP); translational neuroscience; non-invasive stimulation; cervical VNS; auricular VNS; non-motor symtoms of stroke; cognition after stroke; implanted (iVNS); transauricular (taVNS); and transdermal (tVNS)
(This special issue belongs to the Section Neuroscience)
Mechanisms of Neuroendocrine Response to Stress in Insects
edited by
submission deadline 31 Dec 2026 | Viewed by 131 | Submission Open
Keywords: neuroendocrine signaling; insect stress physiology; neuropeptides and hormones; biotic and abiotic stress; stress response pathways; environmental adaptation; insect neurobiology; hormonal regulation
(This special issue belongs to the Section Biochemistry and Molecular Biology)
Redefining Structure–Function Relationships in Biomacromolecules
edited by
submission deadline 31 Dec 2026 | Viewed by 118 | Submission Open
Keywords: structure– function relationship; biomacromolecular assembly; structure-based therapeutic intervention
(This special issue belongs to the Section Biophysics)
Investigating the Structure and Function of Microbial Proteins
edited by Cristiane Rodrigues Guzzo
submission deadline 31 Dec 2026 | Viewed by 115 | Submission Open
Keywords: structural biology; bioinformatics; antimicrobials; bacteriophages; X-ray crystallography; cryo-EM; cryo-ET; NMR; AlphaFold; microbial proteins; protein complexes; multidrug-resistant bacteria; antimicrobial targets; CRISPR genome editing; phage therapy
(This special issue belongs to the Section Biophysics)
Neurotrophin Receptor in Neurological Diseases
edited by Tao Yang
submission deadline 31 Dec 2026 | Viewed by 106 | Submission Open
Keywords: neurotrophin receptors (TrkA; TrkB; TrkC and p75NTR); small molecule; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; neurodegenerative diseases
(This special issue belongs to the Section Neuroscience)
New Insights in Aquatic Microbial Ecology
edited by
submission deadline 1 Jan 2027 | Viewed by 190 | Submission Open
Keywords: microbial ecology; microbiome; community assembly; environmental stressors; microbial interactions; biogeochemical cycles; freshwater; marine; and engineered aquatic environments
(This special issue belongs to the Section Microbiology)
Advances in Ecotoxicology and Environmental Toxicology
edited by and
submission deadline 3 Jan 2027 | 2 articles | Viewed by 1269 | Submission Open
Keywords: ecotoxicology; molecular mechanisms; biological responses; emerging contaminants; zebrafish (Danio rerio); oxidative stress; multi-omics; neurobehavioral toxicity; environmental stressors  
(This special issue belongs to the Section Toxicology)
From Form to Function: Evolutionary Perspectives on Tetrapod Morphology
edited by Maria Laura Ponssa
submission deadline 5 Jan 2027 | Viewed by 185 | Submission Open
Keywords: morphological evolution; tetrapods; anatomy and development; functional morphology; evo-devo; phylogenetic approaches; morphological integration; phenotypic diversity
(This special issue belongs to the Section Zoology)
Decoding the Sugar Code: Understanding the Function of Glycans in Health and Disease submission deadline 15 Jan 2027 | 1 articles | Viewed by 863 | Submission Open
Keywords: glycobiology; glycoproteins; glycolipids; glycosyltransferases; glycoconjugates; glycosylation; glycomics; health and disease; molecular mechanisms; biological functions
(This special issue belongs to the Section Biochemistry and Molecular Biology)
Microtubule in Health and Disease
edited by , and Antonio Currais
submission deadline 15 Jan 2027 | Viewed by 142 | Submission Open
Keywords: microtubules; tubulin heterodimers; post-translational modifications; microtubule-associated proteins (MAPs); microtubule molecular motors; cilia; centrosome; tubulin-targeting drugs; neurodegenerative diseases; cancer; ciliopathies
(This special issue belongs to the Section Cell Biology)
Adapting Vegetable Crops to Environmental Stress Under Climate Change
edited by Vasile Stoleru and
submission deadline 30 Jan 2027 | Viewed by 138 | Submission Open
Keywords: vegetable plant biology; advancements in grafting and nursery technology; plant growing; nutrition; and irrigation; protected cultivation systems; sustainable practices and innovations; pest and disease control; strategies for stress control
(This special issue belongs to the Section Plant Science)
Genetic and Epigenetic Regulation of Gene Expression
edited by
submission deadline 31 Jan 2027 | 6 articles | Viewed by 9182 | Submission Open
Keywords: allele-specific expression; cis-regulatory elements; RNA maturation and stability; DNA methylation; histone modifications; chromatin remodeling; transcription factors; non-coding RNA; small RNA
(This special issue belongs to the Section Genetics and Genomics)
Tumor Biomechanics and Mechanobiology
edited by Xinbin Zhao
submission deadline 31 Jan 2027 | 3 articles | Viewed by 6128 | Submission Open
Keywords: tumor migration; cancer cell invasion; cancer metastasis; biomechanics; tumor microenvironment; extracellular matrix; matrix degradation
(This special issue belongs to the Section Cancer Biology)
Molecular Interactions and Biological Functions of Bioactive Compounds in Food and Health submission deadline 31 Jan 2027 | 2 articles | Viewed by 3388 | Submission Open
Keywords: bioactive compounds; nutraceuticals; food function; healthy effects; antidiabetic action; anti-inflammatory properties; antioxidants
(This special issue belongs to the Section Biochemistry and Molecular Biology)
Sexual Determination and Reproductive Regulation in Aquatic Organisms
edited by Liang Guo
submission deadline 31 Jan 2027 | 2 articles | Viewed by 2823 | Submission Open
Keywords: sex-determining gene; sex chromosome; sex control breeding; sex-determining pathway
(This special issue belongs to the Section Developmental and Reproductive Biology)
Biological Rhythms and Molecular Clockworks in Physiology and Pathology (2nd Edition) submission deadline 31 Jan 2027 | 1 articles | Viewed by 1959 | Submission Open
Keywords: biological rhythms; molecular clockworks; circadian timing system; circadian desynchrony; circadian disruption; chronopathology; chronopharmacology and  chronotherapeutics; chronomedicine
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