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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Drug Discovery, Development and Delivery: Current Status and Future Perspectives

edited by

Shafi Ullah Khan

and

Thet Thet Htar

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1152 | Submission Open

Keywords: drug discovery; rational drug design; computer-aided drug design (CADD); drug repurposing; artificial intelligence (AI) and machine learning (ML); cancer therapeutics; infectious diseases; natural products

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Innovations and Perspectives in Kidney Transplantation

edited by Vassilis Filiopoulos

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1143 | Submission Open

Keywords: bioartificial kidney; immunology; immunosuppression; kidney transplantation; tolerance; graft rejection; graft survival; xenotransplantation; kidney regeneration

(This special issue belongs to the Section Immunology and Immunotherapy)

Recent Advances in Endocrine Disease and Atherosclerosis

edited by

Sergio Martínez-Hervás

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1007 | Submission Open

Keywords: diabetes; dyslipidemia; obesity; insulin resistance; subclinical atherosclerosis; atherosclerosis; cardiovascular disease

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Noncoding RNAs (ncRNAs): The Role in Gene Regulation and Human Diseases

edited by

Liming Chen

and

Yuanshan Zhu

submission deadline 31 Mar 2026 | Viewed by 896 | Submission Open

Keywords: ncRNAs; genomic editing; epigenetics; stem cell biology and regenerative medicine

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Genetic Insights and Pharmacogenomic Approaches in Cancer Treatment

edited by

Ana Fernández-Santander

submission deadline 31 Mar 2026 | 1 articles | Viewed by 788 | Submission Open

Keywords: pharmacogenetics; genetic basis; cancer treatments

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in Skin Diseases

edited by Nazia M. Saiyed and

Noriko Aramaki-Hattori

submission deadline 31 Mar 2026 | 2 articles | Viewed by 747 | Submission Open

Keywords: skin diseases; dermatology; diagnostic innovations; targeted therapies; molecular mechanisms; immunodermatology; translational research; inflammatory skin disorders; clinical dermatology; precision medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Current Perspectives on Human Papillomavirus (HPV)—Second Edition

edited by

Vanja Kaliterna

and

Tomislav Meštrović

submission deadline 31 Mar 2026 | 1 articles | Viewed by 621 | Submission Open

Keywords: human papillomavirus (HPV); molecular mechanisms; diagnosis; treatment; prevention; vaccination; screening; immunotherapy; cancer

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Feature Reviews in Target Identification and Drug Discovery

edited by

Fabio Altieri

submission deadline 31 Mar 2026 | Viewed by 621 | Submission Open

Keywords: drug discovery; biological target; bioactive compounds; pharmacology

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

High-Risk Atrial Fibrillation in Patients with Cardiovascular Disease: Diagnosis, Comprehensive Risk Assessment, Comorbidities, and Anticoagulation Strategies

edited by

Silvia Reverté-Villarroya

and

José-Luis Clúa-Espuny

submission deadline 31 Mar 2026 | 1 articles | Viewed by 600 | Submission Open

Keywords: atrial fibrillation; cardiovascular comorbidity; device-detected atrial fibrillation; treatment

(This special issue belongs to the Section Molecular and Translational Medicine)

Emerging Trends in Liver Diseases and Cirrhosis Research

edited by

Hariklia Kranidioti

submission deadline 31 Mar 2026 | 1 articles | Viewed by 459 | Submission Open

Keywords: pathogenesis of liver fibrosis and cirrhosis; MASLD; hepatitis B; C and D; primary biliary cholangitis (PBC): immunopathology and treatment advances; alcohol-associated liver disease; liver regeneration and stem-cell-based therapies; biomarkers for early diagnosis and prognosis; emerging antifibrotic treatments; liver complications and systemic comorbidities; personalized medicine in liver disease

(This special issue belongs to the Section Molecular and Translational Medicine)

Advanced Research in Antiviral Innate Immunity

edited by Junji Zhu

submission deadline 31 Mar 2026 | Viewed by 408 | Submission Open

Keywords: antiviral immunity; innate immune signaling; toll-like receptors (TLRs); RIG-I-like receptors (RLRs); cGAS-STING pathway; type I interferon; viral infection; post-translational modification (PTM); phase separation; host– pathogen interactions; therapeutic strategies

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Chronic Vascular Impairment in Heart, Brain, and Kidney Disorders: Molecular Mechanisms and Therapeutic Strategies

edited by

Mahdi O. Garelnabi

submission deadline 31 Mar 2026 | 1 articles | Viewed by 394 | Submission Open

Keywords: atherosclerosis; lipoprotein; inflammation; antioxidants; oxidative stress; cardiovascular diseases; neurodegenerative disorders; blood– brain barrier; stroke; Alzheimer's disease; kidney

(This special issue belongs to the Section Cell Biology and Pathology)

Molecular Psychiatry and Antipsychotics

edited by

László Péczely

submission deadline 31 Mar 2026 | 1 articles | Viewed by 388 | Submission Open

Keywords: psychiatric diseases; schizophrenia; antipsychotics; molecular psychiatry; molecular pathways; neurotransmitter systems; positive; negative and cognitive symptoms

(This special issue belongs to the Section Molecular and Translational Medicine)

Neural Plasticity: Mechanisms and Therapeutic Implications

edited by Linlin Sun

submission deadline 31 Mar 2026 | Viewed by 359 | Submission Open

Keywords: neural plasticity; synaptic plasticity; neurogenesis; neural regeneration; brain injury; non-invasive brain stimulation techniques

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Roles of Extracellular Vesicles in Cancer Immunotherapy

edited by Shujing Liu and Zhiyuan Qin

submission deadline 31 Mar 2026 | Viewed by 347 | Submission Open

Keywords: extracellular vesicles; microvesicles; exosomes; cancer biology; cancer immunity; cancer immunotherapy; biomarkers; cancer vaccines; antigen presentation; drug delivery

(This special issue belongs to the Section Cancer Biology and Oncology)

Tumor Immune Microenvironment, Metabolic Remodeling and Mechanism of Cancer Metastasis

edited by

Yuhui Tang

and

Shaoquan Zheng

submission deadline 31 Mar 2026 | Viewed by 316 | Submission Open

Keywords: tumor immune microenvironment; metabolic remodeling; cancer metastasis; immune– metabolic crosstalk; novel therapeutic targets for metastasis

(This special issue belongs to the Section Cancer Biology and Oncology)

Obesity and Obesity-Related Pathology

edited by

Adriana Grigoraș

submission deadline 31 Mar 2026 | Viewed by 293 | Submission Open

Keywords: obesity; obesity-related cardiovascular diseases; obesity-related chronic kidney diseases; diabetes mellitus; depression; obesity-related cancer; adipose tissue; adipocytes; cancer-associated adipocytes; obesity therapies

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Mycobacterial Infections: Insights into Pathogenesis, Diagnosis, and Treatment

edited by

Abhishek Mishra

submission deadline 31 Mar 2026 | Viewed by 285 | Submission Open

Keywords: mycobacterium; pathogenesis; host– pathogen interactions; virulence factors; antimicrobial resistance; diagnosis; therapeutics; host-directed therapy; vaccine development; drug resistance

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Advances in Cancer Biology and Experimental Anticancer Therapies (3rd Edition)

edited by

Letizia Polito

and

Ewa Gajda

submission deadline 31 Mar 2026 | 1 articles | Viewed by 257 | Submission Open

Keywords: cancer biology; experimental anticancer therapies; immunotherapy; immunotoxins; signalling pathways; targeted therapies

(This special issue belongs to the Section Cancer Biology and Oncology)

Head and Neck Cancer: From Mechanisms to Therapeutic Approaches—Advances and Challenges

edited by

Barbara Verro

Carmelo Saraniti

and

Daniela Carlisi

submission deadline 31 Mar 2026 | Viewed by 254 | Submission Open

Keywords: head and neck cancers; target therapy; biomarkers; molecular targets; translational research; pathogenesis; prognosis; diagnostic tool

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in Oral Squamous Cell Carcinoma Research

edited by Sangang Wu

submission deadline 31 Mar 2026 | Viewed by 251 | Submission Open

Keywords: oral squamous cell carcinoma; diagnostic biomarkers; therapeutic strategies; tumor microenvironment; radiotherapy; single-cell sequencing; artificial intelligence in oncology; personalized medicine; molecular mechanism; recurrence and metastasis

(This special issue belongs to the Section Cancer Biology and Oncology)

Epigenetics in the Perioperative Setting

edited by Rump Katharina

submission deadline 31 Mar 2026 | Viewed by 241 | Submission Open

Keywords: epigenetics; perioperative setting; surgical stress; anesthesia; gene expression; cognitive impairment; postoperative delirium; postoperative cognitive dysfunction (POCD); neuroinflammation; therapeutic approaches

(This special issue belongs to the Section Immunology and Immunotherapy)

Advances in Head and Neck Cancer: Mechanisms, Diagnosis, and Therapeutic Progress

edited by

Takuya Yoshimura

and Hideto Saijo

submission deadline 31 Mar 2026 | Viewed by 230 | Submission Open

Keywords: head and neck cancer; oral cancer; laryngeal cancer; nasopharyngeal cancer; thyroid cancer; diagnostic and treatment strategies

(This special issue belongs to the Section Cancer Biology and Oncology)

Lymphomas: From Mechanisms to Therapeutic Approaches

edited by Delfa Radić-Krišto and

Vibor Milunović

submission deadline 31 Mar 2026 | Viewed by 229 | Submission Open

Keywords: aggressive lymphomas; cellular therapy; cellular immunotherapy; translational medicine; lymphomagenesis; indolent lymphomas; phase I/II clinical trials; targeted therapy; biomarkers; in vitro and in vivo models of lymphomas

(This special issue belongs to the Section Cancer Biology and Oncology)

New Advances in the Pathology, Diagnosis and Treatment of Thyroid Tumors

edited by

Przemyslaw Zdziarski

submission deadline 31 Mar 2026 | Viewed by 227 | Submission Open

Keywords: goitre; thyroid cancer; screening; bias; paraneoplastic syndrome ; immunosurveillance ; thyroiditis ; thyroidectomy ; immunotherapy

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Type 2 Diabetes: Current Progress and Future Challenges

edited by

Tomislav Kurevija

submission deadline 31 Mar 2026 | Viewed by 215 | Submission Open

Keywords: type 2 diabetes; cardiovascular risk; novel antidiabetics; clinical guidelines therapeutic inertia; obesity; insulin resistance; metabolic syndrome; diabetology; family medicine

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Epigenetics and Immune Perspectives in Cancer: Overcoming Therapy Resistance

edited by

Xuemin Lu

submission deadline 31 Mar 2026 | Viewed by 210 | Submission Open

Keywords: epigenetics; immunotherapy; therapy resistance; tumor microenvironment; DNA methylation; histone modifications; dietary intervention; non-coding RNAs; immune evasion; combination therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Innovations in Radiation Oncology

edited by

Caressa Hui

submission deadline 31 Mar 2026 | 1 articles | Viewed by 198 | Submission Open

Keywords: adaptive radiotherapy; cancer biomarkers; genomics; artificial intelligence; radiation oncology; machine learning; precision oncology; radiogenomics; ctDNA

(This special issue belongs to the Section Cancer Biology and Oncology)

Leishmaniasis: Pathophysiology, Diagnostics and Current and Emerging Therapeutic Approaches—2nd Edition

edited by

Raimunda Nonata Ribeiro Sampaio

submission deadline 31 Mar 2026 | 1 articles | Viewed by 198 | Submission Open

Keywords: leishmaniasis; pathophysiology; neglected infectious diseases

(This special issue belongs to the Section Molecular and Translational Medicine)

Matrix Biology Insights: Unraveling the Role of Proteinases, Fibroblasts, and Extracellular Matrix Metalloproteinase Inducer in the Tumor Microenvironment

edited by

Eric Huet

submission deadline 31 Mar 2026 | Viewed by 195 | Submission Open

Keywords: tumor microenvironment; proteinases; fibroblasts; EMMPRIN; matrix biology; extracellular matrix (ECM); matrix metalloproteinases (MMPs)

(This special issue belongs to the Section Cancer Biology and Oncology)

Recent Advances in Endothelial Dysfunction

edited by

Manfredi Tesauro

submission deadline 31 Mar 2026 | Viewed by 187 | Submission Open

Keywords: endothelial dysfunction; atherosclerosis; nitric oxide (NO); hyperlipidemia; hypertension; hyperglycemia; vasodilation; perivascular adipose tissue (PVAT); insulin resistance

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Fibromyalgia and Neuroinflammation: Unraveling Pathophysiological Links and Therapeutic Targets

edited by Mario García-Domínguez

submission deadline 31 Mar 2026 | Viewed by 180 | Submission Open

Keywords: fibromyalgia; neuroinflammation; central sensitization; glial activation; cytokines; pain modulation; chronic pain; neuroimmune interaction

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Imaging and Modeling Alzheimer's Disease: The Quest for Mechanistic Understanding, Early Diagnosis, and Novel Treatments

edited by Guoshi Li

submission deadline 31 Mar 2026 | Viewed by 177 | Submission Open

Keywords: biomarker identification; connectome analysis; computational neuroimaging; biophysical modeling; network models; machine learning; brain stimulation; neurodegeneration

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Zebrafish Models: From Basic Research to Translational Medicine

edited by

Surendra Rajpurohit

and Vishal Arora

submission deadline 31 Mar 2026 | Viewed by 176 | Submission Open

Keywords: zebrafish; animal models; in vivo whole model organism imaging; epigenetics; physiological and functional discoveries; genetic engineered transgenic cellular and mutant phenotype; developmental biology; drug discovery; high-throughput drug screening; pharmacogenomics; translational research; toxicology; genomics; cardiology; cardio-oncology; cardiovascular diseases; cardio-oncology; cancer models; melanoma; tumor microenvironment; dermatology; ophthalmology; neuroscience; aging; neurodegenerative disease; diabetes; kidney disease; hematology

(This special issue belongs to the Section Molecular and Translational Medicine)

Inflammatory Mechanisms, Biomarkers and Treatment in Oral Diseases

edited by

Raquel M. Scarel-Caminaga

submission deadline 31 Mar 2026 | Viewed by 176 | Submission Open

Keywords: periodontal diseases; peri-implantitis; oral lichen planus; oral microbial dysbiosis; inflammatory pathways; biomarkers

(This special issue belongs to the Section Molecular and Translational Medicine)

Stem Cell Biology and Tissue Engineering for Cardiology

edited by Otilia Țica

submission deadline 31 Mar 2026 | Viewed by 175 | Submission Open

Keywords: cardiac regeneration; stem cell therapy; cardiac tissue engineering; mesenchymal stem cells (MSCs); induced pluripotent stem cells (iPSCs); cardiomyocyte differentiation; myocardial repair; 3D bioprinting; biomaterials in cardiology; cardiac scaffolds; heart organoids; translational regenerative medicine; cell-based therapy; cardiovascular bioengineering; immunomodulation in cardiac repair

(This special issue belongs to the Section Molecular and Translational Medicine)

Applications of Biomedical Engineering and Biomaterials in Human Diseases

edited by Rui Sang

submission deadline 31 Mar 2026 | Viewed by 171 | Submission Open

Keywords: biosensors and diagnostics; biomedical engineering; nanotechnology in medicine; artificial intelligence in healthcare; precision medicine; drug delivery systems; regenerative medicine; 3D bioprinting; CRISPR-based technologies

(This special issue belongs to the Section Biomedical Engineering and Materials)

Glioblastoma: Novel Multitargeted Approaches

edited by

Wenjing Zeng

submission deadline 31 Mar 2026 | Viewed by 169 | Submission Open

Keywords: glioblastoma; multitargeted therapy; tumor heterogeneity; immunotherapy; targeted agents; nanomedicine; RNA therapeutics; combination therapy; translational oncology

Advancements in the Treatment of Colorectal Cancer

edited by

Andee Dzulkarnaen Zakaria

submission deadline 31 Mar 2026 | Viewed by 168 | Submission Open

Keywords: genomic profiling; advanced nutritional support; AI; MDT; adjuvant therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Sepsis and Systemic Inflammation: Mechanisms and Therapeutic Innovations

edited by

Christian Lehmann

submission deadline 31 Mar 2026 | Viewed by 155 | Submission Open

Keywords: sepsis; systemic inflammation; microcirculation; intravital imaging; immune dysregulation; septic shock; therapeutic innovations

(This special issue belongs to the Section Immunology and Immunotherapy)

Advances in Cardiac Remodeling

edited by Silvio Assis de Oliveira-Junior and André Soares Leopoldo

submission deadline 31 Mar 2026 | Viewed by 154 | Submission Open

Keywords: cardiac remodeling; cardiomyocyte contractile; obesity; diabetes; diets; training; rats; humans

(This special issue belongs to the Section Molecular and Translational Medicine)

Decoding Neurodegeneration: Insights from Multi-Omics and Neuroimaging Integration

edited by

Abdulhakim Al-Ezzi

submission deadline 31 Mar 2026 | Viewed by 147 | Submission Open

Keywords: neurodegenerative; neuroimaging; executive functions; electrophysiology; brain connectivity; multi omics data; bio-molecular data; biomarkers; systems biology; single-cell omics; translational neuroscience

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

New Approaches to Spinal Cord-Related Diseases

edited by Corentin Dauleac

submission deadline 31 Mar 2026 | Viewed by 144 | Submission Open

Keywords: spinal cord; spinal cord injury; stem cell; neuromodulation; rehabilitation; plasticity; spasticity; pain; neuroimaging

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Oxidative Stress, Mitochondrial Dysfunction, and Aβ Pathology: Converging Pathways in Aging and Neurodegeneration

edited by

Swapnil Pandey

, Laxmi Rathor and

Ashish Shukla

submission deadline 31 Mar 2026 | Viewed by 143 | Submission Open

Keywords: oxidative stress; aging; amyloid beta; tau phosphorylation; neurodegeneration; regulated cell death; mitochondrial biogenesis; Drosophila; C. elegans

(This special issue belongs to the Section Cell Biology and Pathology)

Drug Delivery and Nanocarrier

edited by

Jiawei Huo

submission deadline 31 Mar 2026 | Viewed by 140 | Submission Open

Keywords: nanocarriers; targeted drug delivery; controlled release; theranostics; biocompatibility; functionalized nanoparticles; nanomedicine; translational nanotechnology

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Advances in Bone Metabolism, Bone Homeostasis and Osteogenesis

edited by

Youngjae Jeong

and Laura Ortinau

submission deadline 31 Mar 2026 | Viewed by 138 | Submission Open

Keywords: bone homeostasis and maintenance; bone remodeling; osteoblast– osteoclast interaction; endocrine signaling by bone; bone metabolic disease

(This special issue belongs to the Section Cell Biology and Pathology)

Aortic Aneurysm: Mechanisms, Biomarkers, and Therapeutic Strategy

edited by

Mitra Esfandiarei

and

Seda Selamet Tierney

submission deadline 31 Mar 2026 | Viewed by 135 | Submission Open

Keywords: aortic aneurysms; genetic aortic diseases; endothelial dysfunction; extracellular matrix; aortic wall; aortic smooth muscle; angiotensin system; aortic wall elasticity; matrix metalloproteinases

(This special issue belongs to the Section Molecular and Translational Medicine)

Natural and Synthetic Molecules with Anticancer Activity: Pharmacological Basis and Mechanistic Insight—2nd Edition

edited by

Hassan Ebrahim

and

Angela-Patricia Hernández

submission deadline 31 Mar 2026 | Viewed by 129 | Submission Open

Keywords: anticancer; molecular pharmacology; mechanistic mode of action; signal transduction; in vitro; preclinical; natural products; synthesis

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Next-Generation CRISPR and Immune Modulation: Advancing Precision Genome Editing Therapies for Genetic Disorders

edited by Sukanta Jash

submission deadline 31 Mar 2026 | Viewed by 124 | Submission Open

Keywords: CRISPR/Cas9; base editors; prime editors; innate immunity; genome editing; off-target effects; delivery vectors; monogenic disorders; multiplex editing; AI-driven CRISPR

(This special issue belongs to the Section Gene and Cell Therapy)

Recent Advances in Antiviral and Antibacterial Drugs

edited by

Mohammad Anwar Hossain

submission deadline 31 Mar 2026 | Viewed by 116 | Submission Open

Keywords: viral infection; direct-acting antiviral; antimicrobial resistance (AMR); pandemic preparedness; antiviral therapy; infectious disease; viral resistance

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Displaying special issue 351-400 on page 8 of 16.

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