Metabolism in Ovarian Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: closed (15 December 2021) | Viewed by 23574
Special Issue Editors
Interests: ovarian cancer metabolism; bioenergetic adaptations; AMPK; caloric restriction
Interests: ovarian cancer; epithelial mesenchymal transition; immune modulation; immune therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabolic reprogramming is recognized as a hallmark of cancer cells. Almost all oncogenes regulate some aspect of metabolism and aid the tumor cells in altering their metabolism, which enables them to overcome growth constraints, resulting in successful growth and metastasis.
Due to its peritoneal placement, ovarian cancer is exposed to a unique microenvironment enriched in pro-inflammatory factors and bioactive lipids. Studies show that ovarian cancer cells undergo lipid/adipose-mediated metabolic adaptations to facilitate metastasis, acquire a flexible energy metabolism to escape chemotherapy, and retain stem-cell-like characteristics.
However, the complexity and acquisition of metabolic adaptations and the ensuing cellular fitness is still unknown. Understanding the contribution of multiple metabolic processes regulated by nutrients and cellular components of the micro-environment can lead to the development of targeted agents and multi-targeting strategies to repress ovarian tumor progression.
This special issue will highlight the current state in ovarian cancer metabolism, metabolic inhibitors, and future directions for improving ovarian cancer outcomes.Dr. Ramandeep Rattan
Dr. Gil Mor
Guest Editors
Manuscript Submission Information
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Keywords
- chemotherapy
- epithelial mesenchymal transition
- immune metabolism
- chemoresistance
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