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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Concepts Relating Mesenchymal Tumors Based on Genetics and Epigenetics

edited by

Uta Flucke

submission deadline 25 Mar 2025 | 1 articles | Viewed by 1908 | Submission Open

Keywords: mesenchymal tumors; soft tissue; sarcoma; genetics; epigenetics

(This special issue belongs to the Section Cell Microenvironment)

Effective Embryo Maternal Interaction Support Favorable Pregnancy Outcome

edited by Eytan R. Barnea,

Nicoletta Di Simone

and Guarano Alice

submission deadline 25 Mar 2025 | Viewed by 214 | Submission Open

Keywords: pregnancy; fertilization; tubal transport; embryogenesis; maternal quality control

Tumor Stroma Interaction

edited by

Vladimir Jurisic

submission deadline 25 Mar 2025 | Viewed by 132 | Submission Open

Keywords: cells; cancer; inflammation; exocytosis; immune system; tumor stroma

Therapeutic Targets in Glioblastoma

edited by Candice Mazewski and

Frank Eckerdt

submission deadline 28 Mar 2025 | 1 articles | Viewed by 443 | Submission Open

Keywords: glioblastoma; signaling targets; blood-brain-barrier; complementary and alternative medicine; combination therapy; glioma stem cells; progression; resistance; nutrient-sensing

Kinases in Cancer: Advancing Targeted Therapies and Their Implications in Cancer Immunity

edited by Zamal Ahmed and John A. Tainer

submission deadline 30 Mar 2025 | 1 articles | Viewed by 3047 | Submission Open

Keywords: kinase targets; proliferation; cell cycle checkpoints; DNA damage responses; inflammation; cancer immune response; phosphatase targets; adaptor and scaffold targets

(This special issue belongs to the Section Cellular Immunology)

Cellular Differentiation in Health and Disease

edited by Christine K. C. Loo and

Grant A. Ramm

submission deadline 30 Mar 2025 | Viewed by 255 | Submission Open

Keywords: cellular differentiation; tumour microenvironment; human development; regeneration/healing; cell signaling pathways; tumour differentiation

Male Reproductive Health and Infertility: A Look towards the Future II

edited by

Alice Luddi

Paola Piomboni

and

Rosanna Chianese

submission deadline 31 Mar 2025 | 6 articles | Viewed by 12289 | Submission Open

Keywords: sperm; male infertility; spermatogenesis; epigenetics; fertilization; exosomes; cell communication; oxidative stress; biomarkers

(This special issue belongs to the Section Reproductive Cells and Development)

New Insights into Vascular Biology in Health and Disease

edited by Bashir M. Rezk

submission deadline 31 Mar 2025 | 3 articles | Viewed by 6733 | Submission Open

Keywords: vascular diseases; cardiovascular; cancer; hyperhomocyteinemia; endothelial dysfunction; vascular smooth muscle cell; autophagy; alcohol; galectins; angiogenesis; neovascularization

(This special issue belongs to the Section Cells of the Cardiovascular System)

Inflammatory Pathways in Psychiatric Disorders

edited by Teresa Femenía

submission deadline 31 Mar 2025 | 1 articles | Viewed by 6599 | Submission Open

Keywords: inflammation; immune system; psychiatry; emotion; cognition

(This special issue belongs to the Section Cells of the Nervous System)

Stroke Immunology: Mechanisms and Therapeutic Prospects

edited by Emmanuel Pinteaux and

Alba Grayston-Morales

submission deadline 31 Mar 2025 | 2 articles | Viewed by 5652 | Submission Open

Keywords: stroke; neuroimmunology; neuroinflammation; thromboinflammation; blood-brain barrier; glia; immunomodulation

(This special issue belongs to the Section Cellular Immunology)

Diabetes-Induced Organ Damage: Cellular Mechanisms and Therapeutic Opportunities

edited by

Mohammed S. Razzaque

submission deadline 31 Mar 2025 | 1 articles | Viewed by 5411 | Submission Open

Keywords: diabetes mellitus; vascular lesions; nephropathy; cardiomyopathy; neuropathy; retinopathy; therapeutic opportunities

(This special issue belongs to the Section Tissues and Organs)

Cellular and Molecular Basis of Alkaptonuria

edited by

and

submission deadline 31 Mar 2025 | 2 articles | Viewed by 4895 | Submission Open

Keywords: Alkaptonuria; AKU; pathophysiology; post-genomics; histopathology; bioinformatics

(This special issue belongs to the Section Cellular Pathology)

Perinatal Brain Injury—from Pathophysiology to Therapy

edited by Cora H.A. Nijboer,

Bobbi Fleiss

and

Ivo Bendix

submission deadline 31 Mar 2025 | 3 articles | Viewed by 4494 | Submission Open

Keywords: preterm birth; perinatal brain injury; infection; inflammation; hypoxia; ischemia; hyperoxia; malnutrition; regenerative therapies; pharmacological intervention; stem cells

(This special issue belongs to the Section Cells of the Nervous System)

Onco-Hematology and Immunotherapy

edited by

Jean Gabert

and Régis T. Costello

submission deadline 31 Mar 2025 | 2 articles | Viewed by 3428 | Submission Open

Keywords: immunotherapy; onco-hematology; CAR T cells; NK cells; immune system; immune cells; leukemias; lymphomas

(This special issue belongs to the Section Cellular Immunology)

Flow Cytometry in Immunology Research

edited by

Ziv Porat

and Ekaterina Kopitman

submission deadline 31 Mar 2025 | 2 articles | Viewed by 3171 | Submission Open

Keywords: multi-parametric analysis; full-spectrum flow cytometry; imaging flow cytometry; immuno-phenotyping; immune synapse; cytokines; activation markers; cancer immunology; host-pathogen interactions; functional immune assays

(This special issue belongs to the Section Cell Methods)

Antioxidants in Redox Homeostasis of Plant Development

edited by

Dragana Z. Jakovljević

and

Milan Stankovic

submission deadline 31 Mar 2025 | 1 articles | Viewed by 2916 | Submission Open

Keywords: reactive oxygen species; radical scavenging; oxidative stress; plant growth and development; primary and secondary metabolites

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Adipose Tissue, Obesity, and Metabolic Diseases

edited by Takafumi Miyamoto

submission deadline 31 Mar 2025 | 3 articles | Viewed by 2710 | Submission Open

Keywords: adipose tissue; obesity; metabolic diseases; stress; inflammation; gut microbiota

(This special issue belongs to the Section Cellular Metabolism)

Microbe–Heavy Metal Interactions

edited by

Timothy E. Ford

submission deadline 31 Mar 2025 | 1 articles | Viewed by 2604 | Submission Open

Keywords: horizontal gene transfer (HGT); gene duplication; natural selection; mutation; heavy metal resistance genes (MRGs); antibiotic resistance genes (ARGs); acid mine drainage (AMD); heavy metals; plasmids; mobile genetic elements (MGEs); transposons; extreme environments; bioremediation

Signaling Regulation of Bone and Tooth Development

edited by Xiaofang Wang

submission deadline 31 Mar 2025 | 2 articles | Viewed by 2510 | Submission Open

Keywords: bone; tooth; osteogenesis; odontogenesis; enamel; dentin; cementum; amelogenesis; dentinogenesis

Remyelination: From Basic Science to Therapies

edited by

Antonella Ragnini-Wilson

submission deadline 31 Mar 2025 | 1 articles | Viewed by 2383 | Submission Open

Keywords: myelin disease; neurodegeneration; CNS therapy; stem cells; regenerative therapies

(This special issue belongs to the Section Cells of the Nervous System)

Adenosine and Purinergic Receptors: Regulation and Essential Role in Human Disease

edited by Veronica Salmaso,

Stephanie Federico

and

Stefano Moro

submission deadline 31 Mar 2025 | 2 articles | Viewed by 1791 | Submission Open

Keywords: adenosine receptors; adenosine; purinergic signaling; P2 receptors; GPCRs; neurodegeneration; cancer; pain; inflammation; ischemia

(This special issue belongs to the Section Cellular Pathology)

Advances in Neurogenesis: 3rd Edition

edited by

Luisa Alexandra Meireles Pinto

submission deadline 31 Mar 2025 | 1 articles | Viewed by 1519 | Submission Open

Keywords: neurogenesis; gliogenesis; cell plasticity; neurophysiology; behavior; neural circuits; cytogenic regulators; neuropsychiatric disorders; neurodegenerative disorders

New Insights of TGF-Beta Signaling in Cancer

edited by

Hendrik Ungefroren

submission deadline 31 Mar 2025 | 1 articles | Viewed by 1038 | Submission Open

Keywords: cancer; TGF-beta; signaling crosstalk; smad signaling; non-Smad signaling; TGF-beta receptors; TGF-beta signaling inhibitors; TGF-beta paradox; epithelial-mesenchymal transition (EMT); mesenchymal-epithelial transition (MET)

Ca²⁺ Signaling and Calcium-Binding Proteins in Human Disease

edited by Nordine Helassa

submission deadline 31 Mar 2025 | 1 articles | Viewed by 877 | Submission Open

Keywords: calcium signaling; calcium-binding protein; calmodulin; ion channels; cardiac arrhythmia; neurodegenerative disease

State of the Art in Computational Modeling of Cancer Immunotherapy

edited by

Katarzyna A. Rejniak

submission deadline 31 Mar 2025 | Viewed by 367 | Submission Open

Keywords: oncoimmunology; modeling immune– tumor interactions; modeling combination immunotherapies; modeling adoptive cell therapies; mathematical modeling; data-driven models

(This special issue belongs to the Section Cellular Immunology)

Membrane Damage and Repair in Organelles

edited by Yoko Shiba

submission deadline 31 Mar 2025 | Viewed by 341 | Submission Open

Keywords: membrane damage; organelle; pathogen; inorganic material; galectin

(This special issue belongs to the Section Intracellular and Plasma Membranes)

Organellar Ca²⁺ Transport in Plant versus Animal Cells: Can We Learn from Each Other?

edited by Shey-Shing Sheu and Marc Freichel

submission deadline 31 Mar 2025 | Viewed by 341 | Submission Open

Keywords: organellar calcium transport; plant cells; animal cells; intracellular organelle communication; calcium signaling; mitochondria; organelle-targeted florescent Ca2+ indicators; super-resolution imaging

(This special issue belongs to the Section Cell Microenvironment)

Cell Death: Cell–Cell Interactions and Signaling Networks

edited by

Manas Ranjan Gartia

, Sun Chul Kang and

Sukkum Ngullie Chang

submission deadline 31 Mar 2025 | Viewed by 268 | Submission Open

Keywords: apoptosis; necrosis; pyroptosis; autophagic cell death; lysosome-dependent cell death; parthanatos; ferroptosis; anoikis; entosis; necroptosis; NETosis; mitotic catastrophe; healthy cell death tissue homeostasis

Biomolecular Condensates in Oncology and Immunology

edited by

Andrzej Mackiewicz

Pravin B. Sehgal

and

Mariusz Kaczmarek

submission deadline 31 Mar 2025 | Viewed by 259 | Submission Open

Keywords: liquid-liquid phase separation (LLPS); biomolecular condensates; pro-oncogenic signaling; innate and adaptive immunity; transcriptional regulation; epigenetic regulation; condensate targeting; antiviral mechanisms; intercellular adhesion; cell migration and metastasis

(This special issue belongs to the Section Cellular Immunology)

Molecular and Cellular Mechanisms of Liver Regeneration: From Biology to Therapy

edited by

Mustapha Najimi

submission deadline 31 Mar 2025 | Viewed by 200 | Submission Open

Keywords: liver regeneration; hepatocytes; chemokines; growth factors; liver diseases; signaling pathways; inflammation; liver immunobiology; fibrosis; cirrhosis

(This special issue belongs to the Section Tissues and Organs)

The Epigenetic Landscape of Aging: Mechanisms and Impacts During Cellular and Organismal Longevity

edited by Siyu Shen and

Dazhuan Xin

submission deadline 31 Mar 2025 | Viewed by 195 | Submission Open

Keywords: epigenetic regulation; cellular senescence; aging; DNA methylation; histone modification; non-coding RNA; cancer epigenetics; neurodegenerative diseases; musculoskeletal degenerative disorders; cardiovascular diseases

(This special issue belongs to the Section Cellular Aging)

Cellular and Molecular Mechanisms of Liver Diseases

edited by Jieyun Jiang

submission deadline 31 Mar 2025 | Viewed by 194 | Submission Open

Keywords: liver; alcoholic liver disease (ALD); viral hepatitis; metabolic associated steatotic liver disease (MASLD); autoimmune hepatitis; drug-induced liver injury; liver fibrosis and cirrhosis; liver cancer; cellular and molecular mechanisms

(This special issue belongs to the Section Cellular Pathology)

Retinal Pigmented Epithelium (RPE) and the Choroid: Players and Partners for Vision

edited by

Luminita Paraoan

and Janet R. Sparrow

submission deadline 31 Mar 2025 | Viewed by 188 | Submission Open

Keywords: retinal pigment epithelium; photoreceptor cell; choroid; Bruch’ s membrane; neural retina; visual cycle; phagocytosis; secretion; organelles; mitochondria; retinoid; melanin; albinism; age-related macular degeneration

Pathogenic Mechanisms of Chronic Inflammation-Associated Cancer

edited by Emiko Mizoguchi

submission deadline 31 Mar 2025 | Viewed by 186 | Submission Open

Keywords: chronic inflammation; dysplasia; neoplasia; oncogene; cytokine; colitis-associated cancer

(This special issue belongs to the Section Cellular Pathology)

Modulation of P2X Receptors: Emerging Implications for Cellular Signaling and Disease Management

edited by Luca Antonioli and

Clelia Di Salvo

submission deadline 31 Mar 2025 | Viewed by 164 | Submission Open

Keywords: purinergic receptors; purinergic signaling; adenosine; ATP; ADP

Host Immunity to Bacterial Infections

edited by Karine Gloux

submission deadline 31 Mar 2025 | Viewed by 151 | Submission Open

Keywords: host immune systemsbacterial pathogens; innate and adaptive immune responses; pathogen evasion; bacterial infections

(This special issue belongs to the Section Cellular Immunology)

Glial Cells: Physiological and Pathological Perspective

edited by

Qing Richard Lu

submission deadline 31 Mar 2025 | Viewed by 133 | Submission Open

Keywords: neurodegeneration; oligodendrocytes; astrocytes; microglia; neuroinflammation; demyelination neuron– glial interactions; homeostasis; glia-targeted therapies

(This special issue belongs to the Section Cells of the Nervous System)

Cellular Senescence and Senotherapies in the Aging Retina

edited by

Bhavana Chhunchha

submission deadline 31 Mar 2025 | Viewed by 128 | Submission Open

Keywords: retina; senescence; aging; inflammasome; oxidative stress; antioxidant; gene therapy; senotherapies; glaucoma; diabetic retinopathy

(This special issue belongs to the Section Cellular Aging)

CRISPR-Based Genome Editing Approaches in Cancer Therapy

edited by Martin Pal

submission deadline 31 Mar 2025 | Viewed by 121 | Submission Open

Keywords: CRISPR; genome editing; cancer therapy; precision medicine

(This special issue belongs to the Section Cell and Gene Therapy)

Organoids and Models from Stem Cells

edited by Tiziana A. L. Brevini and

Georgia Pennarossa

submission deadline 31 Mar 2025 | Viewed by 119 | Submission Open

Keywords: cellular microenvironment; 3D culture; organoid

(This special issue belongs to the Section Stem Cells)

Impact of Hyponatremia on Cancer Progression and Organ Function: Insights from Murine Models

edited by Giada Marroncini and Mushfiquddin Khan

submission deadline 31 Mar 2025 | Viewed by 54 | Submission Open

Keywords: hyponatremia; cancer progression; neurological disease; heart failure; osteoporosis; liver cirrhosis; kidney injury; vaptans

The Role of Secretory RNases and Extracellular RNAs in the Regulation of Inflammation and Organ Injury

edited by

Mingui Fu

and

Yisong Qian

submission deadline 1 Apr 2025 | 1 articles | Viewed by 970 | Submission Open

Keywords: RNase; extracellular RNAs; inflammation; sepsis; organ injury; innate immunity; neutrophils; monocyte/macrophages; endothelial cells

(This special issue belongs to the Section Tissues and Organs)

Development of PET Radiotracers for Imaging Alpha-Synuclein

edited by

Robert H. Mach

and Jamie Eberling

submission deadline 1 Apr 2025 | Viewed by 200 | Submission Open

Keywords: alpha-synuclein; Parkinson’ s disease; multiple system atrophy; positron emission tomography

(This special issue belongs to the Section Cellular Aging)

Cellular Models in Aging

edited by Michel Satya Naslavsky and Mateus Vidigal

submission deadline 1 Apr 2025 | Viewed by 64 | Submission Open

Keywords: cellular senescence; aging models; DNA repair; neurodegeneration; elderly

(This special issue belongs to the Section Cellular Aging)

Advances in Cell-Based Studies and Therapeutic Approaches for Tissue Regeneration

edited by

Anişoara Cîmpean

and

Andreea-Mariana Negrescu

submission deadline 10 Apr 2025 | 1 articles | Viewed by 718 | Submission Open

Keywords: soft/hard tissue regeneration; therapeutical approaches; cell culture studies; inflammation-based diseases; degenerative diseases

Recent Advances in Astrocyte Neuron Communication

edited by

Stefano Ferroni

and

Francesco Formaggio

submission deadline 10 Apr 2025 | Viewed by 596 | Submission Open

Keywords: astrocytes; calcium signaling; ion channels; gliotransmitters; brain circuits; reactive astrogliosis; astrocyte heterogeneity; astrocyte– neuron networks; synaptic plasticity

(This special issue belongs to the Section Cells of the Nervous System)

Sebaceous Gland in Skin Health and Disease

edited by

Stefania Briganti

and Monica Ottaviani

submission deadline 10 Apr 2025 | Viewed by 431 | Submission Open

Keywords: sebaceous gland; sebocytes; sebaceous lipid; sebum; inflammation; sebaceous gland disease; skin diseases; pathophysiology; biomarkers; therapeutics

(This special issue belongs to the Section Cellular Pathology)

Cellular and Molecular Mechanisms of Lysosomal Storage Disorders

edited by

Ritva Tikkanen

submission deadline 15 Apr 2025 | 2 articles | Viewed by 4844 | Submission Open

Keywords: lysosomes; lysosomal storage disorders; enzyme replacement; gene therapy; substrate reduction; pharmacological chaperones; autophagy; endosomal dysfunction

(This special issue belongs to the Section Cellular Pathology)

Molecular Mechanisms of Autism Spectrum Disorder

edited by Tanya Gandhi and

Charles Lee

submission deadline 15 Apr 2025 | 4 articles | Viewed by 4069 | Submission Open

Keywords: autism spectrum disorder; neurodevelopmental disorders; molecular mechanisms; cellular-molecular mechanisms; neurobiological mechanisms; neural mechanisms; intervention approaches; treatment strategies

(This special issue belongs to the Section Cells of the Nervous System)

Molecular and Cellular Mechanisms of Marfan Syndrome

edited by

Vivian De Waard

Gustavo Egea

and

María Galán

submission deadline 15 Apr 2025 | 1 articles | Viewed by 804 | Submission Open

Keywords: Marfan syndrome; aortic aneurysm; aortic dissection; TGFβ ; BMP; matrix metalloproteinase; NO synthase; mitochondrial dysfunction; oxidative stress; endothelium; aortic vascular smooth muscle cells; phenotypic switching; adventitia; hemodynamics; gene therapy; connective tissue disease

(This special issue belongs to the Section Cellular Pathology)

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