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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Surgical Advances in the Treatment of Gliomas: Preserving Function and Quality of Life

edited by Francesco Vergani and José Pedro Lavrador

submission deadline 7 Jun 2026 | 6 articles | Viewed by 8162 | Submission Open

Keywords: neuro-oncology; brain mapping; neuroimaging; intraoperative neuro-monitoring; functional MRI; transcranial magnetic stimulation; neurorehabilitation

(This special issue belongs to the Section Cancer Therapy)

Existing and Emerging Biomarkers for Immune Checkpoint Immunotherapy in Solid Tumors (2nd Edition)

edited by Nuria Romero-Laorden

submission deadline 10 Jun 2026 | 2 articles | Viewed by 9652 | Submission Open

Keywords: immunotherapy; checkpoint inhibitors; biomarkers; immune biomarkers; PD-L1; TMB; solid tumors

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Histopathology of Urological Cancers

edited by Vikas Mehta, Antoun Toubaji and Vijayalakshmi Ananthanarayanan

submission deadline 10 Jun 2026 | 3 articles | Viewed by 9521 | Submission Open

Keywords: renal cell carcinoma; prostate; testis Ggrm cell tumors; urothelial carcinoma; artificial intelligence; ductal adenocarcinoma of prostate; neuroendocrine differentiation of prostate carcinoma; next-generation sequencing

(This special issue belongs to the Section Cancer Pathophysiology)

Emerging Concepts in Mesothelioma

edited by Georgios T. Stathopoulos and Tonia Adamides

submission deadline 10 Jun 2026 | 2 articles | Viewed by 2589 | Submission Open

Keywords: mesothelioma; asbestos; pleura; tumor suppressor; cell lines; patient-derived xenograft; surgery; chemotherapy; folate antagonist; immunotherapy

(This special issue belongs to the Section Clinical Research of Cancer)

Extracellular Vesicles in Cancer Progression

edited by

Susana García-Silva

submission deadline 10 Jun 2026 | 1 articles | Viewed by 802 | Submission Open

Keywords: extracellular vesicles; cancer progression; tumor microenvironment; tumor– immune landscape; cross-talk pre-metastatic and metastatic niches immune surveillance; EV-based biomarkers; EV-based therapeutic development

(This special issue belongs to the Section Tumor Microenvironment)

New Approaches in Modulating Transcription Factors for Cancer Therapy: 2nd Edition

edited by

Sarah Walker

submission deadline 10 Jun 2026 | Viewed by 401 | Submission Open

Keywords: transcription factors; cancer treatment; degraders; inhibitors

(This special issue belongs to the Section Cancer Therapy)

Precision Cell Therapy in Cancer: From Molecular Profiling to Personalized Treatment

edited by

Biaoru Li

submission deadline 10 Jun 2026 | Viewed by 206 | Submission Open

Keywords: molecular profiling; precision cell therapy; Next-Generation Sequencing (NGS); biomarker identification; CAR T-cell therapy

(This special issue belongs to the Section Cancer Therapy)

Advances and Challenges in Pediatric Surgical Oncology

edited by Joseph Lopez

submission deadline 10 Jun 2026 | Viewed by 204 | Submission Open

Keywords: pediatric surgical oncology; computer-assisted surgery; quality care; surgical outcomes; reconstruction

(This special issue belongs to the Section Pediatric Oncology)

Innovative Surgical Strategies for Thoracic Malignancies

edited by

Gregor J. Kocher

and

Fabrizio Minervini

submission deadline 10 Jun 2026 | Viewed by 188 | Submission Open

Keywords: robotic thoracic surgery; RATS; uRATS; NSCLC; thoracic malignancies; video-assisted thoracic surgery; VATS; uVATS

(This special issue belongs to the Section Methods and Technologies Development)

Nursing and Supportive Care for Cancer Survivors

edited by

Michela Piredda

submission deadline 12 Jun 2026 | 3 articles | Viewed by 5404 | Submission Open

Keywords: cancer survivorship; oncology nursing; symptom management; quality of life; supportive care; psycho-existential distress; pain catastrophizing; palliative care; caregiver support; advanced cancer; patient-centred care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Brain Metastases: From Mechanisms to Treatment

edited by Dawen Zhao and Michael Chan

submission deadline 15 Jun 2026 | 9 articles | Viewed by 22773 | Submission Open

Keywords: brain metastasis; the tumor microenvironment; blood– tumor barrier; novel biomarkers and therapeutics; radiation therapy

(This special issue belongs to the Section Cancer Metastasis)

Recent Studies on Oral Cancer: Diagnostic Technologies, Pathology, and Surgery

edited by

Luisa Limongelli

Gianfranco F. Favia

and

Fabio Dell’Olio

submission deadline 15 Jun 2026 | 4 articles | Viewed by 10102 | Submission Open

Keywords: oral cancer; oral squamous cell carcinoma; oral potentially malignant disorders; diagnostic technologies; oral surgery; maxillo-facial surgery; oncology; radiology; immunohistochemistry; molecular biology

(This special issue belongs to the Section Clinical Research of Cancer)

Application of Large-Scale Genome Data in Identifying Clinically Actionable Targets in Cancer

edited by

Arezou A. Ghazani

submission deadline 15 Jun 2026 | 3 articles | Viewed by 6397 | Submission Open

Keywords: genome; cancers; oncology

(This special issue belongs to the Section Molecular Cancer Biology)

Current Updates and Future Directions in Neuroendocrine Neoplasms (NENs): Understanding Biology, Diagnosis, Management and Research Efforts in NENs (2nd Edition)

edited by

Jaydira del Rivero

and Aman Chauhan

submission deadline 15 Jun 2026 | 2 articles | Viewed by 5321 | Submission Open

Keywords: neuroendocrine neoplasms; NENs; neuroendocrine carcinomas; tumor biology; clinical management; therapeutic management

(This special issue belongs to the Section Cancer Therapy)

Metastatic Progression of Human Melanoma: 2nd Edition

edited by

Jozsef Timar

and

Andrea Ladányi

submission deadline 15 Jun 2026 | 2 articles | Viewed by 5261 | Submission Open

Keywords: human melanoma; metastasis models; oncogenic signaling; organ metastasis; genomics; immune microenvironment; prognosticators; predictors of target therapies

(This special issue belongs to the Section Cancer Pathophysiology)

Advances in Genomics and Molecular Diagnostics in Gynecological Pathology

edited by

Maria Olinca

and

Radu Pirlog

submission deadline 15 Jun 2026 | 2 articles | Viewed by 4614 | Submission Open

Keywords: tumor genomics; molecular diagnosis; targeted therapies; biomarkers

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Radiotherapy of Gastrointestinal Cancers

edited by

Sunil Krishnan

submission deadline 15 Jun 2026 | 2 articles | Viewed by 2343 | Submission Open

Keywords: gastrointestinal cancer; radiotherapy; IMRT; SBRT; MR-guided; proton therapy; adaptive radiotherapy; treatment planning; radiomics; artificial intelligence; combination therapy; immunotherapy; toxicity management; quality of life; personalized medicine

(This special issue belongs to the Section Methods and Technologies Development)

New Perspectives in Skin Cancer: From Biology to Therapy

edited by Marija Buljan

submission deadline 15 Jun 2026 | 1 articles | Viewed by 1002 | Submission Open

Keywords: skin cancer; melanoma and non-melanoma skin cancer; tumor biology; early diagnosis; targeted therapy; immunotherapy; epidemiology

Perioperative Management and Anesthetic Strategies for Improving Cancer Prognosis

edited by

Juan P. Cata

Lucillia Bezu

and

Nicolas Villablanca Uribe

submission deadline 15 Jun 2026 | Viewed by 358 | Submission Open

Keywords: perioperative care; anesthesia; cancer; oncological outcomes

Thoracic Cancer Surgery: From Classic to Robotic Approaches

edited by Sai Yendamuri and

Kenneth Patrick Seastedt

submission deadline 15 Jun 2026 | Viewed by 211 | Submission Open

Keywords: thoracic surgery; robotic surgery; image-guided technologies; minimally invasive surgery

(This special issue belongs to the Section Cancer Therapy)

Surgical Strategies in the Era of Perioperative Immunotherapy for Thoracic Cancer

edited by Tomoyuki Hishida

submission deadline 15 Jun 2026 | Viewed by 187 | Submission Open

Keywords: lung cancer; perioperative treatment; immunotherapy; innmue checkpoint inhibitors; surgery

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Current Progress in Radiotherapy and Particle Therapy of Cancer

edited by

Carla Hajj

submission deadline 16 Jun 2026 | Viewed by 408 | Submission Open

Keywords: radiotherapy; particle therapy; proton therapy; heavy ion therapy; radiobiological; carbon ion therapy

(This special issue belongs to the Section Cancer Therapy)

Novel Insights into Cancer-Related Cognitive Impairment

edited by Danielle Tometich

submission deadline 20 Jun 2026 | 3 articles | Viewed by 9473 | Submission Open

Keywords: cognitive impairment; cognitive dysfunction; cancer survivorship; quality of life; neuropsychological assessment; cognitive rehabilitation

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Histopathology and Pathogenesis of Skin Cancer

edited by

Carlos Torres-Cabala

and

Alessio Giubellino

submission deadline 20 Jun 2026 | 6 articles | Viewed by 9048 | Submission Open

Keywords: skin; tumor; cancer; histopathology; pathogenesis; molecular; immunohistochemistry; pathway; pathology

(This special issue belongs to the Section Cancer Pathophysiology)

Sarcoma Management in Orthopaedic Oncology

edited by

Vasileios Kontogeorgakos

and Jendrik Hardes

submission deadline 20 Jun 2026 | 5 articles | Viewed by 6599 | Submission Open

Keywords: orthopaedic surgical oncology; sarcoma; orthopaedic surgery; bone and soft tissue sarcoma; diagnose; neoadjuvant therapy; targeted therapy; immunotherapy

(This special issue belongs to the Section Methods and Technologies Development)

The Advance of Clinical Therapy and Prognosis in Gastrointestinal Cancer

edited by Liliana Streba and Michael Schenker

submission deadline 20 Jun 2026 | 2 articles | Viewed by 4827 | Submission Open

Keywords: gastrointestinal cancer; tumorigenesis; microbiome; early detection; molecular mechanisms; personalized medicine; novel therapeutics; translational research; clinical application; diagnostic innovations

(This special issue belongs to the Section Clinical Research of Cancer)

IBD-Associated Cancer

edited by Takayuki Ogino

submission deadline 20 Jun 2026 | 2 articles | Viewed by 1805 | Submission Open

Keywords: IBD-associated cancer; Crohn’ s disease; ulcerative colitis; colorectal cancer; small bowel cancer; chemotherapy; radiotherapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

p53 Family in Cancer: How Close Are We to the Clinic? (2nd Edition)

edited by

Lucília Saraiva

and

Marco M. Candeias

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1442 | Submission Open

Keywords: p53; p63; p73; proteins; protein-coding and non-coding genes; genetics; drug discovery; cancer; targeted anticancer therapy

(This special issue belongs to the Section Cancer Therapy)

Advances in Pleural and Peritoneal Mesothelioma

edited by

Rossella Bruno

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1192 | Submission Open

Keywords: pleural mesothelioma; peritoneal mesothelioma; differential diagnosis; biomarkers; next-generation sequencing; gene expression

(This special issue belongs to the Section Molecular Cancer Biology)

Decoding and Remodeling the Suppressive Tumor Immune Microenvironment in Head and Neck Cancer

edited by Andrew G. Sikora and Jennifer L. Anderson

submission deadline 20 Jun 2026 | 1 articles | Viewed by 674 | Submission Open

Keywords: tumor immune microenvironment (TIME); cancer-mediated immunosuppression; myeloid cells; regulatory T cells; cytokines; anti-tumor immunity; immune modulation

(This special issue belongs to the Section Tumor Microenvironment)

Advances in the Ubiquitin–Proteasome System (UPS) in Cancer Biology

edited by

Tarek A. Abbas

submission deadline 20 Jun 2026 | Viewed by 397 | Submission Open

Keywords: ubiquitin– proteasome system (UPS); cancer biology; E3 ubiquitin ligases; deubiquitinating enzymes (DUBs); protein degradation; proteasome inhibitors; ubiquitination signaling; genome stability and DNA repair; PROTACs and molecular glues; targeted cancer therapeutics

(This special issue belongs to the Section Molecular Cancer Biology)

Novel Strategies in the Prevention/Treatment of Colorectal Cancer: 2nd Edition

edited by

William H. Gmeiner

submission deadline 20 Jun 2026 | Viewed by 375 | Submission Open

Keywords: colorectal cancer; chemotherapy; chemoprevention; targeted therapy; kinase inhibitor; immunotherapy

Advances in Squamous Cell Carcinoma: From Pathogenesis to Treatment

edited by Carolin Götz

submission deadline 20 Jun 2026 | Viewed by 275 | Submission Open

Keywords: squamous cell carcinoma (SCC); oncological surgery; carcinogenesis; tumor microenvironment; HPV; immunotherapy; molecular targets; precision oncology; biomarkers; head and neck cancer; translational oncology

(This special issue belongs to the Section Cancer Pathophysiology)

The Next Cutting-Edge Technologies in Abdominal Solid Tumor Treatment

edited by Jerome Canady, Saravana R.K. Murthy, Aviram Nissan and

Michael Keidar

submission deadline 20 Jun 2026 | Viewed by 255 | Submission Open

Keywords: multi-visceral surgical resection for complex advanced gastrointestinal tumors; cytoreductive surgery; colon and gynecological cancers; pancreatic cancer; cold atmospheric plasma (CAP); robotic AI CAP surgical delivery systems; targeted immunotherapies; irreversible electroporation; HIPEC (hyperthermic intraperitoneal chemotherapy); PIPAC (pressurized intraperitoneal aerosol chemotherapy)

(This special issue belongs to the Section Methods and Technologies Development)

Genetic Predisposition to Hematological Malignancies

edited by

Danika Di Giacomo

submission deadline 20 Jun 2026 | Viewed by 216 | Submission Open

Keywords: leukemia predisposition; germline variants; inherited syndromes; myelodysplastic syndrome (MDS); acute myeloid leukemia (AML); precision medicine

(This special issue belongs to the Section Molecular Cancer Biology)

Angiogenesis and Anti-Angiogenic Therapies in Cancer

edited by

Girolamo Ranieri

and Giovanni Mastrandrea

submission deadline 24 Jun 2026 | Viewed by 277 | Submission Open

Keywords: angiogenesis; anti-angiogenic therapies; cancer; tumor vasculature; therapeutic strategies

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Soft Tissue and Bone Sarcoma (2nd Edition)

edited by

Catrin Sian Rutland

submission deadline 25 Jun 2026 | 9 articles | Viewed by 8519 | Submission Open

Keywords: bone sarcoma; soft tissue sarcoma; prognosis; diagnosis; detection; molecular biomarkers; histopathology; treatment

(This special issue belongs to the Section Cancer Therapy)

Digital Pathology in Precision Oncology: Emerging Tools for Diagnosis and Treatment Guidance

edited by Daniela Hartmann and

Maximilian Deussing

submission deadline 25 Jun 2026 | 2 articles | Viewed by 1674 | Submission Open

Keywords: dermatology ; digital pathology ; ex vivo confocal microscopy ; artificial intelligence ; machine learning ; virtual biopsy ; teledermatology ; histopathological images; image analysis algorithms

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Clinical and Translational Research in Head and Neck Cancer—2nd Edition

edited by Young J. Kim

submission deadline 25 Jun 2026 | 1 articles | Viewed by 935 | Submission Open

Keywords: head and neck cancer; immunotherapy; translation; combinatorial clinical trials; oncologic therapeutics

(This special issue belongs to the Section Clinical Research of Cancer)

Surgery for Thoracic Cancer

edited by Andrea Billé and Akshay Patel

submission deadline 25 Jun 2026 | Viewed by 218 | Submission Open

Keywords: thoracic surgery; lung cancer; mesothelioma; thymic malignancies; minimally invasive surgery; robotic-assisted thoracic surgery; multimodal therapy; immunotherapy; perioperative management; surgical outcomes

(This special issue belongs to the Section Cancer Therapy)

Immune Deficiency-Associated Lymphoma

edited by

Régis Thierry Costello

submission deadline 25 Jun 2026 | Viewed by 189 | Submission Open

Keywords: lymphoma; immune; HIV infection

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Advances in the Diagnosis, Stratification, and Targeted Treatment of Myeloproliferative Neoplasms

edited by

Bojana Beleslin Čokić

submission deadline 25 Jun 2026 | Viewed by 154 | Submission Open

Keywords: myeloproliferative neoplasms; molecular diagnostics; targeted therapy; mutational profiling; biomarkers; disease progression; therapy resistance; translational research; personalized medicine

Epigenetic and Metabolic Alterations in the Tumor Microenvironment: 2nd Edition

edited by

Ciro Isidoro

and

Danny N. Dhanasekaran

submission deadline 26 Jun 2026 | 2 articles | Viewed by 5365 | Submission Open

Keywords: tumor microenvironment; hypoxia; inflammation; cytokines; epigenetics; metabolic cross-talk; cancer stroma cells; epigenetic alterations; cancer cell dormancy; cancer cell proliferation; cancer cell migration; cancer cell stemness

(This special issue belongs to the Section Tumor Microenvironment)

New Strategies for Molecular Targeted Therapy in Multiple Myeloma

edited by Daniele Caracciolo

submission deadline 26 Jun 2026 | 1 articles | Viewed by 2387 | Submission Open

Keywords: multiple myeloma; molecular target; drug target; signaling pathway; immunotherapeutic strategy; drug resistance

(This special issue belongs to the Section Cancer Therapy)

Clinical Epidemiology and Risk Prediction for Gastrointestinal Cancers

edited by

Holli Loomans-Kropp

submission deadline 30 Jun 2026 | 11 articles | Viewed by 47527 | Submission Open

Keywords: gastrointestinal cancers; genetic risk; polygenic risk scores; exposome; lifestyle risk factors; biomarkers; chemoprevention

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

New Perspectives in the Management of Breast Cancer

edited by

Sonia Santander Ballestín

and

María José Luesma

submission deadline 30 Jun 2026 | 15 articles | Viewed by 41318 | Submission Open

Keywords: breast cancer; treatment; nutrition; physical exercise; psychosocial impact

(This special issue belongs to the Section Cancer Therapy)

Advances in Clinical Trials: Outcome, Innovations, Challenges, and Ethical Practice in Cancer Research 2025–2026

edited by

Naoto T. Ueno

and David R. Gandara

submission deadline 30 Jun 2026 | 10 articles | Viewed by 37231 | Submission Open

Keywords: phase I; phase II; phase III; phase IV; clinical trials; features; design; implementation; outcomes

(This special issue belongs to the Section Clinical Research of Cancer)

Hematologic Malignancies and Related Disorders: Challenges from Diagnosis to Treatment

edited by

Ioanna Sakellari

and

Eleni Gavriilaki

submission deadline 30 Jun 2026 | 10 articles | Viewed by 34702 | Submission Open

Keywords: hematopoietic cell transplantation; cell therapy; acute myeloid leukemia; graft-versus-host disease; hematologic malignancies; thrombosis; complement; lymphoma; myeloma; COVID-19

(This special issue belongs to the Section Cancer Therapy)

New Challenges for Gastric Cancer—Gut Microbiota, Post-eradication and Chemotherapy

edited by Kazunari Murakami and

Kazuhiro Mizukami

submission deadline 30 Jun 2026 | 7 articles | Viewed by 31167 | Submission Open

Keywords: gastric cancer; microbiota; Helicobacter pylori; after Helicobacter pylori eradication therapy; chemotherapy; immune checkpoint inhibitor

(This special issue belongs to the Section Cancer Therapy)

Advances in the Prevention and Treatment of Liver Cancer

edited by Ewa Janczewska

submission deadline 30 Jun 2026 | 8 articles | Viewed by 27761 | Submission Open

Keywords: new screening techniques; enhanced imaging; biomarker tests; radiofrequency ablation; transarterial chemoembolization

(This special issue belongs to the Section Cancer Therapy)

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