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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Roles of the Extracellular Matrix in Cardiac Structure and Function: A Commemorative Issue in Honor of Dr. Thomas K. Borg

edited by

Wayne Carver

and Edie Goldsmith

submission deadline 30 Jan 2026 | 5 articles | Viewed by 4499 | Submission Open

Keywords: collagen; integrin; extracellular matrix; cardiomyocyte; fibroblast; heart bioengineering

(This special issue belongs to the Section Cell Microenvironment)

Mechanisms Underlying Cardiovascular Aging

edited by Soheil Saeedi

submission deadline 30 Jan 2026 | 2 articles | Viewed by 3033 | Submission Open

Keywords: cardiovascular aging; cellular senescence; epigenetic clock; endothelial cells; perivascular adipose tissue (PVAT); premature aging; senolytics; rejuvenating strategies

(This special issue belongs to the Section Cells of the Cardiovascular System)

Tumor Immune Responsiveness in the Era of T Cell Immunotherapy

edited by

Xin Li

and

Wenjian Wang

submission deadline 30 Jan 2026 | Viewed by 198 | Submission Open

Keywords: T cell-mediated immunity; cancer immune responsiveness; cytokine modulation

Stem Cells, Disease Mechanisms, and Therapeutic Innovations in Breast and Endometrial Disorders

edited by

Walid Shaalan

, Benedikt Schaefgen and

Nourhan Hassan

submission deadline 30 Jan 2026 | Viewed by 195 | Submission Open

Keywords: endometrial stem cells; breast cancer; endometrial diseases; tumor microenvironment; matrix remodeling; regenerative medicine; bioengineering; stem cell therapy; molecular pathogenesis; disease modeling

(This special issue belongs to the Section Stem Cells)

Ubiquitin Ligases in Health and Diseases

edited by Haitao Luan

submission deadline 30 Jan 2026 | Viewed by 105 | Submission Open

Keywords: ubiquitination; E3 ubiquitin ligase; Proteasome; protein degradation; cell cycle regulation; immune response; neurodegeneration; cancer; autoimmune disorders; therapeutic targeting

(This special issue belongs to the Section Cell Signaling)

Advanced Technology for Cellular Imaging

edited by Alessandro Grinzato,

Vittoria Raimondi

and

J. Bernard Heymann

submission deadline 31 Jan 2026 | 8 articles | Viewed by 20961 | Submission Open

Keywords: electron tomography; fluorescence microscopy; live cell imaging; multimodal imaging; super resolution microscopy; cell– cell interaction

(This special issue belongs to the Section Cell Methods)

Molecular and Cellular Mechanisms of Cardiovascular and Metabolic Diseases

edited by

Prathapan Ayyappan

submission deadline 31 Jan 2026 | 7 articles | Viewed by 19060 | Submission Open

Keywords: mitochondrial dysfunction; endoplasmic reticulum (ER) stress; oxidative/nitrosative stress; diabetes; obesity; diet; atherosclerosis; hypertension; metabolomics; cell death; nutraceuticals/functional foods

(This special issue belongs to the Section Cells of the Cardiovascular System)

Cancer-Associated Fibroblasts: Challenges and Directions

edited by

Paul J. Higgins

and

Ramesh Mukkamala

submission deadline 31 Jan 2026 | 5 articles | Viewed by 14949 | Submission Open

Keywords: cancer-associated fibroblast (CAFs); tumor microenvironment (TME); fibroblast activation protein alpha (FAPα ); immunotherapy; cytokines; angiogenesis; metastasis; FAP inhibitors; radioligands; imaging agents

(This special issue belongs to the Section Cell Microenvironment)

Imaging Methods in Cell Biology

edited by

Claudia Moscheni

and

Nicoletta Gagliano

submission deadline 31 Jan 2026 | 6 articles | Viewed by 14824 | Submission Open

Keywords: cellular organelles; molecular function; molecular interaction; disease- and drug-related subcellular phenomena; single-molecule imaging; light microscopy; electron microscopy; fluorescence microscopy; fluorescence correlation methods; fluorescence lifetime imaging microscopy (FLIM); Raman microscopy; spatial biology

(This special issue belongs to the Section Cell Methods)

Neuroinflammation in Brain Health and Diseases

edited by Debashis Dutta and Nemil Bhatt

submission deadline 31 Jan 2026 | 8 articles | Viewed by 13730 | Submission Open

Keywords: neuroinflammation; gliosis; inflammasome; neurodegeneration; neurotherapeutics

(This special issue belongs to the Section Cells of the Nervous System)

Emerging Targets and Therapeutic Potential Drugs in Tumor Progression and Therapeutic Resistance

edited by

Xinyu Wang

Lei Zhu

and Yuancheng Li

submission deadline 31 Jan 2026 | 3 articles | Viewed by 6474 | Submission Open

Keywords: cancer; tumor progression; therapeutic resistance; molecular targets; tumor microenvironment; innovative therapies; targeted drug delivery; natural product

(This special issue belongs to the Section Cell Microenvironment)

Renewing Reasons to Believe in Gene Therapies for Epilepsy

edited by Casper Gøtzsche

submission deadline 31 Jan 2026 | 2 articles | Viewed by 5720 | Submission Open

Keywords: epilepsy; seizure; gene therapy; gene editing; disease modification; transformative; unmet need

(This special issue belongs to the Section Cells of the Nervous System)

Neuro-Oncological Advances in Stem Cell Research: A New Era in Brain Tumor Therapy

edited by

Javier S. Castresana

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2852 | Submission Open

Keywords: brain tumor genetics and epigenetics; brain tumor stem cells; stem cell therapy against brain tumors; mesenchymal stem cells; iPSC; resistance to therapy

(This special issue belongs to the Section Stem Cells)

Novel Therapeutic Strategies to Improve Mitochondrial Function in Neurodegenerative Diseases

edited by Patricia Morcillo

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2035 | Submission Open

Keywords: mitochondria; cellular signaling; neurodegenerative diseases; mitochondrial dynamics; organelles; neurological diseases; therapies; biomarkers

(This special issue belongs to the Section Cellular Aging)

New Advances in Tissue Engineering and Regeneration

edited by

Giorgia Borciani

and

Giorgia Montalbano

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2012 | Submission Open

Keywords: tissue regeneration; tissue engineering; regenerative medicine; musculoskeletal tissues; biomaterials; stem cells; 3D bioprinting; scaffold design; cell therapy; organoids; translational research

(This special issue belongs to the Section Tissues and Organs)

Cell Behavior Under Blood Flow

edited by Alexander Gural, Ivana Pajic-Lijakovic and

Gregory Barshtein

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1294 | Submission Open

Keywords: blood flow; shear stress; red blood cells; white blood cells; platelets; endothelial cells; cell stimulation; mechanical stress

The Role of Macrophages in Leishmaniasis: Current Perspective

edited by Devki Nandan

submission deadline 31 Jan 2026 | 1 articles | Viewed by 878 | Submission Open

Keywords: Leishmania; leishmaniasis; macrophage biology; host– pathogen interactions

Single-Molecule Tracking for Live Cells

edited by

Zeno Földes-Papp

submission deadline 31 Jan 2026 | Viewed by 354 | Submission Open

Keywords: single-molecule level; many-molecule level; biological cell; diluted liquids; single-molecule localization microscopy; nanoscopy; modeling; diffusion; theory

Cellular and Molecular Mechanisms in Immune Regulation—Second Edition

edited by Fábio Rinaldo Santori and Natalia B. Ivanova

submission deadline 31 Jan 2026 | 1 articles | Viewed by 339 | Submission Open

Keywords: innate immunity; dendritic cells; macrophages; T cells; B cells; cytokines; immunotherapy

(This special issue belongs to the Section Cellular Pathology)

Diagnostic and Therapeutic Application of Extracellular Vesicles (EV)

edited by

Maria Magdalena Barreca

and

Chiara Corrado

submission deadline 31 Jan 2026 | Viewed by 304 | Submission Open

Keywords: extracellular vesicles (EVs); diseases biomarkers; therapeutic targets; drugs delivery; engineered extracellular vesicles; EVs therapeutic applications

Mechanisms That Link Olfactory Perception with Aging in Drosophila

edited by

Tuhin Subhra Chakraborty

, Anindya Ganguly and Jordan A. Munroe

submission deadline 31 Jan 2026 | Viewed by 292 | Submission Open

Keywords: olfaction; aging; neuroscience

(This special issue belongs to the Section Cellular Aging)

Autophagy and Neurodegeneration: Unveiling Cellular Pathways in ALS and Beyond

edited by Valeria Gerbino

submission deadline 31 Jan 2026 | 1 articles | Viewed by 223 | Submission Open

Keywords: autophagy; neurodegeneration; amyotrophic lateral sclerosis (ALS); protein aggregation; cellular homeostasis; lysosomal dysfunction; neuronal health; therapeutic targets; molecular pathways; neuroprotective strategies

(This special issue belongs to the Section Cells of the Nervous System)

Gastrointestinal Disorders: Immunity and Inflammation

edited by Faizan Ahmed and

Aditi Bhargava

submission deadline 31 Jan 2026 | Viewed by 193 | Submission Open

Keywords: gastrointestinal disorders; immunity; inflammation; immune system; microbiota; gastroenterology; biomarkers; pathways

Human Organoids: A New Frontier in Disease Modeling

edited by

Priyanka Verma

and Umesh Kumar

submission deadline 31 Jan 2026 | Viewed by 189 | Submission Open

Keywords: 3D organ culture; embryonic stem cells; induced pluripotent stem cells; 3D bioprinting; personalized medicine; regenerative medicine

(This special issue belongs to the Section Tissues and Organs)

Genetics and Gene Regulation

edited by

Yujing Li

and

Han Yang

submission deadline 31 Jan 2026 | Viewed by 173 | Submission Open

Keywords: genetics; gene regulation; human diseases

New Trends and Advances in Molecular Targeted Therapy for Cancers

edited by Dhivya Sridaran and

Jeremy M. Crook

submission deadline 31 Jan 2026 | Viewed by 150 | Submission Open

Keywords: cancer targeted therapy; antibodies; small-molecule inhibitors; antibody– drug conjugates; combination therapies

(This special issue belongs to the Section Cell and Gene Therapy)

Function of Stress Granules in Normal Cells and in Alzheimer’s Disease

edited by

Paul D. Coleman

and Benjamin Wolozin

submission deadline 31 Jan 2026 | Viewed by 149 | Submission Open

Keywords: stress granules; Alzheimer's disease; neurodegenerative diseases

(This special issue belongs to the Section Cellular Aging)

New Perspectives of Respiratory Diseases: From Microbiome, Metabolism, and Immune Response

edited by

Bernhard Ryffel

submission deadline 31 Jan 2026 | Viewed by 147 | Submission Open

Keywords: cell death/stress; DNA/RNA sensor; cGAS/STING; inflammasome; microbiome; FMT or transfer of bacteria; metabolite; viral infection; emphysema; progressive fibrosis; innate immune response; defined inhibitors

Aquaporins at the Crossroads of Human Health and Disease

edited by

Anna Patrizia Gena

submission deadline 31 Jan 2026 | Viewed by 140 | Submission Open

Keywords: aquaporins; membrane molecular transport; channels proteins in health and disease; novel drug targets; cellular biophysics

Examining the Cellular Biology of Adenovirus

edited by Susan J. Morris, Adam C. T. Gillman and Erwan Sallard

submission deadline 31 Jan 2026 | Viewed by 136 | Submission Open

Keywords: adenovirus; replication; maturation; transduction; tropism; intracellular trafficking; targeting; virus– host interactions; transcriptome

Acute Myeloid Leukemia: Unraveling Molecular Drivers, Cellular Plasticity, and Therapeutic Vulnerabilities

edited by Fabio Guolo

submission deadline 31 Jan 2026 | Viewed by 118 | Submission Open

Keywords: acute myeloid leukemia (AML); hematologic malignancy; AML classification; myeloid precursors; hematopoiesis; high-risk AML; biomarkers

(This special issue belongs to the Section Cellular Immunology)

The Language of Neural Cells: Decoding Molecular Signaling in Neurodevelopmental and Neuro-Oncological Disorders

edited by

Marilena Briglia

Alice Foti

and Adriana C. E. Graziano

submission deadline 31 Jan 2026 | Viewed by 111 | Submission Open

Keywords: neural cells; molecular signaling; neurodevelopmental disorders; neuro-oncological disorders; transcriptional dysregulation

(This special issue belongs to the Section Cells of the Nervous System)

Biochemical Mechanisms and Physiological Implication of Stem Cell Differentiation

edited by

Giuliana Mannino

and

Floriana D'Angeli

submission deadline 31 Jan 2026 | Viewed by 108 | Submission Open

Keywords: stem cells; differentiation; 3D cultures; co-cultures; biochemistry; physiology; epigenetics

(This special issue belongs to the Section Stem Cells)

Role of Oxidative Stress in Cardiovascular Diseases

edited by

Nevena Jeremic

and

Vladimir Jakovljevic

submission deadline 31 Jan 2026 | Viewed by 65 | Submission Open

Keywords: oxidative stress; reactive oxygen species (ROS); endothelial dysfunction; inflammation; cardiovascular pathology

(This special issue belongs to the Section Cells of the Cardiovascular System)

Advances in the Role of Lipid Signaling in Diseases

edited by

Roger Schneiter

and

Neng Wan

submission deadline 5 Feb 2026 | Viewed by 176 | Submission Open

Keywords: lipid signaling; membrane lipid dynamics; autophagy; disease pathology; mitochondria; transcription; protein degradation

Role of Alpha-Synuclein in Neurodegenerative Diseases

edited by

Carmela Conte

submission deadline 10 Feb 2026 | 1 articles | Viewed by 1264 | Submission Open

Keywords: Alpha-; Beta-; and Gamma-synuclein; synucleinopathies; neurodegeneration; neuroinflammation; authophagy; Parkinson's disease; non-motor symptoms; Alzheimer's disease; multiple system atrophy; psychiatric diseases

(This special issue belongs to the Section Cellular Aging)

Decoding Cellular Organization Through Spatial Omics

edited by Elizabeth Neumann

submission deadline 10 Feb 2026 | Viewed by 152 | Submission Open

Keywords: spatial proteomics; lipomics; cellular architecture; biomolecular interactions; bioinformatics; integrative biology

Exclusive Review Papers in Autophagy—Second Edition

edited by

Harald W. Platta

submission deadline 15 Feb 2026 | 4 articles | Viewed by 17858 | Submission Open

Keywords: biquitination; autophagy; peroxisomes; macroautophagy; pexophagy; mitophagy; lysosome; vacuole; organellar homeostasis; posttranslational modifications; lipids; signaling cascades

(This special issue belongs to the Section Autophagy)

Cancer Immunotherapy Harnessing Innate and Adaptive Immune Effector Cells and PD-1 Immune Checkpoint Inhibitors

edited by

Yoshimasa Tanaka

submission deadline 15 Feb 2026 | 4 articles | Viewed by 13768 | Submission Open

Keywords: PD-1 immune checkpoint; CAR-T cells; γ δ T cells; NK cells

(This special issue belongs to the Section Cellular Immunology)

State-of-the-Art Research on Histone Deacetylases (HDACs) and Histone Acetyltransferases (HATs)

edited by

Xiaohong Zhang

submission deadline 15 Feb 2026 | 4 articles | Viewed by 9383 | Submission Open

Keywords: histone deacetylases; cancer; metabolism; immunotherapy; tumor microenvironment; DNA damage response; cell cycle

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Molecular Therapeutic Advances for Neurodegenerative Diseases

edited by

Vanessa Castelli

submission deadline 15 Feb 2026 | 3 articles | Viewed by 5119 | Submission Open

Keywords: neurodegenerative diseases; neurodegeneration; neurological disorders

(This special issue belongs to the Section Cellular Aging)

Spotlight on Natural Killer Cells in Immuno-Oncology

edited by

Anahid Jewett

and

Kawaljit Kaur

submission deadline 15 Feb 2026 | 1 articles | Viewed by 3483 | Submission Open

Keywords: natural killer (NK) cells; cancer stem cells (CSCs); poorly differentiated tumors; differentiation; aggressive tumors; suppressor cells

(This special issue belongs to the Section Cellular Immunology)

Epigenetic Mechanisms of Tumorigenesis

edited by

Hengbin Wang

submission deadline 15 Feb 2026 | 1 articles | Viewed by 1691 | Submission Open

Keywords: epigenetics; tumorigenesis; gene expression; cell identity; precise medicine

Cancers and Metabolic Diseases—the Molecular Players in the Game

edited by

T.K.S. Kumar

submission deadline 15 Feb 2026 | Viewed by 134 | Submission Open

Keywords: metabolism; bioenergetics; signaling; cytokines; molecular; mechanisms; receptors; design; therapeutics

GPCR Signaling in PDA: Calcium, cAMP, and Ras Activation in Pancreatic Ductal Adenocarcinoma

edited by

Thomas Wilkie

submission deadline 15 Feb 2026 | Viewed by 112 | Submission Open

Keywords: G protein-coupled receptor (GPCR); receptor tyrosine kinases (RTK); oncogenic Kras; pancreatic ductal adenocarcinoma (PDA); epigenetic regulation; Wnt and Hedgehog (HH); second messengers (cAMP and intracellular calcium); acinar to ductal metaplasia (ADM); tumor microenvironment; therapeutic drugs list of solicited contributors

Cellular Mechanisms and Therapies of Hematologic Malignancies

edited by Sayantani Sinha and Stanley Chun-Wei Lee

submission deadline 15 Feb 2026 | Viewed by 84 | Submission Open

Keywords: AML; ALL and CLL; targeted therapy; combination therapy; small molecule inhibitors; immunotherapy; RNA in hematopoiesis; overcoming resistance

(This special issue belongs to the Section Cellular Pathology)

Phosphodiesterases (PDEs): Therapeutic Targets in Human Health and Disease

edited by

Paul M. Epstein

Stefan Brocke

, Michy P. Kelly and Leila Gobejishvili

submission deadline 20 Feb 2026 | 17 articles | Viewed by 45073 | Submission Open

Keywords: cyclic nucleotide phosphodiesterase; PDE; cAMP; cGMP; signal transduction

(This special issue belongs to the Section Cell Microenvironment)

Motor Neuron Diseases: From Molecular Basic Research to Diagnosis and Therapeutics Implications

edited by

Ilaria Martinelli

and Elisabetta Zucchi

submission deadline 20 Feb 2026 | 5 articles | Viewed by 10781 | Submission Open

Keywords: motor neuron; genetics; oxidative stress; misfolded protein aggregates; biomarkers; gene therapy

(This special issue belongs to the Section Cells of the Nervous System)

Molecular Insight into the Pathogenesis of Spontaneous Preterm Birth

edited by Khondoker M. Akram

submission deadline 20 Feb 2026 | 3 articles | Viewed by 7068 | Submission Open

Keywords: pathogenesis of preterm birth; placental dysfunctions in preterm birth; environmental impacts on placental function in preterm birth; vaginal dysbiosis in preterm birth

(This special issue belongs to the Section Cellular Pathology)

Ovarian Cancer and Endometriosis

edited by

Ji-Hye Ahn

and

Jung-Hye Choi

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3929 | Submission Open

Keywords: ovarian cancer; endometriosis; microenvironment; cell-cell interaction; drug resistance; natural product

(This special issue belongs to the Section Cellular Pathology)

Displaying special issue 201-250 on page 5 of 13.

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