Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Functional Structures in RNA Viruses
edited by Riccardo Delli Ponti, , and Laura Broglia
submission deadline 30 Nov 2025 | Viewed by 34 | Submission Open
Keywords: RNA secondary structure; RNA viruses; machine learning; SHAPE; protein– RNA interactions
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Lipid Signaling in Human Disease
edited by Berit Johansen and Felicity Ashcroft
submission deadline 10 Dec 2025 | Viewed by 64 | Submission Open
Keywords: lipid signaling pathways; membrane-derived lipid signaling molecules; inflammation mechanisms; cellular disease mechanisms; phospholipids; phospholipases; glycerophospholipids; sphingolipids
(This special issue belongs to the Section Lipids)
Mechanisms and Kinetics of Interactions of Biomolecules at Interfaces: 2nd Edition submission deadline 15 Dec 2025 | 4 articles | Viewed by 12408 | Submission Open
Keywords: biomolecule adsorption; kinetics of biomolecule adsorption; mechanisms of biomolecule deposition; interactions of biomolecules; techniques for the detection of biomolecules at solid substrates; interactions of proteins with biomolecules/biopolymers; protein and biomolecule systems; protein and biomolecule complexes
(This special issue belongs to the Section Bio-Engineered Materials)
Antibiotic Resistance Mechanisms and Their Potential Solutions
edited by Sung-Pin Tseng, and
submission deadline 15 Dec 2025 | 4 articles | Viewed by 10585 | Submission Open
Keywords: antibiotic resistance; antimicrobial development; molecular mechanism; priority for antibiotics; newly therapeutic approach
(This special issue belongs to the Section Molecular Biology)
Role of Neuroactive Steroids in Health and Disease: 2nd Edition submission deadline 15 Dec 2025 | 5 articles | Viewed by 7703 | Submission Open
Keywords: neurosteroids; neurodegenerative disorders; psychiatric disorders; physiological effects
(This special issue belongs to the Section Molecular Biology)
Role of TRAF in Regulating Inflammation and Cell Survival
edited by Ali Abdul-Sater
submission deadline 15 Dec 2025 | 2 articles | Viewed by 4099 | Submission Open
Keywords: TRAF; inflammation; inflammasome; TNFRs; apoptosis; cellular survival
(This special issue belongs to the Section Biological Factors)
New Insights into Cardiovascular Immunology
edited by Susanne Sattler, Pilar Martín and Stephen Malin
submission deadline 15 Dec 2025 | 1 articles | Viewed by 3939 | Submission Open
Keywords: inflammation; autoimmunity; atherosclerosis; myocarditis; heart failure
(This special issue belongs to the Section Molecular Medicine)
Epstein-Barr Virus Disease Mechanisms and Stress Responses: 2nd Edition submission deadline 15 Dec 2025 | Viewed by 531 | Submission Open
Keywords: Epstein– Barr virus (EBV); reactivation; immune modulation; stress; aging
(This special issue belongs to the Section Molecular Medicine)
Novel Insights on Cancer Stem Cells
edited by
submission deadline 15 Dec 2025 | Viewed by 451 | Submission Open
Keywords: cancer stem cells; cancer initiating cells; stemness; self-renewal; therapy resistance; epigenetic reprogramming
(This special issue belongs to the Section Molecular Medicine)
Cysteine and Selenocysteine in Antioxidant Defense, Protein Synthesis and Signaling Pathways submission deadline 15 Dec 2025 | Viewed by 241 | Submission Open
Keywords: cysteine; selenocysteine; taurine; hydrogen sulfide; hydrogen selenide; selenoproteins; sulfurtransferases; H2S precursors; antioxidants; diseases related to sulfur metabolism
(This special issue belongs to the Section Molecular Biology)
Nanomaterials and Smart Delivery Systems in Combating Drug-Resistant Infections
edited by Hanif Haidari and
submission deadline 15 Dec 2025 | Viewed by 166 | Submission Open
Keywords: nanomaterials; antimicrobial biomolecules; tissue engineering; metallic nanoparticles; smart hydrogels; drug-resistant infections; controlled drug delivery; biomaterial-tissue interactions
(This special issue belongs to the Section Bio-Engineered Materials)
Recent Molecular Research on Protein Structure and Function
edited by
submission deadline 15 Dec 2025 | Viewed by 139 | Submission Open
Keywords: protein structure; protein function; molecular mechanisms; protein folding; structural biology
(This special issue belongs to the Section Molecular Biology)
Novel Materials for Biomedical Applications: 3rd Edition submission deadline 15 Dec 2025 | Viewed by 15 | Submission Open
Keywords: micro-/nanocarriers; synthesis or conjugation of biomaterials; drug delivery; targeted therapy/immunotherapy for combinatorial treatment; regenerative medicine/tissue engineering
(This special issue belongs to the Section Bio-Engineered Materials)
Metabolism and Milk Quality in Dairy Cows: Dietary Influences and Transcriptomic Insights
edited by
submission deadline 20 Dec 2025 | Viewed by 63 | Submission Open
Keywords: dairy cows; transcriptomics; milk quality; nutrigenomics; epigenomics; diet; ration; transition period; lactation; dry period
Advances in S-Triazine-Based Therapeutics: From Antimicrobials to Neurodegenerative Disease Modulators
edited by
submission deadline 22 Dec 2025 | Viewed by 48 | Submission Open
Keywords: 1; 3; 5-triazine; s-triazine; biological activity; drug discovery; antibacterial agent; antifungal agent; anticancer activity; antiviral agents; antimalarial activity; anti-Alzheimer’ s activity; anti-Alzheimer’ s agents; cholinesterase inhibitors; BACE1 inhibitors; anti-neurodegenerative effects; anti-inflammatory activity; molecular mechanisms of s-triazine activity
(This special issue belongs to the Section Chemical Biology)
Helicases in DNA Repair: From Molecular Mechanisms to Medical and Biotechnological Applications
edited by Li Fan
submission deadline 23 Dec 2025 | Viewed by 40 | Submission Open
Keywords: DNA unwinding; DNA damage response; damage verification; genetic disease; premature aging; cancer; chemotherapy; gene therapy
(This special issue belongs to the Section Molecular Genetics)
Epigenetic Drivers of Cancer Metastasis: From Methylation to Non-Coding RNAs
edited by
submission deadline 30 Dec 2025 | Viewed by 32 | Submission Open
Keywords: epigenetics; metastasis; DNA methylation; RNA methylation; non-coding RNAs
Inflammatory Pathways in Heart Failure
edited by
submission deadline 30 Dec 2025 | Viewed by 21 | Submission Open
Keywords: inflammation; heart failure; molecular mechanism; heart failure therapies
(This special issue belongs to the Section Molecular Medicine)
Biochemistry in Medicine—Honorary Special Issue Commemorating Research and Work of Professors Jan O. Aaseth and Jan Alexander
edited by Sonia Distante and
submission deadline 31 Dec 2025 | 5 articles | Viewed by 29322 | Submission Open
Keywords: medical biochemistry; endocrinology; neurotoxic metals
(This special issue belongs to the Section Molecular Medicine)
Feature Papers in the Natural and Bio-Derived Molecules Section submission deadline 31 Dec 2025 | 9 articles | Viewed by 27402 | Submission Open
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Molecular Advances in Mechanism and Regulation of Lifespan and Aging
edited by Mark McCormick
submission deadline 31 Dec 2025 | 7 articles | Viewed by 17049 | Submission Open
Keywords: aging; lifespan; healthspan
(This special issue belongs to the Section Molecular Biology)
Tissue Calcification in Normal and Pathological Environments
edited by
submission deadline 31 Dec 2025 | 7 articles | Viewed by 13957 | Submission Open
Keywords: calcification; ectopic mineralization; bone; heterotopic ossification; calcium phosphate; calcium carbonate; calcium oxalate; procalcific cell death
(This special issue belongs to the Section Molecular Medicine)
Cell Biology and Biomedical Application of Galectins submission deadline 31 Dec 2025 | 5 articles | Viewed by 11779 | Submission Open
Keywords: galectins; cell differentiation; stem cells; apoptosis; autophagy; cell adhesion; glycobiology; post-translational modifications; transmembrane signaling; protein trafficking; cancer; heart diseases; fibrosis; inflammation; targeted therapeutics; galectin inhibitors
(This special issue belongs to the Section Chemical Biology)
Molecular Mechanisms in DNA and RNA Damage and Repair submission deadline 31 Dec 2025 | 7 articles | Viewed by 11074 | Submission Open
Keywords: reactive oxygen species; DNA damage; DNA repair; RNA damage; RNA repair; molecular mechanisms; biomarkers; antioxidant and redox strategies; oxidative stress
(This special issue belongs to the Section Molecular Biomarkers)
New Insight into the Molecular Genetics of Neurodevelopmental Disorders
edited by and Flavio Faletra
submission deadline 31 Dec 2025 | 4 articles | Viewed by 9837 | Submission Open
Keywords: neurodevelopmental disorders; next generation sequencing; pathomechanisms; phenotypic spectra; phenotype-genotype correlation
(This special issue belongs to the Section Molecular Genetics)
Neuroimmune Interactions in Neuropsychiatric Diseases
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 9712 | Submission Open
Keywords: neurology; psychiatry; immunity; glia
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into Sex and Evolution
edited by and
submission deadline 31 Dec 2025 | 3 articles | Viewed by 9143 | Submission Open
Keywords: sex determination; sex chromosome evolution; reproduction; hybridization; speciation; evolution; animals; vertebrates
(This special issue belongs to the Section Molecular Genetics)
Insights from the Editorial Board Members
edited by
submission deadline 31 Dec 2025 | 11 articles | Viewed by 8762 | Submission Open
Keywords: structure and function; bioactive and biogenic substances; molecular mechanisms; biomaterials
Cellular and Molecular Mechanism of Spermatogenesis
edited by Yanhe Lue
submission deadline 31 Dec 2025 | 4 articles | Viewed by 8486 | Submission Open
Keywords: spermatogenesis; regulation; biomolecules
(This special issue belongs to the Section Molecular Reproduction)
Cardiometabolic Disease: Molecular Basis and Therapeutic Approaches
edited by and Maria Nikolaou
submission deadline 31 Dec 2025 | 2 articles | Viewed by 7996 | Submission Open
Keywords: cardiometabolic medicine; preventive cardiology; cardiovascular endocrinology and metabolism; obesity; diabetes mellitus; cardiovascular disease
(This special issue belongs to the Section Molecular Medicine)
Advances in Melanoma Targeted Therapy
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 7443 | Submission Open
Keywords: melanoma; drug discovery; new targets; target discovery
(This special issue belongs to the Section Molecular Medicine)
Molecular Diagnosis and Regulation of Mitochondrial Dysfunction
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 7413 | Submission Open
Keywords: metabolic conditions; neurological conditions; genetic diseases; mitochondrial dysfunction; mitochondrial disorders; diagnostics; therapies
(This special issue belongs to the Section Biological Factors)
Molecular and Toxicological Profiling of Drugs of Abuse—in Honor of Professor Félix Carvalho submission deadline 31 Dec 2025 | 3 articles | Viewed by 6696 | Submission Open
Keywords: toxicodynamic; toxicokinetic; amphetamine-type stimulants; cannabis and cannabinoids; cocaine; hallucinogens; new psychoactive substances; opioids; immune modulation
(This special issue belongs to the Section Molecular Medicine)
Molecular Mechanisms of Cardiovascular Remodeling
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 6461 | Submission Open
Keywords: vascular remodeling aging; extracellular matrix; atherosclerosis peripheral; artery disease; chronic heart failure; cardiovascular associated cognitive decline
(This special issue belongs to the Section Molecular Biology)
Natural Bioactives as Leading Molecules for Drug Development
edited by , and
submission deadline 31 Dec 2025 | 4 articles | Viewed by 6411 | Submission Open
Keywords: drug discovery; natural products; leading molecules; isolation and identification; phytochemical investigation; omics approaches
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Antitumor Agents from Natural Sources 2024–2025 submission deadline 31 Dec 2025 | 2 articles | Viewed by 6336 | Submission Open
Keywords: antitumor agents; natural sources; cancer prevention and therapy
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Signal Transduction to Transcription Factors in Health and Disease—Honorary Special Issue Commemorating the Work of Prof. Athanasios G. Papavassiliou submission deadline 31 Dec 2025 | 3 articles | Viewed by 6140 | Submission Open
(This special issue belongs to the Section Molecular Medicine)
The Role of Non-Coding RNAs in Health and Disease submission deadline 31 Dec 2025 | 6 articles | Viewed by 5940 | Submission Open
Keywords: non-coding RNA; microRNA (miRNA); long noncoding RNA (lncRNA); circular RNA (circRNA); gene expression regulation; epigenetic modifications
(This special issue belongs to the Section Molecular Genetics)
Integrating Genetics, Immune Dysregulation, and the Gut Microbiome: Advances in Elucidating IBD Pathophysiology and Emerging Therapeutic Strategies submission deadline 31 Dec 2025 | 3 articles | Viewed by 5738 | Submission Open
Keywords: microbiome; biomarkers; Crohn’ s disease; ulcerative colitis; indeterminate colitis; multiomics; gastrointestinal (GI disease); immunology; gut– brain axis; neuropsychology
(This special issue belongs to the Section Molecular Genetics)
Human Reproductive Biology: Uncertainties and Controversies
edited by , and Paola Bianchi
submission deadline 31 Dec 2025 | 2 articles | Viewed by 5710 | Submission Open
Keywords: molecular reproduction; endometriosis; endometrium; implantation; decidualization; placenta; cellular senescence; prostaglandin; inflammation; pregnancy; reproduction; implantation; decidualization; endometriosis; assisted reproductive technology; molecular reproductive biology; reproductive biology; reproductive immunology; reproductive medicine; reproductive endocrinology; molecular regulation of reproductive processes; embryo development; reproductive biology; gametogenesis and fertilization
(This special issue belongs to the Section Molecular Reproduction)
Genetic and Structural Analyses of Coronaviruses: Insights into SARS-CoV-2 and Beyond
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 5234 | Submission Open
Keywords: SARS-CoV-2 variants; protein variants; protein structure; virus evolution; mutations; structural bioinformatics; molecular phylogenesis; host– pathogen molecular interactions; molecular immunology; drug discovery
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Innate Immunomodulation and Inflammation: From Molecular Mechanisms to Pre-Clinical Insights
edited by Fabián Flores-Borja, and
submission deadline 31 Dec 2025 | 3 articles | Viewed by 5111 | Submission Open
Keywords: innate immunity; therapy; immune checkpoints; cancer; autoimmunity; inflammation; infection; danger-associated molecular patterns; pattern recognition receptors
(This special issue belongs to the Section Molecular Medicine)
Biosynthesis and Function of Thyroid Hormones
edited by and Eva K. Wirth
submission deadline 31 Dec 2025 | 4 articles | Viewed by 4992 | Submission Open
Keywords: thyroid gland; thyroid follicle; TH release; iodide; deiodinase; TH transmembrane transport; TH receptors; intracellular TH binding proteins; thyroglobulin; sodium– iodide symporter; thyroperoxidase; dual oxidase; thyroid-relevant trace elements
(This special issue belongs to the Section Biological Factors)
Advances in Galectins
edited by Anu Paul and Diyoly Ayona
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4526 | Submission Open
Keywords: galectins; carbohydrate-binding proteins; galectin– microbe
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Computational Intelligence in Structure and Function Prediction and Modeling of Proteins—2nd Edition
edited by , and Haiting Chai
submission deadline 31 Dec 2025 | 3 articles | Viewed by 3787 | Submission Open
Keywords: protein tertiary structure; protein folding; protein functions; intrinsic disorder; drug discovery; protein– drug interaction; computational intelligent algorithms; artificial intelligence for proteomics; high-throughput proteomics
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Chemical Biology and Biotechnology of Nucleosides, Nucleotides, and Nucleic Acids
edited by and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3580 | Submission Open
Keywords: nucleosides; nucleotides; nanostructure; circular ssDNA; circular RNA; quadruplex; conjugate; lncRNA; DNAzyme; ribozyme
(This special issue belongs to the Section Chemical Biology)
Matrix Metalloproteinases: Mechanisms, Functions and Therapeutic Potential
edited by , Joshua W. Ogony and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 3481 | Submission Open
Keywords: matrix metalloproteinases; endopeptidases; MMP inhibitor; tissue homeostasis; disease progression
Alcohol-Related Organ Damage: Mechanisms, Outcomes, and Treatment Modalities submission deadline 31 Dec 2025 | 2 articles | Viewed by 3246 | Submission Open
Keywords: alcoholic liver disease (ALD); steatohepatitis; fibrosis; cirhosis; parenhymal and non-parenhymal liver cells; brain; gut; lungs; immune responses; oxidative stress; methylation; viral infections; post-translational protein modifications; treatment of ALD
(This special issue belongs to the Section Molecular Medicine)
Neuron–Astrocyte Interactions in Neurological Function and Disease
edited by Micaela Zonta and Alessandro Di Spiezio
submission deadline 31 Dec 2025 | 1 articles | Viewed by 3239 | Submission Open
Keywords: astrocytes; neuron-astrocyte communication; brain function; neurological disease
Recent Advances in the Enzymatic Synthesis of Bioactive Compounds submission deadline 31 Dec 2025 | 3 articles | Viewed by 3191 | Submission Open
Keywords: biocatalysis; biotransformation; enzyme-catalyzed reactions; whole-cell catalysis; green chemistry; enzymes; phenolic compounds; polyphenols; lipases; lipophilization; enzymatic synthesis; esterification; transesterification; green and sustainable chemistry approaches; lipid modification
(This special issue belongs to the Section Natural and Bio-derived Molecules)
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