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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Next-Generation CRISPR and Immune Modulation: Advancing Precision Genome Editing Therapies for Genetic Disorders

edited by Sukanta Jash

submission deadline 31 Mar 2026 | Viewed by 123 | Submission Open

Keywords: CRISPR/Cas9; base editors; prime editors; innate immunity; genome editing; off-target effects; delivery vectors; monogenic disorders; multiplex editing; AI-driven CRISPR

(This special issue belongs to the Section Gene and Cell Therapy)

Leishmaniasis: Pathophysiology, Diagnostics and Current and Emerging Therapeutic Approaches—2nd Edition

edited by

Raimunda Nonata Ribeiro Sampaio

submission deadline 31 Mar 2026 | 1 articles | Viewed by 118 | Submission Open

Keywords: leishmaniasis; pathophysiology; neglected infectious diseases

(This special issue belongs to the Section Molecular and Translational Medicine)

New Insights in Thyroid Cancer

edited by

Rodis D. Paparodis

submission deadline 31 Mar 2026 | Viewed by 113 | Submission Open

Keywords: thyroid carcinoma; molecular diagnostics; targeted therapy; genetic mutations; radioiodine therapy; radiofrequency ablation therapy; active surveillance; precision oncology

(This special issue belongs to the Section Molecular and Translational Medicine)

Recent Advances in Antiviral and Antibacterial Drugs

edited by

Mohammad Anwar Hossain

submission deadline 31 Mar 2026 | Viewed by 111 | Submission Open

Keywords: viral infection; direct-acting antiviral; antimicrobial resistance (AMR); pandemic preparedness; antiviral therapy; infectious disease; viral resistance

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Alpha-Synuclein in Neurodegeneration: From Pathophysiologic Mechanisms to Therapeutic Strategies

edited by

Sujung Yeo

submission deadline 31 Mar 2026 | Viewed by 107 | Submission Open

Keywords: alpha-synuclein; neurodegeneration; Parkinson's disease; pathophysiology; mechanism; therapy; synucleinopathy

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Emerging Trends and Applications in Nanomedicine and Targeted Therapies

edited by

Marzieh Ramezani Farani

submission deadline 31 Mar 2026 | Viewed by 104 | Submission Open

Keywords: nanomedicine; drug delivery systems; targeted therapy; biomaterials; cancer therapy; smart nanocarriers; biodegradable nanoparticles; photothermal therapy; nano-diagnostics; translational nanotechnology

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Brain Disorders: Bridging Molecular Insights and Innovative Therapies

edited by

Karol Wiśniewski

and

Bartosz Szmyd

submission deadline 31 Mar 2026 | Viewed by 100 | Submission Open

Keywords: neurosurgery; neuro-oncology; glioma; innovations; cancer predisposing syndrome; neurofibromatosis; CMMRD

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Clinical and Translational Advances in Neuro-Ophthalmology

edited by Hyun-jin Shin

submission deadline 31 Mar 2026 | Viewed by 100 | Submission Open

Keywords: neuro-ophthalmology; translational medicine; optic neuropathy; ocular motility disorders; visual pathway disorders; neuroimaging and electrophysiology; biomarkers in vision science; gene and stem cell therapy; artificial intelligence in neuro-ophthalmology; clinical trials in vision disorders

(This special issue belongs to the Section Molecular and Translational Medicine)

Insulin Resistance and Hyperinsulinemia: From Molecular Mechanisms to Clinical Translation

edited by

Anindya Ghosh

submission deadline 31 Mar 2026 | Viewed by 96 | Submission Open

Keywords: insulin resistance; type 2 diabetes; metabolic syndrome; obesity

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Pathology, Complications, and Prognosis of Type 1 Diabetes (T1D)

edited by Tadesse Melaku Abegaz

submission deadline 31 Mar 2026 | Viewed by 93 | Submission Open

Keywords: type 1 diabetes; complications; prognosis; cardiovascular disease; neuropathy; retinopathy; nephropathy; disease mechanisms; clinical outcomes

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Advances in Molecular and Cellular Mechanisms in Metabolic Bone and Cartilage Disorders

edited by

Mohamad Alaa Terkawi

submission deadline 31 Mar 2026 | Viewed by 92 | Submission Open

Keywords: metabolic bone; cartilage disorders; osteoporosis; osteoarthritis; impaired fracture healing; rare metabolic skeletal diseases

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Next-Generation Approaches to Hepatobiliary Disorders

edited by

Lorenzo Petagna

submission deadline 31 Mar 2026 | Viewed by 86 | Submission Open

Keywords: hepatobiliary disorders; interventional radiology; interventional endoscopy; advances in HPB surgery; advances in liver transplantation; liver transplant viability biomarkers

(This special issue belongs to the Section Molecular and Translational Medicine)

Pulmonary Arterial Hypertension: From Molecular Basis to Therapeutic Approaches—2nd Edition

edited by

Rui Adão

submission deadline 31 Mar 2026 | Viewed by 85 | Submission Open

Keywords: pulmonary arterial hypertension; right ventricle; right heart failure; therapy; vascular disease; translational research

(This special issue belongs to the Section Molecular and Translational Medicine)

Emerging Trends in Reproductive Endocrinology and Pregnancy-Related Disorders

edited by

Theodoros Kalampokas

submission deadline 31 Mar 2026 | Viewed by 84 | Submission Open

Keywords: pregnancy-related disorders; eclampsia; preeclampsia; hypertensive disorders of pregnancy; gestational diabetes; reproductive endocrinology; precision medicine

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Post-Viral Syndromes and Long-Term Health Impacts

edited by Sophia X. Sui

submission deadline 31 Mar 2026 | Viewed by 83 | Submission Open

Keywords: post-viral syndrome; long COVID; ME/CFS; immune dysregulation; neuroinflammation; metabolism; biomarkers; therapeutic targets; basic research; translational research

(This special issue belongs to the Section Molecular and Translational Medicine)

Gastrointestinal Diseases: From Pathophysiology to Therapeutics

edited by Ali H. Zaidi and Neda Dadgar

submission deadline 31 Mar 2026 | Viewed by 83 | Submission Open

Keywords: gastrointestinal diseases; pathophysiology; gastrointestinal cancer; esophageal cancer; gastric cancer; colorectal cancer; pancreatic cancer; hepatocellular cancer; appendiceal cancer; cancer biomarker

(This special issue belongs to the Section Molecular and Translational Medicine)

Head and Neck Cancer: Molecular Mechanisms to Therapeutic Advances

edited by Jacopo Zocchi, Irene H. Nauta and

Carlos M. Chiesa-Estomba

submission deadline 31 Mar 2026 | Viewed by 82 | Submission Open

Keywords: head and neck cancer; molecular mechanisms; molecular biomarkers; immunotherapy; liquid biopsy; treatment resistance; targeted therapies; precision medicine

(This special issue belongs to the Section Cancer Biology and Oncology)

Pancreatic Cancer: From Mechanisms to Therapeutic Approaches (4th Edition)

edited by

Satoshi Wada

submission deadline 31 Mar 2026 | Viewed by 78 | Submission Open

Keywords: pancreatic cancer; tumor microenvironment; biomarker; immune environment in pancreatic cancer

(This special issue belongs to the Section Cancer Biology and Oncology)

Autoimmune and Inflammatory Disorders: From Pathogenesis to Therapeutic Targeting

edited by

Yu-Wei Chang

submission deadline 31 Mar 2026 | Viewed by 70 | Submission Open

Keywords: inflammasome; inflammation; sepsis; autoimmune; microbiota; immunomodulation

(This special issue belongs to the Section Immunology and Immunotherapy)

Recent Advanced Research in Hypertension

edited by Rodrigo Maranon

submission deadline 31 Mar 2026 | Viewed by 67 | Submission Open

Keywords: hypertension; sex differences; pathophysiology; precision medicine; novel therapeutics; digital health; cardiovascular disease

(This special issue belongs to the Section Cell Biology and Pathology)

Emerging Technologies for In Vitro Models of Wound Healing

edited by

Maurizio Sabbatini

and

Filippo Renò

submission deadline 31 Mar 2026 | Viewed by 63 | Submission Open

Keywords: wound healing; immunity; oral mucosa; bioprinting; cell culture; organoid; multicellular co-culture models

(This special issue belongs to the Section Biomedical Engineering and Materials)

To Instill, to Deliver, to Implant, to Incise, to Protect: Innovations in Glaucoma Management—A Pharmaceutical Perspective

edited by Luca Agnifili, Matteo Sacchi and

Michele Figus

submission deadline 31 Mar 2026 | Viewed by 56 | Submission Open

Keywords: glaucoma; medical therapy; drug formulation; drug delivery systems; pharmaceutical biotechnology; implantable devices; pharmacokinetics; pharmacodynamics; laser therapy; minimally invasive glaucoma surgery; neuroprotection; gene therapy; neuroregeneration

Recent Advances in Diagnosis, Therapeutics, and Mechanistic Research of Multiple Myeloma

edited by Xiaoqing Dong

submission deadline 31 Mar 2026 | Viewed by 48 | Submission Open

Keywords: multiple myeloma; diagnosis; therapeutics; mechanistic research; drug resistance; tumor microenvironment; biomarker; therapeutic target

(This special issue belongs to the Section Cancer Biology and Oncology)

Molecular Research in Genitourinary Oncology

edited by

Ilias Giannakodimos

, Ioannis Zachos and Vassilios P. Tzortzis

submission deadline 31 Mar 2026 | Viewed by 48 | Submission Open

Keywords: genitourinary oncology; molecular biomarkers; genomics and epigenomics; tumor microenvironment; liquid biopsy

(This special issue belongs to the Section Cancer Biology and Oncology)

The Role of Cytokines in Health and Disease: 3rd Edition

edited by

Monika Zajkowska

submission deadline 20 Apr 2026 | 9 articles | Viewed by 11533 | Submission Open

Keywords: cytokine; chemokine; neurodegenerative disease; cancer; inflammatory mediator; diagnosis; biomarker

(This special issue belongs to the Section Cell Biology and Pathology)

Cellular and Molecular Mechanisms in Gastrointestinal Tract Disease: 2nd Edition

edited by Felipe Leite De Oliveira

submission deadline 29 Apr 2026 | Viewed by 97 | Submission Open

Keywords: cellular mechanisms; molecular mechanisms; diagnosis; treatment; experimental models; signaling pathways; comorbidities

(This special issue belongs to the Section Cell Biology and Pathology)

Women’s Special Issue Series: Biomedicines (2nd Edition)

edited by

Letizia Polito

Federica Falà

and

Riuko Ohashi

submission deadline 30 Apr 2026 | 6 articles | Viewed by 21374 | Submission Open

Keywords: antibody; biomedicines; biopharmaceutical products; cancer therapy; drug delivery; immunoconjugates; immunotoxins; immunotherapy; immunotargeting; nanodelivery; toxins

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Fetal Medicine and Neonatology

edited by

Robert Brawura-Biskupski-Samaha

submission deadline 30 Apr 2026 | 8 articles | Viewed by 16871 | Submission Open

Keywords: fetal medicine; neonatology; research innovations; perinatal care; clinical practices

(This special issue belongs to the Section Molecular and Translational Medicine)

Head and Neck Tumors, 4th Edition

edited by

Silvia Di Agostino

and

Jan B. Vermorken

submission deadline 30 Apr 2026 | 6 articles | Viewed by 14278 | Submission Open

Keywords: head and neck tumors; predictive markers; liquid biopsy; therapy; precision medicine; biomaterials

(This special issue belongs to the Section Cancer Biology and Oncology)

Neurodevelopmental Disorders: From Pathophysiology to Novel Therapeutic Approaches—2nd Edition

edited by Nader Perroud and Markus Mathaus Kosel

submission deadline 30 Apr 2026 | 5 articles | Viewed by 13420 | Submission Open

Keywords: intellectual disability; autism spectrum disorder; attention-deficit/hyperactivity disorder; drug treatment; neuroimaging

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Thyroid Disorders: Current Status and Future Prospects

edited by Anna Małgorzata Kucharska

submission deadline 30 Apr 2026 | 3 articles | Viewed by 8438 | Submission Open

Keywords: thyroid diseases; autoimmune thyroid diseases; hypothyroidism; hyperthyroidism; treatment; children; adults

(This special issue belongs to the Section Molecular and Translational Medicine)

Biomedicine in Dental and Oral Rehabilitation

edited by

Sanda Mihaela Popescu

and

Mihaela Ionescu

submission deadline 30 Apr 2026 | 6 articles | Viewed by 5162 | Submission Open

Keywords: diagnosis; treatment; oral rehabilitation; dental and oral disease; biomedicine; biomaterial; regeneration; functional; esthetics

(This special issue belongs to the Section Biomedical Engineering and Materials)

Role of Endothelial Cells in Cardiovascular Disease—2nd Edition

edited by

Lorenzo Falsetti

and

Vincenzo Zaccone

submission deadline 30 Apr 2026 | 2 articles | Viewed by 3568 | Submission Open

Keywords: endothelial cells; endothelial dysfunction; cardiovascular disease; endothelial progenitor cells; atherosclerosis; thrombosis; vessel inflammation; regenerative medicine

(This special issue belongs to the Section Cell Biology and Pathology)

Obesity-Related Gastrointestinal Disorders: Uncovering Mechanisms Behind Cardiometabolic Improvement with Weight Loss

edited by

Wissam Ghusn

submission deadline 30 Apr 2026 | 2 articles | Viewed by 3045 | Submission Open

Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); gastro-esophageal reflux disease (GERD); obesity; cardiometabolic comorbidities; type 2 diabetes; hypertension; gut hormones; gastrointestinal function

(This special issue belongs to the Section Endocrinology and Metabolism Research)

New Challenges in Liver Diseases: From Molecular Pathogenesis to Therapeutic Approaches

edited by Yefu Wang

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2475 | Submission Open

Keywords: liver fibrosis; NAFLD/NASH; ACLF; HBV cure; immunotherapy; precision medicine; metabolic liver diseases; gut– liver axis; regenerative medicine; biomarkers

(This special issue belongs to the Section Molecular and Translational Medicine)

Advanced Research in Metabolic Syndrome (2nd Edition)

edited by

Balazs Varga

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2470 | Submission Open

Keywords: obesity; diabetes; dyslipidemia; hypertension; microcirculatory damage; ischemia– reperfusion; necro-apopto-autophagy; laboratory animals; bioactive agents

(This special issue belongs to the Section Cell Biology and Pathology)

Unraveling New Horizon in Vascular Diseases: From Pathophysiology to Novel Therapeutic

edited by Miguel A. Ortega and

Raul Diaz-Pedrero

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2272 | Submission Open

Keywords: vascular diseases; artery; venous disease; venous hypertension; heart; lymph; diabetes; surgery; immune system; translational medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Stroke Neuroprotection and Repair

edited by

Konstantinos Tsamakis

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2165 | Submission Open

Keywords: stroke; cerebral infarction; neuronal damage; neural regeneration; neuroprotection

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

New Perspectives in the Treatment of Head and Neck Vascular Malformations

edited by Paolo Gennaro

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2100 | Submission Open

Keywords: vascular anomalies; vascular malformations; AVMs; venous malformations; electrosclerotherapy

(This special issue belongs to the Section Molecular and Translational Medicine)

Epigenetic Regulation of Kidney Development

edited by Hongbing Liu

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1625 | Submission Open

Keywords: epigenetic regulation; kidney development; gene expression patterns; targeted therapeutic strategies; epigenetic regulation of kidney development

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Biomaterials for Bone Regeneration: 2nd Edition

edited by

Kyeong-Hyeon Park

submission deadline 30 Apr 2026 | 2 articles | Viewed by 1578 | Submission Open

Keywords: bone regeneration; bone defect; induced membrane technique; bone transport; biomaterials

(This special issue belongs to the Section Biomedical Engineering and Materials)

Gastrointestinal Diseases: From Pathophysiology to Innovative Therapeutic Approaches

edited by

Francisco Tustumi

submission deadline 30 Apr 2026 | 2 articles | Viewed by 1478 | Submission Open

Keywords: gastrointestinal diseases; pathophysiology; microbiome; inflammation; gastrointestinal cancer; translational medicine; therapeutic innovation; personalized treatment

(This special issue belongs to the Section Molecular and Translational Medicine)

Mechanobiology and Extracellular Vesicle-Based Strategies for Osteochondral Regeneration

edited by Zhen Yang

submission deadline 30 Apr 2026 | 2 articles | Viewed by 1195 | Submission Open

Keywords: biomechanics; stem cells; osteoarthritis; tissue engineering; extracellular vesicles

(This special issue belongs to the Section Biomedical Engineering and Materials)

Advances in Skin Tumors: From Pathogenesis to Treatment Strategies

edited by Zhongxin Yu and Sepideh Nikki Asadbeigi

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1101 | Submission Open

Keywords: melanoma skin; tumor epigenetic alterations; genetic mutations; tumor microenvironment immunotherapy; targeted therapy; nanomedicine

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in Periodontal Disease and Systemic Disease

edited by

Hye-Sun Shin

submission deadline 30 Apr 2026 | 2 articles | Viewed by 1010 | Submission Open

Keywords: periodontal disease; systemic health; inflammation; oral microbiome; cardiovascular disease; diabetes; cancer; oral– gut– brain axis; precision medicine; biomarkers

(This special issue belongs to the Section Molecular and Translational Medicine)

Pathogenesis, Diagnosis and Treatment of Melanoma

edited by Vijayasteltar B. Liju

submission deadline 30 Apr 2026 | 1 articles | Viewed by 830 | Submission Open

Keywords: melanoma; metastasis; targeted therapies; immunotherapy; tumor microenvironment; combination therapies; molecular pathways

(This special issue belongs to the Section Molecular and Translational Medicine)

Decoding Colorectal Cancer: Innovations in Biomarkers, Microbiota, and Therapeutic Resistance

edited by

Yinghao Cao

submission deadline 30 Apr 2026 | 1 articles | Viewed by 823 | Submission Open

Keywords: colorectal cancer; tumor biomarkers; nanomaterials; drug delivery; microbiome– tumor interaction; therapeutic resistance; exosomes; tumor microenvironment; prognostic model; neoadjuvant therapy; conversion therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Innovative Approaches in Drug Discovery

edited by Jitendra Gour

submission deadline 30 Apr 2026 | Viewed by 767 | Submission Open

Keywords: PROTACs; molecular glue; personalized medicine; high-throughput screening (HTS); targeted therapy; drug repurposing; safety profiles

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Heart Failure: New Diagnostic and Therapeutic Approaches, 2nd Edition

edited by

Anand Prakash Singh

submission deadline 30 Apr 2026 | 1 articles | Viewed by 690 | Submission Open

Keywords: heart failure; clinical treatment; basic cardiac research; future perspective; heart failure therapy; cardiotoxicity

(This special issue belongs to the Section Molecular and Translational Medicine)

From Pathogenesis to Therapies: Innovations in Kidney Disease

edited by

Tao Qiu

Jiefu Zhu

and Chenglin Wu

submission deadline 30 Apr 2026 | 1 articles | Viewed by 678 | Submission Open

Keywords: renal ischemia-reperfusion injury; acute kidney injury; renal fibrosis; chronic kidney disease; ureteral obstructive nephropathy; kidney transplantation; macrophage-myofibroblast transition; inflammation; fibroblast activation; chronic allograft rejection; potential therapy

(This special issue belongs to the Section Molecular and Translational Medicine)

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