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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Autophagy in Neurological Disorders

edited by

Natalia Jimenez-Moreno

and

Ciro Isidoro

submission deadline 20 Oct 2025 | Viewed by 105 | Submission Open

Keywords: autophagy; selective autophagy; neurodegeneration; proteostasis; lysosomes; aging; oxidative stress; aging; biomarkers; pharmacological agents

(This special issue belongs to the Section Cells of the Nervous System)

Cell Death and Its Clearance in Health and Disease

edited by

Turan Tufan

submission deadline 20 Oct 2025 | Viewed by 96 | Submission Open

Keywords: cell death; phagocytosis; immune homeostasis; inflammation

(This special issue belongs to the Section Cellular Pathology)

New Advances in Anticancer Therapy

edited by

Dooil Jeoung

submission deadline 20 Oct 2025 | Viewed by 95 | Submission Open

Keywords: antibody-based immunotherapy; cell therapy; personalized anticancer therapy; RNA vaccines; nanotechnology

(This special issue belongs to the Section Cellular Pathology)

The Cellular and Molecular Mechanisms of Immunity to Infectious Viruses

edited by

Dimitrios Vlachakis

Tassos Georgakopoulos

and

Marios Agelopoulos

submission deadline 20 Oct 2025 | Viewed by 88 | Submission Open

Keywords: viral infections; immune cell biology; gene expression programs; epigenetics; chromatin architecture; cis-regulatory elements; functional genomics; computational biology applications

(This special issue belongs to the Section Cellular Pathology)

Unraveling Protein–Protein Interactions for Innovative Therapeutics and Nanodelivery

edited by Roberta Montanari and

Alberto Vitali

submission deadline 20 Oct 2025 | Viewed by 58 | Submission Open

Keywords: protein– protein interactions; PPI modulators; nanodelivery; molecular mechanisms

(This special issue belongs to the Section Cellular Biophysics)

Recent Advances in Regenerative Dentistry—Second Edition

edited by

Li Xiao

submission deadline 25 Oct 2025 | 5 articles | Viewed by 9858 | Submission Open

Keywords: oral stem cells; oral tissue regeneration; bioengineering; dental materials; stem cell banking

(This special issue belongs to the Section Tissues and Organs)

Adult Stem Cells in Human Disease

edited by Esther Wolfs, Tim Vangansewinkel and

Annelies Bronckaers

submission deadline 25 Oct 2025 | 1 articles | Viewed by 2442 | Submission Open

Keywords: dental pulp stem cells; disease; regenerative medicine; disease modeling

(This special issue belongs to the Section Stem Cells)

3D Cultures and Organ-on-a-Chip in Cell and Tissue Cultures

edited by

Annunziata Mauro

Barbara Barboni

and

Giovanna Della Porta

submission deadline 25 Oct 2025 | 1 articles | Viewed by 1160 | Submission Open

Keywords: three-dimensional cell culture; organ-on-a-chip; tissue engineering; regenerative medicine; drug testing; microfluidics; in vitro models; personalized medicine; cellular interaction; disease modeling

(This special issue belongs to the Section Cell Methods)

Beyond Bystanders: The Emerging Roles of Glia in Brain Health and Disease

edited by

Ruqayya Afridi

submission deadline 25 Oct 2025 | Viewed by 154 | Submission Open

Keywords: astrocytes; microglia; oligodendrocytes; neuroinflammation; neuroimmunology; synaptic plasticity; blood– brain barrier; neuropsychiatric disorders

(This special issue belongs to the Section Cells of the Nervous System)

Molecular Anatomy and Function of Sensory Organs and Sensory Tissues

edited by

Frank Schmitz

submission deadline 25 Oct 2025 | Viewed by 117 | Submission Open

Keywords: sensory organ; sensory tissue; vision; hearing; skin; sensory structures of internal organs

(This special issue belongs to the Section Tissues and Organs)

Regenerating Poorly Vascularized Tissues

edited by Simone Pacini

submission deadline 25 Oct 2025 | Viewed by 115 | Submission Open

Keywords: regenerative medicine; avascular tissue; angiogenesis; vasculogenesis; cell-based medicinal products; bioengineered materials; cell transplantation

(This special issue belongs to the Section Tissues and Organs)

Therapeutic Targeting of MicroRNAs in Human Cancer

edited by

Behzad Mansoori

submission deadline 28 Oct 2025 | Viewed by 90 | Submission Open

Keywords: microRNAs; nanoparticle platforms; spatial miRNomics; combination therapeutic strategies

(This special issue belongs to the Section Cell and Gene Therapy)

Immunoregulatory Functions of Mesenchymal Stem Cells (MSCs)

edited by

Joni H. Ylostalo

submission deadline 30 Oct 2025 | 1 articles | Viewed by 452 | Submission Open

Keywords: mesenchymal stem cells; MSCs; immunoregulation; immunosuppression

(This special issue belongs to the Section Stem Cells)

Emerging Topics in Smooth Muscle Cell Fate and Plasticity in Atherosclerosis

edited by

Mandy Grootaert

and

Julián Albarrán-Juárez

submission deadline 30 Oct 2025 | 1 articles | Viewed by 365 | Submission Open

Keywords: vascular smooth muscle cells; lineage tracing; fate mapping; VSMC plasticity; (single cell) (spatial) omics; vascular heterogeneity; atherosclerosis

(This special issue belongs to the Section Cellular Pathology)

Advances in Cellular and Molecular Treatment of Autoimmune Diseases—Second Edition

edited by

Panagiotis Athanassiou

Dimitrios P. Bogdanos

and

Ifigenia Kostoglou-Athanassiou

submission deadline 30 Oct 2025 | Viewed by 208 | Submission Open

Keywords: autoimmune diseases; disease activity; TNFa inhibitors; tocilizumab; infliximab; golimumab; etanercept; JAK inhibitors; cellular targets; molecular targets

(This special issue belongs to the Section Cellular Immunology)

Thirty plus Years’ Journey—Painting the Molecular Picture of E-C Coupling

edited by Jianjie Ma, Long-Sheng Song,

Jingsong Zhou

and

Hua Zhu

submission deadline 30 Oct 2025 | Viewed by 110 | Submission Open

Keywords: E-C coupling; calcium signaling; muscle physiology; cardiovascular disease

Molecular Cell Biology of T Cells in Cancer and Infectious Diseases

edited by

Gustavo P. Amarante-Mendes

and João Viola

submission deadline 30 Oct 2025 | Viewed by 92 | Submission Open

Keywords: T cells; cancer; infectious diseases; genomics; proteomics; metabolomics; metabolism

(This special issue belongs to the Section Cellular Immunology)

New Advances in Cancer Cell Biology: Biomarkers and Therapeutic Targets

edited by

Verena Damiani

submission deadline 30 Oct 2025 | Viewed by 92 | Submission Open

Keywords: cancer; biomarkers; therapeutic targets

(This special issue belongs to the Section Cellular Immunology)

Perinatal Brain Injury—from Pathophysiology to Therapy

edited by Cora H.A. Nijboer,

Bobbi Fleiss

and

Ivo Bendix

submission deadline 31 Oct 2025 | 6 articles | Viewed by 11253 | Submission Open

Keywords: preterm birth; perinatal brain injury; infection; inflammation; hypoxia; ischemia; hyperoxia; malnutrition; regenerative therapies; pharmacological intervention; stem cells

(This special issue belongs to the Section Cells of the Nervous System)

Gastrointestinal Disease: From Cellular Mechanisms to Targeted Therapy

edited by

Grazia Serino

and

Amilcare Barca

submission deadline 31 Oct 2025 | 3 articles | Viewed by 8113 | Submission Open

Keywords: gastrointestinal cancer; gastric cancer; colorectal cancer; esophageal cancer; liver cancer; pancreatic cancer; inflammatory bowel disease; miRNAs; in vitro and in vivo models; molecular networks; molecular pathways; translational medicine; epithelial barrier functions/processes

(This special issue belongs to the Section Cellular Pathology)

Small Molecular Therapeutics Promoting Neuronal Plasticity, Hippocampal Learning, and Memory

edited by

Avik Roy

submission deadline 31 Oct 2025 | 2 articles | Viewed by 3791 | Submission Open

Keywords: synaptic transmission; dendritic spines; metabotropic calcium influx; dendritic morphogenesis; small molecular therapeutics promoting neuronal plasticity

(This special issue belongs to the Section Cells of the Nervous System)

Immune Cell Effect on the Endothelium

edited by

Constantinos Mikelis

and Margarita Lamprou

submission deadline 31 Oct 2025 | 1 articles | Viewed by 3777 | Submission Open

Keywords: immune cells; endothelial cells; cytokines; extracellular vesicles; angiogenesis; vascular permeability

(This special issue belongs to the Section Cellular Immunology)

Non-Coding and Coding RNAs in Targeted Cancer Therapy

edited by

César López-Camarillo

and

Macrina B. Silva-Cázares

submission deadline 31 Oct 2025 | 4 articles | Viewed by 3573 | Submission Open

Keywords: gene expression; non-coding RNAs; lncRNAs; microRNAs; piwi-associated RNA; circular RNAs; therapeutic targets

(This special issue belongs to the Section Cell and Gene Therapy)

Cilia-Based New Discoveries: Ciliogenesis, Function, and Human Diseases

edited by

Lisbeth Birk Møller

submission deadline 31 Oct 2025 | 2 articles | Viewed by 3397 | Submission Open

Keywords: primary cilium; human disease; cell signaling; mTOR; Hedgehog; WNT; PDGFRalpha

Advances in Cell-Based Studies and Therapeutic Approaches for Tissue Regeneration

edited by

Anişoara Cîmpean

and

Andreea-Mariana Negrescu

submission deadline 31 Oct 2025 | 4 articles | Viewed by 3121 | Submission Open

Keywords: soft/hard tissue regeneration; therapeutical approaches; cell culture studies; inflammation-based diseases; degenerative diseases

(This special issue belongs to the Section Tissues and Organs)

The Role of Oxidative Stress in Cardiovascular Diseases—2nd Edition

edited by

Liya Yin

and

Chuanxi Cai

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2494 | Submission Open

Keywords: oxidative stress; antioxidants; apoptosis; atherosclerosis; blood vessel; heart failure; hypertension; inflammation; mitochondria; microcirculation; reactive oxygen species

(This special issue belongs to the Section Cells of the Cardiovascular System)

New Discoveries in Calcium Signaling-Related Neurological Disorders

edited by Matheus De Castro Fonseca

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2005 | Submission Open

Keywords: Ca2+ signaling; neurons; neurological disorders; intracellular signaling; synaptic dysfunction

(This special issue belongs to the Section Cells of the Nervous System)

How Can We Optimise Cancer Therapy? Tumour Microenvironment and Immune Evasion Strategies

edited by

Agnieszka Bojarska-Junak

and

Michal Zarobkiewicz

submission deadline 31 Oct 2025 | 2 articles | Viewed by 1660 | Submission Open

Keywords: immunosurveillance; immune evasion in cancer; tumour microenvironment; immune suppression; immunotherapy; immune checkpoints; cancer immunity; drug intervention

(This special issue belongs to the Section Cell Microenvironment)

Natural Killer (NK) Cells in Immunity: Limitations and Potential

edited by Rehan Mujeeb Faridi

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1435 | Submission Open

Keywords: natural killer cells; adaptive NK cells; infection

(This special issue belongs to the Section Cellular Immunology)

Glial Cells: Physiological and Pathological Perspective

edited by

Qing Richard Lu

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1196 | Submission Open

Keywords: neurodegeneration; oligodendrocytes; astrocytes; microglia; neuroinflammation; demyelination neuron– glial interactions; homeostasis; glia-targeted therapies

(This special issue belongs to the Section Cells of the Nervous System)

Galectins in Cancer, Fibrosis and Immune Modulation: Mechanisms, Therapeutic Strategies and Translational Advances

edited by Tsung-Chieh Shih

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1094 | Submission Open

Keywords: Galectin; tumor microenvironment; immunosuppression; fibrosis; epithelial– mesenchymal transition (EMT); cancer metastasis; immune evasion; therapy resistance; myeloid-derived suppressor cells (MDSCs); tumor-associated macrophages (TAMs); extracellular matrix remodeling; Galectin-targeted therapy; combination immunotherapy; fibroblast activation; chronic inflammation; tumor– stroma interactions; novel inhibitors of Galectins

(This special issue belongs to the Section Cellular Immunology)

Recent Advances in Astrocyte Neuron Communication

edited by

Stefano Ferroni

and

Francesco Formaggio

submission deadline 31 Oct 2025 | Viewed by 834 | Submission Open

Keywords: astrocytes; calcium signaling; ion channels; gliotransmitters; brain circuits; reactive astrogliosis; astrocyte heterogeneity; astrocyte– neuron networks; synaptic plasticity

(This special issue belongs to the Section Cells of the Nervous System)

Molecular Research of Cardiomyopathy

edited by

Luigi Sansone

and

Manuel Belli

submission deadline 31 Oct 2025 | Viewed by 393 | Submission Open

Keywords: cardiomyopathy; heart failure; hypertrophic cardiomyopathy; cellular and molecular rehabilitation

(This special issue belongs to the Section Cells of the Cardiovascular System)

Updates and Perspectives on Prion-Like Tau Pathology Propagation

edited by Kunie Ando, Jean-Pierre Brion and Siranjeevi Nagaraj

submission deadline 31 Oct 2025 | Viewed by 337 | Submission Open

Keywords: tau; amyloid beta; prion-like; propagation; Alzheimer’ s disease; neurodegenerative diseases; protein-protein interactions; synaptic dysfunction; aggregation; protein misfolding; risk factors; post-translational modifications

Cellular Pathways on Brain Control of Energy Metabolism

edited by Liangyou Rui

submission deadline 31 Oct 2025 | Viewed by 245 | Submission Open

Keywords: energy balance neurocircuit; molecular pathways governing energy balance neurocircuits; gut– brain axis in obesity; neuroinflammation in obesity and metabolic disease; neural sensing of metabolites and hormones

Advances in Bacterial Cell Biophysics: Metabolic Engineering and Host Interactions

edited by Shahid Khan

submission deadline 31 Oct 2025 | Viewed by 233 | Submission Open

Keywords: bacterial cell biophysics; mechanical properties; biophysical techniques; host interactions; metabolic engineering

Autophagy in Cancer Regulation

edited by Tejinder Pal Khaket

submission deadline 31 Oct 2025 | Viewed by 223 | Submission Open

Keywords: autophagy; drug resistance; immune response: cancer stemness

(This special issue belongs to the Section Autophagy)

Cell and Tissue Engineering for Functional Analysis (2nd Edition)

edited by

Masamichi Kamihira

submission deadline 31 Oct 2025 | Viewed by 200 | Submission Open

Keywords: animal cell engineering; tissue engineering; genome engineering; stem cell technology; synthetic biology

(This special issue belongs to the Section Tissues and Organs)

Potential Therapeutic Biomarkers for Prostate Cancer

edited by Benyi Li

submission deadline 31 Oct 2025 | Viewed by 145 | Submission Open

Keywords: prostate cancer; novel biomarkers; treatment

(This special issue belongs to the Section Cellular Pathology)

Kidney and Lung Disorders: The Role of Tubular and Alveolar Epithelia in Health, Disease, Infection, and Organ Crosstalk

edited by Aparna Renigunta and

Poornima Mahavadi

submission deadline 31 Oct 2025 | Viewed by 130 | Submission Open

Keywords: renal tubular disorders; alveolar lung diseases; transport mechanism; intracellular signaling; viral infection; crosstalk; dialysis; ventilation

Role of Lysosomes in Mediating Cancer Drug Resistance

edited by

Petr Mlejnek

submission deadline 31 Oct 2025 | Viewed by 119 | Submission Open

Keywords: drug resistance; autophagic cell death; lysosomal-mediated cell death; autophagy; apoptosis; lysosomal exocytosis; lysosomal sequestration; tumor microenvironment

(This special issue belongs to the Section Cell Microenvironment)

Mechanisms Underlying Cell Growth and Development

edited by

Rustem E. Uzbekov

submission deadline 31 Oct 2025 | Viewed by 110 | Submission Open

Keywords: cell growth; cell development; cell differentiation; cell cycle; mitosis; meiosis; molecular rearrangements; chromosomes; gene expression

From Bench to Bedside: Animal Models and Molecular Mechanisms in Cancer Therapeutics

edited by Sijana H. Dzinic

submission deadline 31 Oct 2025 | Viewed by 93 | Submission Open

Keywords: animal models in cancer research; cancer therapeutics; preclinical research; drug development; efficacy testing of novel anticancer agents; translational research

Cellular and Molecular Mechanisms in Peritoneal Malignancies: Insights into Pathogenesis and Therapeutic Advances

edited by

Tarkan Jäger

, Ibrahim Büdeyri and Jan Philipp Ramspott

submission deadline 31 Oct 2025 | Viewed by 85 | Submission Open

Keywords: peritoneal metastasis; cytoreductive surgery; HIPEC; PIPAC; biomarker; tumor microenvironment; epigenetics; precision oncology; tumor metabolism; immunotherapy

(This special issue belongs to the Section Cellular Pathology)

Plasticity of Skeletal, Cardiac and Smooth Muscles in COPD: Repair and Remodeling

edited by Joaquim Gea Guiral

submission deadline 31 Oct 2025 | Viewed by 75 | Submission Open

Keywords: injury; repair; adaptation; aerobic metabolism; muscle mass; limb muscles; respiratory muscles; proteolysis

Exploring Mitochondrial Dysfunction and Neuroinflammation in Neurodegeneration for New Therapeutic Advances

edited by Hanhan Liu

submission deadline 31 Oct 2025 | Viewed by 58 | Submission Open

Keywords: mitochondria; neuroinflammation; neurodegeneration; neuroprotective therapy; innate immunity

(This special issue belongs to the Section Cellular Pathology)

Functional Differences in Periostin Splicing Isoforms in Cancer and Inflammatory Disorders

edited by

Yoshiaki Taniyama

and Nobutaka Koibuchi

submission deadline 31 Oct 2025 | Viewed by 57 | Submission Open

Keywords: periostin; splicing variant; treatment-resistant cancer; diagnostics; periostin suppression therapy

Macrophages in Cancer: Immunosuppression, Immunoregulation, and Immunotherapy

edited by Abdullah Saeed

submission deadline 5 Nov 2025 | 1 articles | Viewed by 2310 | Submission Open

Keywords: macrophage; immunosuppression; immunoregulation; immunotherapy; tumor immune microenvironment

(This special issue belongs to the Section Cellular Immunology)

Stem Cells in Cancer

edited by

Ajit Kumar Sharma

submission deadline 10 Nov 2025 | 2 articles | Viewed by 3456 | Submission Open

Keywords: cancer stem cells; heterogeneity; metastasis; plasticity; self-renewal

(This special issue belongs to the Section Stem Cells)

Molecular Mechanism and Therapeutic Opportunities of Breast Cancer

edited by

Athanasios A. Panagiotopoulos

submission deadline 10 Nov 2025 | 2 articles | Viewed by 1602 | Submission Open

Keywords: breast cancer; molecular mechanisms; targeted therapy; genomic profiling; hormone receptors; tumor microenvironment; immunotherapy; drug resistance; metastasis; precision medicine

(This special issue belongs to the Section Cellular Pathology)

Displaying special issue 201-250 on page 5 of 11.

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