Special Issues

Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Interaction Between Microbiota and Immunity in Health and Diseases
edited by Giuseppe Merra
submission deadline 31 Oct 2025 | Viewed by 101 | Submission Open
Keywords: microbiota; microbiome; inflammation; immunity; epithelial barrier
(This special issue belongs to the Section Microbiology in Human Health and Disease)
Immune Checkpoint Regulation and Signaling Pathways in Cancer
edited by Sreeja C. Sekhar
submission deadline 31 Oct 2025 | Viewed by 97 | Submission Open
Keywords: tumor-immune evasion and interaction; immune check point inhibition; PD-1/PDL-1 pathway; T-cell exhaustion and tumor microenvironment; single-cell profiling; therapeutic resistance; tumor-infiltrating cells; checkpoint inhibitors and immune modulation
(This special issue belongs to the Section Immunology and Immunotherapy)
Advanced Research in Anticancer Inhibitors and Targeted Therapy
edited by Changmin Peng and
submission deadline 31 Oct 2025 | Viewed by 93 | Submission Open
Keywords: histone deacetylases (HDACs); YAP signaling; targeted therapy; oncogenic signaling; biomarker discovery; small-molecule inhibitors; cancer drug resistance; epigenetic therapy
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Cardiac and Vascular Diseases: Pathogenesis, Pharmacological Treatments, Advances in Therapies (3rd Edition) submission deadline 31 Oct 2025 | Viewed by 92 | Submission Open
Keywords: endothelial function; cardiomyopathies; cardiovascular pharmacology; cardiac therapeutics; noninvasive vascular treatments; molecular cardiac biomarkers; molecular vascular biomarkers
(This special issue belongs to the Section Molecular and Translational Medicine)
The Intricacies of Developmental and Epileptic Encephalopathies: A Journey Towards Innovative Therapies
edited by Muhammad Nauman Arshad and Paul Davies
submission deadline 31 Oct 2025 | Viewed by 92 | Submission Open
Keywords: cognitive; behavioral deficits
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Fetal Medicine: New Insight and Future Direction submission deadline 31 Oct 2025 | Viewed by 91 | Submission Open
Keywords: fetal medicine; spontaneous preterm birth; early-onset pre-eclampsia; fetal hypoxia; poor growth
(This special issue belongs to the Section Cell Biology and Pathology)
Mechanistic Insights into Protein Dynamics: Membrane Interactions, Phase Separation, and Disease-Linked Aggregation
edited by Ramesh Prasad
submission deadline 31 Oct 2025 | Viewed by 91 | Submission Open
Keywords: protein conformational dynamics; membrane-mediated interactions; liquid– liquid phase separation (LLPS); neurodegenerative protein aggregation; structural biology techniques
(This special issue belongs to the Section Cell Biology and Pathology)
Antipsychotics: 70 Years—2nd Edition submission deadline 31 Oct 2025 | Viewed by 91 | Submission Open
Keywords: polypharmacology; multi-target drugs; emerging therapeutic targets; repurposing; complementary medicine; psychosis; schizophrenia; bipolar disorder; Alzheimer’ s disease
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Biological Role of Oxidative Stress in Inflammatory Processes submission deadline 31 Oct 2025 | Viewed by 89 | Submission Open
Keywords: oxidative stress; redox balance; antioxidants; NRF2; microbiota; bilirubin; Tlr4; inflammation
(This special issue belongs to the Section Cell Biology and Pathology)
New Molecular Insights into the Pathogenesis and Drug Development of Neurodegenerative Diseases: 2nd Edition
edited by Aifang Cheng, Beika Zhu and Fulin Ma
submission deadline 31 Oct 2025 | Viewed by 88 | Submission Open
Keywords: neurodegenerative diseases; pathogenesis; molecular mechanisms; high-throughput drug screening; drug repurposing; cellular and animal models; brain organoids; mode of action; pharmacological evaluations; preclinical study
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Male Reproductive Medicine: From Basic to Clinical Research
edited by Donghui Huang
submission deadline 31 Oct 2025 | Viewed by 88 | Submission Open
Keywords: male reproductive function; spermatogenesis; hormonal regulation; genetic and epigenetic influences; environmental toxicology; male reproductive health
(This special issue belongs to the Section Molecular and Translational Medicine)
Emerging Trends in Cancer: Biomarkers, Therapeutic Strategies and Future Directions
edited by Nedime Serakinci
submission deadline 31 Oct 2025 | Viewed by 87 | Submission Open
Keywords: cancer biomarkers; stem cells; personalized medicine; emerging cancer therapies; tumor microenvironment
(This special issue belongs to the Section Cancer Biology and Oncology)
Regulation of Bone Homeostasis: Crosstalk Between Osteoblasts and Osteoclasts
edited by
submission deadline 31 Oct 2025 | Viewed by 83 | Submission Open
Keywords: bone homeostasis; bone remodeling; osteoporosis; vascular calcification; osteoblast; osteoclast; signaling pathways; cellular communication; regulatory mechanisms
(This special issue belongs to the Section Cell Biology and Pathology)
Neurodevelopmental Disorders: From Mechanisms to Therapeutic Approaches
edited by Manuel López-Aranda
submission deadline 31 Oct 2025 | Viewed by 79 | Submission Open
Keywords: neurodevelopmental disorders; autism spectrum disorder (ASD); attention-deficit/hyperactivity disorder (ADHD); intellectual disability; schizophrenia; neuroimaging; molecular mechanisms; genetic and epigenetic factors; translational neuroscience; therapeutic interventions
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Obesity-Related Gastrointestinal Disorders: Uncovering Mechanisms Behind Cardiometabolic Improvement with Weight Loss
edited by
submission deadline 31 Oct 2025 | Viewed by 71 | Submission Open
Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); gastro-esophageal reflux disease (GERD); obesity; cardiometabolic comorbidities; type 2 diabetes; hypertension; gut hormones; gastrointestinal function
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Pathogenesis, Diagnosis and Treatment of Melanoma
edited by Vijayasteltar B. Liju
submission deadline 31 Oct 2025 | Viewed by 71 | Submission Open
Keywords: melanoma; metastasis; targeted therapies; immunotherapy; tumor microenvironment; combination therapies; molecular pathways
(This special issue belongs to the Section Molecular and Translational Medicine)
Platelets in Human Health and Diseases
edited by Joanna Sikora
submission deadline 31 Oct 2025 | Viewed by 70 | Submission Open
Keywords: platelet; hemostasis; thrombosis; antiplatelet drugs; inflammation; cancer; cardiovascular diseases
(This special issue belongs to the Section Cell Biology and Pathology)
Advances in Airway Inflammation and Lung Dysfunction
edited by Aruni Jha
submission deadline 31 Oct 2025 | Viewed by 68 | Submission Open
Keywords: airway inflammation; lung dysfunction; acute respiratory distress syndrome (ARDS); chronic obstructive pulmonary disease (COPD); asthma; airway remodeling; therapeutic strategies; inflammation mechanisms
(This special issue belongs to the Section Molecular and Translational Medicine)
Pancreatic, Liver, Biliary Tract and Intestinal Diseases: Pathogenesis, Diagnostics and Therapy—2nd Edition submission deadline 31 Oct 2025 | Viewed by 67 | Submission Open
Keywords: inflammatory bowel disease; gastrointestinal tumor; gastrointestinal cancer; acute pancreatitis; chronic pancreatitis; pancreatic cyst; biliary cyst; liver disease; biliary tract disease
(This special issue belongs to the Section Molecular and Translational Medicine)
Diagnostic Biomarkers and Novel Therapeutics Targets for Fragile X Syndrome, Autism Spectrum Disorders and Genetic Neurodevelopmental Diseases: Advances and Challenges, 2nd Edition
edited by Yolanda De Diego-Otero and Rocio Calvo-Medina
submission deadline 31 Oct 2025 | Viewed by 62 | Submission Open
Keywords: fragile X syndrome; autism spectrum disorders; neurodevelopmental disorders; developmental neuroscience; cognitive development
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Advances in 3D Bioprinting: From Materials to Functional Tissue Constructs
edited by
submission deadline 31 Oct 2025 | Viewed by 61 | Submission Open
Keywords: 3D bioprinting; tissue engineering; biofabrication; regenerative medicine; bioprinted skin; organ-on-a-chip; biomaterials; vascularized constructs
(This special issue belongs to the Section Biomedical Engineering and Materials)
Neutrophils in Immunity and Diseases: 2nd Edition submission deadline 31 Oct 2025 | Viewed by 57 | Submission Open
Keywords: neutrophils; inflammation; neutrophil biology; immunity; NETs
(This special issue belongs to the Section Cell Biology and Pathology)
From Multinodular Goiter to Thyroid Cancer—Diagnosis and Treatment
edited by
submission deadline 31 Oct 2025 | Viewed by 55 | Submission Open
Keywords: multinodular goiter; thyroid cancer; thyroid disorders; thyroid nodules; thyroid gland
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Nanomaterials and Nanotechnology in Biomedical Research
edited by
submission deadline 31 Oct 2025 | Viewed by 36 | Submission Open
Keywords: nanotechnology; nanomaterials in drug delivery; biosensing; regenerative medicine; theranostics
(This special issue belongs to the Section Nanomedicine and Nanobiology)
Recent Advances in Photodynamic Therapy for Dental Diseases
edited by Patricia Comeau
submission deadline 31 Oct 2025 | Viewed by 16 | Submission Open
Keywords: photodynamic therapy; biomaterials; nanoparticles; dental; bone tissue engineering; drug delivery
(This special issue belongs to the Section Biomedical Engineering and Materials)
Spinal Muscular Atrophy: Pathogenesis, Diagnosis, Therapeutics and Future Directions
edited by , and Valentino Rački
submission deadline 15 Nov 2025 | Viewed by 294 | Submission Open
Keywords: genetic diseases; neuromuscular disorders; rare diseases; spinal muscular atrophy; survival motor neuron protein
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
“The Power of Light” in Biomedical and Pharmaceutics: New Approaches for Photodynamic Purposes submission deadline 20 Nov 2025 | Viewed by 75 | Submission Open
Keywords: light; photosensitizers; photochemistry; photobiology; photodynamic therapy
(This special issue belongs to the Section Molecular and Translational Medicine)
Advances in Head and Neck Cancer submission deadline 29 Nov 2025 | 3 articles | Viewed by 3932 | Submission Open
Keywords: modern therapeutic approach; nasopharyngeal carcinoma; head and neck cancer; particle therapy; cancer survivorship; sinonasal cancer
(This special issue belongs to the Section Molecular and Translational Medicine)
The End of the COVID-19 Pandemic—What Is Currently Known and What Could Have Been Useful Four Years Ago? (2nd Edition) submission deadline 30 Nov 2025 | 15 articles | Viewed by 27698 | Submission Open
Keywords: COVID-19; SARS-CoV-2; pandemic; diagnosis; biomarkers; treatment; immunity; inflammation; cytokines; vaccine
(This special issue belongs to the Section Molecular and Translational Medicine)
Dopamine Signaling Pathway in Health and Disease—2nd Edition submission deadline 30 Nov 2025 | 8 articles | Viewed by 17514 | Submission Open
Keywords: differentiation; disease modeling  ; dopamine and drugs; gene expression; human stem cells; neuronal development; reprogramming; signaling pathways; neurodegeneration; neuromodulation
(This special issue belongs to the Section Molecular and Translational Medicine)
New Diagnostic and Therapeutic Approaches in Diabetic Microvascular Complications, 2nd Edition submission deadline 30 Nov 2025 | 6 articles | Viewed by 9520 | Submission Open
Keywords: diabetic retinopathy; diabetic foot ulcer; inflammatory biomarkers; microbiota; novel therapies
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Progress in Neurodevelopmental Disorders Research submission deadline 30 Nov 2025 | 5 articles | Viewed by 9489 | Submission Open
Keywords: neurodevelopmental disorders; autism spectrum disorder; attention deficit hyperactivity disorder
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Women’s Special Issue Series: Biomedicines (2nd Edition) submission deadline 30 Nov 2025 | 4 articles | Viewed by 9100 | Submission Open
Keywords: antibody; biomedicines; biopharmaceutical products; cancer therapy; drug delivery; immunoconjugates; immunotoxins; immunotherapy; immunotargeting; nanodelivery; toxins
(This special issue belongs to the Section Molecular and Translational Medicine)
Acute and Chronic Heart Failure: Pathophysiology and New Therapeutic Developments, 2nd Edition
edited by and Valentina Mercurio
submission deadline 30 Nov 2025 | 11 articles | Viewed by 6944 | Submission Open
Keywords: heart failure with reduced ejection fraction; heart failure with preserved ejection fraction; pathophysiological novelties; treatment advances; pulmonary arterial hypertension; at-home follow-up of patients with heart failure
(This special issue belongs to the Section Molecular and Translational Medicine)
Emerging Trends in Gastrointestinal Tract Disease Therapies
edited by , Jenwei Chou and
submission deadline 30 Nov 2025 | 2 articles | Viewed by 6373 | Submission Open
Keywords: gut microbiota; fecal microbiota transplantation; inflammatory bowel disease; advanced endoscopy; endoscopic bariatric therapy; endoscopic anti-reflux therapy natural orifice transluminal endoscopic surgery; artificial intelligence
(This special issue belongs to the Section Molecular and Translational Medicine)
Neonatal Disease: From Pathophysiology to Current and Emerging Therapeutic Approaches (2nd Edition)
edited by
submission deadline 30 Nov 2025 | 4 articles | Viewed by 6237 | Submission Open
Keywords: fetal therapy; neonatal diseases; pathophysiology; innovative therapeutic approaches
(This special issue belongs to the Section Cell Biology and Pathology)
The Neuropharmacology of Cannabinoids: Developments in Medicine
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 5804 | Submission Open
Keywords: THC; CBD; cannabis; endocannabinoid system; therapeutic; disease; health
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Feature Reviews on Cardiovascular and Metabolic Diseases
edited by
submission deadline 30 Nov 2025 | 4 articles | Viewed by 5312 | Submission Open
Keywords: cardiovascular diseases; metabolic diseases; global health; disease prevention; innovative treatments
(This special issue belongs to the Section Cell Biology and Pathology)
Extracellular Vesicles for Diagnosis and Treatment of Human Diseases
edited by
submission deadline 30 Nov 2025 | 4 articles | Viewed by 5165 | Submission Open
Keywords: human diseases; extracellular vesicles; biomarkers; diagnosis; prognosis; therapeutic targets; therapeutic applications; EV engineering; physiology; pathology
(This special issue belongs to the Section Molecular and Translational Medicine)
From Bench to Bedside: Advances in Non-small Cell Lung Cancer in the Era of Precision Oncology
edited by Iyare Izevbaye
submission deadline 30 Nov 2025 | 2 articles | Viewed by 4400 | Submission Open
Keywords: non-small-cell lung cancer; precision medicine; liquid biopsy; biomarkers; predictive modeling; comprehensive genomic profiling; biomarkers; immuno-oncology; lung cancer biology
(This special issue belongs to the Section Cancer Biology and Oncology)
The Development of Cancer Immunotherapy
edited by
submission deadline 30 Nov 2025 | 4 articles | Viewed by 4400 | Submission Open
Keywords: cancer immunotherapy; immune checkpoint inhibitors; genetically modified T-cell therapy; hematological cancers; solid tumors
(This special issue belongs to the Section Cancer Biology and Oncology)
New Insights into Bone and Cartilage Biology
edited by Vincent Yuan
submission deadline 30 Nov 2025 | 4 articles | Viewed by 4362 | Submission Open
Keywords: bone remodeling; cartilage degeneration; osteoporosis; osteoarthritis; mitochondrial function; protein modifications; immune signaling; therapeutic strategies
(This special issue belongs to the Section Molecular and Translational Medicine)
Neuroinflammation and Neuroprotection
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 4322 | Submission Open
Keywords: neuroinflammation; neurodegeneration; mechanisms; disease progression; ER stress; oxidative stress; mitochondrial dysfunction
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Tendinopathy and Myopathy: From Molecular Basis to Therapy
edited by and Carl Pai Chu Chen
submission deadline 30 Nov 2025 | 2 articles | Viewed by 4225 | Submission Open
Keywords: musculoskeletal disorder; tendinopathy; myopathy
(This special issue belongs to the Section Molecular and Translational Medicine)
Novel Insights into Liver Metabolism submission deadline 30 Nov 2025 | 3 articles | Viewed by 3796 | Submission Open
Keywords: liver; metabolism; oxidative stress; mi-RNAs; cirrhosis; alcohol-related liver disease; autoimmune liver disorders; hepatocellular cancer; liver steatosis; microbiota; diagnostic markers
(This special issue belongs to the Section Endocrinology and Metabolism Research)
New Insights and Latest Advances in Corneal and Ocular Surface Diseases
edited by Isabella M. Y. Cheung and Akilesh Gokul
submission deadline 30 Nov 2025 | 5 articles | Viewed by 3762 | Submission Open
Keywords: corneal disease; ocular surface disease prevention; diagnosis; management; pathobiology; epidemiology; health service delivery
(This special issue belongs to the Section Molecular and Translational Medicine)
Bioinformatics Analysis of RNA for Human Health and Disease
edited by Jihwan Ha
submission deadline 30 Nov 2025 | 3 articles | Viewed by 3149 | Submission Open
Keywords: bioinformatics; computational biology; machine learning; multi-omics data analysis; biomarker detection; biomedical AI convergence; medical and public health informatics; RNA sequencing (RNA-Seq); functional genomics; RNA-protein interactions; experimental validation of biomarkers; RNA structural biology; transcriptome-wide association studies (TWAS); gene expression profiling; RNA modifications (e.g.; m6A; pseudouridylation); in vitro and in vivo RNA functional studies; single-cell RNA analysis; RNA therapeutics development
(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)
Advanced Research in Pulmonary Pathophysiology
edited by Ourania S. Kotsiou and Erasmia Rouka
submission deadline 30 Nov 2025 | 1 articles | Viewed by 2893 | Submission Open
Keywords: pathophysiology; aging; disease; injury; microbiome; small airways; pleura; lung cancer; infections; critical care
(This special issue belongs to the Section Cell Biology and Pathology)
Diagnostics and Therapy for Malignant Tumors: New Developments
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 2883 | Submission Open
Keywords: metabolites; immunity; microbiome; microenvironment; inflammation
(This special issue belongs to the Section Cancer Biology and Oncology)
Bench-to-Bedside Approach to Migraine: How Pathophysiology Could Influence Novel Therapeutic Approaches and Back
edited by Alessandro Vigano and Matteo Castaldo
submission deadline 30 Nov 2025 | 3 articles | Viewed by 2467 | Submission Open
Keywords: migraine; comorbidities; pathophysiology; pharmacological interventions; non-pharmacological interventions; chronicization; neurophysiological or neuroimaging for disability or clinical response
(This special issue belongs to the Section Molecular and Translational Medicine)
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