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Review

40 Pages

Preclinical Diagnosis of Type 1 Diabetes: Reality or Utopia

Tatyana A. Marakhovskaya,
Dmitry V. Tabakov,
Olga V. Glushkova,
Zoya G. Antysheva,
Yaroslava S. Kiseleva,
Ekaterina S. Petriaikina,
Nickolay A. Bugaev-Makarovskiy,
Anna S. Tashchilova,
Vasiliy E. Akimov and
Julia A. Krupinova
+ 17 authors

Biomedicines2025, 13(10), 2444;https://doi.org/10.3390/biomedicines13102444

7 October 2025

Type 1 Diabetes Mellitus (T1D) is an autoimmune disease characterized by the destruction of pancreatic β-cells, predominantly manifesting in childhood or adolescence. The lack of clearly interpretable biological markers in the early stages, comb...

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Editorial

9 Pages

Unraveling the Complexity of Metabolic Disorders Through Biomarkers: A Focus on Obesity and Type 2 Diabetes Mellitus

Anna Różańska-Walędziak and
Maciej Walędziak

Biomedicines2025, 13(10), 2443;https://doi.org/10.3390/biomedicines13102443

7 October 2025

In recent decades, metabolic disorders, obesity, and type 2 diabetes mellitus have become global health problems [...]

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Article

12 Pages

Synergic Elevation of Systemic Inflammation by the Coexistence of Periodontitis and Diabetes Mellitus: A Nationwide Analysis of Korean Adults

Hye-Sun Shin

Biomedicines2025, 13(10), 2441;https://doi.org/10.3390/biomedicines13102441

7 October 2025

Background/Objectives: This study aimed to evaluate the additive effect of periodontitis and diabetes mellitus on systemic inflammation, measured by high-sensitivity C-reactive protein (hs-CRP), in a nationally representative Korean population. Metho...

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Article

19 Pages

Cyclophilin Inhibitor Rencofilstat Combined with Proteasome Inhibitor Ixazomib Increases Proteotoxic Cell Death in Advanced Prostate Cancer Cells with Minimal Effects on Non-Cancer Cells

Carlos Perez-Stable,
Alicia de las Pozas,
Medhi Wangpaichitr,
Robert T. Foster and
Daren R. Ure

Biomedicines2025, 13(10), 2442;https://doi.org/10.3390/biomedicines13102442

7 October 2025

Background/Objective: Proteotoxic stress induced by inhibitors of the ubiquitin–proteasome system has been successful in multiple myeloma but not in solid cancers such as prostate cancer. Our objective is to find a combination with proteasome i...

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Article

9 Pages

Efficacy and Safety of Topical 5% Cannabidiol Plus Myrcene for the Treatment of Vestibulodynia: A Multi-Centric Randomized Controlled Trial

Filippo Murina,
Giuseppe Ettore,
Cecilia Fochesato,
Maria Grazia Castiglione,
Melania Caruso,
Ilenia Fonti and
Valeria Savasi

Biomedicines2025, 13(10), 2440;https://doi.org/10.3390/biomedicines13102440

7 October 2025

Background/Objectives: Vestibulodynia is the prevalent form of vulvodynia, causing burning, irritation, rawness, and dyspareunia sensations. This sensory abnormality suggests sensitization to neuropathic pain. Methods: This was a randomized double-bl...

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Editorial

4 Pages

Innovative Approaches to Hepatocellular Carcinoma: Diagnostic Breakthroughs, Biomarker Integration, and Artificial Intelligence

Evangelos Koustas,
Eleni-Myrto Trifylli,
Panagiotis Sarantis and
Michalis V. Karamouzis

Biomedicines2025, 13(10), 2439;https://doi.org/10.3390/biomedicines13102439

7 October 2025

Primary liver cancer is the fifth most common malignancy globally and the second most common cause of cancer-related deaths [...]

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Article

39 Pages

Re-Evaluating the Treatment Plan for Diabetic Macular Edema Based on Early Identification of Response and Possible Biochemical Predictors of Non-Response After the First Intravitreal Ranibizumab Injection

Sameh Mohamed Elgouhary,
Noha Rabie Bayomy,
Mohamed Khaled Elfarash,
Sara Zakaria Aboali,
Sara Abdelmageed Barakat,
Mona Abdelhamid Elnaggar and
Noha Khirat Gaber

Biomedicines2025, 13(10), 2438;https://doi.org/10.3390/biomedicines13102438

7 October 2025

Background: This study aimed to change the current concept of diabetic macular edema (DME) management through (1) early categorization of our DME patients into either responders or non-responders after the first intravitreal Ranibizumab (IVR) injecti...

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Review

16 Pages

Endoscopic Bariatric Therapies for Metabolic Dysfunction-Associated Steatotic Liver Disease: Mechanistic Insights and Metabolic Implications

Wissam Ghusn,
Mira Sridharan,
Rachel Fromer,
Muhammet Ozdemir,
Madeleine G. Haff and
Eric J. Vargas

Biomedicines2025, 13(10), 2437;https://doi.org/10.3390/biomedicines13102437

7 October 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is rapidly emerging as the leading cause of chronic liver disease, closely tied to rising global obesity rates. Endoscopic bariatric therapies (EBTs), including endoscopic sleeve gastro...

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Article

17 Pages

Shunt Dysfunction Assessment in Shunted Patients via Multiparametric Non-Invasive ICP Waveform Monitoring

Raphael Bertani,
Gabriel Semione,
Milene Zanella Capitanio,
Sérgio Brasil,
Sávio Batista,
Gabriel André da Silva Mendes,
Caio Perret,
Christian Ferreira,
Wellingson Silva Paiva and
Fernando Campos Gomes Pinto

Biomedicines2025, 13(10), 2436;https://doi.org/10.3390/biomedicines13102436

7 October 2025

Background/Objectives: Ventriculoperitoneal shunts are the standard treatment for adults diagnosed with several CSF disorders, but often face dysfunction, leading interest in non-invasive methods for diagnosing shunt issues. This study evaluates the...

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Review

22 Pages

Unlocking the Secrets of the Endometrium: Stem Cells, Niches and Modern Methodologies

Lijun Huang,
Miaoxian Ou,
Dunjin Chen and
Shuang Zhang

Biomedicines2025, 13(10), 2435;https://doi.org/10.3390/biomedicines13102435

6 October 2025

The endometrium is a highly dynamic tissue central to female reproductive function, undergoing nearly 500 cycles of proliferation, differentiation, shedding, and regeneration throughout a woman’s reproductive life. This remarkable regenerative...

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