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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Emerging Trends in Liver Diseases and Cirrhosis Research

edited by

Hariklia Kranidioti

submission deadline 31 Mar 2026 | 1 articles | Viewed by 542 | Submission Open

Keywords: pathogenesis of liver fibrosis and cirrhosis; MASLD; hepatitis B; C and D; primary biliary cholangitis (PBC): immunopathology and treatment advances; alcohol-associated liver disease; liver regeneration and stem-cell-based therapies; biomarkers for early diagnosis and prognosis; emerging antifibrotic treatments; liver complications and systemic comorbidities; personalized medicine in liver disease

(This special issue belongs to the Section Molecular and Translational Medicine)

Leishmaniasis: Pathophysiology, Diagnostics and Current and Emerging Therapeutic Approaches—2nd Edition

edited by

Raimunda Nonata Ribeiro Sampaio

submission deadline 31 Mar 2026 | 1 articles | Viewed by 537 | Submission Open

Keywords: leishmaniasis; pathophysiology; neglected infectious diseases

(This special issue belongs to the Section Molecular and Translational Medicine)

Chronic Vascular Impairment in Heart, Brain, and Kidney Disorders: Molecular Mechanisms and Therapeutic Strategies

edited by

Mahdi O. Garelnabi

submission deadline 31 Mar 2026 | 1 articles | Viewed by 516 | Submission Open

Keywords: atherosclerosis; lipoprotein; inflammation; antioxidants; oxidative stress; cardiovascular diseases; neurodegenerative disorders; blood– brain barrier; stroke; Alzheimer's disease; kidney

(This special issue belongs to the Section Cell Biology and Pathology)

Zebrafish Models: From Basic Research to Translational Medicine

edited by

Surendra Rajpurohit

and Vishal Arora

submission deadline 31 Mar 2026 | 1 articles | Viewed by 468 | Submission Open

Keywords: zebrafish; animal models; in vivo whole model organism imaging; epigenetics; physiological and functional discoveries; genetic engineered transgenic cellular and mutant phenotype; developmental biology; drug discovery; high-throughput drug screening; pharmacogenomics; translational research; toxicology; genomics; cardiology; cardio-oncology; cardiovascular diseases; cardio-oncology; cancer models; melanoma; tumor microenvironment; dermatology; ophthalmology; neuroscience; aging; neurodegenerative disease; diabetes; kidney disease; hematology

(This special issue belongs to the Section Molecular and Translational Medicine)

Advancements in the Treatment of Colorectal Cancer

edited by

Andee Dzulkarnaen Zakaria

submission deadline 31 Mar 2026 | 1 articles | Viewed by 424 | Submission Open

Keywords: genomic profiling; advanced nutritional support; AI; MDT; adjuvant therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Inflammatory Mechanisms, Biomarkers and Treatment in Oral Diseases

edited by

Raquel M. Scarel-Caminaga

submission deadline 31 Mar 2026 | 1 articles | Viewed by 420 | Submission Open

Keywords: periodontal diseases; peri-implantitis; oral lichen planus; oral microbial dysbiosis; inflammatory pathways; biomarkers

(This special issue belongs to the Section Molecular and Translational Medicine)

Advanced Research in Antiviral Innate Immunity

edited by Junji Zhu

submission deadline 31 Mar 2026 | Viewed by 411 | Submission Open

Keywords: antiviral immunity; innate immune signaling; toll-like receptors (TLRs); RIG-I-like receptors (RLRs); cGAS-STING pathway; type I interferon; viral infection; post-translational modification (PTM); phase separation; host– pathogen interactions; therapeutic strategies

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Advances in Cancer Biology and Experimental Anticancer Therapies (3rd Edition)

edited by

Letizia Polito

and

Ewa Gajda

submission deadline 31 Mar 2026 | 1 articles | Viewed by 385 | Submission Open

Keywords: cancer biology; experimental anticancer therapies; immunotherapy; immunotoxins; signalling pathways; targeted therapies

(This special issue belongs to the Section Cancer Biology and Oncology)

Neural Plasticity: Mechanisms and Therapeutic Implications

edited by Linlin Sun

submission deadline 31 Mar 2026 | Viewed by 383 | Submission Open

Keywords: neural plasticity; synaptic plasticity; neurogenesis; neural regeneration; brain injury; non-invasive brain stimulation techniques

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Innovations in Radiation Oncology

edited by

Caressa Hui

submission deadline 31 Mar 2026 | 1 articles | Viewed by 378 | Submission Open

Keywords: adaptive radiotherapy; cancer biomarkers; genomics; artificial intelligence; radiation oncology; machine learning; precision oncology; radiogenomics; ctDNA

(This special issue belongs to the Section Cancer Biology and Oncology)

Roles of Extracellular Vesicles in Cancer Immunotherapy

edited by Shujing Liu and Zhiyuan Qin

submission deadline 31 Mar 2026 | Viewed by 357 | Submission Open

Keywords: extracellular vesicles; microvesicles; exosomes; cancer biology; cancer immunity; cancer immunotherapy; biomarkers; cancer vaccines; antigen presentation; drug delivery

(This special issue belongs to the Section Cancer Biology and Oncology)

Tumor Immune Microenvironment, Metabolic Remodeling and Mechanism of Cancer Metastasis

edited by

Yuhui Tang

and

Shaoquan Zheng

submission deadline 31 Mar 2026 | Viewed by 341 | Submission Open

Keywords: tumor immune microenvironment; metabolic remodeling; cancer metastasis; immune– metabolic crosstalk; novel therapeutic targets for metastasis

(This special issue belongs to the Section Cancer Biology and Oncology)

Mycobacterial Infections: Insights into Pathogenesis, Diagnosis, and Treatment

edited by

Abhishek Mishra

submission deadline 31 Mar 2026 | Viewed by 295 | Submission Open

Keywords: mycobacterium; pathogenesis; host– pathogen interactions; virulence factors; antimicrobial resistance; diagnosis; therapeutics; host-directed therapy; vaccine development; drug resistance

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Head and Neck Cancer: From Mechanisms to Therapeutic Approaches—Advances and Challenges

edited by

Barbara Verro

Carmelo Saraniti

and

Daniela Carlisi

submission deadline 31 Mar 2026 | Viewed by 271 | Submission Open

Keywords: head and neck cancers; target therapy; biomarkers; molecular targets; translational research; pathogenesis; prognosis; diagnostic tool

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in Oral Squamous Cell Carcinoma Research

edited by Sangang Wu

submission deadline 31 Mar 2026 | Viewed by 261 | Submission Open

Keywords: oral squamous cell carcinoma; diagnostic biomarkers; therapeutic strategies; tumor microenvironment; radiotherapy; single-cell sequencing; artificial intelligence in oncology; personalized medicine; molecular mechanism; recurrence and metastasis

(This special issue belongs to the Section Cancer Biology and Oncology)

Epigenetics in the Perioperative Setting

edited by Rump Katharina

submission deadline 31 Mar 2026 | Viewed by 247 | Submission Open

Keywords: epigenetics; perioperative setting; surgical stress; anesthesia; gene expression; cognitive impairment; postoperative delirium; postoperative cognitive dysfunction (POCD); neuroinflammation; therapeutic approaches

(This special issue belongs to the Section Immunology and Immunotherapy)

Lymphomas: From Mechanisms to Therapeutic Approaches

edited by Delfa Radić-Krišto and

Vibor Milunović

submission deadline 31 Mar 2026 | Viewed by 246 | Submission Open

Keywords: aggressive lymphomas; cellular therapy; cellular immunotherapy; translational medicine; lymphomagenesis; indolent lymphomas; phase I/II clinical trials; targeted therapy; biomarkers; in vitro and in vivo models of lymphomas

(This special issue belongs to the Section Cancer Biology and Oncology)

Type 2 Diabetes: Current Progress and Future Challenges

edited by

Tomislav Kurevija

submission deadline 31 Mar 2026 | Viewed by 239 | Submission Open

Keywords: type 2 diabetes; cardiovascular risk; novel antidiabetics; clinical guidelines therapeutic inertia; obesity; insulin resistance; metabolic syndrome; diabetology; family medicine

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Advances in Head and Neck Cancer: Mechanisms, Diagnosis, and Therapeutic Progress

edited by

Takuya Yoshimura

and Hideto Saijo

submission deadline 31 Mar 2026 | Viewed by 238 | Submission Open

Keywords: head and neck cancer; oral cancer; laryngeal cancer; nasopharyngeal cancer; thyroid cancer; diagnostic and treatment strategies

(This special issue belongs to the Section Cancer Biology and Oncology)

New Advances in the Pathology, Diagnosis and Treatment of Thyroid Tumors

edited by

Przemyslaw Zdziarski

submission deadline 31 Mar 2026 | Viewed by 234 | Submission Open

Keywords: goitre; thyroid cancer; screening; bias; paraneoplastic syndrome ; immunosurveillance ; thyroiditis ; thyroidectomy ; immunotherapy

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Epigenetics and Immune Perspectives in Cancer: Overcoming Therapy Resistance

edited by

Xuemin Lu

submission deadline 31 Mar 2026 | Viewed by 216 | Submission Open

Keywords: epigenetics; immunotherapy; therapy resistance; tumor microenvironment; DNA methylation; histone modifications; dietary intervention; non-coding RNAs; immune evasion; combination therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Recent Advances in Endothelial Dysfunction

edited by

Manfredi Tesauro

submission deadline 31 Mar 2026 | Viewed by 207 | Submission Open

Keywords: endothelial dysfunction; atherosclerosis; nitric oxide (NO); hyperlipidemia; hypertension; hyperglycemia; vasodilation; perivascular adipose tissue (PVAT); insulin resistance

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Matrix Biology Insights: Unraveling the Role of Proteinases, Fibroblasts, and Extracellular Matrix Metalloproteinase Inducer in the Tumor Microenvironment

edited by

Eric Huet

submission deadline 31 Mar 2026 | Viewed by 200 | Submission Open

Keywords: tumor microenvironment; proteinases; fibroblasts; EMMPRIN; matrix biology; extracellular matrix (ECM); matrix metalloproteinases (MMPs)

(This special issue belongs to the Section Cancer Biology and Oncology)

Fibromyalgia and Neuroinflammation: Unraveling Pathophysiological Links and Therapeutic Targets

edited by Mario García-Domínguez

submission deadline 31 Mar 2026 | Viewed by 193 | Submission Open

Keywords: fibromyalgia; neuroinflammation; central sensitization; glial activation; cytokines; pain modulation; chronic pain; neuroimmune interaction

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Imaging and Modeling Alzheimer's Disease: The Quest for Mechanistic Understanding, Early Diagnosis, and Novel Treatments

edited by Guoshi Li

submission deadline 31 Mar 2026 | Viewed by 191 | Submission Open

Keywords: biomarker identification; connectome analysis; computational neuroimaging; biophysical modeling; network models; machine learning; brain stimulation; neurodegeneration

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Glioblastoma: Novel Multitargeted Approaches

edited by

Wenjing Zeng

submission deadline 31 Mar 2026 | Viewed by 190 | Submission Open

Keywords: glioblastoma; multitargeted therapy; tumor heterogeneity; immunotherapy; targeted agents; nanomedicine; RNA therapeutics; combination therapy; translational oncology

Stem Cell Biology and Tissue Engineering for Cardiology

edited by Otilia Țica

submission deadline 31 Mar 2026 | Viewed by 187 | Submission Open

Keywords: cardiac regeneration; stem cell therapy; cardiac tissue engineering; mesenchymal stem cells (MSCs); induced pluripotent stem cells (iPSCs); cardiomyocyte differentiation; myocardial repair; 3D bioprinting; biomaterials in cardiology; cardiac scaffolds; heart organoids; translational regenerative medicine; cell-based therapy; cardiovascular bioengineering; immunomodulation in cardiac repair

(This special issue belongs to the Section Molecular and Translational Medicine)

Applications of Biomedical Engineering and Biomaterials in Human Diseases

edited by Rui Sang

submission deadline 31 Mar 2026 | Viewed by 182 | Submission Open

Keywords: biosensors and diagnostics; biomedical engineering; nanotechnology in medicine; artificial intelligence in healthcare; precision medicine; drug delivery systems; regenerative medicine; 3D bioprinting; CRISPR-based technologies

(This special issue belongs to the Section Biomedical Engineering and Materials)

Advances in Cardiac Remodeling

edited by Silvio Assis de Oliveira-Junior and André Soares Leopoldo

submission deadline 31 Mar 2026 | Viewed by 165 | Submission Open

Keywords: cardiac remodeling; cardiomyocyte contractile; obesity; diabetes; diets; training; rats; humans

(This special issue belongs to the Section Molecular and Translational Medicine)

Sepsis and Systemic Inflammation: Mechanisms and Therapeutic Innovations

edited by

Christian Lehmann

submission deadline 31 Mar 2026 | Viewed by 164 | Submission Open

Keywords: sepsis; systemic inflammation; microcirculation; intravital imaging; immune dysregulation; septic shock; therapeutic innovations

(This special issue belongs to the Section Immunology and Immunotherapy)

Aortic Aneurysm: Mechanisms, Biomarkers, and Therapeutic Strategy

edited by

Mitra Esfandiarei

and

Seda Selamet Tierney

submission deadline 31 Mar 2026 | Viewed by 159 | Submission Open

Keywords: aortic aneurysms; genetic aortic diseases; endothelial dysfunction; extracellular matrix; aortic wall; aortic smooth muscle; angiotensin system; aortic wall elasticity; matrix metalloproteinases

(This special issue belongs to the Section Molecular and Translational Medicine)

Drug Delivery and Nanocarrier

edited by

Jiawei Huo

submission deadline 31 Mar 2026 | Viewed by 158 | Submission Open

Keywords: nanocarriers; targeted drug delivery; controlled release; theranostics; biocompatibility; functionalized nanoparticles; nanomedicine; translational nanotechnology

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Decoding Neurodegeneration: Insights from Multi-Omics and Neuroimaging Integration

edited by

Abdulhakim Al-Ezzi

submission deadline 31 Mar 2026 | Viewed by 152 | Submission Open

Keywords: neurodegenerative; neuroimaging; executive functions; electrophysiology; brain connectivity; multi omics data; bio-molecular data; biomarkers; systems biology; single-cell omics; translational neuroscience

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Next-Generation CRISPR and Immune Modulation: Advancing Precision Genome Editing Therapies for Genetic Disorders

edited by Sukanta Jash

submission deadline 31 Mar 2026 | Viewed by 151 | Submission Open

Keywords: CRISPR/Cas9; base editors; prime editors; innate immunity; genome editing; off-target effects; delivery vectors; monogenic disorders; multiplex editing; AI-driven CRISPR

(This special issue belongs to the Section Gene and Cell Therapy)

Oxidative Stress, Mitochondrial Dysfunction, and Aβ Pathology: Converging Pathways in Aging and Neurodegeneration

edited by

Swapnil Pandey

, Laxmi Rathor and

Ashish Shukla

submission deadline 31 Mar 2026 | Viewed by 151 | Submission Open

Keywords: oxidative stress; aging; amyloid beta; tau phosphorylation; neurodegeneration; regulated cell death; mitochondrial biogenesis; Drosophila; C. elegans

(This special issue belongs to the Section Cell Biology and Pathology)

Advances in Bone Metabolism, Bone Homeostasis and Osteogenesis

edited by

Youngjae Jeong

and Laura Ortinau

submission deadline 31 Mar 2026 | Viewed by 148 | Submission Open

Keywords: bone homeostasis and maintenance; bone remodeling; osteoblast– osteoclast interaction; endocrine signaling by bone; bone metabolic disease

(This special issue belongs to the Section Cell Biology and Pathology)

New Approaches to Spinal Cord-Related Diseases

edited by Corentin Dauleac

submission deadline 31 Mar 2026 | Viewed by 148 | Submission Open

Keywords: spinal cord; spinal cord injury; stem cell; neuromodulation; rehabilitation; plasticity; spasticity; pain; neuroimaging

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Natural and Synthetic Molecules with Anticancer Activity: Pharmacological Basis and Mechanistic Insight—2nd Edition

edited by

Hassan Ebrahim

and

Angela-Patricia Hernández

submission deadline 31 Mar 2026 | Viewed by 145 | Submission Open

Keywords: anticancer; molecular pharmacology; mechanistic mode of action; signal transduction; in vitro; preclinical; natural products; synthesis

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Advances in Biomarkers for Neurodegenerative Diseases: From Molecular Discovery to Early Diagnosis

edited by

Sujung Yeo

submission deadline 31 Mar 2026 | Viewed by 128 | Submission Open

Keywords: alpha-synuclein; neurodegeneration; Parkinson's disease; pathophysiology; mechanism; therapy; synucleinopathy

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Recent Advances in Antiviral and Antibacterial Drugs

edited by

Mohammad Anwar Hossain

submission deadline 31 Mar 2026 | Viewed by 128 | Submission Open

Keywords: viral infection; direct-acting antiviral; antimicrobial resistance (AMR); pandemic preparedness; antiviral therapy; infectious disease; viral resistance

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

New Insights in Thyroid Cancer

edited by

Rodis D. Paparodis

submission deadline 31 Mar 2026 | Viewed by 124 | Submission Open

Keywords: thyroid carcinoma; molecular diagnostics; targeted therapy; genetic mutations; radioiodine therapy; radiofrequency ablation therapy; active surveillance; precision oncology

(This special issue belongs to the Section Molecular and Translational Medicine)

Brain Disorders: Bridging Molecular Insights and Innovative Therapies

edited by

Karol Wiśniewski

and

Bartosz Szmyd

submission deadline 31 Mar 2026 | Viewed by 114 | Submission Open

Keywords: neurosurgery; neuro-oncology; glioma; innovations; cancer predisposing syndrome; neurofibromatosis; CMMRD

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Emerging Trends and Applications in Nanomedicine and Targeted Therapies

edited by

Marzieh Ramezani Farani

submission deadline 31 Mar 2026 | Viewed by 110 | Submission Open

Keywords: nanomedicine; drug delivery systems; targeted therapy; biomaterials; cancer therapy; smart nanocarriers; biodegradable nanoparticles; photothermal therapy; nano-diagnostics; translational nanotechnology

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Pathology, Complications, and Prognosis of Type 1 Diabetes (T1D)

edited by Tadesse Melaku Abegaz

submission deadline 31 Mar 2026 | Viewed by 109 | Submission Open

Keywords: type 1 diabetes; complications; prognosis; cardiovascular disease; neuropathy; retinopathy; nephropathy; disease mechanisms; clinical outcomes

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Clinical and Translational Advances in Neuro-Ophthalmology

edited by Hyun-jin Shin

submission deadline 31 Mar 2026 | Viewed by 106 | Submission Open

Keywords: neuro-ophthalmology; translational medicine; optic neuropathy; ocular motility disorders; visual pathway disorders; neuroimaging and electrophysiology; biomarkers in vision science; gene and stem cell therapy; artificial intelligence in neuro-ophthalmology; clinical trials in vision disorders

(This special issue belongs to the Section Molecular and Translational Medicine)

Insulin Resistance and Hyperinsulinemia: From Molecular Mechanisms to Clinical Translation

edited by

Anindya Ghosh

submission deadline 31 Mar 2026 | Viewed by 106 | Submission Open

Keywords: insulin resistance; type 2 diabetes; metabolic syndrome; obesity

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Next-Generation Approaches to Hepatobiliary Disorders

edited by

Lorenzo Petagna

submission deadline 31 Mar 2026 | Viewed by 102 | Submission Open

Keywords: hepatobiliary disorders; interventional radiology; interventional endoscopy; advances in HPB surgery; advances in liver transplantation; liver transplant viability biomarkers

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Molecular and Cellular Mechanisms in Metabolic Bone and Cartilage Disorders

edited by

Mohamad Alaa Terkawi

submission deadline 31 Mar 2026 | Viewed by 99 | Submission Open

Keywords: metabolic bone; cartilage disorders; osteoporosis; osteoarthritis; impaired fracture healing; rare metabolic skeletal diseases

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Pulmonary Arterial Hypertension: From Molecular Basis to Therapeutic Approaches—2nd Edition

edited by

Rui Adão

submission deadline 31 Mar 2026 | Viewed by 97 | Submission Open

Keywords: pulmonary arterial hypertension; right ventricle; right heart failure; therapy; vascular disease; translational research

(This special issue belongs to the Section Molecular and Translational Medicine)

Emerging Trends in Reproductive Endocrinology and Pregnancy-Related Disorders

edited by

Theodoros Kalampokas

submission deadline 31 Mar 2026 | Viewed by 94 | Submission Open

Keywords: pregnancy-related disorders; eclampsia; preeclampsia; hypertensive disorders of pregnancy; gestational diabetes; reproductive endocrinology; precision medicine

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Displaying special issue 351-400 on page 8 of 16.

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