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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Insights in Gastric, Colorectal, and Pancreatic Cancer

edited by

John K. Triantafillidis

submission deadline 31 Mar 2026 | 4 articles | Viewed by 7472 | Submission Open

Keywords: gastric cancer ; colorectal cancer ; pancreatic cancer; immunotherapy

(This special issue belongs to the Section Molecular and Translational Medicine)

Connective Tissue Disorders: Pathogenetic, Diagnostic and Therapeutic Perspectives

edited by

Katarzyna Winsz-Szczotka

submission deadline 31 Mar 2026 | 3 articles | Viewed by 6982 | Submission Open

Keywords: connective tissue disorders; pathophysiological mechanisms; inflammation; autoimmunity; extracellular matrix; fibrosis; biomarkers; treatment; therapeutic targets

(This special issue belongs to the Section Molecular and Translational Medicine)

Gynecological Diseases in Cellular and Molecular Perspectives

edited by

Iwona Wertel

and

Anna Pawłowska-Łachut

submission deadline 31 Mar 2026 | 4 articles | Viewed by 5926 | Submission Open

Keywords: gynaecological diseases; endometriosis; biomarkers; immune checkpoints; immunotherapy; tumor microenvironment; tumor-infiltrating immune cells; cancer immunology; cellular interactions

(This special issue belongs to the Section Molecular and Translational Medicine)

Drug Resistance and Tumor Microenvironment in Human Cancers

edited by

Tiago Miguel Amaral Carvalho

Silvia Socorro

and Marília Isabel Neto Figueira

submission deadline 31 Mar 2026 | 2 articles | Viewed by 5378 | Submission Open

Keywords: cancer therapy; drug resistance; tumor microenvironment; targeted therapy; precision medicine; cancer-related mechanisms

(This special issue belongs to the Section Cancer Biology and Oncology)

Skin Diseases and Cell Therapy

edited by Nives Pondeljak, Maryam Heidari Kharaji and Mirna Šitum

submission deadline 31 Mar 2026 | 2 articles | Viewed by 4967 | Submission Open

Keywords: dermatology; psoriasis; atopic dermatitis; vitiligo; alopecia; cutaneous leishmaniasis; and skin fibrosis; skin cancers; innovative therapeutic strategies; molecular mechanisms

(This special issue belongs to the Section Gene and Cell Therapy)

Next-Generation Nanoparticles: Innovations in Biomedical Applications and Theranostics

edited by

Md Amdadul Huq

submission deadline 31 Mar 2026 | 1 articles | Viewed by 4270 | Submission Open

Keywords: nanoparticles; nanoconjugates; antimicrobial agents; anticancer agents; biomedical applications

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Advanced Research in Thyroid and Parathyroid Diseases

edited by Anping Su

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3869 | Submission Open

Keywords: thyroid cancer treatment; tumor microenvironment; immunotherapy; targeted therapy; precision medicine

(This special issue belongs to the Section Cancer Biology and Oncology)

New Advances in Ovarian Cancer

edited by

Zhenshan Yang

and

Hengrui Liu

submission deadline 31 Mar 2026 | 5 articles | Viewed by 3344 | Submission Open

Keywords: ovarian cancer; biomarkers; cell biology; gene regulation; target therapy; therapeutic resistance; precision medicine

(This special issue belongs to the Section Cancer Biology and Oncology)

New Horizons in Enzyme Inhibitor Discovery: Targets, Design and Evaluation

edited by Chenzhou Hao, Jing Guo, Yin Sun and Tongchao Liu

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3274 | Submission Open

Keywords: enzyme inhibitors; drug design; inhibitor screening; medicinal chemistry; targets validation; structure– activity relationship; structure– property relationship

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Impacts of Exercise, Nutrition, Obesity, Metabolism and Ageing on Regenerative Medicine and Their Applications in Tissue Engineering and Therapeutics

edited by

Abdelaziz Ghanemi

submission deadline 31 Mar 2026 | 2 articles | Viewed by 3031 | Submission Open

Keywords: obesity; exercise; nutrition (diet); obesity; metabolism; ageing; regenerative medicine; tissue engineering; therapeutics

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Pathogenesis and Treatment of Ophthalmic Diseases

edited by

Da-Wen Lu

submission deadline 31 Mar 2026 | 1 articles | Viewed by 3017 | Submission Open

Keywords: ophthalmology; AI; ocular; eye diseases; retina; cornea; glaucoma; neuro-ophthalmology

(This special issue belongs to the Section Molecular and Translational Medicine)

New Insights in Hypoxic Response Modulation

edited by Rafał Bartoszewski

submission deadline 31 Mar 2026 | 2 articles | Viewed by 2943 | Submission Open

Keywords: hypoxia; oxygen homeostasis; oxidative damage; cell death; ischemic events; stroke; myocardial infarction; tumor microenvironment (TME); noncoding RNA; MicroRNAs; long noncoding RNAs; PiRNA; hypoxia-inducible factors (HIFs); targeted delivery; hypoxic cells; regulatory networks; therapeutic opportunities

(This special issue belongs to the Section Cell Biology and Pathology)

Imaging Technology for Human Diseases

edited by Emanuele David

submission deadline 31 Mar 2026 | 4 articles | Viewed by 2921 | Submission Open

Keywords: technological advances; imaging; X-ray; mammography; CT; MRI; ultrasound; angiography

(This special issue belongs to the Section Biomedical Engineering and Materials)

Emerging Insights in Thoracic Diseases: From Diagnostics to Biomarkers and Therapeutic Implications Through Interdisciplinarity

edited by

Radu Adrian Crisan-Dabija

and

Alexandru Burlacu

submission deadline 31 Mar 2026 | 4 articles | Viewed by 2763 | Submission Open

Keywords: chronic obstructive pulmonary disease; acute respiratory diseases; cardionephrology; interstitial lung disease; interventional cardiology; pulmonary fibrosis; tuberculosis; research methodology; biomarkers; therapeutics; artificial intelligence

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Immunotherapy and Radiation Therapy for Cancer (2nd Edition)

edited by

Ivaylo B. Mihaylov

and Benjamin Spieler

submission deadline 31 Mar 2026 | 2 articles | Viewed by 2708 | Submission Open

Keywords: radiotherapy; immunotherapy; outcome; toxicity; normal tissue; abscopal; tumor; systemic; local; response

(This special issue belongs to the Section Cancer Biology and Oncology)

Stem Cell Therapy: Traps and Tricks

edited by

Martina Perše

and Željka Večerić-Haler

submission deadline 31 Mar 2026 | 2 articles | Viewed by 2591 | Submission Open

Keywords: mesenchymal stem cells; MSC therapy; preclinical research; regenerative medicine

(This special issue belongs to the Section Biomedical Engineering and Materials)

Advances in Immune Cell Biology: Insights from Molecular Perspectives

edited by

Paolo Fagone

submission deadline 31 Mar 2026 | 2 articles | Viewed by 2500 | Submission Open

Keywords: immune cell biology; cell signaling cascades; autoimmune disorders; immunoinflammatory pathways; hematological disorders

(This special issue belongs to the Section Cell Biology and Pathology)

Diabetes Mellitus: Pharmacological Innovations and Related Therapeutic Benefits

edited by

Cristina-Mihaela Lăcătuşu

submission deadline 31 Mar 2026 | 2 articles | Viewed by 2476 | Submission Open

Keywords: therapy of diabetes mellitus; pharmacological innovations; incretins; GLP-1 receptor agonists; SGLT-2 inhibitors; weight control; diabetes-related cardiovascular risk; non-glycemic benefits of diabetes drugs; diabetes-related technologies; diabetes outcomes

(This special issue belongs to the Section Molecular and Translational Medicine)

Oral Cancer: From Pathophysiology to Novel Therapeutic Approach

edited by

Chan-Yen Kuo

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2342 | Submission Open

Keywords: oral cancer and pathophysiology; molecular mechanisms; biomarkers; immunological and targeted therapy; precision medicine and personalized therapies

(This special issue belongs to the Section Molecular and Translational Medicine)

Biomarkers and Therapeutic Targets in Gastric Cancer: From Basic Research to Clinical Applications

edited by

Laura Georgiana Necula

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2007 | Submission Open

Keywords: gastric cancer; tumor microenvironment; gastric cancer metastasis; cancer stem cells; diagnosis and treatment; biomarkers

(This special issue belongs to the Section Cancer Biology and Oncology)

Drug-Resistant Bacterial Infections and Alternative Therapies—2nd Edition

edited by

Vijay Singh Gondil

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1938 | Submission Open

Keywords: alternative agents; antibiotics; phages; endolysins; phytochemicals; drug discovery; nanoparticles; biofilms

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Microbial Metabolites and Their Impact on Gut Homeostasis

edited by

Federica Laudisi

and

Carmine Stolfi

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1931 | Submission Open

Keywords: intestinal microbiota; microbial metabolites; gut homeostasis; inflammatory response; intestinal epithelial barrier; immune response; diet

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Skin Fibrosis and Cutaneous Wound Healing—2nd Edition

edited by

Noriko Aramaki-Hattori

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1853 | Submission Open

Keywords: fibroblasts; inflammation; fibrosis; cutaneous wound healing

(This special issue belongs to the Section Molecular and Translational Medicine)

Brain Imaging and Cognitive Deficits in Psychiatric Disorders, 2nd Edition

edited by

Wenbin Guo

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1803 | Submission Open

Keywords: cognitive deficits; psychiatric disorders; schizophrenia; brain imaging

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Medical Imaging in Brain Tumor: Charting the Future

edited by

Subrata Bhattacharjee

and

Mansoor Hayat

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1749 | Submission Open

Keywords: brain tumor diagnosis; artificial intelligence (AI) in medical imaging; imaging biomarkers for brain tumor; detection; segmentation and classification; radiomics and radiogenomics; precision oncology; deep learning and machine learning; neuro oncology; digital pathology; treatment response monitoring

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Central Role of Mitochondrial Oxidative Stress in the Pathophysiology of Disorders (2nd Edition)

edited by

Guilhian Leipnitz

and André Quincozes-Santos

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1665 | Submission Open

Keywords: mitochondrial dysfunction; reactive oxygen species; bioenergetics; mitochondrial quality control; pathologies; protective agents

(This special issue belongs to the Section Molecular and Translational Medicine)

New Trends in Regional Anesthesia and Pain Management

edited by

Jui-An Lin

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1651 | Submission Open

Keywords: regional anesthesia; ultrasound-guided/stimulator-guided nerve blocks; novel techniques for motor-sparing neural intervention; continuous catheter infusions; opioid-sparing techniques; perioperative pain management; novel local anesthetics; cadaveric dissection exploring the anatomical knowledge of motor-sparing techniques; modalities (techniques; technologies; or drug regimen) to prolong the effect of local anesthetics; ERAS-related studies; AI applications in regional anesthesia and pain management; innovations and protocols/curriculum regarding regional anesthesia and pain management in the battlefield; studies comparing new technologies/simulation (such as EpiFaith; SPRint PNS system; or CompuFlo) with traditional methods in improving regional anesthesia and pain management; regenerative medicine; nutritional pain medicine; application of bone marrow aspirate concentration or other stem cell components in pain medicine; multidisciplinary/comprehensive care program; transarterial embolization for pain management; joint denervation for pain management

(This special issue belongs to the Section Molecular and Translational Medicine)

Recent Advances in Molecular Neuroimaging

edited by

Wenliang Fan

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1153 | Submission Open

Keywords: molecular neuroimaging; imaging techniques; clinical applications; imaging probes; personalized medicine; diagnostic imaging; therapeutic monitoring; clinical decision support

(This special issue belongs to the Section Molecular and Translational Medicine)

Innovations and Perspectives in Kidney Transplantation

edited by Vassilis Filiopoulos

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1028 | Submission Open

Keywords: bioartificial kidney; immunology; immunosuppression; kidney transplantation; tolerance; graft rejection; graft survival; xenotransplantation; kidney regeneration

(This special issue belongs to the Section Immunology and Immunotherapy)

Drug Discovery, Development and Delivery: Current Status and Future Perspectives

edited by

Shafi Ullah Khan

and

Thet Thet Htar

submission deadline 31 Mar 2026 | 1 articles | Viewed by 984 | Submission Open

Keywords: drug discovery; rational drug design; computer-aided drug design (CADD); drug repurposing; artificial intelligence (AI) and machine learning (ML); cancer therapeutics; infectious diseases; natural products

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Recent Advances in Endocrine Disease and Atherosclerosis

edited by

Sergio Martínez-Hervás

submission deadline 31 Mar 2026 | 1 articles | Viewed by 963 | Submission Open

Keywords: diabetes; dyslipidemia; obesity; insulin resistance; subclinical atherosclerosis; atherosclerosis; cardiovascular disease

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Noncoding RNAs (ncRNAs): The Role in Gene Regulation and Human Diseases

edited by

Liming Chen

and

Yuanshan Zhu

submission deadline 31 Mar 2026 | Viewed by 887 | Submission Open

Keywords: ncRNAs; genomic editing; epigenetics; stem cell biology and regenerative medicine

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Genetic Insights and Pharmacogenomic Approaches in Cancer Treatment

edited by

Ana Fernández-Santander

submission deadline 31 Mar 2026 | 1 articles | Viewed by 735 | Submission Open

Keywords: pharmacogenetics; genetic basis; cancer treatments

(This special issue belongs to the Section Cancer Biology and Oncology)

Feature Reviews in Target Identification and Drug Discovery

edited by

Fabio Altieri

submission deadline 31 Mar 2026 | Viewed by 611 | Submission Open

Keywords: drug discovery; biological target; bioactive compounds; pharmacology

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Advances in Skin Diseases

edited by Nazia M. Saiyed and

Noriko Aramaki-Hattori

submission deadline 31 Mar 2026 | 1 articles | Viewed by 580 | Submission Open

Keywords: skin diseases; dermatology; diagnostic innovations; targeted therapies; molecular mechanisms; immunodermatology; translational research; inflammatory skin disorders; clinical dermatology; precision medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Current Perspectives on Human Papillomavirus (HPV)—Second Edition

edited by

Vanja Kaliterna

and

Tomislav Meštrović

submission deadline 31 Mar 2026 | 1 articles | Viewed by 555 | Submission Open

Keywords: human papillomavirus (HPV); molecular mechanisms; diagnosis; treatment; prevention; vaccination; screening; immunotherapy; cancer

(This special issue belongs to the Section Microbiology in Human Health and Disease)

High-Risk Atrial Fibrillation in Patients with Cardiovascular Disease: Diagnosis, Comprehensive Risk Assessment, Comorbidities, and Anticoagulation Strategies

edited by

Silvia Reverté-Villarroya

and

José-Luis Clúa-Espuny

submission deadline 31 Mar 2026 | 1 articles | Viewed by 405 | Submission Open

Keywords: atrial fibrillation; cardiovascular comorbidity; device-detected atrial fibrillation; treatment

(This special issue belongs to the Section Molecular and Translational Medicine)

Advanced Research in Antiviral Innate Immunity

edited by Junji Zhu

submission deadline 31 Mar 2026 | Viewed by 403 | Submission Open

Keywords: antiviral immunity; innate immune signaling; toll-like receptors (TLRs); RIG-I-like receptors (RLRs); cGAS-STING pathway; type I interferon; viral infection; post-translational modification (PTM); phase separation; host– pathogen interactions; therapeutic strategies

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Roles of Extracellular Vesicles in Cancer Immunotherapy

edited by Shujing Liu and Zhiyuan Qin

submission deadline 31 Mar 2026 | Viewed by 335 | Submission Open

Keywords: extracellular vesicles; microvesicles; exosomes; cancer biology; cancer immunity; cancer immunotherapy; biomarkers; cancer vaccines; antigen presentation; drug delivery

(This special issue belongs to the Section Cancer Biology and Oncology)

Neural Plasticity: Mechanisms and Therapeutic Implications

edited by Linlin Sun

submission deadline 31 Mar 2026 | Viewed by 329 | Submission Open

Keywords: neural plasticity; synaptic plasticity; neurogenesis; neural regeneration; brain injury; non-invasive brain stimulation techniques

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Tumor Immune Microenvironment, Metabolic Remodeling and Mechanism of Cancer Metastasis

edited by

Yuhui Tang

and

Shaoquan Zheng

submission deadline 31 Mar 2026 | Viewed by 284 | Submission Open

Keywords: tumor immune microenvironment; metabolic remodeling; cancer metastasis; immune– metabolic crosstalk; novel therapeutic targets for metastasis

(This special issue belongs to the Section Cancer Biology and Oncology)

Mycobacterial Infections: Insights into Pathogenesis, Diagnosis, and Treatment

edited by

Abhishek Mishra

submission deadline 31 Mar 2026 | Viewed by 278 | Submission Open

Keywords: mycobacterium; pathogenesis; host– pathogen interactions; virulence factors; antimicrobial resistance; diagnosis; therapeutics; host-directed therapy; vaccine development; drug resistance

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Obesity and Obesity-Related Pathology

edited by

Adriana Grigoraș

submission deadline 31 Mar 2026 | Viewed by 274 | Submission Open

Keywords: obesity; obesity-related cardiovascular diseases; obesity-related chronic kidney diseases; diabetes mellitus; depression; obesity-related cancer; adipose tissue; adipocytes; cancer-associated adipocytes; obesity therapies

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Molecular Psychiatry and Antipsychotics

edited by

László Péczely

submission deadline 31 Mar 2026 | Viewed by 252 | Submission Open

Keywords: psychiatric diseases; schizophrenia; antipsychotics; molecular psychiatry; molecular pathways; neurotransmitter systems; positive; negative and cognitive symptoms

(This special issue belongs to the Section Molecular and Translational Medicine)

Head and Neck Cancer: From Mechanisms to Therapeutic Approaches—Advances and Challenges

edited by

Barbara Verro

Carmelo Saraniti

and

Daniela Carlisi

submission deadline 31 Mar 2026 | Viewed by 247 | Submission Open

Keywords: head and neck cancers; target therapy; biomarkers; molecular targets; translational research; pathogenesis; prognosis; diagnostic tool

(This special issue belongs to the Section Cancer Biology and Oncology)

Epigenetics in the Perioperative Setting

edited by Rump Katharina

submission deadline 31 Mar 2026 | Viewed by 238 | Submission Open

Keywords: epigenetics; perioperative setting; surgical stress; anesthesia; gene expression; cognitive impairment; postoperative delirium; postoperative cognitive dysfunction (POCD); neuroinflammation; therapeutic approaches

(This special issue belongs to the Section Immunology and Immunotherapy)

Advances in Oral Squamous Cell Carcinoma Research

edited by Sangang Wu

submission deadline 31 Mar 2026 | Viewed by 234 | Submission Open

Keywords: oral squamous cell carcinoma; diagnostic biomarkers; therapeutic strategies; tumor microenvironment; radiotherapy; single-cell sequencing; artificial intelligence in oncology; personalized medicine; molecular mechanism; recurrence and metastasis

(This special issue belongs to the Section Cancer Biology and Oncology)

Lymphomas: From Mechanisms to Therapeutic Approaches

edited by Delfa Radić-Krišto and

Vibor Milunović

submission deadline 31 Mar 2026 | Viewed by 225 | Submission Open

Keywords: aggressive lymphomas; cellular therapy; cellular immunotherapy; translational medicine; lymphomagenesis; indolent lymphomas; phase I/II clinical trials; targeted therapy; biomarkers; in vitro and in vivo models of lymphomas

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in Head and Neck Cancer: Mechanisms, Diagnosis, and Therapeutic Progress

edited by

Takuya Yoshimura

and Hideto Saijo

submission deadline 31 Mar 2026 | Viewed by 224 | Submission Open

Keywords: head and neck cancer; oral cancer; laryngeal cancer; nasopharyngeal cancer; thyroid cancer; diagnostic and treatment strategies

(This special issue belongs to the Section Cancer Biology and Oncology)

New Advances in the Pathology, Diagnosis and Treatment of Thyroid Tumors

edited by

Przemyslaw Zdziarski

submission deadline 31 Mar 2026 | Viewed by 217 | Submission Open

Keywords: goitre; thyroid cancer; screening; bias; paraneoplastic syndrome ; immunosurveillance ; thyroiditis ; thyroidectomy ; immunotherapy

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Displaying special issue 401-450 on page 9 of 17.

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