Advances in Chronic Lymphocytic Leukemia Microenvironment: The Disruption of the Supportive Leukemic/Accessory Cells Interactions to Improve Therapy Response
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: 15 September 2024 | Viewed by 11430
Special Issue Editors
Interests: lymphoproliferative disorders; tumor microenvironment; cytokines; myeloid suppressor cells
Special Issue Information
Dear Colleagues,
Chronic Lymphocytic leukemia (CLL) is a lymphoproliferative disorder characterized by the relentless accumulation of leukemic B cells in the blood, secondary lymphoid tissue and bone marrow. It has become increasingly clear that the stimuli derived by the cross-talk between the neoplastic cells and the microenvironment have a critical role in CLL-pathogenesis: this finding suggests the importance of disrupting survival advantages conferred by growth-favorable niches to improve the response to therapy. Indeed, several cytokines released within the microenvironment and specific cell–cell contacts favor clonal B cells expansion and resistance to drug treatments. It is further worth noting that leukemic B cells shape their microenvironment and polarize M1 vs. M2 or Th1 vs. Th2 cells, causing, therefore, suppression of the immune response.
Novel therapeutic agents targeting the BCR signaling pathways can also be effective in modulating these interactions, but we still need to better understand cell-intrinsic and -extrinsic causes of therapy failure, further taking into account the opportunity of combined therapies usage.
Today, the exploitation of CLL–tumor-microenvironment (TME) interactions by innovative 3D models, mimicking a more reliable and physiological neoplastic/accessory cells in vivo setting, will further shed new lights and be of interest for both research and clinical purposes.
This Special Issue encompasses new research articles and reviews to advance our knowledge in CLL–TME cross-talk and to highlight novel treatments optimized to reshape the protumor microenvironment and to potentiate current therapies.
Dr. Daniela De Totero
Dr. Paolo Giannoni
Guest Editors
Manuscript Submission Information
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Keywords
- chronic lymphocytic leukemia
- tumor microenvironment
- cytokines
- targeted therapy
- combination therapy
- 2D/3D models of CLL–tumor microenviroment
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