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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advanced Research in Surgical Treatment for Spinal Tumors

edited by Alessandro Gasbarrini, Stefano Bandiera and

Giuseppe Tedesco

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1517 | Submission Open

Keywords: spine oncology; primary tumors; metastatic tumors; spondylectomy; en bloc resection; minimally invasive surgery; anterior reconstruction; biomaterials; radiosurgery; electrochemotherapy

(This special issue belongs to the Section Cancer Therapy)

Advances in Stereotactic Body Radiation Therapy for Thoracic and Abdominopelvic Tumors

edited by

Yin Zhang

and

Kai Ding

submission deadline 30 Jun 2026 | 2 articles | Viewed by 1512 | Submission Open

Keywords: stereotactic body radiation therapy (SBRT); adaptive radiation therapy (ART); image-guided radiation therapy (IGRT); motion management; thoracic tumors; abdominopelvic tumors

(This special issue belongs to the Section Methods and Technologies Development)

Research and Treatment of Hepatocellular Carcinoma

edited by Chung Cheung Thomas Yau

submission deadline 30 Jun 2026 | 2 articles | Viewed by 1464 | Submission Open

Keywords: hepatobiliary cancer; biomarker; immunotherapy; targeted therapy; combination treatments

(This special issue belongs to the Section Cancer Therapy)

Autophagy and Apoptosis in Cancer Progression

edited by Antonio Ieni

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1461 | Submission Open

Keywords: autophagy; apoptosis; cancer progression; cell death pathways; therapeutic resistance

(This special issue belongs to the Section Molecular Cancer Biology)

Molecular Mechanisms of Cancer Progression and Metastasis

edited by

Babak Behnam

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1445 | Submission Open

Keywords: metastasis; molecular mechanisms; tumor microenvironment (TME); epithelial-to-mesenchymal transition (EMT); cancer stem cell; therapeutic strategies; immune evasion

(This special issue belongs to the Section Cancer Metastasis)

Modern Diagnostics and Treatment of Gastrointestinal and Endocrine Cancers

edited by

Kamil Safiejko

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1337 | Submission Open

Keywords: colorectal cancer; gastric cancer; pancreatic cancer; liver metastases; thyroid cancer; adrenal cancer; robotic surgery; artificial intelligence; endoscopy; Rth

(This special issue belongs to the Section Cancer Therapy)

Role of BCL-2 Family Proteins in Cancer: Therapeutic Advancements and Challenges

edited by

Sajid Khan

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1257 | Submission Open

Keywords: BCL-2 family proteins; apoptosis; BH3 mimetics; thrombocytopenia; proteolysis-targeting chimeras; drug resistance; combination therapy; targeted drug delivery

(This special issue belongs to the Section Cancer Therapy)

Emerging Therapies for Germ Cell Tumors

edited by

Ratnakar Singh

and Krinio Giannikou

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1238 | Submission Open

Keywords: testicular cancer; embryonal carcinoma; germ cell tumors; cisplatin; immunotherapy; epigenetics; microRNA; chemoresistance; animal models; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Hepatocellular Carcinoma: Clinical Evidence and Emerging Therapeutic Benefits

edited by

Alessandro Loglio

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1116 | Submission Open

Keywords: artificial intelligence; downstaging; immunotherapy; multidisciplinary approaches; risk factors; nutrition

(This special issue belongs to the Section Cancer Therapy)

Radiation Therapy for Metastatic Cancer

edited by Johnny Kao

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1105 | Submission Open

Keywords: metastasis; radiation therapy; tumor agnostic; oligometastases; survivorship; combined modality therapy

(This special issue belongs to the Section Cancer Therapy)

Modulating the Acidic Tumor Microenvironment to Enhance the Efficacy and Reduce the Toxicity of Cancer Treatment

edited by Hiromi Wada, Keisuke Shirai and

Dario Marchetti

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1104 | Submission Open

Keywords: Alkalization therapy; tumor microenvironment; Warburg effect; pH gradient; mitochondrial metabolism; redox balance; immune modulation; dissipative structure; personalized oncology; thermodynamic homeostasis

(This special issue belongs to the Section Tumor Microenvironment)

Optimizing Surgical Procedures and Enhancing Outcomes in the Management of Gastrointestinal Cancer

edited by Tim Strate and

Jonas Herzberg

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1099 | Submission Open

Keywords: gastrointestinal malignancies; surgical oncology; postoperative outcome; quality of life; anastomotic leakage; anastomotic technique; HIPEC; PIPAC

(This special issue belongs to the Section Cancer Therapy)

Artificial Intelligence and Machine Learning in Cancer Diagnosis, Treatment, and Prognosis

edited by Iakovos Amygdalos

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1039 | Submission Open

Keywords: artificial intelligence in oncology and oncological surgery; machine learning for cancer diagnosis; multimodal data integration; precision oncology and prognostic modeling; federated and explainable AI

(This special issue belongs to the Section Methods and Technologies Development)

Symptom Burden in Cancer: Assessment and Management: 2nd Edition

edited by Sam M. Salek,

Esther Natalie Oliva

and Tatyana Ionova

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1031 | Submission Open

Keywords: symptom burden; patient-reported outcomes; symptom assessment; symptom management; cancer survivorship; quality of life

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

A New Road for Cancer Drug Discovery

edited by

Navnath S. Gavande

and

Yubin Ge

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1019 | Submission Open

Keywords: cancer drug discovery; artificial intelligence in drug discovery and development; targeted therapy; precision oncology; targeted protein degrades; small-molecule therapeutics; immuno-oncology; undruggable targets; drug resistance mechanisms; combination therapy

(This special issue belongs to the Section Cancer Drug Development)

Diagnostic and Pathological Markers in Human Cancer

edited by

Zuoren Yu

Shengqiong Deng

and Qian Zhao

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1010 | Submission Open

Keywords: cancer; biomarker; early diagnosis; pathological markers; prognostic model

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

CDK4/6 Inhibitors in Cancer: Efficacy, Resistance, and Combination Approaches

edited by

Boshi Wang

submission deadline 30 Jun 2026 | 1 articles | Viewed by 979 | Submission Open

Keywords: CDK4/6 inhibitors; palbociclib; abemaciclib; ribociclib; cancer; senescence; combinatorial therapy; prognosis; molecular mechanisms

(This special issue belongs to the Section Cancer Therapy)

Advances in Treatment of Bladder Cancer

edited by

Murat Akand

and

Guglielmo Mantica

submission deadline 30 Jun 2026 | 1 articles | Viewed by 959 | Submission Open

Keywords: bladder cancer; diagnostic biomarkers; genomics; therapeutic approaches

(This special issue belongs to the Section Cancer Therapy)

Surgery for Head and Neck Cancer

edited by

Boban M. Erovic

Blazen Marijic

and Stefan Grasl

submission deadline 30 Jun 2026 | 1 articles | Viewed by 959 | Submission Open

Keywords: head and neck cancer; oncologic surgery; minimally invasive surgery; transoral robotic surgery; neck dissection; reconstructive surgery; multidisciplinary treatment; functional outcomes

(This special issue belongs to the Section Cancer Therapy)

Recent Advances in the Molecular Biology of Urologic Cancers: Integrative Insights from Pathogenesis to Clinical Applications

edited by

Whi-An Kwon

submission deadline 30 Jun 2026 | 1 articles | Viewed by 925 | Submission Open

Keywords: urologic cancers; molecular biology; pathogenesis; precision medicine; biomarkers; multi-omics; targeted therapies; immunotherapy; translational research; clinical applications

(This special issue belongs to the Section Molecular Cancer Biology)

Innovations in Soft Tissue Sarcoma Diagnosis and Treatment (2nd Edition)

edited by Erlinda M. Gordon,

Sant P. Chawla

and Frederick L. Hall

submission deadline 30 Jun 2026 | 1 articles | Viewed by 916 | Submission Open

Keywords: soft tissue sarcoma; gene therapy; natural killer cell therapy; immune and cell cycle checkpoint inhibitors; targeted therapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Biomarkers for Cancer Immunotherapy

edited by Xin Du

submission deadline 30 Jun 2026 | 1 articles | Viewed by 913 | Submission Open

Keywords: cancer immunotherapy; predictive biomarkers; tumor immune microenvironment

(This special issue belongs to the Section Cancer Biomarkers)

Diagnosis and Treatment of Gynecological Cancers

edited by

Yang Xiang

submission deadline 30 Jun 2026 | 1 articles | Viewed by 877 | Submission Open

Keywords: gynecological cancers; diagnosis; treatment; clinical research; translational medicine; multidisciplinary management

Fertility and Pregnancy in Cancer

edited by

Bettina Böttcher

submission deadline 30 Jun 2026 | 1 articles | Viewed by 874 | Submission Open

Keywords: cancer; gonadotoxic treatment; pregnancy; offspring; long term survivorship; fertility preservation

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Surgical Perspectives in Lung Cancer: From Technique to Outcome

edited by Takahiro Homma and Hyun Koo Kim

submission deadline 30 Jun 2026 | Viewed by 576 | Submission Open

Keywords: minimally invasive surgery; enhanced recovery after surgery (ERAS); uniportal VATS; robotic-assisted thoracic surgery (RATS); surgical education; perioperative management; energy devices; lung cancer surgery

(This special issue belongs to the Section Cancer Therapy)

Innovative Treatments Based on Genomic Aberrations in Leukemia and Lymphoma

edited by

Vera Ulrike Bacher

and

Ashwini K. Yenamandra

submission deadline 30 Jun 2026 | Viewed by 570 | Submission Open

Keywords: leukemia; lymphoma; AI and predictive modeling; MRD; B-ALL; DLBCL; genomics; treatment

(This special issue belongs to the Section Cancer Therapy)

Recent Updates on Treatment of Uveal Melanoma

edited by Richard D. Carvajal, Shaheer Khan and Brian Peter Marr

submission deadline 30 Jun 2026 | Viewed by 564 | Submission Open

Keywords: uveal melanoma; systemic therapies; surgical innovations; radiotherapy; genetic and molecular insights; translational research

(This special issue belongs to the Section Cancer Therapy)

Advances in the Pathogenesis of Hematopoietic Neoplasms

edited by

Raju K. Pillai

and

Steven T. Rosen

submission deadline 30 Jun 2026 | Viewed by 553 | Submission Open

Keywords: B cell lymphoma; T cell lymphoma; Hodgkin lymphoma; leukemia; myeloma; pathogenesis; genomics; microenvironment

(This special issue belongs to the Section Cancer Pathophysiology)

Research Challenges in Adolescent and Young Adult Cancer

edited by

Lorna A. Fern

and Jeremy Lewin

submission deadline 30 Jun 2026 | Viewed by 441 | Submission Open

Keywords: adolescents and young adults; research enrollment and retention; clinical trials; access; barriers

(This special issue belongs to the Section Pediatric Oncology)

New Insights in Parotid Tumors

edited by Chiara Gaudino and Stefan Rohde

submission deadline 30 Jun 2026 | Viewed by 433 | Submission Open

Keywords: advanced imaging in parotid tumors; artificial intelligence tools; parotid gland surgery; facial nerve preservation and reconstruction; chemotherapy in parotid gland malignant tumors; radiotherapy and proton therapy in malignant parotid gland tumors

(This special issue belongs to the Section Cancer Therapy)

Signaling Networks Controlling Ovarian Cancer Progression and Response to Therapy

edited by

Luca Tamagnone

and Roberta Mastrantonio

submission deadline 30 Jun 2026 | Viewed by 430 | Submission Open

Keywords: ovarian cancer; patient-derived models; mesothelium; ascites; immunotherapy; chemotherapy; drug resistance; metastasis; peritoneum; p53; BRCA; signaling pathway; metabolism

(This special issue belongs to the Section Tumor Microenvironment)

Circadian Rhythms, Cancers and Chronotherapy (2nd Edition)

edited by

Francis Levi

Pasquale F. Innominato

and Esra Tasali

submission deadline 30 Jun 2026 | Viewed by 416 | Submission Open

Keywords: drug development and chronotherapy; chemotherapy; immunotherapy; targeted agents; radiotherapy; surgery; circadian host or tumor biomarkers; electronic patient-reported outcomes; circadian rhythms and sleep; sex- and age specificities; clinical trial designs; mathematical models and artificial intelligence; digital healthcare; telemedicine and logistics

(This special issue belongs to the Section Cancer Therapy)

Evolving Management of Gastroesophageal Cancers: From Local Therapies to Precision Oncology

edited by Matthew Strickland

submission deadline 30 Jun 2026 | Viewed by 388 | Submission Open

Keywords: gastric cancer; esophageal cancer; immunotherapy targeted therapy; radiation therapy; surgical oncology; precision oncology; molecular biomarkers; multimodal treatment

(This special issue belongs to the Section Cancer Therapy)

Advances in Targeted Therapies and Pharmacogenomics of Leukemia

edited by

Nicolas Nassar

submission deadline 30 Jun 2026 | Viewed by 383 | Submission Open

Keywords: blood cancer; targeted therapy; immunotherapy; primary and secondary resistance; pharmacogenetics; combination therapy; tumor microenvironment

(This special issue belongs to the Section Molecular Cancer Biology)

The Extracellular Matrix and Tissue Engineering: Roles in the Tumor Microenvironment and Implications for Cancer Treatment

edited by

Maria Georgiadou

Eirini Velliou

and

Eugenia Roupakia

submission deadline 30 Jun 2026 | Viewed by 330 | Submission Open

Keywords: extracellular matrix remodeling; stiffness; cancer progression; tumor metastasis; tissue engineering; 3D models; anti-cancer therapies

(This special issue belongs to the Section Cancer Therapy)

Human Carcinogens—New Insights from Occupational Exposure

edited by

Enrico Oddone

and

Roberta Pernetti

submission deadline 30 Jun 2026 | Viewed by 318 | Submission Open

Keywords: occupational carcinogens; chemical exposure; cancer prevention; artificial intelligence (AI); workplace health policy

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Redox Balance, Antioxidant Defenses, and Inflammation in Cancer: From Initial Changes to Tumor Progression

edited by Andrej Veljković,

Gordana Kocic

and

Aleksandra Klisic

submission deadline 30 Jun 2026 | Viewed by 307 | Submission Open

Keywords: oxidative stress; inflammation; cancer progression; pre-malignant changes; biomarkers; tumor microenvironment; cell signaling; therapeutic targets

(This special issue belongs to the Section Tumor Microenvironment)

Emerging Opportunities in Radiation Oncology: AI, Radiomics, and Particle Therapy Breakthroughs

edited by

Antonio Pontoriero

and

Sara Lillo

submission deadline 30 Jun 2026 | Viewed by 306 | Submission Open

Keywords: radiotherapy; artificial intelligence; radiomics; machine learning; adaptive planning; proton therapy; hadron therapy; precision oncology; particle radiotherapy; clinical outcomes

Tumor Heterogeneity in Breast Cancer—the “Omics” Revolution

edited by

Angeliki Magklara

and

Spyros Foutadakis

submission deadline 30 Jun 2026 | Viewed by 301 | Submission Open

Keywords: breast cancer; tumor heterogeneity; tumor microenvironment; transcriptional regulation; single-cell RNA-seq; spatial transcriptomics; genomics; epigenomics; proteomics; metabolomics

(This special issue belongs to the Section Molecular Cancer Biology)

Leukemia Cell Signaling Pathways: Recent Advances, Future Perspectives, and Potential Clinical Applications

edited by

Bac Viet Le

and

Srinivas Chatla

submission deadline 30 Jun 2026 | Viewed by 300 | Submission Open

Keywords: leukemia; cell signaling; bone marrow microenvironment; leukemic transformation; drug resistance; therapeutic discovery; cell signaling inhibitors; precision medicine

(This special issue belongs to the Section Tumor Microenvironment)

Psychosocial Health and Quality of Life Across the Cancer Care Continuum

edited by

Qin Xiang Ng

and Serene Si Ning Goh

submission deadline 30 Jun 2026 | Viewed by 299 | Submission Open

Keywords: cancer survivorship; psychological outcomes; quality of life; health-related quality of life; patient-reported outcomes; fear of recurrence; cancer-related fatigue; mental health; body image; supportive care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Pharmacokinetics in Cancer Treatment

edited by Jing Li

submission deadline 30 Jun 2026 | Viewed by 292 | Submission Open

Keywords: pharmacokinetics (PK); pharmacodynamics (PD); population PK/PD modeling; PBPK modeling; clinical pharmacology; personalized oncology; cancer treatment; pharmacogenetics; molecular pharmacology

(This special issue belongs to the Section Cancer Drug Development)

Cancer and Aging: Challenges in Geriatric Cancer Survivorship

edited by

Ruth Parks

and Dana E. Giza

submission deadline 30 Jun 2026 | Viewed by 290 | Submission Open

Keywords: geriatric oncology; survivorship; advance care planning; quality of life; de-escalation of treatment

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Genomics and Genetics in Brain Cancer Treatment, Diagonals, and Prognosis

edited by

Nan Hu

submission deadline 30 Jun 2026 | Viewed by 289 | Submission Open

Keywords: genomics; genetics; brain tumor; brain cancer; glioblastoma multiform; glioma; cancer diagnosis; cancer prognosis

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Tumor Microenvironment of Thyroid Carcinoma

edited by

Juan Carlos Jaume

submission deadline 30 Jun 2026 | Viewed by 288 | Submission Open

Keywords: thyroid cancer; tumor immune microenvironment (TIME); double-negative T cells (DN T cells); tumor-associated macrophages (TAMs)

(This special issue belongs to the Section Tumor Microenvironment)

Basic and Translational Science in Ocular Oncology

edited by Anthony B. Daniels,

Arun D. Singh

and

Jens Folke Kiilgaard

submission deadline 30 Jun 2026 | Viewed by 287 | Submission Open

Keywords: ocular oncology; eye cancer; tumors; melanoma; retinoblastoma; hemangioma; hemangioblastoma; lymphoma

(This special issue belongs to the Section Cancer Pathophysiology)

Advancements in Multimodal Imaging Techniques for Brain Tumor Diagnosis and Treatment

edited by

Keisuke Miyake

submission deadline 30 Jun 2026 | Viewed by 284 | Submission Open

Keywords: multimodal imaging; brain tumors; PET; advanced MRI; imaging biomarkers; glioblastoma; image-guided surgery; tumor infiltration; precision neuro-oncology

(This special issue belongs to the Section Methods and Technologies Development)

Prostate Cancer Pathology and Grade

edited by

Stefano Marletta

and