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Cancers
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Connecting the Dots between Breast Cancer and Metabolic Health: Lifestyle,...
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Connecting the Dots between Breast Cancer and Metabolic Health: Lifestyle, Genetic and Epigenetics

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Epidemiology and Prevention".

Deadline for manuscript submissions: closed (28 July 2023) | Viewed by 3010

Special Issue Editors

Dr. Umaima Al-Alem

E-Mail Website
Guest Editor
Division of Epidemiology and Biostatistics, School of Public health, The University of Illinois, 1603 W. Taylor St., Chicago, IL 60612, USA
Interests: breast cancer; glucocorticoid receptor; immunohistochemical staining; racial disparity; allergy hiv
Dr. Abeer M. Mahmoud

E-Mail Website
Guest Editor
Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Interests: cardiovascular disease; obesity; diabetes; metabolic disease; vascular biology; exercise physiology; molecular biology; pathology; nutrition; epigenetics; translational research; dietary interventions; biomarkers; chemoprevention; cancer biology; racial disparity; clinical trials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Despite the progress achieved in diagnosis and treatments, breast cancer remains the second leading cause of death in women globally. There appears to be an association between metabolic health and breast cancer. There is no universal definition for a metabolically unhealthy phenotype; however, it is usually defined as the presence of metabolic risk factors for chronic diseases, such as cardiovascular disease and diabetes. Metabolic health perturbations, influenced by lifestyle, genetic and epigenetic factors, share several molecular pathways associated with breast cancer. This Special Issue of Cancers aims to collect reviews and original research articles pertaining to the impact of metabolic perturbations on the pathogenesis and outcomes of breast cancer, as well as research exploring the influence of cancer treatments on metabolism. 

Dr. Umaima Al-Alem
Dr. Abeer M. Mahmoud
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • breast cancer
  • metabolic health
  • lifestyle
  • genetic polymorphism
  • epigenetic
  • cancer treatment

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Published Papers (2 papers)

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Review

14 pages, 2217 KiB  
Review
Understanding the Role of Toll-Like Receptors 9 in Breast Cancer
by Umaima Al-alem, Alaa Al-Saruri, Hasan Bamahros, Abeer M. Mahmoud, Emily Sible and Uzma A. Hasan
Cancers 2024, 16(15), 2679; https://doi.org/10.3390/cancers16152679 - 27 Jul 2024
Viewed by 606
Abstract
Breast cancer is a significant global issue, ranking as the second most common cancer among women worldwide and a leading cause of cancer-related deaths. Although the exact causes of this increase remain unclear, factors such as genetics, epigenetics, obesity, sedentary lifestyle, tobacco use, [...] Read more.
Breast cancer is a significant global issue, ranking as the second most common cancer among women worldwide and a leading cause of cancer-related deaths. Although the exact causes of this increase remain unclear, factors such as genetics, epigenetics, obesity, sedentary lifestyle, tobacco use, and vitamin D deficiency have been implicated. The Toll-like receptor 9 (TLR9) is recognized for its role in inflammation and innate immunity; however, its specific involvement in breast cancer pathogenesis requires further investigation. This study aims to systematically review the existing literature on TLR9 expression in normal and cancerous breast tissue, providing current knowledge and identifying gaps. Relevant articles in English were from PubMed, Scopus, and Google Scholar, with the inclusion criteria focusing on studies evaluating TLR9 mRNA and protein expression. The review found that TLR9 mRNA and protein exhibit variable expressions in both normal and cancerous breast tissue, highlighting the need for further research to clarify TLR9’s role in breast cancer. Full article
(This article belongs to the Special Issue Connecting the Dots between Breast Cancer and Metabolic Health: Lifestyle, Genetic and Epigenetics)
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19 pages, 286 KiB  
Review
Common Misconceptions about Diet and Breast Cancer: An Unclear Issue to Dispel
by Anastasia Lalioti, Laura Verzeletti, Paola Tiberio, Riccardo Gerosa, Mariangela Gaudio, Giuseppe Saltalamacchia, Manuela Pastore, Alberto Zambelli, Armando Santoro and Rita De Sanctis
Cancers 2024, 16(2), 306; https://doi.org/10.3390/cancers16020306 - 11 Jan 2024
Cited by 1 | Viewed by 1894
Abstract
Breast cancer (BC) constitutes a prevalent health condition among women. Recent years have witnessed the identification of dietary proto-oncogenic factors that deserve attention. Besides the well-known role of alcohol and red and processed meat in BC development, the impact of other dietary components [...] Read more.
Breast cancer (BC) constitutes a prevalent health condition among women. Recent years have witnessed the identification of dietary proto-oncogenic factors that deserve attention. Besides the well-known role of alcohol and red and processed meat in BC development, the impact of other dietary components remains unclear. Our narrative review aims to explore the diet-BC relationship, focusing on sugar, dairy, and soy consumption. We conducted a PubMed literature search covering the last decade (2013–2023) and included 35 papers. We found limited evidence on the association between high sugar intake and BC incidence. On the other hand, dairy and soy consumption displayed a protective effect in the majority of the analyzed papers. However, a significant degree of heterogeneity was reported among the results. Menopausal status and the specific BC molecular subtypes were the main factors influencing the interpretation of the results. Exploring dietary factors and BC revealed inconsistencies: high glycemic index post-menopause may be a risk factor, while sugar-sweetened drinks and artificial sweeteners yielded conflicting results; fermented dairy showed potential benefits, non-fermented dairy presented inconsistent findings; soy impact on BC varied according to molecular subtype, with some studies suggesting a positive association in luminal-like BC. Hence, further investigation is crucial to obtain a uniform consensus on the diet-BC relationship. Full article
(This article belongs to the Special Issue Connecting the Dots between Breast Cancer and Metabolic Health: Lifestyle, Genetic and Epigenetics)
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