Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Mitochondria Beyond Energy: Signaling, Immunity, and Cell Fate
edited by and Mohd Parvez Khan
submission deadline 31 May 2026 | Viewed by 282 | Submission Open
Keywords: mitochondria; stem cells; cell fate; organogenesis; immunometabolism
Cancer and Vessels: Insights at the Cellular and Molecular Levels
edited by Francesco Pezzella and Tom Donnem
submission deadline 31 May 2026 | Viewed by 274 | Submission Open
Keywords: angiogenesis; vessel co-option; tumor microenvironment; tumor blood vessels; tumor vasculature; metastasis
(This special issue belongs to the Section Cellular Pathology)
Extracellular Vesicles in Reproductive Communication: From Gametogenesis to Implantation
edited by and Osvaldo Bogado Pascottini
submission deadline 31 May 2026 | Viewed by 272 | Submission Open
Keywords: extracellular vesicles; reproductive biology; gametogenesis; oocyte maturation; embryo-maternal communication; implantation; reproductive disorders; epigenetic regulation; EV Cargo; intercellular signaling
Molecular Mechanisms of Drug Delivery in Ophthalmology
edited by Alekha K. Dash and Surabhi Shukla
submission deadline 31 May 2026 | Viewed by 270 | Submission Open
Keywords: drug delivery; ophthalmology; nanocarriers; ocular barriers; molecular transport; targeted therapy; ocular gene delivery
(This special issue belongs to the Section Tissues and Organs)
Inflammatory Signaling and Vascular Dysfunction in Atherosclerosis
edited by and Jianzhong Shen
submission deadline 31 May 2026 | Viewed by 268 | Submission Open
Keywords: inflammation in atherosclerosis; atherothrombosis; cell signaling
Cellular and Molecular Mechanisms of Heart Development
edited by Jun K. Takeuchi
submission deadline 31 May 2026 | Viewed by 255 | Submission Open
Keywords: heart development; cardiovascular; epigenetics; cell fate; differentiation; cardiac growth; cardiac morphogenesis; heart regeneration; cardiac organoid
Skeletal Muscle Aging and Regeneration: Mitochondrial Health, Molecular Signaling, and Therapeutic Interventions
edited by
submission deadline 31 May 2026 | Viewed by 246 | Submission Open
Keywords: aging; skeletal muscle; regeneration; satellite cells; muscle stem cells; muscle wasting; mitochondria; fibro-adipogenic progenitor cells; repair
Immunotherapy-Induced Cardiotoxicity: Unraveling the Immune Landscape of Myocarditis
edited by
submission deadline 31 May 2026 | Viewed by 246 | Submission Open
Keywords: immunotherapy; immune checkpoints; adoptive cell therapy; cardiac adverse events; cardiac inflammation; immune checkpoint inhibitor associated myocarditis; cardiac immune landscape; innate immune response; adaptive immune response; myeloid cells; macrophages; antigen presentation & phagocytosis; T cells; T cell clonality; cytokines; chemokines; chemotaxis; immune crosstalk; immune– stromal crosstalk; multi-omics
Molecular Mechanisms and Therapeutic Strategies for Skeletal Muscle Disorders submission deadline 31 May 2026 | Viewed by 229 | Submission Open
Keywords: skeletal muscle; muscular disorders; myokines; muscle regeneration; muscle atrophy; inflammation; stress response; myoblast
Regulatory Mechanisms of Vascular Smooth Muscle Cells and Immune Cells in Vascular Disease Progression
edited by and
submission deadline 31 May 2026 | Viewed by 220 | Submission Open
Keywords: vascular smooth muscle cells; immune cells; inflammation; vascular disease; atherosclerosis; aneurysm; cellular crosstalk; phenotypic transition
(This special issue belongs to the Section Cells of the Cardiovascular System)
Epigenetic and Cellular Regulation in Hematologic Disorders
edited by
submission deadline 31 May 2026 | Viewed by 211 | Submission Open
Keywords: epigenetics; hematologic disorders; leukemia; myelodysplastic syndrome; thrombosis; thrombocytopenia; bleeding
New Advances in Cardiac and Vascular Physiology
edited by Robert M. Lust
submission deadline 31 May 2026 | Viewed by 209 | Submission Open
Keywords: environmental exposure; immune responses; remodeling; receptors; ischemia; pre-conditioning; post-conditioning; heart failure
(This special issue belongs to the Section Tissues and Organs)
DNA Damage and Repair in Targeted Cancer Therapy
edited by , Sajad Ahmad Bhat and
submission deadline 31 May 2026 | Viewed by 200 | Submission Open
Keywords: cancer cells; DNA damage and repair mechanism; genome organization; BER; NER; MMR; HR; and NHEJ; targeted therapy; inhibitors/PROATCS; drug resistance; drug toxicity; biomarkers; personalized medicine
Endometrial Cancer: From Molecular Mechanisms to Therapeutic Approaches
edited by Tomaž Büdefeld and
submission deadline 31 May 2026 | Viewed by 196 | Submission Open
Keywords: endometrial cancer; genetic mutation; epigenetics; cell signaling; TIME; metastasis; biomarker; therapy; drug delivery; risk factor
Advances in Ion Channel Biology: From Molecular Mechanisms to Therapeutic Targets
edited by Shridhar Sanghvi, and
submission deadline 31 May 2026 | Viewed by 196 | Submission Open
Keywords: ion channels; electrophysiology; cryo-electron microscopy; channelopathy; membrane protein; gating mechanism; structural biology
Decoding Heart Failure: From Mechanisms to Treatment
edited by and Dirk L. Brutsaert
submission deadline 31 May 2026 | Viewed by 174 | Submission Open
Keywords: heart failure; pathological process; molecular mechanisms; cellular mechanisms; genetic mechanisms; therapeutic target
Molecular Bases Underlying Early Embryonic Development in Mammals
edited by , Julio Ávila Marrero and Angela Palumbo
submission deadline 31 May 2026 | Viewed by 163 | Submission Open
Keywords: embryonic development; early embryogenesis; gene expression; miRNA profile; reproductive physiology; cell signalling; embryo quality; developmental competence; in vitro embryo culture
(This special issue belongs to the Section Reproductive Cells and Development)
Advancements in Research on Metabolic Syndrome
edited by Gautam Kumar Pandey
submission deadline 31 May 2026 | Viewed by 154 | Submission Open
Keywords: metabolic syndrome; multi-omics; insulin resistance; cell signaling in metabolic disease
Stem Cell-Based Strategies for Cardiac Tissue Engineering and Regeneration
edited by Munira Xaymardan and
submission deadline 31 May 2026 | Viewed by 144 | Submission Open
Keywords: cardiac tissue engineering; stem cells; cardiomyocytes; cardiac organoids; engineered heart tissues; biomaterials; scaffolds; gene therapy; RNA reprogramming; cardiac fibrosis; cardiac regeneration; myocardial repair; translational studies
(This special issue belongs to the Section Stem Cells)
Human Pluripotent Stem Cells and Organoids: Current Trends and Future Perspectives submission deadline 1 Jun 2026 | 2 articles | Viewed by 2537 | Submission Open
Keywords: human pluripotent stem cells; organoids; disease modeling; regenerative medicine; genome editing; single-cell omics; tissue engineering; drug discovery; precision medicine
(This special issue belongs to the Section Stem Cells)
Mechanisms, Biomarkers, and Therapeutics of Neurodegeneration
edited by
submission deadline 1 Jun 2026 | 1 articles | Viewed by 1031 | Submission Open
Keywords: neurodegeneration; biomarkers; mechanistic studies; protein aggregation; protein degradation; neuroinflammation; targeted therapies; genetics; precision medicine
(This special issue belongs to the Section Cellular Neuroscience)
Molecular Mechanisms of Fibrosis in Chronic Liver Diseases
edited by , Regina Golan-Gerstl and Ihab Ansari
submission deadline 1 Jun 2026 | Viewed by 356 | Submission Open
Keywords: liver fibrosis; MASH; immune checkpoints; epigenetic regulation; hepatic stellate cells (HSCs); antifibrotic therapy; molecular mechanisms; inflammation; ROS
Macrophages in Cancer: Immunosuppression, Immunoregulation, and Immunotherapy
edited by
submission deadline 5 Jun 2026 | 4 articles | Viewed by 16652 | Submission Open
Keywords: macrophage; immunosuppression; immunoregulation; immunotherapy; tumor immune microenvironment
(This special issue belongs to the Section Cellular Immunology)
Novel Insights into Molecular Mechanisms and Therapy of Myeloma
edited by and
submission deadline 10 Jun 2026 | 7 articles | Viewed by 24508 | Submission Open
Keywords: multiple myeloma; CAR-T therapy; relapse; methylation; drug resistance; treatment strategy; molecular mechanism; novel target; biomarker
(This special issue belongs to the Section Cellular Pathology)
Advances in Pulmonary Fibrosis
edited by Sergio Piñeiro Hermida
submission deadline 10 Jun 2026 | 3 articles | Viewed by 2752 | Submission Open
Keywords: pulmonary fibrosis; animal models; biomarkers; experimental therapeutics
(This special issue belongs to the Section Cellular Pathology)
Molecular Mechanisms of Cardiac Repair and Regeneration
edited by Mahesh Thirunavukkarasu
submission deadline 10 Jun 2026 | 1 articles | Viewed by 1115 | Submission Open
Keywords: cardiac repair and regeneration; cardiomyocyte; cardiac fibrosis; signaling pathways; immune regulation; extracellular vesicles; stem cell therapies; epigenetics; biomarkers
(This special issue belongs to the Section Cells of the Cardiovascular System)
The Metabolic Edge: How Cancer Cells Adapt, Survive, and Resist Therapy
edited by
submission deadline 10 Jun 2026 | Viewed by 243 | Submission Open
Keywords: cancer metabolism; metabolic rewiring; therapy resistance; metabolic plasticity; nutrient uptake; mitochondrial remodeling; tumor microenvironment; metabolic vulnerabilities
(This special issue belongs to the Section Cellular Metabolism)
Lipid Mediators in Cardiometabolic Regulation and Disease
edited by Adeniyi Michael Adebesin
submission deadline 10 Jun 2026 | Viewed by 160 | Submission Open
Keywords: lipid mediators; lipoprotein; fatty acid metabolites; cellular membranes; cardiometabolic regulation; cellular metabolism; adipogenesis; signaling pathways; receptors; lipid transport proteins
(This special issue belongs to the Section Cellular Metabolism)
The Role of Oxidative Stress in Cardiovascular Diseases—2nd Edition
edited by and
submission deadline 15 Jun 2026 | 4 articles | Viewed by 5923 | Submission Open
Keywords: oxidative stress; antioxidants; apoptosis; atherosclerosis; blood vessel; heart failure; hypertension; inflammation; mitochondria; microcirculation; reactive oxygen species
(This special issue belongs to the Section Cells of the Cardiovascular System)
Genomics and Cellular Mechanisms in Ovarian Cancer
edited by Hao Huang
submission deadline 15 Jun 2026 | 3 articles | Viewed by 2900 | Submission Open
Keywords: ovarian cancer; tumor heterogeneity; genomics and epigenomics; therapy resistance; tumor microenvironment
(This special issue belongs to the Section Tissues and Organs)
Novel Insights into Developing Therapeutic Strategies for Neurological Disorders
edited by , Joanna A. Korecka and
submission deadline 15 Jun 2026 | 1 articles | Viewed by 1641 | Submission Open
Keywords: neurological disorders; RNA therapeutics; gene therapy; antisense oligonucleotides; gene editing; cell therapy; precision medicine; neurodegenerative diseases; neurodevelopmental disorders; neurogenetic disorders
Cellular Metabolism and Immune Regulation in Cancer Progression and Metastasis
edited by Xu Jing
submission deadline 15 Jun 2026 | 1 articles | Viewed by 1089 | Submission Open
Keywords: cellular metabolism; tumor immunology; cancer progression; metastasis; immunometabolism; metabolic reprogramming; tumor microenvironment; immune evasion; cancer therapy; metabolic biomarkers
(This special issue belongs to the Section Cellular Metabolism)
Decoding Cellular Organization Through Spatial Omics
edited by Elizabeth Neumann
submission deadline 15 Jun 2026 | 1 articles | Viewed by 1077 | Submission Open
Keywords: spatial proteomics; lipomics; cellular architecture; biomolecular interactions; bioinformatics; integrative biology
Cellular Origin of Glioma: From Triggers to Treatments
edited by Katherine Karakoula
submission deadline 15 Jun 2026 | 1 articles | Viewed by 1059 | Submission Open
Keywords: glioblastoma; brain tumour; tumour heterogeneity; targeted therapy; glioma stem cells
Regulation of Hormone Secretion from Islets in Health and Disease
edited by
submission deadline 15 Jun 2026 | Viewed by 320 | Submission Open
Keywords: islet hormone secretion; paracrine signaling; autocrine regulation; intra-islet communication; islet cell plasticity; transdifferentiation; multi-hormonal dysregulation; circadian regulation; single-cell omics; islet inflammation and immune crosstalk
Bone and Soft Tissue Tumors: Molecular Mechanisms and Emerging Therapeutics
edited by
submission deadline 15 Jun 2026 | Viewed by 263 | Submission Open
Keywords: sarcoma; bone and soft tissue tumors; molecular pathology; dysregulated signaling pathways; genetic and epigenetic alterations; therapeutic resistance; novel molecular biomarkers; therapeutic strategies; in vitro and in vivo models
Overcoming Resistance to Immune Checkpoint Inhibitors in Cancer: Mechanisms, Models, and Therapeutic Strategies
edited by Nai-Yun Sun, and
submission deadline 15 Jun 2026 | Viewed by 209 | Submission Open
Keywords: immune checkpoint inhibitors; primary resistance; acquired resistance; tumor microenvironment; immune exhaustion; preclinical cancer models; genetic and epigenetic alterations; excluded/desert tumors; inflamed tumors; cancer immunotherapy
Decoding the Complexity of Angiogenesis: Insights into Vascular Formation and Disease submission deadline 20 Jun 2026 | 3 articles | Viewed by 5299 | Submission Open
Keywords: angiogenesis; vasculogenesis; development; physiological angiogenesis; pathophysiology; cell– cell communication; cell signaling
(This special issue belongs to the Section Cells of the Cardiovascular System)
Molecular Mechanism of Liver Transplantation
edited by Carmen Peralta and Juan Carlos Cutrin
submission deadline 20 Jun 2026 | 1 articles | Viewed by 4910 | Submission Open
Keywords: liver transplantation; ischemia-reperfusion injury; signaling pathways; graft dysfunction; sterile inflammation; liver regeneration; fatty grafts; normothermic machine perfusion; defatting strategies
(This special issue belongs to the Section Tissues and Organs)
Mechanisms of Antimicrobial Treatment in Human Diseases
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 3464 | Submission Open
Keywords: multidrug resistance; epidemiology; novel antimicrobial resistance traits
(This special issue belongs to the Section Cellular Pathology)
Progress of Nanoparticles in the Treatment of Cancers
edited by , Nafees Ahamad and
submission deadline 20 Jun 2026 | 2 articles | Viewed by 2615 | Submission Open
Keywords: nanoparticles; cancer treatment; cellular mechanisms; molecular biology; pathophysiology; drug delivery; drug resistance; immunotherapy; tumor microenvironment
(This special issue belongs to the Section Cell Microenvironment)
Beyond Bystanders: The Emerging Roles of Glia in Brain Health and Disease
edited by
submission deadline 20 Jun 2026 | 2 articles | Viewed by 2399 | Submission Open
Keywords: astrocytes; microglia; oligodendrocytes; neuroinflammation; neuroimmunology; synaptic plasticity; blood– brain barrier; neuropsychiatric disorders
(This special issue belongs to the Section Cellular Neuroscience)
Biomolecular Condensates in Oncology and Immunology submission deadline 20 Jun 2026 | 1 articles | Viewed by 2116 | Submission Open
Keywords: liquid-liquid phase separation (LLPS); biomolecular condensates; pro-oncogenic signaling; innate and adaptive immunity; transcriptional regulation; epigenetic regulation; condensate targeting; antiviral mechanisms; intercellular adhesion; cell migration and metastasis
(This special issue belongs to the Section Cellular Immunology)
Molecular and Cellular Mechanisms of Insulin Secretion
edited by
submission deadline 20 Jun 2026 | Viewed by 1877 | Submission Open
Keywords: insulin secretion; beta-cells; pancreatic islets; diabetes; exocytosis; Ca2+
(This special issue belongs to the Section Cellular Metabolism)
Molecular Anatomy and Function of Sensory Organs and Sensory Tissues
edited by
submission deadline 20 Jun 2026 | 2 articles | Viewed by 1355 | Submission Open
Keywords: sensory organ; sensory tissue; vision; hearing; skin; sensory structures of internal organs
(This special issue belongs to the Section Tissues and Organs)
Research on Islet Cell Biology
edited by Mazhar Kanak
submission deadline 20 Jun 2026 | 1 articles | Viewed by 730 | Submission Open
Keywords: islet inflammation; hypoxia in islets; functional assessment of islets ex vivo and in vivo; islet stress and EVs as markers of stress; encapsulation strategies for islet transplantation; hot topics in islet and SC-beta cell transplantation
New Insights into Astrocytes in Health and Disease
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 302 | Submission Open
Keywords: astrocytes heterogeneity; blood-brain barrier (BBB); synaptic modulation; metabolic support; neuroinflammation; ageing; neurodegenerative disorders; neurodevelopmental disorders; stress response
(This special issue belongs to the Section Cellular Neuroscience)
Metabolic Reprogramming in Organ Fibrosis and Regeneration
edited by and Dong Yang
submission deadline 20 Jun 2026 | Viewed by 252 | Submission Open
Keywords: metabolic reprogramming; fibrosis; tissue regeneration; cellular metabolism; mitochondrial dysfunction; tissue repair and remodeling
(This special issue belongs to the Section Cellular Metabolism)
The Orchestration of Glial Cells in Health and Disease
edited by Keying Zhu
submission deadline 25 Jun 2026 | 1 articles | Viewed by 1986 | Submission Open
Keywords: microglia; oligodendrocytes; astrocytes; myelin; neuroinflammation
Cutaneous Regeneration and Tissue Engineering: From Hair Follicle Regeneration to Skin Restoration
edited by Soung-Hoon Lee
submission deadline 25 Jun 2026 | 3 articles | Viewed by 1502 | Submission Open
Keywords: skin regeneration; hair follicle regeneration; tissue engineering; regenerative biology; biomaterial scaffolds; organoids and 3D skin models; wound healing; acellular matrices; exosome-based therapy; translational dermatology
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