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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Type 2 Diabetes: Current Progress and Future Challenges

edited by

Tomislav Kurevija

submission deadline 31 Oct 2026 | 4 articles | Viewed by 5990 | Submission Open

Keywords: type 2 diabetes; cardiovascular risk; novel antidiabetics; clinical guidelines therapeutic inertia; obesity; insulin resistance; metabolic syndrome; diabetology; family medicine

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Multidisciplinary Approaches to Neurodegenerative Disorders

edited by

Toomas Toomsoo

submission deadline 31 Oct 2026 | 3 articles | Viewed by 5968 | Submission Open

Keywords: neurodegenerative disorders; lipid metabolism; comorbidity patterns super-agers; precision medicine; biomarker discovery; AI-assisted diagnostics; translational neuroscience; multi-omics integration; neuroinflammation

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Neuroimmunology and Neurological Infection

edited by

Mariya Ivanovska

submission deadline 31 Oct 2026 | 2 articles | Viewed by 5962 | Submission Open

Keywords: neuroimmunology; neurological infections; immune-mediated diseases; neurodegeneration; biomarkers; immunotherapy; neuroinflammation; clinical neurology

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Recent Advances in Adipokines (3nd Edition)

edited by

Christa Büchler

submission deadline 31 Oct 2026 | 7 articles | Viewed by 5774 | Submission Open

Keywords: adiponectin; receptor; agonist; biomarker; inflammation; cancer

(This special issue belongs to the Section Cell Biology and Pathology)

Emerging Technologies in Liquid Biopsy of Cancers

edited by Lingdi Yin

submission deadline 31 Oct 2026 | 2 articles | Viewed by 5181 | Submission Open

Keywords: liquid biopsy; circulating tumor cells (CTCs); circulating tumor DNA (ctDNA); exosomes; cancer diagnostics; biomarker discovery; minimally invasive monitoring; emerging technologies; clinical translation; molecular profiling

(This special issue belongs to the Section Cancer Biology and Oncology)

Biomarkers in Metabolic Disorders, Obesity and Type 2 Diabetes Mellitus—2nd Edition

edited by

Maciej Walędziak

and Anna Maria Różańska-Walędziak

submission deadline 31 Oct 2026 | 3 articles | Viewed by 5070 | Submission Open

Keywords: metabolic disorders; obesity; type 2 diabetes mellitus; bariatric surgery; laboratory parameters

(This special issue belongs to the Section Endocrinology and Metabolism Research)

New Insights into the Diagnosis and Treatment of Hepatocellular Carcinoma—2nd Edition

edited by

Evangelos Koustas

submission deadline 31 Oct 2026 | 1 articles | Viewed by 5015 | Submission Open

Keywords: checkpoint inhibitors; combinatorial treatments; hepatocellular carcinoma (HCC); immunotherapy; liver cancer; therapy; targeted therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Fertility and Reproductive Health: Understanding of Reproductive Physiology and Pathology

edited by Sevastiani Antonouli and

Valentina Di Nisio

submission deadline 31 Oct 2026 | 1 articles | Viewed by 4667 | Submission Open

Keywords: female infertility; male infertility; oocyte quality; embryo implantation; follicular dynamics; gamete and embryo ultrastructure; assisted reproduction technologies; reproductive aging; fertility preservation; oncofertility challenges

(This special issue belongs to the Section Gene and Cell Therapy)

Advances in Single-Cell and Spatial Transcriptomics: Decoding Tumor Heterogeneity and Microenvironment

edited by

Guanhu Yang

submission deadline 31 Oct 2026 | 2 articles | Viewed by 4507 | Submission Open

Keywords: single-cell sequencing; spatial transcriptomics; tumor microenvironment; heterogeneity; immunotherapy resistance

(This special issue belongs to the Section Cancer Biology and Oncology)

Aortic Aneurysm: Mechanisms, Biomarkers, and Therapeutic Strategy

edited by

Mitra Esfandiarei

and

Seda Selamet Tierney

submission deadline 31 Oct 2026 | 6 articles | Viewed by 4497 | Submission Open

Keywords: aortic aneurysms; genetic aortic diseases; endothelial dysfunction; extracellular matrix; aortic wall; aortic smooth muscle; angiotensin system; aortic wall elasticity; matrix metalloproteinases

(This special issue belongs to the Section Molecular and Translational Medicine)

Human Stem Cells in Disease Modelling and Treatment (2nd Edition)

edited by Sofia M. Calado and

Álvaro Plaza Reyes

submission deadline 31 Oct 2026 | 3 articles | Viewed by 4216 | Submission Open

Keywords: induced pluripotent stem cells (iPSCs); embryonic stem cells (ESCs); disease models; cell therapies; cell therapy medicinal products (CTMPs); regenerative medicine

(This special issue belongs to the Section Biomedical Engineering and Materials)

Multisystem Crosstalk in Health and Disease

edited by

Mehmet Bostancıklıoğlu

submission deadline 31 Oct 2026 | 1 articles | Viewed by 4204 | Submission Open

Keywords: systems biology; immunometabolism; inflammation; integrative physiology; molecular pathways; translational research; multi-omics; chronic disease; host–microbe interactions; metabolic regulation

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Neurovascular Dysfunction: Mechanisms and Therapeutic Strategies

edited by

Deepti Diwan

submission deadline 31 Oct 2026 | 3 articles | Viewed by 4159 | Submission Open

Keywords: neurovascular; blood vessels; nervous system; neurological diseases

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

New Trends in Regional Anesthesia and Pain Management

edited by

Jui-An Lin

submission deadline 31 Oct 2026 | 3 articles | Viewed by 3999 | Submission Open

Keywords: regional anesthesia; ultrasound-guided/stimulator-guided nerve blocks; novel techniques for motor-sparing neural intervention; continuous catheter infusions; opioid-sparing techniques; perioperative pain management; novel local anesthetics; cadaveric dissection exploring the anatomical knowledge of motor-sparing techniques; modalities (techniques, technologies, or drug regimen) to prolong the effect of local anesthetics; ERAS-related studies; AI applications in regional anesthesia and pain management; innovations and protocols/curriculum regarding regional anesthesia and pain management in the battlefield; studies comparing new technologies/simulation (such as EpiFaith, SPRint PNS system, or CompuFlo) with traditional methods in improving regional anesthesia and pain management; regenerative medicine; nutritional pain medicine; application of bone marrow aspirate concentration or other stem cell components in pain medicine; multidisciplinary/comprehensive care program; transarterial embolization for pain management; joint denervation for pain management

(This special issue belongs to the Section Molecular and Translational Medicine)

Mycobacterial Infections: Insights into Pathogenesis, Diagnosis, and Treatment

edited by

Abhishek Mishra

submission deadline 31 Oct 2026 | 2 articles | Viewed by 3838 | Submission Open

Keywords: mycobacterium; pathogenesis; host–pathogen interactions; virulence factors; antimicrobial resistance; diagnosis; therapeutics; host-directed therapy; vaccine development; drug resistance

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Chronic Pain: From Prevention to Therapeutic Strategies—Third Edition

edited by Isaura Tavares and

Daniel Humberto Pozza

submission deadline 31 Oct 2026 | 2 articles | Viewed by 3505 | Submission Open

Keywords: pain pathophysiology; pain prevention; predictive sensory testing; pre- and postoperative chronic pain; new biomarkers in pain; pain management and novel treatments; preemptive analgesia; inflammatory pain

(This special issue belongs to the Section Molecular and Translational Medicine)

Nervous System Injury and Repair: From Molecular Mechanism to Therapeutic Perspectives

edited by

Shuchao Wang

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2694 | Submission Open

Keywords: nervous system injury; neuron; astrocytes; microglial cells; excitotoxicity; inflammation; oxidative stress; neuroprotection

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Progress in Cytotoxicity of Biomaterials

edited by Lakkamraju Vijayalakshmi

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2585 | Submission Open

Keywords: biomaterial cytotoxicity; biocompatibility assessment; in vitro and in vivo toxicity; surface modification; nanomaterials in medicine; oxidative stress and inflammation; tissue engineering materials; drug delivery systems; biodegradable polymers; regulatory perspectives on biomaterial safety

(This special issue belongs to the Section Biomedical Engineering and Materials)

Recent Advanced Research in Hypertension

edited by Rodrigo Maranon

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2548 | Submission Open

Keywords: hypertension; sex differences; pathophysiology; precision medicine; novel therapeutics; digital health; cardiovascular disease

(This special issue belongs to the Section Cell Biology and Pathology)

Phenotypes and Endotypes in Interstitial Lung Diseases—Second Edition

edited by

Francesco Amati

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2406 | Submission Open

Keywords: interstitial lung diseases (ILDs); heterogeneity; pathogenesis; progressive pulmonary fibrosis (PPF); molecular biomarkers

(This special issue belongs to the Section Immunology and Immunotherapy)

Oxidative Stress, Mitochondrial Dysfunction, and Aβ Pathology: Converging Pathways in Aging and Neurodegeneration

edited by

Swapnil Pandey

, Laxmi Rathor and

Ashish Shukla

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2167 | Submission Open

Keywords: oxidative stress; aging; amyloid beta; tau phosphorylation; neurodegeneration; regulated cell death; mitochondrial biogenesis; Drosophila; C. elegans

(This special issue belongs to the Section Cell Biology and Pathology)

Advances in Cancer Treatment

edited by

Vlasios Karageorgos

and

George Liapakis

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2000 | Submission Open

Keywords: targeted therapy; bio-conjugates; biologic agents; precision oncology; personalized cancer treatment; biomarker-guided therapy; cancer drug development; biopharmaceuticals

(This special issue belongs to the Section Cancer Biology and Oncology)

From Gut to Vascular Health: The Role of Probiotics, Polyphenols, and Diet in Neuroinflammation and Cardiovascular Dysfunction

edited by Maria Serra and

Roberta Macri

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1915 | Submission Open

Keywords: nutrition supplements; plant extract; polyphenols; oxidative stress; inflammation; neuroinflammation; microbiota; cardiometabolic dysfunction

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Biomarker, Phenotyping and Therapeutics for Asthma

edited by

Ran Wang

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1841 | Submission Open

Keywords: allergy; biomarkers; pathogenesis; exhaled breath; multi-omics; lung physiology; phenotyping; endotypes; therapeutic targets

(This special issue belongs to the Section Molecular and Translational Medicine)

Immunotherapy and Immune-Related Adverse Events in Cancer

edited by

Ivana Mikolašević

and

Marin Golčić

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1784 | Submission Open

Keywords: immunotherapy; cancer; PD-1 inhibitors; immune-related adverse effects; management

(This special issue belongs to the Section Immunology and Immunotherapy)

Molecular Psychiatry and Antipsychotics

edited by

László Péczely

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1573 | Submission Open

Keywords: psychiatric diseases; schizophrenia; antipsychotics; molecular psychiatry; molecular pathways; neurotransmitter systems; positive, negative and cognitive symptoms

(This special issue belongs to the Section Molecular and Translational Medicine)

Crosstalk Between Depression, Anxiety, Dementia, and Chronic Pain Comorbidity in Behavioral Neurology and Neuropsychiatry—4th Edition

edited by Masaru Tanaka and Simone Battaglia

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1558 | Submission Open

Keywords: depression; anxiety; dementia; chronic pain; Alzheimer’s disease; Parkinson’s disease; multiple sclerosis; stroke; depressive disorder; anxiety disorder; schizophrenia; somatic symptom disorder; antidepressants; anxiolytics; nootropic agents; analgesics; neurodegeneration; neuroprotection; psychotherapy; serotonin; kynurenine

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

New Insights in Immunological Pathways

edited by

Wan-Chung Hu

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1556 | Submission Open

Keywords: immune response; immune signal pathway; cytokine storm

(This special issue belongs to the Section Immunology and Immunotherapy)

Advances in Immunometabolism: Molecular Pathways, Regulatory Networks, and Therapeutic Opportunities

edited by

Sebastian Mertowski

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1401 | Submission Open

Keywords: immunometabolism; metabolic reprogramming; immune-cell signaling; inflammation; tumor microenvironment; mitochondrial dysfunction; oxidative stress; immunometabolic checkpoints; biomarkers; targeted therapy

(This special issue belongs to the Section Immunology and Immunotherapy)

Chronic Liver Disease: From Mechanisms to Therapeutic Approaches

edited by

Xuefeng Luo

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1280 | Submission Open

Keywords: chronic liver disease; cirrhosis; portal hypertension; hepatocellular carcinoma; variceal bleeding; transjugular intrahepatic portosystemic shunt (TIPS)

(This special issue belongs to the Section Molecular and Translational Medicine)

Head and Neck Cancer: From Mechanisms to Therapeutic Approaches—Advances and Challenges

edited by

Barbara Verro

Carmelo Saraniti

and

Daniela Carlisi

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1276 | Submission Open

Keywords: head and neck cancers; target therapy; biomarkers; molecular targets; translational research; pathogenesis; prognosis; diagnostic tool

(This special issue belongs to the Section Cancer Biology and Oncology)

Small Molecules, from Natural Sources, in Drug Discovery

edited by

Marisa Machado

and Cláudia Pinho

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1143 | Submission Open

Keywords: natural products; translational research; drug discovery; herbal therapy; small molecules; therapeutic leads; pharmacology; natural bioactive compounds

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Pharmacogenetics and Pharmacogenomics: Driving Forces in Modern Precision Medicine

edited by Miriam Saiz-Rodríguez and Dora Koller

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1135 | Submission Open

Keywords: pharmacogenetics; pharmacogenomics; precision medicine; polygenic risk scores; phenoconversion; drug response; genetic biomarkers; personalized therapy; underrepresented populations; clinical implementation

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Advances in Liver Fibrosis: From Mechanisms to Therapeutics

edited by

Kun Zhang

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1127 | Submission Open

Keywords: liver fibrosis; therapeutic target; biomarker; hepatocyte; macrophage; LSEC; HSC; immune cells; extracellular matrix

(This special issue belongs to the Section Molecular and Translational Medicine)

Next-Generation CRISPR and Immune Modulation: Advancing Precision Genome Editing Therapies for Genetic Disorders

edited by Sukanta Jash

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1076 | Submission Open

Keywords: CRISPR/Cas9; base editors; prime editors; innate immunity; genome editing; off-target effects; delivery vectors; monogenic disorders; multiplex editing; AI-driven CRISPR

(This special issue belongs to the Section Gene and Cell Therapy)

Molecular Signatures and Therapeutic Strategies in Urological Cancers

edited by Haoyue Sheng

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1065 | Submission Open

Keywords: urological cancers; molecular signatures; precision medicine; non-coding RNAs; tumor microenvironment

(This special issue belongs to the Section Molecular and Translational Medicine)

Thoracic Malignancies: From Pathophysiology to Novel Therapeutic Approaches: 2nd Edition

edited by Yanyun Gao

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1036 | Submission Open

Keywords: thoracic malignancies; lung cancer; esophageal cancer; pleural mesothelioma (PM); molecular subtypes; drug resistance; target therapy; biomarkers; immunotherapy; preclinical models

(This special issue belongs to the Section Cancer Biology and Oncology)

Pancreatic Cancer: From Mechanisms to Therapeutic Approaches (4th Edition)

edited by

Satoshi Wada

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1009 | Submission Open

Keywords: pancreatic cancer; tumor microenvironment; biomarker; immune environment in pancreatic cancer

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in Lung Cancer: From Bench to Bedside (2nd Edition)

edited by

Seung Hyeun Lee

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1001 | Submission Open

Keywords: lung cancer; immunotherapy; targeted therapy; translational oncology; biomarkers; EGFR; ALK; ROS1

(This special issue belongs to the Section Cancer Biology and Oncology)

Pulmonary Arterial Hypertension: From Molecular Basis to Therapeutic Approaches—2nd Edition

edited by

Rui Adão

submission deadline 31 Oct 2026 | 1 articles | Viewed by 987 | Submission Open

Keywords: pulmonary arterial hypertension; right ventricle; right heart failure; therapy; vascular disease; translational research

(This special issue belongs to the Section Molecular and Translational Medicine)

Demyelinating Diseases: Pathophysiology and Emerging Therapeutic Targets

edited by Jude Taylor

submission deadline 31 Oct 2026 | Viewed by 819 | Submission Open

Keywords: demyelinating diseases; pathophysiological processes; diagnostic accuracy and predicting disease; emerging strategies

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Advances in Molecular and Cellular Mechanisms in Metabolic Bone and Cartilage Disorders

edited by

Mohamad Alaa Terkawi

submission deadline 31 Oct 2026 | 1 articles | Viewed by 768 | Submission Open

Keywords: metabolic bone; cartilage disorders; osteoporosis; osteoarthritis; impaired fracture healing; rare metabolic skeletal diseases

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Gynecologic Research: New Diagnostic and Therapeutic Approaches

edited by Dimitrios Zouzoulas and Dimitrios Tsolakidis

submission deadline 31 Oct 2026 | 1 articles | Viewed by 753 | Submission Open

Keywords: precision gynecology; liquid biopsy in gynecologic oncology; fertility preservation; gynecologic cancers; pelvic disorders; hormonal therapies

(This special issue belongs to the Section Molecular and Translational Medicine)

3D Cell Culture Systems for Biomedical Research, 2nd Edition

edited by

Agnieszka Rusak

and

Benita Wiatrak

submission deadline 31 Oct 2026 | 1 articles | Viewed by 664 | Submission Open

Keywords: 3D; scaffolds; spheroids; biomaterials; tumour model; bioengineering; tissue regeneration; regenerative medicine; targeted therapies; tissue mimics; angiogenesis; cancerogenesis; drug development; 3D printing; material functionalisation

(This special issue belongs to the Section Biomedical Engineering and Materials)

Decoding Resistance: Molecular Drivers of Therapy Failure in Advanced Prostate Cancer

edited by

Jyoti Kaushal

submission deadline 31 Oct 2026 | Viewed by 504 | Submission Open

Keywords: prostate cancer; androgen deprivation therapy; molecular signaling; epigenetic remodeling; cancer stem cell; tumor microenvironment

(This special issue belongs to the Section Cancer Biology and Oncology)

Lymphomas: From Mechanisms to Therapeutic Approaches

edited by Delfa Radić-Krišto and

Vibor Milunović

submission deadline 31 Oct 2026 | Viewed by 490 | Submission Open

Keywords: aggressive lymphomas; cellular therapy; cellular immunotherapy; translational medicine; lymphomagenesis; indolent lymphomas; phase I/II clinical trials; targeted therapy; biomarkers; in vitro and in vivo models of lymphomas

(This special issue belongs to the Section Cancer Biology and Oncology)

Immune and Metabolic Dysregulation in Neurological and Neuropsychiatric Disorders

edited by

Qingkun Liu

and

Xin-An Liu

submission deadline 31 Oct 2026 | Viewed by 489 | Submission Open

Keywords: neuroimmune interaction; neuroinflammation; metabolic regulation; gut–brain axis; microbiome; neuroendocrine system; neurodegeneration; psychiatric disorders; brain injuries

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Dopamine in Health and Disease (3rd Edition)

edited by

Marc Ekker

submission deadline 31 Oct 2026 | Viewed by 398 | Submission Open

Keywords: dopamine; disease models; mitochondria; Parkinson’s disease; schizophrenia

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Current Challenges and Future Perspectives of Antimicrobial Therapy

edited by

Carmen Maximiliana Dobrea

and

Anca-Maria Arseniu

submission deadline 31 Oct 2026 | Viewed by 371 | Submission Open

Keywords: antibiotics; antifungals; antimicrobial resistance; antimicrobial stewardship; drug safety and efficacy; resistance mechanisms

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Molecular Mechanisms of Cardiovascular Diseases (CVDs)

edited by

Xiaoquan Rao

submission deadline 31 Oct 2026 | Viewed by 339 | Submission Open

Keywords: cardiovascular diseases (CVDs); molecular mechanisms; metabolic dysregulation; immunity; immunometabolism

(This special issue belongs to the Section Molecular and Translational Medicine)

Displaying special issue 301-350 on page 7 of 14.

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