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Biosensors
Special Issues
Fluorescent Probe for Biosensing and Cell Imaging
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Fluorescent Probe for Biosensing and Cell Imaging

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".

Deadline for manuscript submissions: closed (10 December 2023) | Viewed by 3251

Special Issue Editors

Dr. Jian Xu

E-Mail Website
Guest Editor
Development Center for Eco-material and Eco-Chemistry, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China
Interests: fluorescent probe; biosensing; cell imaging
Dr. Yonglei Chen

E-Mail Website
Guest Editor
College of Chemistry and Chemical Engineering, State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000, China
Interests: nanoprobe; fluorescent probes; molecular spectroscopy
Special Issues, Collections and Topics in MDPI journals
Dr. Jia Chen

E-Mail Website
Guest Editor
Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China
Interests: biomarker detection; drug separation

Special Issue Information

Dear Colleagues，

Over the past decades, the enormous growth in the diversity of artificially synthesized fluorescent probes has greatly promoted the development of cell biology. For imaging different cellular structures, a series of molecular probes have been designed to target cytoskeletal proteins, mitochondria, lysosomes, peroxisomes, the ER, Golgi apparatuses, cell nuclei, lipid droplets, and plasma membranes. Typically, fluorescent probes can serve as highly sensitive indicators to detect the intrinsically non-fluorescent species and parameters of cells, such as metal ions, glutathione, reactive oxygen species (ROS), adenosine triphosphate (ATP), pH values, membrane potentials, and so on. Nonetheless, the demand for high-quality fluorescent probes that are of a high quantum yield, highly selective and sensitive, biocompatible, near-infrared emission, easy to use, and, in particular, can be used for super-resolution imaging is ever increasing. Therefore, this Special Issue, “Fluorescent Probe for Biosensing and Cell Imaging”, focuses on the recent advances in the production of novel cell probes, including small-molecule dyes, fluorescent antibodies, and fluorescent nanomaterials (inorganic QDs, carbon dots, fluorescent metal nanoclusters, and fluorescent dye-loaded NPs). We invite submissions of research that help to advance the field of fluorescent probe technology and its applications for microscopic image analyses of biomarkers.

Kind regards,

Dr. Jian Xu
Dr. Yonglei Chen
Dr. Jia Chen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fluorescent probe
  • biosensing
  • cell imaging
  • cellular structure
  • small-molecule dye
  • fluorescent antibody
  • fluorescent nanomaterial
  • microscopic image
  • biomarker

Published Papers (2 papers)

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Research

11 pages, 2032 KiB  
Article
An Anthracene Carboxamide-Based Fluorescent Probe for Rapid and Sensitive Detection of Mitochondrial Hypochlorite in Living Cells
by Xueling Liu, Yali Wang, Guangshuai Zhou and Wenzhou Zhang
Biosensors 2023, 13(9), 883; https://doi.org/10.3390/bios13090883 - 12 Sep 2023
Cited by 1 | Viewed by 1112
Abstract
Mitochondrial hypochlorite (ClO−) plays important and often contradictory roles in maintaining the redox balance of mitochondria. Abnormal ClO− levels can induce mitochondrial inactivation and further cause cell apoptosis. Herein, we have developed an anthracene carboxyimide-based fluorescent probe mito-ACS for imaging [...] Read more.
Mitochondrial hypochlorite (ClO−) plays important and often contradictory roles in maintaining the redox balance of mitochondria. Abnormal ClO− levels can induce mitochondrial inactivation and further cause cell apoptosis. Herein, we have developed an anthracene carboxyimide-based fluorescent probe mito-ACS for imaging mitochondrial ClO− in living cells. This probe exhibits some distinctive features as excellent resistance to photobleaching, high selectivity and sensitivity, as well as good water solubility. Mito-ACS showed a noticeable fluorescence response toward ClO− with a fast response (within 6 s) and a low detection limit (23 nM). Moreover, the introduction of triphenylphosphonium makes the probe soluble in water and selectively localizes to mitochondria. Furthermore, mito-ACS was successfully applied to image mitochondria ClO− in living cells with low toxicity. Remarkably. the less used fluorophore anthracene carboxyimide exhibiting excellent photostability and desirable optical properties provides a promising application prospect in biological systems. Full article
(This article belongs to the Special Issue Fluorescent Probe for Biosensing and Cell Imaging)
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12 pages, 3319 KiB  
Article
A Novel and Sensitive Fluorescent Probe for Glyphosate Detection Based on Cu2+ Modulated Polydihydroxyphenylalanine Nanoparticles
by Xiqiong Mu, Jian Xu and Fankui Zeng
Biosensors 2023, 13(5), 510; https://doi.org/10.3390/bios13050510 - 28 Apr 2023
Cited by 2 | Viewed by 1877
Abstract
A novel and sensitive fluorescent probe based on Cu2+-modulated polydihydroxyphenylalanine nanoparticles (PDOAs) has been developed for the detection of glyphosate pesticides. Compared to conventional instrumental analysis techniques, fluorometric methods have obtained good results in the field of agricultural residue detection. However, [...] Read more.
A novel and sensitive fluorescent probe based on Cu2+-modulated polydihydroxyphenylalanine nanoparticles (PDOAs) has been developed for the detection of glyphosate pesticides. Compared to conventional instrumental analysis techniques, fluorometric methods have obtained good results in the field of agricultural residue detection. However, most of the fluorescent chemosensors reported still have some limitations, such as long response times, the high limit of detection, and complex synthetic procedures. In this paper, a novel and sensitive fluorescent probe based on Cu2+ modulated polydihydroxyphenylalanine nanoparticles (PDOAs) has been developed for the detection of glyphosate pesticides. The fluorescence of PDOAs can be effectively quenched by Cu2+ through the dynamic quenching process, which was confirmed by the time-resolved fluorescence lifetime analysis. In the presence of glyphosate, the fluorescence of the PDOAs-Cu2+ system can be effectively recovered due to the higher affinity of glyphosate for Cu2+, and thus released the individual PDOAs. Due to the admirable properties such as high selectivity to glyphosate pesticide, “turn on” fluorescence response, and ultralow detection limit of 1.8 nM, the proposed method has been successfully applied for the determination of glyphosate in environmental water samples. Full article
(This article belongs to the Special Issue Fluorescent Probe for Biosensing and Cell Imaging)
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