Management of Glioblastomas
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 14899
Special Issue Editors
Interests: neuro-oncology; epilepsy; headache; clinical neurophysiology; EEG
Interests: neuro-oncology; epilepsy; sleep medicine; clinical neurophysiology; EEG
Special Issue Information
Dear Colleagues,
Glioblastoma (GBM) is the most common malignant tumor of the central nervous system in adults, and is characterized by rapid progression and poor prognosis. In addition to high mortality, glioblastoma is associated with high morbidity. Symptoms like seizures, headache, and cognitive decline may occur from the earliest stages of the disease, causing a rapid deterioration of independence in activities of daily living. Despite multimodal treatment efforts, the survival rate for patients with glioblastoma has not significantly improved over the last several decades. Current research is aimed at studying new molecular markers that could allow the early identification of GBM, as well as prompt therapeutic and prognostic definition. However, the field still lacks in-depth knowledge on pathological mechanisms underlying tumor growth and invasiveness.
Moreover, the 2021 World Health Organization Classification of Central Nervous System tumors has defined new molecular entities, including IDH-mutant grade 4 astrocytoma and IDH-wild type molecularly defined glioblastoma, whose behavior and response to standardized GBM treatments remain to be defined.
The aim of this Special Issue is to discuss current knowledge on the mechanisms of glioblastoma development and progression, as well as research on the early diagnosis and management of GBM and GBM-associated symptoms.
In this Special Issue, original research articles and reviews are welcome.
We look forward to receiving your contributions.
Dr. Marco Russo
Dr. Jessica Rossi
Guest Editors
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Keywords
- glioblastoma
- biology
- management
- mortality
- prognosis
- markers
- early diagnosis
- targeted therapy
- overall survival (OS)
- progression-free survival (PFS)
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