Targeting Mechanisms of Protein Degradation for Cancer Therapy
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: closed (15 January 2023) | Viewed by 20352
Special Issue Editor
Interests: autophagy; NEDD8-mediated protein turnover; experimental therapeutics; drug discovery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Timed protein degradation is an essential component of maintaining cellular homeostasis. However, this process frequently becomes dysregulated during oncogenesis and malignant progression. Aberrant protein turnover contributes to poor outcomes and drug resistance in a number of forms of cancer. The disrupted protein homeostasis in malignant cells creates an opportunity for selective, targeted therapeutic approaches based on the specific alterations in the protein degradation machinery that affect individual tumor types. The proof of concept that antagonizing dysregulated protein turnover yields anticancer benefits was first demonstrated with the proteasome inhibitor bortezomib, which became the first drug with this specific mechanism of action to ultimately earn FDA approval. The success of bortezomib prompted the development of 2nd-generation proteasome inhibitors as well as many other new agents that more specifically target key regulators of protein turnover. This Special Issue will focus on current approaches to selectively target mechanisms of protein degradation for cancer therapy.
Prof. Dr. Jennifer S. Carew
Guest Editor
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Keywords
- protein degradation
- proteasome inhibitor
- cancer therapy
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