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8.3
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Journals
Biomolecules
Special Issues
Mechanobiology in Health and Disease
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Mechanobiology in Health and Disease

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: closed (30 April 2019) | Viewed by 3975

Special Issue Editor

Dr. Yubing Sun

E-Mail Website
Guest Editor
1. Department of Mechanical and Industrial Engineering, University of Massachusetts, Amherst, MA 01003, USA
2. Department of Biomedical Engineering, University of Massachusetts, Amherst, MA 01003, USA
Interests: stem cell biology; mechanotransduction; biomaterials; tissue engineering

Special Issue Information

Dear Colleagues,

In various psychological and pathological conditions, the role of mechanical cues, including mechanical forces, material properties of matrices and cells, geometrical confinement, fluid flow, etc., has gained increasing attention over the past three decades. Recent studies start to depict the connections between biomechanical factors and biochemical signals to elucidate the molecular machinery and mechanisms for cells to sense and respond to the complex biophysical microenvironment. This Special Issue aims to include a collection of original research and review articles that facilitate our understanding of biomechanical regulations on cell, tissue, and organ levels. We envision that these works will promote the dissemination of state-of-the-art mechanobiology research outcomes to the broad biology community, and stimulate exciting new ideas and directions.

Prof. Yubing Sun
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mechanotransduction
  • biophysics
  • matrix stiffness
  • nanotopography
  • morphogenesis
  • tissue engineering
  • biomaterials
  • tumor microenvironment

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Published Papers (1 paper)

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Research

15 pages, 2540 KiB  
Article
Host-Microbiome Synergistic Control on Sphingolipid Metabolism by Mechanotransduction in Model Arthritis
by Xiaoyuan Zhou, Valentina Devescovi, Yuanhua Liu, Jennifer E. Dent and Christine Nardini
Biomolecules 2019, 9(4), 144; https://doi.org/10.3390/biom9040144 - 9 Apr 2019
Cited by 6 | Viewed by 3431
Abstract
Chronic inflammatory autoimmune disorders are systemic diseases with increasing incidence and still lack a cure. More recently, attention has been placed in understanding gastrointestinal (GI) dysbiosis and, although important progress has been made in this area, it is currently unclear to what extent [...] Read more.
Chronic inflammatory autoimmune disorders are systemic diseases with increasing incidence and still lack a cure. More recently, attention has been placed in understanding gastrointestinal (GI) dysbiosis and, although important progress has been made in this area, it is currently unclear to what extent microbiome manipulation can be used in the treatment of autoimmune disorders. Via the use of appropriate models, rheumatoid arthritis (RA), a well-known exemplar of such pathologies, can be exploited to shed light on the currently overlooked effects of existing therapies on the GI microbiome. In this direction, we here explore the crosstalk between the GI microbiome and the host immunity in model arthritis (collagen induced arthritis, CIA). By exploiting omics from samples of limited invasiveness (blood and stools), we assess the host-microbiome responses to standard therapy (methotrexate, MTX) combined with mechanical subcutaneous stimulation (MS) and to mechanical stimulation alone. When MS is involved, results reveal the sphingolipid metabolism as the trait d’union among known hallmarks of (model) RA, namely: Imbalance in the S1P-S1PR1 axis, expansion of Prevotella sp., and invariant Natural Killer T (iNKT)-penia, thus offering the base of a rationale to mechanically modulate this pathway as a therapeutic target in RA. Full article
(This article belongs to the Special Issue Mechanobiology in Health and Disease)
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