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Cancers
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Advances in Oral and Oropharyngeal Cancer: From Translational Research to...
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Advances in Oral and Oropharyngeal Cancer: From Translational Research to Clinical Practice

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 3384

Special Issue Editors

Prof. Dr. Giancarlo Pecorari

E-Mail Website
Guest Editor
Division of Otorhinolaryngology, Department of Surgical Sciences, University of Turin, 10126 Torino, Italy
Interests: head and neck cancer; head and neck surgery; skull base surgery; laryngeal surgery; organ preservation; flap reconstruction; oral cancer; laryngeal cancer
Special Issues, Collections and Topics in MDPI journals
Dr. Giuseppe Riva

E-Mail Website
Guest Editor
Department of Surgical Sciences, University of Turin, 10126 Torino, Italy
Interests: head and neck cancer; head and neck surgery; sinonasal cancer; laryngeal surgery; organ preservation; flap reconstruction; oral cancer; HPV-related head and neck cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oral and oropharyngeal cancers still represent a challenge because of different etiologies (smoke, alcohol, and human papillomavirus) and carcinogenesis. Flap reconstruction and transoral robotic surgery facilitate better functional results, while de-escalation trails have been performed for HPV-related oropharyngeal tumors. However, the recurrence rate and mortality did not decrease in recent years. Furthermore, despite the emerging role of immunotherapy for recurrent/metastatic cancer, the treatment of advanced tumors remains challenging.

This Special Issue aims to highlight the current state of the art and describe future perspectives for the management of oral and oropharyngeal cancer. In particular, original articles and reviews from translational research to clinical practice are welcome.

We look forward to receiving your contributions.

Prof. Dr. Giancarlo Pecorari
Dr. Giuseppe Riva
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • head and neck cancer
  • human papillomavirus
  • biomarkers
  • head and neck surgery
  • immunotherapy
  • radiation therapy
  • chemotherapy
  • organ preservation
  • flap reconstruction
  • translational research

Published Papers (2 papers)

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Review

13 pages, 1107 KiB  
Review
Atypical Tongue Abscesses Mimicking Submucosal Malignancies: A Review of the Literature Focusing on Diagnostic Challenges
by Andrea Rampi, Alberto Tettamanti, Ilaria Bertotto, Lara Valentina Comini, Bright Oworae Howardson, Paolo Luparello, Davide Di Santo and Stefano Bondi
Cancers 2023, 15(24), 5871; https://doi.org/10.3390/cancers15245871 - 17 Dec 2023
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Abstract
Tongue abscesses are rare conditions that usually follow mucosal disruption due to mechanical trauma or foreign body impaction. They typically manifest abruptly as a rapidly growing, hard mass or swelling in the context of tongue muscles; the patient frequently complains of pain, difficulties [...] Read more.
Tongue abscesses are rare conditions that usually follow mucosal disruption due to mechanical trauma or foreign body impaction. They typically manifest abruptly as a rapidly growing, hard mass or swelling in the context of tongue muscles; the patient frequently complains of pain, difficulties in swallowing or speaking, and fever. Nonetheless, the features of its presentation, together with accurate clinical evaluation, blood tests, and appropriate imaging tests, are usually sufficient to easily discern a tongue abscess from a malignancy. However, in rare cases, they may occur with slowly progressing and subtle symptoms, nuanced objective and laboratory findings, and inconclusive radiological evidence, leading to difficult differential diagnosis with submucosal malignancy. Herein, we review the literature, available on Pubmed, Embase, and Scopus, on publications reporting tongue abscesses, with atypical presentation suggesting an oral tumor. Our review confirms that tongue abscesses may manifest as a slowly growing and moderately painful swelling without purulent discharge and minimal mucosal inflammation; in this case, they may constitute an actual diagnostic challenge with potentially severe impact on correct management. Atypical tongue abscesses must therefore be considered in the differential diagnosis of tongue malignancy with submucosal extension, even when other diagnostic elements suggest a neoplasia; in this case, a deep biopsy under general anesthesia is essential for differential diagnosis, and simultaneous drainage of the necrotic and abscessual material may resolve the condition. Full article
(This article belongs to the Special Issue Advances in Oral and Oropharyngeal Cancer: From Translational Research to Clinical Practice)
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11 pages, 512 KiB  
Review
The Flex Robotic System in Head and Neck Surgery: A Review
by Giuseppe Riva, Ester Cravero, Marco Briguglio, Pasquale Capaccio and Giancarlo Pecorari
Cancers 2022, 14(22), 5541; https://doi.org/10.3390/cancers14225541 - 11 Nov 2022
Cited by 2 | Viewed by 1694
Abstract
The Flex Robotic System is a device intended for robot-assisted visualization and surgical site access to the head and neck. The aim of this review is to summarize the current knowledge about the Flex Robotic System in head and neck transoral robotic surgery [...] Read more.
The Flex Robotic System is a device intended for robot-assisted visualization and surgical site access to the head and neck. The aim of this review is to summarize the current knowledge about the Flex Robotic System in head and neck transoral robotic surgery (TORS). The primary search was performed using the term “Flex Robot” across several databases (PubMed, Embase, Cochrane, Scopus). Patients were treated for both benign and malignant diseases. The oropharynx was the most frequent site of disease, followed by the supraglottic larynx, hypopharynx, glottic larynx, oral cavity, and salivary glands. Most of the studies did not reveal major intra- or post-operative complications. Bleeding incidence was low (1.4–15.7%). Visualization of the lesion was 95–100%, while surgical success was 91–100%. In conclusion, lesions of the oropharynx, hypopharynx, or larynx can be successfully resected, thus making the Flex Robotic System a safe and effective tool, reducing the morbidity associated with traditional open surgery. Full article
(This article belongs to the Special Issue Advances in Oral and Oropharyngeal Cancer: From Translational Research to Clinical Practice)
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