The Role of Chromosomal Instability in Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 30 September 2024 | Viewed by 3372
Special Issue Editor
Interests: cancer evolution; chromosomal coding; karyotype mediated-drug resistance; fuzzy inheritance; genome instability and chaos; genome theory; mechanism of heterogeneity; system inheritance
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The current Cancer Genome Project has unexpectedly thrown chromosomal instability (CIN) into the spotlight. While it is hard to identify the common recurrent gene mutation pattern for the majority of cancer types, the phenomenon of elevated CIN is overwhelming across all. Furthermore, landscapes of chromosomal or genome-level changes have better clinical prediction power than gene mutation profiles. Such facts challenge the somatic gene mutation theory of cancer and call for a search for new conceptual frameworks and technological platforms.
In recent years, our understanding of cancer evolution mechanisms has undergone significant progress. Two-phased evolution, comprising a chromosomal alteration-mediated punctuated macroevolutionary phase and gene mutation-mediated gradual microevolutionary phase, has been identified; the Genome Architecture Theory of evolution has been proposed to explain how the karyotype (comprised of chromosomal sets) codes a “system inheritance” that organizes gene interaction; and genome chaos, rapid genome reorganization (including chromothripsis and polyploid giant cancer cells), has been identified as powerful source of new genomic information.
The role of CIN in cancer is highly significant and deserves further, timely research. Thus, this issue may include the following topics:
- A case study that links CIN to any hallmark of cancer (via specific molecular mechanisms).
- The mechanistic study of CIN.
- The study of the relationship between different types of chromosomal variations (e.g., aneuploidy, polyploidy, chromosome translocations, chromothripsis, and other subtypes of genome chaos).
- Studies measuring CIN (e.g., single-cell data, high-C data, converting sequence data into cytogenetic data, and 3D image analysis).
- Studies using CIN as a biomarker for prognosis and diagnosis.
- Studies on the relationship between CIN and major phase transitions such as transformation, metastasis, and drug resistance.
Prof. Dr. Henry H. Heng
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- aneuploidy
- cancer evolution
- chromothripsis
- chromosomal translocation
- genome chaos
- genome instability
- heterogeneity
- karyotype coding
- polyploid giant cancer cells
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.