New Insight in TME-Cancer Cells Crosstalk: The Impact of Gender on Cancer Progression and Response to Therapy

Dear Colleagues,

The tumor microenvironment (TME) is the result of a complex gathering of different types of cells including not only cancer cells but also fibroblasts, macrophages, endothelial cells, and cells of the immune system. The complexity of TME is additionally exacerbated by its special extracellular milieu, characterized by areas of extracellular acidity and hypoxia, whether or not they overlap. The effort spent to unravel the role of the crosstalk between TME and malignant cells highlights that cancer cell metabolic reprogramming has a fundamental role in cancer progression and drug resistance. Despite this, there is still something missing in the scenario. Indeed, epidemiological studies have long reported differences in the incidence and severity of different types of cancers between the sexes.

This Special Issue of Cancers will give the opportunity to investigate and discuss the impact that sex-specific or gender-specific molecular mechanisms may exert on TME–cancer cells crosstalk in cancer progression and drug resistance to develop a more specific anticancer personalized therapy. 

Dr. Francesca Bianchini
Guest Editor

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