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Brain Sciences
Special Issues
Recent Updates in Astrocyte Research
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Recent Updates in Astrocyte Research

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neuroglia".

Deadline for manuscript submissions: closed (22 January 2024) | Viewed by 3348

Special Issue Editors

Dr. Song Qin

E-Mail Website
Guest Editor
1. Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fudan University, Shanghai, China
2. State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China
Interests: neurogenesis and astrogenesis; neurodevelopment and neuroregeneration
Dr. Shinghua Ding

E-Mail Website
Guest Editor
Dalton Cardiovascular Research Center, Columbia, SC, USA
Interests: glia-neuron interactions; glial function; ischemic stroke; neural degeneration and regeneration

Special Issue Information

Dear Colleagues,

Astrocytes are the most abundant cell type, and are widely distributed throughout the central nervous system. Increasing amounts of evidence indicate that astrocytes play a critical role in various aspects of physiological functions, including in the secretion of nutrients, maintenance of the neuronal microenvironment, regulation of the permeability of the blood–brain barrier, etc. The dysfunction of astrocytes contributes to neurological diseases, such as Alzheimer's disease, epilepsy, depression, and amyotrophic lateral sclerosis, which were thought to arise entirely from neuronal dysfunction. This Special Issue of Brain Sciences aims to present a collection of studies detailing the most recent advancements in the field of astrocyte research. Authors are invited to submit cutting-edge research and reviews that address a broad range of topics related to astrocytes, including the following: brain development, cellular fate specification, cytoskeleton and morphology, metabolism, biomarkers, neural injury, regeneration, aging, neurodegenerative diseases, and neuropsychiatric disorders.

Dr. Song Qin
Dr. Shinghua Ding
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • astrocyte development
  • astrocyte–neuron interactions
  • neurological disease
  • neuropsychiatric disorders
  • astrocyte physiology
  • astrocyte heterogeneity
  • astrocyte cytoskeleton
  • astrocyte metabolism

Published Papers (2 papers)

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Research

13 pages, 20586 KiB  
Article
Dynamic Changes in Neuroglial Reaction and Tissue Repair after Photothrombotic Stroke in Neonatal Mouse
by Yitong Liu, Pifang Gong, Guibo Qi, Han Tang, Runshan Gui, Congcong Qi and Song Qin
Brain Sci. 2024, 14(2), 152; https://doi.org/10.3390/brainsci14020152 - 1 Feb 2024
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Abstract
Perinatal and neonatal ischemic stroke is a significant cause of cognitive and behavioral impairments. Further research is needed to support models of neonatal ischemic stroke and advance our understanding of the mechanisms of infarction formation following such strokes. We used two different levels [...] Read more.
Perinatal and neonatal ischemic stroke is a significant cause of cognitive and behavioral impairments. Further research is needed to support models of neonatal ischemic stroke and advance our understanding of the mechanisms of infarction formation following such strokes. We used two different levels of photothrombotic stroke (PTS) models to assess stroke outcomes in neonatal mice. We measured brain damage, dynamic changes in glial cells, and neuronal expression at various time points within two weeks following ischemic injury. Our results from 2,3,5-Triphenyltetrazolium chloride (TTC) staining and immunofluorescence staining showed that in the severe group, a dense border of astrocytes and microglia was observed within 3 days post infarct. This ultimately resulted in the formation of a permanent cortical cavity, accompanied by neuronal loss in the surrounding tissues. In the mild group, a relatively sparse arrangement of glial borders was observed 7 days post infarct. This was accompanied by intact cortical tissue and the restoration of viability in the brain tissue beyond the glial boundary. Additionally, neonatal ischemic injury leads to the altered expression of key molecules such as Aldh1L1 and Olig2 in immature astrocytes. In conclusion, we demonstrated the dynamic changes in glial cells and neuronal expression following different degrees of ischemic injury in a mouse model of PTS. These findings provide new insights for studying the cellular and molecular mechanisms underlying neuroprotection and neural regeneration after neonatal ischemic injury. Full article
(This article belongs to the Special Issue Recent Updates in Astrocyte Research)
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14 pages, 23274 KiB  
Article
Visualization and Characterization of the Brain Regional Heterogeneity of Astrocyte–Astrocyte Structural Interactions by Using Improved Iontophoresis with Dual-Fluorescent Dyes
by Qingran Li, Bin Zhou, Mengchan Su, Ping Liao, Fan Lei, Xin Li, Daqing Liao, Xia Zhang and Ruotian Jiang
Brain Sci. 2023, 13(12), 1644; https://doi.org/10.3390/brainsci13121644 - 27 Nov 2023
Viewed by 1440
Abstract
Astrocytes are morphologically intricate cells and actively modulate the function of the brain. Through numerous fine processes, astrocytes come into contact with neurons, blood vessels, and other glia cells. Emerging evidence has shown that astrocytes exhibit brain regional diversity in their morphology, transcriptome, [...] Read more.
Astrocytes are morphologically intricate cells and actively modulate the function of the brain. Through numerous fine processes, astrocytes come into contact with neurons, blood vessels, and other glia cells. Emerging evidence has shown that astrocytes exhibit brain regional diversity in their morphology, transcriptome, calcium signaling, and functions. However, little is known about the brain regional heterogeneity of astrocyte–astrocyte structural interaction. So far, the visualization and characterization of the morphological features of adjacent astrocytes have been difficult, and as a result, it is still well-accepted that astrocytes in the adult brain share non-overlapped territory. In contrast, employing an approach that combines viral labeling with dual-fluorescent dyes iontophoresis under brightfield and imaging using confocal microscopy allows for the efficient and specific labeling of adjacent astrocytes, enabling a comprehensive visualization of their fine processes and the degree of their territorial overlap. Our study in the hypothalamic regions of the brain revealed a marked spatial overlap among adjacent astrocytes, which differs from the conventional understanding based on more extensively studied regions, like the hippocampus. Additionally, we revealed the heterogeneity of the astrocyte–neuron ratio across brain regions and conducted an assessment of the photostability and labeling efficiency of fluorescent dyes used for labeling adjacent astrocytes. Our study provides new insights for studying the morphological heterogeneity of astrocytes across the central nervous system. Full article
(This article belongs to the Special Issue Recent Updates in Astrocyte Research)
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