Extracellular Vesicles in Cancer Progression: From Basic Analysis to Translational Research

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 2353

Special Issue Editor


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Guest Editor
Centro Nacional de Investigaciones Oncológicas, Madrid, Spain
Interests: exosomes; extracellular vesicles; metastasis; tumour immunity; liquid biopsy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Extracellular vesicles (EVs) are a heterogenous group of membrane-bound vesicles secreted by cells across all living kingdoms. They take part in cell-to-cell communication, and the mechanisms, messages and efficiency of this exchange system are currently under extensive investigation as they are involved in multiple physiological as well as pathological processes.

Remarkably, EV secretion appears to be augmented in tumor cells and has a relevant role in cancer progression, offering a highly effective way to modulate the tumor microenvironment, contributing to the formation of pre-metastatic and metastatic niches and participating in the tumor–immune landscape cross-talk.

This Special Issue of Cancers seeks original articles and review manuscripts focused on (1) analyzing tumor EV cargo, (2) EV function in tumor–microenvironment interplay, (3) the role as modulators of pre-metastatic and metastatic niches across cancer types, (4) EVs’ influence on immune surveillance against tumors and finally (5) EV-based biomarkers and therapeutic development in cancer research.

Dr. Susana García-Silva
Guest Editor

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Keywords

  • extracellular vesicles
  • cancer progression
  • tumor microenvironment
  • tumor–immune landscape cross-talk pre-metastatic and metastatic niches
  • immune surveillance
  • EV-based biomarkers
  • EV-based therapeutic development

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Published Papers (1 paper)

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Research

23 pages, 2847 KiB  
Article
Unraveling the Role of EV-Derived miR-150-5p in Prostate Cancer Metastasis and Its Association with High-Grade Gleason Scores: Implications for Diagnosis
by Marian Cruz-Burgos, Sergio A. Cortés-Ramírez, Alberto Losada-García, Miguel Morales-Pacheco, Eduardo Martínez-Martínez, Jorge Gustavo Morales-Montor, Alejandro Servín-Haddad, J. Samuel Izquierdo-Luna, Griselda Rodríguez-Martínez, María del Pilar Ramos-Godínez, Vanessa González-Covarrubias, Abraham Cañavera-Constantino, Imelda González-Ramírez, Boyang Su, Hon S. Leong and Mauricio Rodríguez-Dorantes
Cancers 2023, 15(16), 4148; https://doi.org/10.3390/cancers15164148 - 17 Aug 2023
Cited by 5 | Viewed by 2019
Abstract
Metastasis remains the leading cause of mortality in prostate cancer patients. The presence of tumor cells in lymph nodes is an established prognostic indicator for several cancer types, such as melanoma, breast, oral, pancreatic, and cervical cancers. Emerging evidence highlights the role of [...] Read more.
Metastasis remains the leading cause of mortality in prostate cancer patients. The presence of tumor cells in lymph nodes is an established prognostic indicator for several cancer types, such as melanoma, breast, oral, pancreatic, and cervical cancers. Emerging evidence highlights the role of microRNAs enclosed within extracellular vesicles as facilitators of molecular communication between tumors and metastatic sites in the lymph nodes. This study aims to investigate the potential diagnostic utility of EV-derived microRNAs in liquid biopsies for prostate cancer. By employing microarrays on paraffin-embedded samples, we characterized the microRNA expression profiles in metastatic lymph nodes, non-metastatic lymph nodes, and primary tumor tissues of prostate cancer. Differential expression of microRNAs was observed in metastatic lymph nodes compared to prostate tumors and non-metastatic lymph node tissues. Three microRNAs (miR-140-3p, miR-150-5p, and miR-23b-3p) were identified as differentially expressed between tissue and plasma samples. Furthermore, we evaluated the expression of these microRNAs in exosomes derived from prostate cancer cells and plasma samples. Intriguingly, high Gleason score samples exhibited the lowest expression of miR-150-5p compared to control samples. Pathway analysis suggested a potential regulatory role for miR-150-5p in the Wnt pathway and bone metastasis. Our findings suggest EV-derived miR-150-5p as a promising diagnostic marker for identifying patients with high-grade Gleason scores and detecting metastasis at an early stage. Full article
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