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Biosensors
Special Issues
Advanced Optical Methods for Biosensing
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Advanced Optical Methods for Biosensing

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 2620

Special Issue Editors

Dr. Pinkie Jacob Eravuchira

E-Mail Website
Guest Editor
Environment and People: A Centre for Scientific Research and Innovation, Kerala 670645, India
Interests: biosensors; optical spectroscopy; microfluidics
Special Issues, Collections and Topics in MDPI journals
Dr. Chih-Tsung Yang

E-Mail Website
Guest Editor
Future Industries Institute, University of South Australia, Mawson Lakes Campus, Adelaide, SA 5095, Australia
Interests: biomaterials; biosensing; microfluidics and organ-on-a-chip model
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Nathan Lindquist

E-Mail Website
Guest Editor
Physics Department, Bethel University, St. Paul, MN 55112, USA
Interests: nano-photonics and plasmonics; super-resolution imaging and microscopy; digital holographic microscopy; optical biosensing; spectroscopy; nanofabrication
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biosensors are analytical tools that facilitate the accurate diagnosis and analysis of biological states and diseases in living systems. These diagnostic devices detect and quantitatively measure biological and pathological analytes in order to aid a better understanding of the biological processes and changes in cells and tissues. Much innovative research is being carried out to create high-accuracy and cost-effective optical biosensors that can help with disease diagnoses. New advancements, especially in the field of optical methods for biosensing, are essential as these biological detection and imaging tools find a wide range of potential applications in healthcare, medicine, and more.

In this Special Issue of Biosensors, we invite you to contribute high-quality research on Advanced Optical Methods for Biosensing and Bioimaging. Contributions that cover both experimental and theoretical work on the latest developments in the field of optical biosensors will be considered. Original research papers, communication, research notes, and comprehensive review articles are welcome. Manuscripts will be internationally peer-reviewed.

Dr. Pinkie Jacob Eravuchira
Dr. Chih-Tsung Yang
Prof. Dr. Nathan Lindquist
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • optical biosensors
  • lab-on-a-chip
  • point-care devices
  • mi-crofluidics

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Published Papers (3 papers)

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Research

12 pages, 6188 KiB  
Article
Bi-Plane Multicolor Scanning Illumination Microscopy with Multispot Excitation and a Distorted Diffraction Grating
by Siwei Li, Yunke Zhang, Zhiwen Liao, Zengyuan Tian, Hairulazwan Hashim, Youjun Zeng and Yandong Zhang
Biosensors 2024, 14(11), 550; https://doi.org/10.3390/bios14110550 - 13 Nov 2024
Viewed by 417
Abstract
Multifocus microscopy has previously been demonstrated to provide volumetric information from a single shot. However, the practical application of this method is challenging due to its weak optical sectioning and limited spatial resolution. Here, we report on the combination of a distorted diffraction [...] Read more.
Multifocus microscopy has previously been demonstrated to provide volumetric information from a single shot. However, the practical application of this method is challenging due to its weak optical sectioning and limited spatial resolution. Here, we report on the combination of a distorted diffraction grating and multifocal scanning illumination microscopy to improve spatial resolution and contrast. DG is introduced in the emission path of the multifocal scanning illumination microscopy, which splits the fluorescence signal from different sample layers into different diffraction orders. After postprocessing, super-resolution wide-field images of different sample layers can be reconstructed from single 2D scanning. Full article
(This article belongs to the Special Issue Advanced Optical Methods for Biosensing)
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12 pages, 3019 KiB  
Article
Analysis of Random Lasing in Human Blood
by Sergio de Armas-Rillo, Beatriz Abdul-Jalbar, Josmar Salas-Hernández, Jose María Raya-Sánchez, Tomás González-Hernández and Fernando Lahoz
Biosensors 2024, 14(9), 441; https://doi.org/10.3390/bios14090441 - 13 Sep 2024
Viewed by 750
Abstract
Random lasing (RL) is an optical phenomenon that arises from the combination of light amplification with optical feedback through multiple scattering events. In this paper, we present our investigations of RL generation from human blood samples. We tested mixtures of rhodamine B dye [...] Read more.
Random lasing (RL) is an optical phenomenon that arises from the combination of light amplification with optical feedback through multiple scattering events. In this paper, we present our investigations of RL generation from human blood samples. We tested mixtures of rhodamine B dye solutions with different blood components, including platelets, lymphocytes, erythrocytes, and whole blood. Intense coherent RL was obtained in all cases at relatively low pump thresholds, except for erythrocytes. We also studied the potential of RL signal analysis for biosensing applications using blood samples from healthy individuals and patients suffering from Chronic Lymphocytic Leukemia (CLL). CLL is a blood disease characterized by a high count of lymphocytes with significant morphological changes. A statistical analysis of the RL spectra based on principal component and linear discriminant analyses was conducted for classification purposes. RL-based sample discrimination was conducted for whole blood, platelet, and lymphocyte samples, being especially successful (86.7%) for the latter. Our results highlight the potential of RL analysis as a sensing tool in blood. Full article
(This article belongs to the Special Issue Advanced Optical Methods for Biosensing)
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12 pages, 1037 KiB  
Article
Brillouin Biosensing of Viscoelasticity across Phase Transitions in Ovine Cornea
by Chingis Kharmyssov and Zhandos Utegulov
Biosensors 2024, 14(8), 371; https://doi.org/10.3390/bios14080371 - 30 Jul 2024
Cited by 1 | Viewed by 1187
Abstract
Noninvasive in situ monitoring of viscoelastic characteristics of corneal tissue at elevated temperatures is pivotal for mechanical property-informed refractive surgery techniques, including thermokeratoplasty and photorefractive keratectomy, requiring precise thermal modifications of the corneal structure during these surgical procedures. This study harnesses Brillouin light [...] Read more.
Noninvasive in situ monitoring of viscoelastic characteristics of corneal tissue at elevated temperatures is pivotal for mechanical property-informed refractive surgery techniques, including thermokeratoplasty and photorefractive keratectomy, requiring precise thermal modifications of the corneal structure during these surgical procedures. This study harnesses Brillouin light scattering spectroscopy as a biosensing platform to noninvasively probe the viscoelastic properties of ovine corneas across a temperature range of 25–64 °C. By submerging the tissue samples in silicone oil, consistent hydration and immiscibility are maintained, allowing for their accurate sensing of temperature-dependent mechanical behaviors. We identify significant phase transitions in the corneal tissue, particularly beyond 40 °C, likely due to collagen unfolding, marking the beginning of thermal destabilization. A subsequent transition, observed beyond 60 °C, correlates with collagen denaturation. These phase transformations highlight the cornea’s sensitivity to both physiologically reversible and irreversible viscoelastic changes induced by mild to high temperatures. Our findings underscore the potential of the Brillouin biosensing technique for real-time diagnostics of corneal biomechanics during refractive surgeries to attain optimized therapeutic outcomes. Full article
(This article belongs to the Special Issue Advanced Optical Methods for Biosensing)
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