Sex Differences in Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 15 October 2024 | Viewed by 10962
Special Issue Editors
2. Trans-Divisional Research Program (TDRP), Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), Bethesda, MD, USA
Interests: cancer; epidemiology; biostatistics; informatics; bioinformatics; sex differences
Interests: epidemiology; sex differences; transgender and gender-diverse
Special Issue Information
Dear Colleagues,
The genetic, epigenetic, and hormone actions of sexual differentiation interact with a multitude of mechanisms, resulting in sex differences that can be observed in disease. In cancer, sexual differentiation interacts with both cancer protection and oncogenic mechanisms. Most non-reproductive cancers exhibit sex differences in incidence and clinical outcomes, with males being more prone to develop and die from cancer compared to females. Recent studies have demonstrated that these differences are not solely attributed to underlying risk behaviors in males, but instead due to underlying biological sex differences. Despite the well-known differences between males and females, most cancer patients still receive the same treatment. Historically, sex differences are often overlooked at all levels of research (design, analysis, and reporting); e.g., preclinical treatment studies performed exclusively in male animals and clinical trials enrolling more males than females. As we are now beginning to fully realize the impact of this bias, efforts by the National Institute of Health to increase consideration of sex differences have been implemented. Studies focused on sex differences in cancer will add to our body of knowledge, generate additional potential material for research investigations, drive hypotheses, and aid in the generation of personalized, sex-based medicine tailored to the unique vulnerabilities of male and female cancer patients.
Dr. Jill S. Barnholtz-Sloan
Dr. Sarah S. Jackson
Dr. Kristin A. Waite
Guest Editors
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Keywords
- cancer
- sex differences
- cancer biology
- cancer epidemiology
- sex-based medicine
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