NUTM1-Rearranged Neoplasia: Understanding an Expanding Family of Aggressive Cancers
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 5337
Special Issue Editors
Interests: NUT carcinoma; pathology; molecular biology; oncology; epigenetics
Special Issue Information
Dear Colleagues,
NUTM1-rearranged cancers are defined by rearrangement and formation of NUT-fusion oncoproteins. NUT carcinoma, typified by presence of the BRD4-NUTM1 and other NUTM1- fusions, was for years the only known NUTM1-rearranged neoplasm. This changed upon the emergence of next-generation sequencing, which has revealed that cancers with diverse histologies can harbor various NUTM1-fusions. These include sarcomas, leukemias, and cutaneous carcinomas.
NUT, the protein encoded by NUTM1, normally functions in testes as a sperm maturation factor that recruits p300 to hyperacetylate chromatin prior to nucleosome eviction and chromatin condensation. When fused to BRD4 or other chromatin-interacting factors, NUT pathologically recruits p300 and the fusion serves as a transcriptional activator. In the case of NUT carcinoma, MYC is targeted and upregulated by BRD4-NUT, driving growth and blocking differentiation of the host cell. It is believed that this same general mechanism occurs in other histologies with differing NUT-fusion oncoproteins.
Though rare, NUT-rearranged cancers are with few exceptions aggressive, NUT carcinoma being one of the most lethal solid tumors in humans. Despite progress in developing targeted inhibitors, there are no effective treatments for many of these cancers, particularly NUT carcinoma, and thus better understanding of the pathogenesis of this group of emerging entities is needed. This Special Issue will highlight the role of NUT-fusions in neoplasia and will cover both basic and translational scientific progress in the field.
Dr. Christopher Alexander French
Dr. Geoffrey I. Shapiro
Guest Editors
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Keywords
- NUTM1
- BRD4
- BRD4-NUTM1
- NUT carcinoma
- porocarcinoma
- sarcoma
- leukemia
- bromodomain
- p300
- MYC
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