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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Motor Neuron Diseases: From Molecular Basic Research to Diagnosis and Therapeutics Implications

edited by

Ilaria Martinelli

and Elisabetta Zucchi

submission deadline 20 Feb 2026 | 5 articles | Viewed by 11906 | Submission Open

Keywords: motor neuron; genetics; oxidative stress; misfolded protein aggregates; biomarkers; gene therapy

(This special issue belongs to the Section Cellular Neuroscience)

Molecular Insight into the Pathogenesis of Spontaneous Preterm Birth

edited by Khondoker M. Akram

submission deadline 20 Feb 2026 | 3 articles | Viewed by 7748 | Submission Open

Keywords: pathogenesis of preterm birth; placental dysfunctions in preterm birth; environmental impacts on placental function in preterm birth; vaginal dysbiosis in preterm birth

(This special issue belongs to the Section Cellular Pathology)

Ovarian Cancer and Endometriosis

edited by

Ji-Hye Ahn

and

Jung-Hye Choi

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4236 | Submission Open

Keywords: ovarian cancer; endometriosis; microenvironment; cell-cell interaction; drug resistance; natural product

(This special issue belongs to the Section Cellular Pathology)

T Cells in Inflammation and Cancer

edited by

Kihong Lim

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3493 | Submission Open

Keywords: T cell; immunity; disease; infection; cancer; inflammation; pathology; immunotherapy

(This special issue belongs to the Section Cellular Immunology)

Molecular Mechanisms of Leukemias

edited by

María Hernández Valladares

and Frode Selheim

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2115 | Submission Open

Keywords: acute lymphoblastic leukemia (ALL); chronic lymphocytic leukemia (CLL); acute myelogenous leukemia (AML); chronic myelogenous leukemia (CML)

(This special issue belongs to the Section Cellular Pathology)

The Cell Biology of Heart Disease

edited by Rajeshwary Ghosh and

Samreen Sadaf

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2068 | Submission Open

Keywords: cardiomyopathy; endothelial dysfunction; cellular senescence; fibrosis; myocardial infarction; inflammation; mitochondrial dysfunction; CAD; arrhythmia; heart failure

(This special issue belongs to the Section Cells of the Cardiovascular System)

Role of Gene Regulation in Neurological Disorders

edited by

Yujing Li

and Yulin Jin

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1738 | Submission Open

Keywords: gene regulation; neurological disorders; central nervous system (CNS); peripheral nervous system (PNS); Alzheimer's disease (AD); Parkinson's disease (PD); Huntington's disease (HD); autism spectrum disorder (ASD); fragile X syndrome (FXS); fragile X-associated tremor/ataxia syndrome (FXTAS); amyotrophic lateral sclerosis (ALS); multiple sclerosis (MS)

(This special issue belongs to the Section Cell and Gene Therapy)

Current Advances in Plant Gene Regulatory Networks

edited by

Laszlo Kozma-Bognar

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1068 | Submission Open

Keywords: plants; light signaling; circadian clock; thermomorphogenesis; hormonal regulation; a/biotic stress-responsive gene expression; flowering time

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Advances in Molecular Research on Cancer Drug Targets and Drug Resistance

edited by

Yuhao Xie

Concettina La Motta

and Rakesh Kumar Srivastava

submission deadline 20 Feb 2026 | Viewed by 321 | Submission Open

Keywords: cancer therapy; drug targets; drug resistance; molecular mechanisms; targeted therapy; tumor microenvironment; personalized medicine; biomarkers

Transient Receptor Potential (TRP) Channels and Health and Disease

edited by Hiroki Kittaka and Makoto Tominaga

submission deadline 20 Feb 2026 | Viewed by 269 | Submission Open

Keywords: Transient Receptor Potential (TRP) channels; cell signaling; cell physiology

Elucidating Roles of Cell Adhesion Molecules in Health and Disease

edited by Vladimir Sytnyk

submission deadline 20 Feb 2026 | Viewed by 191 | Submission Open

Keywords: cell adhesion molecules (CAMs); immunoglobulin superfamily CAMs（IgSF-CAMs); integrins; cadherins; selectins; proteoglycans

Molecular Cell Biology of T Cells in Cancer and Infectious Diseases

edited by

Gustavo P. Amarante-Mendes

and João Viola

submission deadline 20 Feb 2026 | Viewed by 165 | Submission Open

Keywords: T cells; cancer; infectious diseases; genomics; proteomics; metabolomics; metabolism

(This special issue belongs to the Section Cellular Immunology)

Advances in T Cell Targeting for Cancer Immunotherapy

edited by Ryma Toumi

submission deadline 20 Feb 2026 | Viewed by 133 | Submission Open

Keywords: immunotherapy; immune checkpoint blockade; immunosuppressive microenvironment; exhaustion; armored T cells; adoptive cell therapy

Autophagic Signatures in Health and Disease: Molecular Insights and Clinical Applications

edited by

Simone Patergnani

and

Alberto Danese

submission deadline 20 Feb 2026 | Viewed by 87 | Submission Open

Keywords: autophagy; pathology; physiology; therapy; methods

(This special issue belongs to the Section Autophagy)

Astrocytes: Roles and Functions in the Brain

edited by

Victor Huang

and

Rita Raisman-Vozari

submission deadline 21 Feb 2026 | Viewed by 130 | Submission Open

Keywords: astrocyte biology; glial cells; synaptic regulation; CNS disorders; neuroinflammation; blood– brain barrier; brain metabolism; reactive astrocytes; neuron– glia interaction; therapeutic targeting

Recent Advances in Regenerative Dentistry—Second Edition

edited by

Li Xiao

submission deadline 25 Feb 2026 | 6 articles | Viewed by 23811 | Submission Open

Keywords: oral stem cells; oral tissue regeneration; bioengineering; dental materials; stem cell banking

(This special issue belongs to the Section Tissues and Organs)

Natural Products and Their Derivatives Against Human Disease

edited by

Mamunur Rashid

submission deadline 25 Feb 2026 | 6 articles | Viewed by 12071 | Submission Open

Keywords: natural products; immunomodulatory; diseases; molecular mechanism of immunity

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Molecular and Signaling Pathways in Pathological Changes of Esophageal, Gastric and Intestinal Epithelial Cells and Methods of Cell Protective Treatment

edited by

Tomasz Brzozowski

submission deadline 25 Feb 2026 | 1 articles | Viewed by 2020 | Submission Open

Keywords: gastrointestinal epithelial cells; cellular signaling; molecular pathways; cell damage; cell protection; esophageal integrity; gastric secretion; gastric ulcer; duodenal ulcer; intestinal digestion and absorption; intestinal integrity; inflammatory bowel disease; irritable bowel syndrome; ulcerative colitis; Crohn’ s disease

Research on Extracellular Vesicles in Health and Disease

edited by

Maria Concetta Cufaro

submission deadline 25 Feb 2026 | 1 articles | Viewed by 863 | Submission Open

Keywords: extracellular vesicles; molecular mechanism; biomarker discovery; therapeutics; translational medicine; proteins; DNA and RNA

Molecular, Cellular and Biochemical Approaches of Anti-Cancer Drugs

edited by

Gamaleldin Ibrahim Harisa

submission deadline 25 Feb 2026 | 1 articles | Viewed by 612 | Submission Open

Keywords: anti-cancer drugs; chemosensitizers; multidrug resistance; cellular techniques; nanoparticle delivery; in silico studies; in vivo studies; targeted therapies; cancer progression; bioactive compounds

Remyelination: From Molecular Mechanism to Therapy

edited by

Antonella Ragnini-Wilson

and

Gaetano Barbato

submission deadline 25 Feb 2026 | 1 articles | Viewed by 512 | Submission Open

Keywords: demyelination; oligodendroglia differentiation; regenerative therapies; myelin disease; neurodegeneration

Small Molecule Inhibitors: A New Era in Cancer Treatment

edited by

Natarajan Aravindan

Kousalya Lavudi

and Suman Asalla

submission deadline 25 Feb 2026 | Viewed by 250 | Submission Open

Keywords: small-molecule inhibitors; CAR-T cell therapy; immune responsiveness; cancer cell resistance

New Trends and Advances in Induced Neural Cells and iPSC Technologies

edited by

Guoqiang Sun

submission deadline 25 Feb 2026 | Viewed by 159 | Submission Open

Keywords: induced neural cells; induced pluripotent stem cell (iPSC); neurological disease modeling

(This special issue belongs to the Section Cellular Neuroscience)

Molecular and Cellular Mechanisms of Ischemic Stroke

edited by Milani Deb-Chatterji

submission deadline 25 Feb 2026 | Viewed by 146 | Submission Open

Keywords: ischemic stroke; neuroinflammation; blood– brain barrier; neurovascular unit; molecular targets for stroke therapy

Antigen Processing in Autoimmunity and Cancer—Mechanisms and Translational Perspectives

edited by Peter Van Endert

submission deadline 25 Feb 2026 | Viewed by 145 | Submission Open

Keywords: major histocompatibility molecule; antigen processing; antigen presentation; protease; endoplasmic reticulum aminopeptidase; antitumor immunity; autoimmunity; immunotherapy

Molecular Mechanisms of Treatment Resistance in Prostate Cancer

edited by

Christopher J. Ong

submission deadline 25 Feb 2026 | Viewed by 133 | Submission Open

Keywords: metastatic castration-resistant prostate cancer (mCRPC); molecular mechanisms; novel treatment strategies; systemic precision treatments; epigenetics; cellular plasticity; tumor microenvironment signaling; therapeutic resistance

The Role of the Extracellular Matrix in Tissue Development, Repair, and Disease

edited by

Stacey C. Schutte

Wei-Chih Lien

and

Ching-Yun Chen

submission deadline 26 Feb 2026 | Viewed by 115 | Submission Open

Keywords: extracellular matrix; matrisome; cell– ECM interactions; cell signaling

(This special issue belongs to the Section Tissues and Organs)

Mitophagy and Mitochondrial Quality Control in Neurodegenerative Disorders

edited by Mohamed Eldeeb

submission deadline 27 Feb 2026 | 1 articles | Viewed by 1687 | Submission Open

Keywords: protein degradation; protein quality control; proteasome; ubiquitin; autophagy; mitophagy; mitochondrial quality control; mitochondrial import; proteolysis; neurodegeneration

(This special issue belongs to the Section Mitochondria)

Advances in Smart and Innovative Nanoparticles for Precision Tumor Therapy: Design, Delivery, Immune Modulation, and Clinical Translation

edited by Hari Krishna Reddy Rachamala and

Naga Malleswara Rao Nakka

submission deadline 27 Feb 2026 | 1 articles | Viewed by 1488 | Submission Open

Keywords: smart nanoparticles; tumor-targeted drug delivery; immune modulation; stimuli-responsive nanocarriers; clinical translation in oncology

(This special issue belongs to the Section Cell Methods)

Novel Insights into Mechanism and Treatment of Degenerative Disc Disease

edited by Yejia Zhang

submission deadline 27 Feb 2026 | 1 articles | Viewed by 1477 | Submission Open

Keywords: intervertebral disc (IVD) degeneration; back pain; age; genetics; injury

(This special issue belongs to the Section Cellular Pathology)

Targeting of Cancer Cells with Small Molecule Drugs

edited by

Jannet Kocerha

submission deadline 27 Feb 2026 | Viewed by 121 | Submission Open

Keywords: small molecule drugs; cancer cell targeting; targeted cancer therapy; drug delivery systems; precision oncology

(This special issue belongs to the Section Cellular Pathology)

Pathogenesis of Alcohol-Associated Hepatitis and Its Therapies

edited by Kyle Lauren Poulsen

submission deadline 27 Feb 2026 | Viewed by 112 | Submission Open

Keywords: alcohol-associated hepatitis; drug screening; drug delivery; pathophysiology; therapeutics

Ion Channels in Cancer: From Molecular Mechanisms to Therapeutic Targets

edited by Saverio Gentile

submission deadline 27 Feb 2026 | Viewed by 112 | Submission Open

Keywords: ion channels; cancer therapeutic targeting; tumor microenvironment

Role of Extracellular Matrix in Cancer and Disease

edited by

Maurizio Onisto

Marco Franchi

and

Valentina Masola

submission deadline 28 Feb 2026 | 6 articles | Viewed by 14725 | Submission Open

Keywords: extracellular matrix; cancer; disease; ECM targeting; ECM turn-over and remodeling

(This special issue belongs to the Section Cell Microenvironment)

Signaling in Cancer Stem Cells

edited by Upasana Ray

submission deadline 28 Feb 2026 | 3 articles | Viewed by 14343 | Submission Open

Keywords: cancer stem cells (CSCs); stem cells signaling pathways; cancer progression and metastasis; therapeutic resistance; targeting cancer stem cells signaling; cancer heterogeneity; targeted therapy for CSCs; identifying biomarkers for CSCs

(This special issue belongs to the Section Stem Cells)

The Role of IgE and IgG Antibodies in Allergic Reactions: Cellular Mechanisms and Biological Implications

edited by

Monique Vogel

and

Paul Engeroff

submission deadline 28 Feb 2026 | 3 articles | Viewed by 12465 | Submission Open

Keywords: IgE; IgG; allergy; inflammation; glycosylation; immunotherapy; autoantibodies; Fc receptors; soluble receptors

(This special issue belongs to the Section Cellular Immunology)

Cellular Pathology: Emerging Discoveries and Perspectives in the USA

edited by

Mohammed S. Razzaque

submission deadline 28 Feb 2026 | 2 articles | Viewed by 6635 | Submission Open

Keywords: cellular pathology; diseases; mechanisms

(This special issue belongs to the Section Cellular Pathology)

The Potential of Induced Pluripotent Stem Cells

edited by Yun Chang

submission deadline 28 Feb 2026 | 2 articles | Viewed by 6022 | Submission Open

Keywords: pluripotent stem cells; reprogramming; engineering; regenerative medicine; differentiation; therapeutic applications; biomaterials

(This special issue belongs to the Section Stem Cells)

Cell Migration and Invasion

edited by Veronika Miskolci

submission deadline 28 Feb 2026 | 3 articles | Viewed by 5114 | Submission Open

Keywords: cell migration; cell invasion; cancer metastasis; molecular mechanisms; therapeutic strategies; signaling pathways

Adipose Tissue Functioning in Health and Diseases

edited by Richard C Chang

submission deadline 28 Feb 2026 | 3 articles | Viewed by 4456 | Submission Open

Keywords: adipose tissue biology; adipogenesis; lipolysis; adipose tissue inflammation; diet-induced obesity; non-coding RNA in metabolism; PPARγ signaling; metabolic health and disease; obesogens; epigenetics and chromatin regulation; transgenerational inheritance

(This special issue belongs to the Section Tissues and Organs)

Biomarkers in Human Diseases and Emerging Diagnostic Technologies for Their Identification and Application

edited by

Andrea Cruz

and

Carla Carvalho

submission deadline 28 Feb 2026 | 2 articles | Viewed by 3592 | Submission Open

Keywords: biomarkers; human diseases; disease mechanisms; biomarker validation; early detection; accurate diagnosis; prognosis evaluation; treatment monitoring; diagnostic technologies; biosensors; microfluidics

Membrane Dynamics and the Role of Aquaporins in Plant Cells

edited by

Farzana Sabir

submission deadline 28 Feb 2026 | 2 articles | Viewed by 3522 | Submission Open

Keywords: aquaporins; membrane dynamics; plant cell; water transport; osmoregulation; cell membrane permeability; aquaglyceroporins; stress response; membrane trafficking

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Skeletal Muscle: Structure, Physiology and Diseases

edited by

Vincenzo Sorrentino

submission deadline 28 Feb 2026 | 2 articles | Viewed by 3452 | Submission Open

Keywords: excitation– contraction coupling; store-operated calcium entry; sarcomeric proteins; skeletal muscle metabolism; skeletal muscle diseases; muscle plasticity; development; sarcopenia; aging

(This special issue belongs to the Section Tissues and Organs)

Cell Therapeutics for Corneal Diseases

edited by

Dimitrios Karamichos

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2833 | Submission Open

Keywords: cell therapies; corneal diseases; drug development; tissue engineering; stem cells; regeneration; tissue repair

(This special issue belongs to the Section Tissues and Organs)

Unconventional T Cells in Health and Disease

edited by Lauren Howson

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2409 | Submission Open

Keywords: MR1-restricted T cells; γ δ T cells; CD1-restricted T cells; unconventional T cells

(This special issue belongs to the Section Cellular Immunology)

Cellular and Molecular Mechanisms in Gynecological Disorders—Second Edition

edited by

Qiwei Yang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2145 | Submission Open

Keywords: uterus; ovary; fallopian tubes; cervix; vagina; endometriosis; polycystic ovary syndrome; primary ovarian insufficiency; ovarian cysts; adenomyosis; endometriosis; leiomyoma (uterine fibroids); endometrial cancer; leiomyosarcoma; female infertility; breast cancer; cell atlas; biomarkers; stem cells; pathways; transcriptome; proteomics; epigenome

(This special issue belongs to the Section Cellular Pathology)

Signal Transduction and Targeted Therapy for Tumors

edited by

Rodolfo Daniel Cervantes-Villagrana

submission deadline 28 Feb 2026 | Viewed by 1277 | Submission Open

Keywords: cancer progression; metastasis; invasion; cancer signaling; cell communication; cancer neuroscience; tumor angiogenesis; target therapy; immunotherapy; drug resistance; anti-tumor therapy

(This special issue belongs to the Section Cell Signaling)

The Pivotal Role of Tumor Stem Cells in Glioblastoma: Second Edition

edited by

Paola Palumbo

and Silvano J. Santini

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1136 | Submission Open

Keywords: glioblastoma stem cells; resistance; cancer therapy; signaling pathways; tumor microenvironment

Kidney Disease: The Role of Cellular Mechanisms in Renal Pathology

edited by

Jinu Kim

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1058 | Submission Open

Keywords: kidney fibrosis; acute kidney injury (AKI); chronic kidney disease (CKD); epithelial-to-mesenchymal transition (EMT); renal cell populations; stem cell therapy; renal regeneration; inflammation in kidney disease; cell-based models; renal repair mechanisms

(This special issue belongs to the Section Tissues and Organs)

Cellular Mechanisms in Oral Cavity Homeostasis and Disease

edited by

Mohamed Mekhemar

submission deadline 28 Feb 2026 | 1 articles | Viewed by 878 | Submission Open

Keywords: oral cavity; cell signaling; periodontal disease; stem cells; regeneration; inflammation; oral epithelium; tissue homeostasis; immunomodulation; cellular microenvironment

Displaying special issue 201-250 on page 5 of 14.

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