Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genomics and Cellular Mechanisms in Ovarian Cancer
edited by Hao Huang
submission deadline 31 Dec 2025 | Viewed by 124 | Submission Open
Keywords: ovarian cancer; tumor heterogeneity; genomics and epigenomics; therapy resistance; tumor microenvironment
(This special issue belongs to the Section Tissues and Organs)
Thoracic Tumors: Decoding Cellular Heterogeneity, Tumor Microenvironment Crosstalk, and Therapeutic Vulnerabilities
edited by and Dragana Jovanovic
submission deadline 31 Dec 2025 | Viewed by 111 | Submission Open
Keywords: NSCLC; SCLC; mesothelioma; thymoma; thymic carcinoma; immunotherapy; molecular therapy; chemotherapy
(This special issue belongs to the Section Cell Microenvironment)
The Role of the Gene Expression and Regulation of the Pathogenesis of Oral Submucous Fibrosis
edited by
submission deadline 31 Dec 2025 | Viewed by 87 | Submission Open
Keywords: oral submucous fibrosis (OSMF); collagen deposition; epigenetic modifications; next-generation sequencing; oral cancer; progressive fibrosis
(This special issue belongs to the Section Cellular Pathology)
Molecular and Genetic Pathogenesis of Hematological Disorders
edited by
submission deadline 10 Jan 2026 | 1 articles | Viewed by 2047 | Submission Open
Keywords: hematological disorders; molecular and genetic mechanisms; signal transduction pathways; microenvironment; gene editing technologies; targeted therapies; novel biomarkers; mechanisms of treatment resistance; innovative therapeutic strategies
(This special issue belongs to the Section Cellular Pathology)
New Insights into Therapeutic Targets for Cardiovascular Diseases submission deadline 15 Jan 2026 | 3 articles | Viewed by 11660 | Submission Open
Keywords: cardiovascular disease prevention and treatment; ischemic cardiomyopathies; endothelium injury/damage; cardiac remuscularization and repair; cardiovascular/angiogenic targets and biomarkers; targeted delivery platforms/systems/formulations; precision nanomedicine; targeted nano-theranostic applications; localized and systemic administration; safety and efficacy
(This special issue belongs to the Section Cells of the Cardiovascular System)
Mechanisms of Lung Growth and Regeneration submission deadline 15 Jan 2026 | 1 articles | Viewed by 1899 | Submission Open
Keywords: stem cells; niche; aging; growth factors; extracellular matrix; organoids; fibrosis; single-cell RNAseq
(This special issue belongs to the Section Cell Microenvironment)
Recent Progress on Fibrosis and Cardiac Dysfunction submission deadline 15 Jan 2026 | Viewed by 437 | Submission Open
Keywords: regeneration; cardiac fibrosis; cardiac dysfunction; ischemic heart disease; hypertension; atrial fibrillation; inflammation
(This special issue belongs to the Section Cells of the Cardiovascular System)
New Insights into Gene Research and Therapy for Diabetes Mellitus submission deadline 15 Jan 2026 | Viewed by 129 | Submission Open
Keywords: gene therapy; type 1 diabetes; type 2 diabetes; glycemic control; beta-cell transcription factors; insulin granules; viral vectors
Targeting Breast Cancer: Mechanisms of Resistance and Innovative Therapeutic Strategies
edited by Stefania Belli, and
submission deadline 15 Jan 2026 | Viewed by 122 | Submission Open
Keywords: breast cancer; targeted therapies; novel therapeutic targets; mechanisms of drug resistance; innovative therapeutic strategies; targeting tumor microenvironment; immunotherapy in breast cancer
(This special issue belongs to the Section Cell Microenvironment)
Organ Regeneration: Cells, Organoids and Organs
edited by Jia Huang
submission deadline 15 Jan 2026 | 1 articles | Viewed by 114 | Submission Open
Keywords: organ regeneration; stem cells; organoids; tissue engineering; 3D bioprinting; regenerative medicine; interspecies chimera; blastocyst complementation; vascularization; immune compatibility
(This special issue belongs to the Section Tissues and Organs)
Oral Stem Cells in Regenerative Biology
edited by
submission deadline 15 Jan 2026 | Viewed by 97 | Submission Open
Keywords: stem cells; differentiation; regenerative medicine; angiogenesis; inflammation; secretome; oral tissue induced pluripotent stem cells
(This special issue belongs to the Section Stem Cells)
Signaling Pathways in Endometrial Cancer Cells
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 9270 | Submission Open
Keywords: endometrial cancer; cellular signaling; cell metabolism; DNA damage repair pathway; the PI3K/AKT/mTOR pathway; the RAS/MAPK pathway; molecular classification
(This special issue belongs to the Section Cell Signaling)
Adipose-Derived Stem Cells: Current Applications and Future Directions
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 6387 | Submission Open
Keywords: cell therapy; regenerative medicine; adipose-derived stem cells (ADSCs); exosome; cytokine
(This special issue belongs to the Section Stem Cells)
Pathophysiology of Signal Transduction in Cardiovascular and Pulmonary Disease: 2nd Edition
edited by and
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2173 | Submission Open
Keywords: cardiac arrhythmia; atrium; ventricle; pulmonary; vascular; signal transduction
(This special issue belongs to the Section Cellular Pathology)
Mitochondria at the Crossroad of Health and Disease—Second Edition submission deadline 20 Jan 2026 | 1 articles | Viewed by 1629 | Submission Open
Keywords: mitochondria; oxidative phosphorylation; mitochondrial ion transport; permeability transition pore; mitochondrial ROS generation; mitochondrial quality control; mitochondrial traffic; mitochondrial morphology; mitochondrial dynamics; mitophagy
(This special issue belongs to the Section Cellular Aging)
Neurotoxicity and Neurodegenerative Diseases: The Potential of Regenerative Medicine
edited by Elisabetta Mormone, Paola Crociani and
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1461 | Submission Open
Keywords: inflammation; iPSCs; MSCs; neural stem cells niche; neurodegeneration; regenerative medicine; ROS; PRP
(This special issue belongs to the Section Cellular Aging)
Applications of Proteomics in Human Diseases and Treatments submission deadline 20 Jan 2026 | 1 articles | Viewed by 1106 | Submission Open
Keywords: biomarkers; clinical proteomics; single-cell proteomics; next-generation proteomics; biofluids; high-throughput proteomics
(This special issue belongs to the Section Cell Methods)
Role of Cell Organelles in Normal Aging, Senescence, and Cancer
edited by and Christopher Albanese
submission deadline 20 Jan 2026 | Viewed by 506 | Submission Open
Keywords: aging; accumulated damage; ROS-induced damage; protein aggregation; senescence; cancer; senescence escape; cell organelles; mitochondria; lysosomes; SASP; inflammation; IL1-beta/IL-6/IL-8
(This special issue belongs to the Section Cellular Aging)
Cellular Origin of Glioma: From Triggers to Treatments
edited by Katherine Karakoula
submission deadline 20 Jan 2026 | Viewed by 319 | Submission Open
Keywords: glioblastoma; brain tumour; tumour heterogeneity; targeted therapy; glioma stem cells
Study on Human Mesenchymal Stem Cells—2nd Edition
edited by
submission deadline 20 Jan 2026 | Viewed by 318 | Submission Open
Keywords: mesenchymal stem cells; disease; cardiac; therapy
(This special issue belongs to the Section Stem Cells)
The Evolving Landscape of Cell and Gene Therapy—Opportunities, Challenges and the Road Ahead submission deadline 20 Jan 2026 | Viewed by 160 | Submission Open
Keywords: cell therapy; gene therapy/gene editing; micro RNAs; rare diseases; metabolic disease; cancer; diabetes; proatherogenic lipoproteins; drug discovery; ASO
Intestinal Stem Cells submission deadline 20 Jan 2026 | Viewed by 158 | Submission Open
Keywords: stem cells; self-renewal; enterocytes; intestinal organoid; villus; crypt
(This special issue belongs to the Section Stem Cells)
Gliomas: Molecular Insights, Next-Generation Therapies, and Precision Targeting
edited by
submission deadline 20 Jan 2026 | Viewed by 118 | Submission Open
Keywords: gliomas; molecular targets; precision oncology; immunotherapy; gene editing; tumor microenvironment
Molecular Basis of Gynecological Disorders and Associated Infertility submission deadline 20 Jan 2026 | Viewed by 84 | Submission Open
Keywords: gynecological disorders; endometriosis; polycystic ovary syndrome (PCOS); cervical cancer; ovarian cancer; uterine and vaginal pathologies
(This special issue belongs to the Section Cellular Pathology)
Fibrosis in Chronic Inflammatory Diseases submission deadline 25 Jan 2026 | 8 articles | Viewed by 16298 | Submission Open
Keywords: fibrosis; fibroblasts; myofibroblasts; inflammation; molecular pathways; pathogenetic mechanisms; therapeutic targets
(This special issue belongs to the Section Cellular Pathology)
Targeting Hallmarks of Cancer submission deadline 25 Jan 2026 | 3 articles | Viewed by 5900 | Submission Open
Keywords: epigenetic regulators; organotypic culture models; anticancer drugs; hallmarks of cancer
Soluble Interleukin-6 Receptor (sIL-6R): Role in Health and Disease submission deadline 25 Jan 2026 | 1 articles | Viewed by 1031 | Submission Open
Keywords: sIL-6R; IL-6 signalling; IL-6ST; genetic polymorphism; health; disease; exercise physiology; therapeutics; mental health
(This special issue belongs to the Section Cell Signaling)
The Role of T Cells in Type 1 Diabetes submission deadline 25 Jan 2026 | Viewed by 507 | Submission Open
Keywords: T cells; inflammation; T cell receptor; type 1 diabetes
(This special issue belongs to the Section Cellular Immunology)
Decoding the Tumor-Immune Intersection: Opportunities for Breakthroughs in Cancer Therapies
edited by
submission deadline 25 Jan 2026 | Viewed by 170 | Submission Open
Keywords: immuno-oncology; tumor-immune interface; tumor microenvironment; cancer immunotherapy; targeted therapy; immunometabolism; oncometabolism; epigenetics; combination strategies
(This special issue belongs to the Section Cellular Immunology)
Metabolic Flexibility in Cancer: How Tumor Cells Adapt Their Metabolism to Growth and Spread
edited by Erica Pranzini
submission deadline 25 Jan 2026 | Viewed by 162 | Submission Open
Keywords: cancer metabolism; metabolic plasticity; tumor microenvironment; oncometabolites; targeting cancer metabolism
Targeting Immune Dysfunction in Aging and Age-Related Diseases
edited by and
submission deadline 25 Jan 2026 | Viewed by 161 | Submission Open
Keywords: immunosenescence; inflammaging; immune dysfunction; aging; age-related diseases (ARDs); immune– metabolic interactions; immunomodulators; immunoceuticals; senotherapeutics; lifestyle interventions
Induced Pluripotent Stem Cells (iPSCs): Molecular and Cellular Mechanisms
edited by Masmoudi-Kouki Olfa and
submission deadline 25 Jan 2026 | Viewed by 128 | Submission Open
Keywords: iPSCs; gene regulation; epigenetic reprogramming; cellular signaling; disease modeling
(This special issue belongs to the Section Stem Cells)
Plant Stress and Acclimation Responses During Global Warming submission deadline 25 Jan 2026 | Viewed by 119 | Submission Open
Keywords: acclimatory responses in plants; chloroplast retrograde and nuclear anterograde signaling; excess light and heat shock responses; global warming and regulation of gene expression; energy dissipation as heat and cell death regulation; photosynthesis; stomatal conductance and transpiration regulation during heat waves
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Immune Cell Signaling Networks in Tumor and Regenerative Stem Cell Niches
edited by
submission deadline 25 Jan 2026 | Viewed by 77 | Submission Open
Keywords: tumor microenvironment; stem cell niche; macrophage polarization; T-cell activation; immune checkpoints; targetable signaling pathways; engineered biomaterials; immune signaling in 3D culture; organ-on-chip models; single-cell omics
(This special issue belongs to the Section Stem Cells)
The Developments and Applications of Vibrational Spectroscopy in Cellular Research
edited by
submission deadline 25 Jan 2026 | Viewed by 66 | Submission Open
Keywords: vibrational spectroscopy; FT-IR spectroscopy; Raman spectroscopy; biomedical diagnostics; cancer research; Alzheimer’ s disease; neurodegeneration; tissue engineering; spectroscopic biomarkers; label-free imaging
(This special issue belongs to the Section Cell Methods)
Insights into the Pathophysiology of NeuroCOVID: Current Topics submission deadline 26 Jan 2026 | 1 articles | Viewed by 1240 | Submission Open
Keywords: neuroCOVID; longCOVID; neurocognitive; cellular and molecular neurobiology; brain fog; anxiety; depression; biomarkers; translational biomedicine; neurodegenerative diseases
(This special issue belongs to the Section Cellular Pathology)
Neuronal Development and Disease: From Molecular Bases to Neurological Disorders
edited by Ramiro Almeida
submission deadline 30 Jan 2026 | 4 articles | Viewed by 4784 | Submission Open
Keywords: neuronal development; neurological disorders; neurogenesis; neuroinflammation; synaptic plasticity
(This special issue belongs to the Section Cells of the Nervous System)
The Roles of the Extracellular Matrix in Cardiac Structure and Function: A Commemorative Issue in Honor of Dr. Thomas K. Borg
edited by and Edie Goldsmith
submission deadline 30 Jan 2026 | 5 articles | Viewed by 3668 | Submission Open
Keywords: collagen; integrin; extracellular matrix; cardiomyocyte; fibroblast; heart bioengineering
(This special issue belongs to the Section Cell Microenvironment)
Mechanisms Underlying Cardiovascular Aging
edited by Soheil Saeedi
submission deadline 30 Jan 2026 | 2 articles | Viewed by 2831 | Submission Open
Keywords: cardiovascular aging; cellular senescence; epigenetic clock; endothelial cells; perivascular adipose tissue (PVAT); premature aging; senolytics; rejuvenating strategies
(This special issue belongs to the Section Cells of the Cardiovascular System)
Tumor Immune Responsiveness in the Era of T Cell Immunotherapy
edited by and
submission deadline 30 Jan 2026 | Viewed by 184 | Submission Open
Keywords: T cell-mediated immunity; cancer immune responsiveness; cytokine modulation
Stem Cells, Disease Mechanisms, and Therapeutic Innovations in Breast and Endometrial Disorders
edited by , Benedikt Schaefgen and
submission deadline 30 Jan 2026 | Viewed by 176 | Submission Open
Keywords: endometrial stem cells; breast cancer; endometrial diseases; tumor microenvironment; matrix remodeling; regenerative medicine; bioengineering; stem cell therapy; molecular pathogenesis; disease modeling
(This special issue belongs to the Section Stem Cells)
Ubiquitin Ligases in Health and Diseases
edited by Haitao Luan
submission deadline 30 Jan 2026 | Viewed by 98 | Submission Open
Keywords: ubiquitination; E3 ubiquitin ligase; Proteasome; protein degradation; cell cycle regulation; immune response; neurodegeneration; cancer; autoimmune disorders; therapeutic targeting
(This special issue belongs to the Section Cell Signaling)
Advanced Technology for Cellular Imaging
edited by Alessandro Grinzato, and
submission deadline 31 Jan 2026 | 8 articles | Viewed by 20539 | Submission Open
Keywords: electron tomography; fluorescence microscopy; live cell imaging; multimodal imaging; super resolution microscopy; cell– cell interaction
(This special issue belongs to the Section Cell Methods)
Molecular and Cellular Mechanisms of Cardiovascular and Metabolic Diseases
edited by
submission deadline 31 Jan 2026 | 7 articles | Viewed by 18058 | Submission Open
Keywords: mitochondrial dysfunction; endoplasmic reticulum (ER) stress; oxidative/nitrosative stress; diabetes; obesity; diet; atherosclerosis; hypertension; metabolomics; cell death; nutraceuticals/functional foods
(This special issue belongs to the Section Cells of the Cardiovascular System)
Cancer-Associated Fibroblasts: Challenges and Directions submission deadline 31 Jan 2026 | 5 articles | Viewed by 14354 | Submission Open
Keywords: cancer-associated fibroblast (CAFs); tumor microenvironment (TME); fibroblast activation protein alpha (FAPα ); immunotherapy; cytokines; angiogenesis; metastasis; FAP inhibitors; radioligands; imaging agents
(This special issue belongs to the Section Cell Microenvironment)
Imaging Methods in Cell Biology submission deadline 31 Jan 2026 | 6 articles | Viewed by 14113 | Submission Open
Keywords: cellular organelles; molecular function; molecular interaction; disease- and drug-related subcellular phenomena; single-molecule imaging; light microscopy; electron microscopy; fluorescence microscopy; fluorescence correlation methods; fluorescence lifetime imaging microscopy (FLIM); Raman microscopy; spatial biology
(This special issue belongs to the Section Cell Methods)
Neuroinflammation in Brain Health and Diseases
edited by Debashis Dutta and Nemil Bhatt
submission deadline 31 Jan 2026 | 8 articles | Viewed by 12190 | Submission Open
Keywords: neuroinflammation; gliosis; inflammasome; neurodegeneration; neurotherapeutics
(This special issue belongs to the Section Cells of the Nervous System)
Emerging Targets and Therapeutic Potential Drugs in Tumor Progression and Therapeutic Resistance
edited by , and Yuancheng Li
submission deadline 31 Jan 2026 | 3 articles | Viewed by 6097 | Submission Open
Keywords: cancer; tumor progression; therapeutic resistance; molecular targets; tumor microenvironment; innovative therapies; targeted drug delivery; natural product
(This special issue belongs to the Section Cell Microenvironment)
Renewing Reasons to Believe in Gene Therapies for Epilepsy
edited by Casper Gøtzsche
submission deadline 31 Jan 2026 | 2 articles | Viewed by 5382 | Submission Open
Keywords: epilepsy; seizure; gene therapy; gene editing; disease modification; transformative; unmet need
(This special issue belongs to the Section Cells of the Nervous System)
Neuro-Oncological Advances in Stem Cell Research: A New Era in Brain Tumor Therapy submission deadline 31 Jan 2026 | 2 articles | Viewed by 2437 | Submission Open
Keywords: brain tumor genetics and epigenetics; brain tumor stem cells; stem cell therapy against brain tumors; mesenchymal stem cells; iPSC; resistance to therapy
(This special issue belongs to the Section Stem Cells)
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