Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.4
5.2
Journals
Cancers
Special Issues
Head and Neck Cancer Metastases
share announcement

Head and Neck Cancer Metastases

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Metastasis".

Deadline for manuscript submissions: 1 February 2025 | Viewed by 3644

Special Issue Editors

Prof. Dr. Pawel Golusinski

E-Mail Website
Guest Editor
Department of Otolaryngology and Maxillofacial Surgery, University of Zielona Góra, Zyty 26, 65-046 Zielona Góra, Poland
Interests: head and neck cancer
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Michal Masternak

E-Mail Website
Co-Guest Editor
Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA
Interests: insulin resistance; cell biology; animal physiology; insulin signaling; aging; molecular biology; metabolism; fat; adipose tissue; quantitative PCR

Special Issue Information

Dear Colleagues,

Squamous carcinoma of head and neck (HNSCC) arising from the mucosa of the common part of the upper respiratory and digestive systems is the 6th most common malignancy in the world.

The most important risk factors for HNSCC development are tobacco use and extensive alcohol consumption. Moreover, infection with oncogenic types of human papillomavirus (HPV) has also been identified as a significant risk factor for a particular subset of HNSCC : tumors arising from the oropharynx. To date, head and neck oncology can offer a plethora of treatment modalities, including surgical resection with reconstructive options, radiotherapy (including proton therapy), conventional and targeted systemic treatment, and also, as of late, immunotherapy. The success rates of treatments can vary significantly between particular patients, but despite great advances in available treatment modalities and increasing amount of information regarding tumor biology, the overall survival rate in this disease remains relatively low. The main reasons for failure in HNSCC treatment, and the strongest adverse factors for prognosis, are the spread of the disease to the regional lymph nodes and formation of distant metastasis. Especially distant extent of the disease significantly reduce treatment options and is associated with poor prognosis. Thus, the biggest future challenges lies in customization of the multidisciplinary treatments, based not only on the clinical assessment of disease advancement determined by stage, but also on the biological factors of the tumor.

Prof. Dr. Pawel Golusinski
Guest Editor

Prof. Dr. Michal Masternak
Co-Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (4 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

16 pages, 2831 KiB  
Article
A Matter of Margins in Oral Cancer—How Close Is Enough?
by Mateusz Szewczyk, Jakub Pazdrowski, Piotr Pieńkowski, Bartosz Wojtera, Barbara Więckowska, Paweł Golusiński and Wojciech Golusiński
Cancers 2024, 16(8), 1488; https://doi.org/10.3390/cancers16081488 - 12 Apr 2024
Viewed by 457
Abstract
In patients with oral cancer, the risk factors for local, regional, and distant recurrence according to margin status have not been well established. We aimed to determine the risk factors for recurrence by margin status and to identify a margin cut-off point for [...] Read more.
In patients with oral cancer, the risk factors for local, regional, and distant recurrence according to margin status have not been well established. We aimed to determine the risk factors for recurrence by margin status and to identify a margin cut-off point for improved survival in patients with close margins. We retrospectively reviewed adult patients treated at our centre from 2009 to 2021 for primary oral cancer. Margins were classified as positive (<1 mm), close (1 to 4.9 mm), or clear (>5 mm). Univariate and multivariate analyses were performed. A total of 326 patients (210 men) were included. The mean age was 59.1 years. Margin status was close (n = 168, 51.5%), clear (n = 83, 25.4%), or positive (n = 75, 23.0%). In the univariate analysis, positive surgical margins (HR = 7.53) had the greatest impact on distant failure. Positive surgical margins—without nodal involvement—had the greatest impact on the risk of distant failure. In the close margin group, the optimal cut-off for disease-free survival (AUC = 0.58) and overall survival (AUC = 0.63) was a deep margin > 3 mm, with survival outcomes that were comparable to the clear margin group. These finding suggest that margins < 5 mm may be sufficient in certain well-defined cases. Prospective studies are warranted to confirm these findings. Full article
(This article belongs to the Special Issue Head and Neck Cancer Metastases)
►▼ Show Figures

Figure 1

16 pages, 888 KiB  
Article
Extra-Capsular Spread of Lymph Node Metastasis in Oral, Oropharyngeal and Hypopharyngeal Cancer: A Comparative Subsite Analysis
by Yung Jee Kang, Goeun Park, Sung Yool Park, Taehwan Kim, Eunhye Kim, Yujin Heo, Changhee Lee and Han-Sin Jeong
Cancers 2024, 16(3), 659; https://doi.org/10.3390/cancers16030659 - 3 Feb 2024
Viewed by 941
Abstract
Background: The extra-capsular spread (ECS) of lymph node metastasis (LNM) is a hallmark of aggressive primary tumor phenotype in head and neck cancer (HNC); however, the factors influencing ECS are poorly understood. Patients and Methods: This was a retrospective study, including 190 cases [...] Read more.
Background: The extra-capsular spread (ECS) of lymph node metastasis (LNM) is a hallmark of aggressive primary tumor phenotype in head and neck cancer (HNC); however, the factors influencing ECS are poorly understood. Patients and Methods: This was a retrospective study, including 190 cases of oral tongue cancer (OTC), 148 cases of oropharyngeal cancer (OPC) (118 HPV-positive and 30 HPV-negative), and 100 cases of hypopharyngeal cancer (HPC). Tumor dimension, tumor biological variables (lymphovascular/perineural invasion and histologic grade), and LNM variables (LNM number and size) were analyzed according to the presence of ECS using multivariable logistic regression and receiver operating characteristic (ROC) curve analyses. Results: LNM variables were significant factors for ECS in all subsites of HNC (p < 0.05), except HPV-positive OPC. In OTC, tumor dimensional variables were significantly related to ECS (p < 0.01). Meanwhile, in OPC and HPC, neither the primary tumor dimension nor the T status were significant factors for ECS occurrence. The predictability of ECS by ROC curve using multiple variables was 0.819 [95% confidence interval: 0.759–0.878] in OTC, 0.687 [0.559–0.815] in HPV-positive OPC, 0.823 [0.642–1.000] in HPV-negative OPC, and 0.907 [0.841–0.973] in HPC. Conclusion: LNM variables were correlated with ECS occurrence for most HNC subsites, and site-dependent primary tumor characteristics might contribute differentially to the ECS development of LNM in HNC. Full article
(This article belongs to the Special Issue Head and Neck Cancer Metastases)
►▼ Show Figures

Figure 1

12 pages, 876 KiB  
Article
Age and Post-Lobectomy Recurrence after Endoscopic or Robotic Thyroid Surgery: A Retrospective Cohort Study of 2348 Papillary Thyroid Carcinoma Patients
by Jin-Seong Cho, Yong-Min Na and Hee Kyung Kim
Cancers 2023, 15(23), 5506; https://doi.org/10.3390/cancers15235506 - 21 Nov 2023
Viewed by 975
Abstract
The biology of papillary thyroid carcinoma (PTC) in young patients is poorly understood, and there are conflicting data regarding the recurrence for younger patients compared to older patients. We retrospectively analyzed 2348 clinically node-negative (cN0) PTC patients who underwent a thyroid lobectomy between [...] Read more.
The biology of papillary thyroid carcinoma (PTC) in young patients is poorly understood, and there are conflicting data regarding the recurrence for younger patients compared to older patients. We retrospectively analyzed 2348 clinically node-negative (cN0) PTC patients who underwent a thyroid lobectomy between 2008 and 2017. Young age was defined as less than 35 years old. The clinicopathological characteristics and oncologic outcomes of the young age group were compared to those of the older age group. The number of young age cN0 PTC patients accounted for 20.7% of the enrolled patients, and 24.2% were upstaged into pathologic N1a. The young age group had a significantly larger proportion of females, endoscopic/robotic thyroid lobectomies, stage N1a, and larger tumor sizes. Post-lobectomy recurrences were significantly higher in the young age group. In the Cox analysis, young age, large tumor size, and stage N1a were significant risk factors. The multivariate analysis reveals that young age and stage N1a are significant risk factors. Conversely, minimally invasive or robot-endoscopic thyroidectomies were not risk factors for post-lobectomy recurrence compared to conventional thyroidectomies. While young patients with a stage N1a had a significant risk factor for post-lobectomy recurrence, endoscopic/robotic thyroidectomy was as feasible and safe as conventional thyroidectomies in the median seven-year oncologic follow-up. Further high-quality studies are needed to elucidate the relationship between age and the risk of post-lobectomy recurrence. Full article
(This article belongs to the Special Issue Head and Neck Cancer Metastases)
►▼ Show Figures

Figure 1

12 pages, 672 KiB  
Article
Prognostic Value of Hematological Parameters in Oral Squamous Cell Carcinoma
by Lorenzo Fernandes Moça Trevisani, Isabelle Fernandes Kulcsar, Marco Aurélio Vamondes Kulcsar, Rogerio Aparecido Dedivitis, Luiz Paulo Kowalski and Leandro Luongo Matos
Cancers 2023, 15(21), 5245; https://doi.org/10.3390/cancers15215245 - 31 Oct 2023
Viewed by 843
Abstract
Introduction: Oral squamous cell carcinoma (OSCC) remains a significant public health concern. The variables utilized to determine appropriate treatment for this disease also represent its most unfavorable prognostic factors, with these parameters solely determined by the neoplasm and its behavior. However, a lack [...] Read more.
Introduction: Oral squamous cell carcinoma (OSCC) remains a significant public health concern. The variables utilized to determine appropriate treatment for this disease also represent its most unfavorable prognostic factors, with these parameters solely determined by the neoplasm and its behavior. However, a lack of well-established indices is evident in the literature that specifically relate to the patient and indicate a worse prognosis. Objective: To assess the prognostic impact of hematological indices in patients with OSCC. Methods: This retrospective cohort study included patients with oral squamous cell carcinoma (OSCC) who underwent curative-intent treatment. Treatment encompassed surgery, followed by adjuvant therapy, as necessary. Laboratory tests were conducted immediately prior to surgery, and demographic information was obtained from medical records. Results: The cohort comprised 600 patients, with 73.5% being male subjects. Adjuvant treatment was recommended for 60.3% of patients. Throughout the follow-up period, 48.8% of participants died. Univariate analysis indicated that perineural invasion, angiolymphatic invasion, pT4 tumors, lymph node metastases, extranodal extravasation, RDW > 14.3%, NLR (neutrophil–lymphocyte ratio) > 3.38, PLR (platelet–lymphocyte ratio) > 167.3, and SII (systemic inflammatory/immune response index) > 416.1 were factors associated with increased mortality. These threshold values were established through ROC curve analysis. In the multivariate analysis, angiolymphatic invasion (HR = 1.43; 95% CI: 1.076–1.925; p = 0.014), pT4a/b tumors (HR = 1.761; 95% CI: 1.327–2.337; p < 0.001), extranodal extravasation (HR = 1.420; 95% CI: 1.047–1.926; p = 0.024), and RDW (HR = 1.541; 95% CI: 1.153–2.056; p = 0.003) were identified as independent risk factors for decreased overall survival. Conclusions: RDW > 14.3% was proven to be a reliable parameter for assessing overall survival in patients with OSCC. Further studies are required to evaluate the clinical applicability of other hematological indices. Full article
(This article belongs to the Special Issue Head and Neck Cancer Metastases)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-4
Back to TopTop