New Insights into the Molecular Mechanism of Epithelial Plasticity in Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: closed (16 April 2023) | Viewed by 20590
Special Issue Editor
Interests: cancer; epithelial plasticity; metastasis; drug resistance; small-molecule inhibitors; E3 ubiquitin-ligase; targeted therapy
Special Issue Information
Dear Colleagues,
Epithelial cell plasticity is a reversible program that refers to the ability of epithelial cells to dynamically switch between different phenotypic cellular states. This program has been highlighted during the epithelial-to-mesenchymal transition (EMT) in tumour progression and metastasis. Tumour cells undergo EMT loose cell-cell and cell-extracellular matrix interactions, leading to cell migration and invasion. It has become evident that transcriptional, post-transcriptional, and post-translational events are critical regulators of the EMT. Moreover, in recent years, EMT has been associated to stemness and therapy resistance, critically representing one of the major challenges in oncology. Indeed, EMT has been proposed as a good therapeutic target for the designing of novel strategies against cancer.
In this Special Issue, we focus on new molecular mechanisms implicated by the epithelial plasticity in cancer and novel therapeutic strategies against EMT to overcome drug resistance and metastasis.
Dr. Angélica Figueroa
Guest Editor
Manuscript Submission Information
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Keywords
- Cancer
- Epithelial plasticity
- Metastasis
- Drug resistance
- Stemness
- Target therapy
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