Involvement of Pro-inflammatory Mediators in Chronic Inflammatory Diseases and Related Psychiatric Disorders

Dear Colleagues,

In recent decades, there has been a progressive lengthening of life expectancy, with a consequent increase in susceptibility to chronic morbidity. This increased susceptibility appears to stem from the tendency of older organisms to develop a generalized pro-inflammatory state, characterized by elevated levels of pro-inflammatory markers in cells and tissues, a condition often called "inflammaging".

This pro-inflammatory condition is a direct consequence of cellular senescence processes, characterized by the transition from a naive phenotype to that of memory T cells and type 1 to a profile of type 2 cytokines, with consequent secretion of pro-inflammatory cytokines including IL-6 and IL-8 implicated in age-related chronic diseases, including atherosclerosis and cardiovascular diseases, type 2 diabetes, dementia, major depression, osteoporosis and sarcopenia.

The pro-inflammatory cytokines released in chronic inflammatory diseases also appear to be involved in the development of biological mechanisms capable of influencing individual behavior, including the development of psychiatric disorders capable of significantly influencing the patient's quality of life and therefore the management of the disease.

Given these premises, this Special Issue aims to relate the psycho-social impact of chronic inflammatory diseases with their clinical severity and their impact on QoL in order to identify their main prognostic factors.

Dr. Giuseppe Murdaca
Dr. Sebastiano Gangemi
Dr. Gabriella Martino
Guest Editors

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