Integrins and Tumor Microenvironment, New Perspectives in Targeted Treatments
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 2984
Special Issue Editors
Interests: tumor microenvironment (TME); cancer cell biology; extracellular acidity; nanomedicine; targeted drug delivery and personalized anticancer therapy
Special Issues, Collections and Topics in MDPI journals
Interests: drug discovery; organic synthesis; medicinal chemistry; molecular imaging; diversity-oriented synthesis; peptidomimetics; chemoinformatics; enzyme inhibitors; angiogenesis; Alzheimer’s disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Integrins are a family of cell surface receptors with a longstanding history in cancer. The integrin-mediated binding of extracellular matrix components (ECM) by cancer cells leads to essential signaling for cancer cell survival, proliferation, migration, extravasation, and metastatic dissemination to secondary organs.
Recently, the role of integrins in cancer has been enriched with further peculiarities, mostly because of the emerging role of the tumor microenvironment (TME) in the promotion of cancer aggressiveness and resistance to therapy. Indeed, integrins are expressed not only on cancer cells, but also on stromal cells, such as endothelial cells and cancer-associated fibroblasts (CAFs), and on host immune cells, such as tumor-associated macrophages (TAMs) and tumor-infiltrating lymphocytes (TILs).
Thus, the aim of this issue is to unravel the role of integrins in cancer–TME crosstalk, exploring novel molecular pathways by which integrins might promote cancer progression and resistance to anticancer therapy, and suggesting innovative targets for therapeutic interventions. Translational approaches and contributions arising from different disciplines such as molecular oncology, pharmacology, and organic chemistry will be welcome to develop innovative and personalized anticancer treatment.
We solicit contributions on all topics connected to this area, including, but not limited to:
- Integrins in cancer cell – TME interactions driving drug resistance
- Integrins in cancer immune evasion strategies
- Development of antibody/small-molecule–drug conjugates
- Integrins as tools for molecular imaging
Dr. Francesca Bianchini
Dr. Andrea Trabocchi
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- integrins
- cancer
- tumor microenvironment
- stromal cells
- immune cells
- drug development