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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Decoding Colorectal Cancer: Innovations in Biomarkers, Microbiota, and Therapeutic Resistance

edited by

Yinghao Cao

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1060 | Submission Open

Keywords: colorectal cancer; tumor biomarkers; nanomaterials; drug delivery; microbiome– tumor interaction; therapeutic resistance; exosomes; tumor microenvironment; prognostic model; neoadjuvant therapy; conversion therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

New Advances in Neuropharmacology

edited by

Yu-Cheng Ho

and

Ming Tatt Lee

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1044 | Submission Open

Keywords: behavioral neuropharmacology; molecular neuropharmacology; neuropharmacology; neurological disorders; neurodegenerative diseases

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Mechanisms and Novel Therapeutic Approaches for Neurodegenerative Diseases (3rd Edition)

edited by

Fernando Cardona

submission deadline 30 Apr 2026 | 2 articles | Viewed by 980 | Submission Open

Keywords: neurodegenerative diseases; cellular mechanisms; molecular mechanisms; mutations; neurodegeneration models; protein misfolding; protein aggregation; neuronal death; molecular therapy; cellular therapy; therapeutics; medical chemistry; drug screening

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

From Pathogenesis to Therapies: Innovations in Kidney Disease

edited by

Tao Qiu

Jiefu Zhu

and Chenglin Wu

submission deadline 30 Apr 2026 | 1 articles | Viewed by 868 | Submission Open

Keywords: renal ischemia-reperfusion injury; acute kidney injury; renal fibrosis; chronic kidney disease; ureteral obstructive nephropathy; kidney transplantation; macrophage-myofibroblast transition; inflammation; fibroblast activation; chronic allograft rejection; potential therapy

(This special issue belongs to the Section Molecular and Translational Medicine)

Heart Failure: New Diagnostic and Therapeutic Approaches, 2nd Edition

edited by

Anand Prakash Singh

submission deadline 30 Apr 2026 | 1 articles | Viewed by 852 | Submission Open

Keywords: heart failure; clinical treatment; basic cardiac research; future perspective; heart failure therapy; cardiotoxicity

(This special issue belongs to the Section Molecular and Translational Medicine)

Innovative Approaches in Drug Discovery

edited by Jitendra Gour

submission deadline 30 Apr 2026 | Viewed by 783 | Submission Open

Keywords: PROTACs; molecular glue; personalized medicine; high-throughput screening (HTS); targeted therapy; drug repurposing; safety profiles

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Emerging Trends in Kidney Disease (2nd Edition)

edited by Andrea Angioi

submission deadline 30 Apr 2026 | 1 articles | Viewed by 685 | Submission Open

Keywords: kidney disease; glomerular diseases; vasculitis; dialysis; hypertension; pediatric nephrology; transplantation; precision medicine; therapeutic advancements

(This special issue belongs to the Section Molecular and Translational Medicine)

Recent Advances in Hypertension, Hypercholesterolemia and Type 2 Diabetes—2nd Edition

edited by

Tomislav Bulum

submission deadline 30 Apr 2026 | Viewed by 663 | Submission Open

Keywords: type 2 diabetes; hypertension; LDL-cholesterol; serum lipids; metabolic syndrome; cardiovascular disease; chronic complications; nephropathy

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Digestive Disorders: Translation and Bridging the Gap Between Research, Diagnosis, and Treatment (2nd Edition)

edited by Goran Poropat and Goran Hauser

submission deadline 30 Apr 2026 | 1 articles | Viewed by 652 | Submission Open

Keywords: acute pancreatitis; clinical nutrition; metabolic disorders; NAFLD; obesity; DGBA; gut microbiota

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Natural and Synthetic Anticancer Agents: Mechanistic Insights and Translational Pathways

edited by

Gul-E-Saba Chaudhry

submission deadline 30 Apr 2026 | 1 articles | Viewed by 630 | Submission Open

Keywords: cancer; drug discovery; synthetic anti-cancer; natural bioactive compounds; nano targeted targeted drug delivery; cancer biomarkers; mechanism of cell death; novel anti-cancer compounds

(This special issue belongs to the Section Cancer Biology and Oncology)

Isoflavones as Therapeutic Leads: From Natural Sources to Mechanisms and Translational

edited by

Bruno Kaufmann Robbs

and

Lucas Silva Abreu

submission deadline 30 Apr 2026 | 1 articles | Viewed by 618 | Submission Open

Keywords: isoflavones; phytoestrogens; natural bioactive compounds; mechanisms of action; translational medicine; therapeutic development; drug discovery

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

The Brain–Body Interplay in Pain, Anesthesia, and Oncology

edited by

Hui Xu

submission deadline 30 Apr 2026 | 1 articles | Viewed by 535 | Submission Open

Keywords: brain– body axis; neuroimmune communication; microbiome– gut– brain axis; nociception; anesthetic outcomes; cancer biology

(This special issue belongs to the Section Molecular and Translational Medicine)

Advancements in Understanding and Treating Oral Pathologies: From Dry Mouth to Oral Cancer—2nd Edition

edited by Eleni Georgakopoulou and George Laskaris

submission deadline 30 Apr 2026 | 1 articles | Viewed by 501 | Submission Open

Keywords: oral pathologies; oral diseases; pathogenesis; therapeutic interventions; interdisciplinary nature of oral healthcare; xerostomia; dysgeusia; oral cancer; precancerous lesions; oral inflammatory conditions

(This special issue belongs to the Section Cell Biology and Pathology)

Selective Glucocorticoid Receptor Agonists and Modulators (SEGRAMs)

edited by

Dimitra Mitsiou

submission deadline 30 Apr 2026 | Viewed by 408 | Submission Open

Keywords: glucocorticoid receptor; glucocorticoids; transactivation; transrepression; selective glucocorticoid receptor agonists; selective glucocorticoid receptor modulators; inflammation; anti-inflammatory action; side effects; therapeutic potential

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Post Tuberculosis Lung Disease from Lung Damage to the Loss of Lung Function

edited by

Oana Cristina Arghir

and Ariadna Petronela Fildan

submission deadline 30 Apr 2026 | Viewed by 385 | Submission Open

Keywords: post-tuberculosis lung disease (PTLD); post-TB conditions; TB sequelae; obstructive post-TB disease; post-TB syndromes

(This special issue belongs to the Section Molecular and Translational Medicine)

Targeted Biologic Therapies for Allergic Conditions: From Bench to Bedside

edited by

Antonio Francesco Maria Giuliano

and Maria Teresa Ventura

submission deadline 30 Apr 2026 | 1 articles | Viewed by 350 | Submission Open

Keywords: biologics; allergic disease; atopic dermatitis; allergic rhinitis; asthma; precision medicine; biomarkers; immunotherapy

(This special issue belongs to the Section Immunology and Immunotherapy)

Bone Diseases: Pathophysiology and Molecular Biology

edited by

Tommaso Greco

Carlo Perisano

and Nicola De Gasperis

submission deadline 30 Apr 2026 | Viewed by 295 | Submission Open

Keywords: bone diseases; osteoporosis; osteoarthritis; Paget’ s disease; bone tumors

(This special issue belongs to the Section Molecular and Translational Medicine)

Bone Metabolism in Health and Disease

edited by

Kun Chen

submission deadline 30 Apr 2026 | Viewed by 278 | Submission Open

Keywords: bone remodeling; skeletal stem cells; osteocyte; osteoblasts; osteoclasts; osteoporosis; osteoarthritis; bone regeneration; bone aging; bone therapeutics

(This special issue belongs to the Section Molecular and Translational Medicine)

Oxidative Stress, Inflammation and Endothelial Dysfunction in COVID-19 Era and Long COVID-19 Complications

edited by

Ekaterina Georgieva

submission deadline 30 Apr 2026 | Viewed by 268 | Submission Open

Keywords: oxidative stress; redox-disbalance; COVID-19; post-COVID-19; cytokines; mitochondrial dysfunction; endothelial damages; ROS and RNS; thrombosis; antioxidant therapy; oxidative shock

(This special issue belongs to the Section Molecular and Translational Medicine)

Molecular and Cellular Mechanisms of Cardiovascular Diseases: 2nd Edition

edited by

Antonella Galeone

submission deadline 30 Apr 2026 | Viewed by 253 | Submission Open

Keywords: hypertension; diabetes; coronary heart disease; valvular heart disease; infective endocarditis; aortic dissection; aortic aneurysm; heart failure; cardiomyopathy

(This special issue belongs to the Section Molecular and Translational Medicine)

Nanoparticle-Labeled Exosomes as Theranostic Agents

edited by Karrer M. Alghazali

submission deadline 30 Apr 2026 | Viewed by 240 | Submission Open

Keywords: exosomes; nanotheranostic agent; nanoparticles; exosome labeling; photothermal therapy; drug delivery vehicle; imaging probe

(This special issue belongs to the Section Cell Biology and Pathology)

New Advances in Oral Pathology and Medicine

edited by

Christian Bacci

submission deadline 30 Apr 2026 | Viewed by 226 | Submission Open

Keywords: molecular diagnostics; imaging technologies; artificial intelligence; targeted therapies; regenerative medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Selected Papers from the Tanawwo Workshop on Clinical Research in Precision Medicine, Rare Diseases, and Pharmacogenomics (Doha, Qatar, 2025)

edited by

Felipe Fregni

and Radja Messai Badji

submission deadline 30 Apr 2026 | Viewed by 202 | Submission Open

Keywords: precision medicine; rare diseases; pharmacogenomics; adaptive and platform trials; multi-omics integration; artificial intelligence in clinical research; big data and digital health; translational medicine

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Mechanisms and Novel Therapeutic Approaches for Gliomas: 2nd Edition

edited by Maria V. Chatziathanasiadou

submission deadline 30 Apr 2026 | Viewed by 199 | Submission Open

Keywords: glioma; molecular mechanisms; tumour immunity; tumour metabolism; tumour microenvironment; metabolic therapies; immunotherapies; combination treatment

(This special issue belongs to the Section Cancer Biology and Oncology)

Correlative Light and Electron Microscopy (CLEM) in Biomedicine: Advances and Applications

edited by

Hideya Kawasaki

submission deadline 30 Apr 2026 | Viewed by 172 | Submission Open

Keywords: CLEM; correlative microscopy; biomedicine; pathology; virology; oncology; immunolabeling; cryo-microscopy; ultrastructure; image analysis

(This special issue belongs to the Section Cell Biology and Pathology)

Cancer Genetics: Bench-to-Bedside Advances

edited by

Hengrui Liu

submission deadline 30 Apr 2026 | Viewed by 169 | Submission Open

Keywords: cancer genetics; somatic mutations; biomarkers; cfDNA/ctDNA; epigenetics; tumor microenvironment; multi-omics; precision medicine

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Advances in Ocular Surface Disease

edited by

Kofi Asiedu

submission deadline 30 Apr 2026 | Viewed by 158 | Submission Open

Keywords: dry eye disease; corneal neuroimmune interactions; meibomian gland dysfunction; microbial keratitis; ocular allergy; corneal degeneration

(This special issue belongs to the Section Molecular and Translational Medicine)

State-of-the-Art Drug Discovery and Development in Poland (3rd Edition)

edited by

Aleksandra Romaniuk-Drapała

submission deadline 30 Apr 2026 | Viewed by 153 | Submission Open

Keywords: in silico drug target profiling; drug delivery systems; drug– drug interaction; target-based screening; phenotypic screening; pharmaceutical modeling; computational chemistry; targeted therapy; biomarkers; bioimaging

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Integrative Roles of Natural Products in Cancer Treatment and Chronic Inflammatory Disease

edited by

Seungho Baek

submission deadline 30 Apr 2026 | 1 articles | Viewed by 147 | Submission Open

Keywords: natural products; cancer; chronic inflammatory diseases; therapy; oxidative stress

(This special issue belongs to the Section Molecular and Translational Medicine)

Nanoparticles in Biomedical Engineering: From Drug Delivery to Tissue Engineering

edited by Jia Nong

submission deadline 30 Apr 2026 | Viewed by 144 | Submission Open

Keywords: nanoparticle; nanomedicine; nanoconjugates; drug delivery; biomaterials; wound healing; angiogenesis; antimicrobial agents; regenerative medicine; theranostics

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Animal Models in Pulmonary Research: Shaping the Future of Translational Respiratory Medicine

edited by

Badrul Hisham Yahaya

submission deadline 30 Apr 2026 | Viewed by 135 | Submission Open

Keywords: pulmonary disease; lung regeneration and repair; animal models; genetically modified models; lung injury induction; translational research

(This special issue belongs to the Section Molecular and Translational Medicine)

Recent Advances in Research on Neuroendocrine Neoplasms and Endocrine Sequelae After Oncological Disease

edited by Hermann L. Müller

submission deadline 30 Apr 2026 | Viewed by 126 | Submission Open

Keywords: neuroendocrine tumors; endocrinology; hormones; cancer; sequelae; late effects; neurogenic tumors

(This special issue belongs to the Section Cancer Biology and Oncology)

Recent Advances in Cancer Metastasis Models

edited by

Lin Zhang

submission deadline 30 Apr 2026 | Viewed by 125 | Submission Open

Keywords: cancer metastasis; tumor microenvironment; metastasis models; 3D cell culture; organoids; artificial intelligence in oncology; machine learning; bioinformatics; in vivo imaging; multi-omics integration

(This special issue belongs to the Section Cancer Biology and Oncology)

Extracellular Vesicles: A New Frontier in Liquid Biopsy

edited by Chen Zhao and You-Ren Ji

submission deadline 30 Apr 2026 | Viewed by 124 | Submission Open

Keywords: extracellular vesicles (EVs); liquid biopsy; circulating biomarkers; exosome; nanomedicine; translational oncology; precision medicine

(This special issue belongs to the Section Cell Biology and Pathology)

Roles of Extracellular Vesicles in Health and Diseases

edited by David R. Brigstock and Xinlei Li

submission deadline 30 Apr 2026 | Viewed by 123 | Submission Open

Keywords: extracellular vesicle; exosome; pathogenesis; therapy; cancer; neurodegenerative diseases; pulmonary diseases; cardiovascular diseases; inflammatory diseases; infectious diseases; kidney diseases; gastrointestinal diseases; aging; diabetes; autoimmune disorders

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Research on Spermatozoa and Male Infertility: From Molecular Mechanism to Therapeutic Perspectives

edited by

Francesca Paola Luongo

and

Alice Luddi

submission deadline 30 Apr 2026 | Viewed by 121 | Submission Open

Keywords: spermatozoa biology; molecular mechanisms of spermatogenesis; oxidative stress and sperm function; therapeutic strategies for addressing male infertility

(This special issue belongs to the Section Molecular and Translational Medicine)

Decoding Aging with AI and Computational Modeling

edited by Bingrui Li, Xuanye Cao and Wen Jiang

submission deadline 30 Apr 2026 | Viewed by 119 | Submission Open

Keywords: aging; computational modeling; AI; healthspan and lifespan prediction; systems biology

(This special issue belongs to the Section Cell Biology and Pathology)

Alzheimer's Disease: Pathogenesis, Diagnostics and Novel Treatment Options

edited by

Rui Zhong

and Ling Li

submission deadline 30 Apr 2026 | Viewed by 117 | Submission Open

Keywords: amyloid and tau pathology; neuroinflammation and oxidative stress; neuromodulation; fluid biomarkers; imaging and other diagnostic approaches; small-molecule therapeutics; novel therapeutics and emerging therapies; disease-modifying therapies; experimental and clinical pharmacology

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Cardiometabolic Diseases: Molecular Biomarkers and Treatment Strategies

edited by

Jelena Radovanović

and

Sonja Zafirovic

submission deadline 30 Apr 2026 | Viewed by 116 | Submission Open

Keywords: cardiometabolic disease; obesity; diabetes mellitus; insulin resistance; lipid status; biomarkers; hypertension; metabolic dysregulation; personalized therapy; omics technologies

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Artificial Intelligence in Cancer Imaging: Advancing Precision Oncology

edited by Farhan Akram

submission deadline 30 Apr 2026 | Viewed by 113 | Submission Open

Keywords: artificial intelligence; cancer imaging; digital pathology; machine learning; deep learning; radiomics; tumor characterization; precision oncology; biomarker discovery; clinical translation

(This special issue belongs to the Section Cancer Biology and Oncology)

Personalized Diagnosis and Therapy in Endocrinology and Gynecology

edited by

Sarah Allegra

submission deadline 30 Apr 2026 | Viewed by 111 | Submission Open

Keywords: personalized medicine; endocrine disorders; gynecological diseases; reproductive endocrinology; pharmacogenomics; hormonal therapy; polycystic ovary syndrome (PCOS); precision medicine; biomarkers; women’ s health

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Chronic Obstructive Pulmonary Disease (COPD)

edited by Fabio Manzo and

Pasquale Ambrosino

submission deadline 30 Apr 2026 | Viewed by 111 | Submission Open

Keywords: chronic obstructive pulmonary disease; COPD; emphysema; chronic bronchitis; chronic disease; disability; rehabilitation

(This special issue belongs to the Section Cell Biology and Pathology)

Genome Engineering Technologies for Diseases

edited by Kosuke Ishikawa

submission deadline 30 Apr 2026 | Viewed by 110 | Submission Open

Keywords: genome engineering; gene editing; gene delivery; transposable elements; insertinal mutagenesis; functional genomics; in silico analysis; cell-based assays; disease modeling; cell therapy

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

New Insights into the Tumor Microenvironment: Mechanisms and Therapeutic Strategies

edited by

Denggang Fu

submission deadline 30 Apr 2026 | Viewed by 106 | Submission Open

Keywords: tumor microenvironment (TME); immune evasion; tumor– immune interaction; stromal remodeling; cancer immunotherapy; metabolic reprogramming; epigenetic regulation; multi-omics and spatial analysis; anticancer drug development

(This special issue belongs to the Section Immunology and Immunotherapy)

Brain Tumor: From Pathophysiology to Novel Therapies

edited by

Paulo Linhares

submission deadline 30 Apr 2026 | Viewed by 106 | Submission Open

Keywords: glioblastoma; immunotherapy; molecular subtype; radiotherapy; molecular therapy; emerging treatment; drug resistance; MRI; immune surveillance

(This special issue belongs to the Section Cancer Biology and Oncology)

Nanocarriers in Mucosal Drug Delivery

edited by

Hatem Hassan

submission deadline 30 Apr 2026 | Viewed by 104 | Submission Open

Keywords: nanocarriers; mucosal drug delivery; mucoadhesion; mucus penetration; controlled release; bioavailability enhancement; targeted delivery; stimuli-responsive systems

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Gynecological Cancers: Progress and Challenges

edited by

Yi-Fen Chiang

submission deadline 30 Apr 2026 | Viewed by 104 | Submission Open

Keywords: gynecological cancer; therapeutic targets; precision medicine; immunotherapy; drug resistance; biomarkers; molecular mechanisms; natural compound; translational research; adjuvant therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Biomaterials and Nanotechnology for Advanced Wound Dressings

edited by Javad Esmaeili

submission deadline 30 Apr 2026 | Viewed by 102 | Submission Open

Keywords: wound dressings; wound healing; biomaterials and nanotechnology; regenerative medicine; targeted delivery

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Epilepsy: From Mechanisms to Therapeutic Approaches (2nd Edition)

edited by

Prosper N'Gouemo

submission deadline 30 Apr 2026 | Viewed by 100 | Submission Open

Keywords: genetic epilepsy; acquired epilepsy; neonatal seizures; epileptogenesis; pharmacoresistant epilepsy; ion channels; calcium signaling

(This special issue belongs to the Section Molecular and Translational Medicine)

Neuropathology: Understanding Local and Systemic Influence of Disease and Vice-Versa

edited by

Kumar Vaibhav

Pankaj Gaur

, Meenakshi Ahluwalia,

Pankaj Ahluwalia

and Shashi Nandar Kumar

submission deadline 30 Apr 2026 | Viewed by 100 | Submission Open

Keywords: brain pathologies; brain injury; Parkinson’ s disease; Alzheimer’ s disease; stroke; neurodegeneration; hemorrhages; hypoxia; neuroinflammation; translational approaches; oxidative stress; COVID-19; gut– brain axis; systemic influence; immune interaction; synaptic plasticity; ageing; senescence; bone marrow and neuropathology; pesticides; preservatives and environmental contamination; lungs and brain; liver and brain; cardiovascular effect of brain pathology and vice-versa; acute and chronic neuro-immune interaction; therapeutic strategies and intervention; alternative medicines in brain pathologies

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Displaying special issue 351-400 on page 8 of 15.

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