RNA Sequencing Data Research on Ageing and Age-Related Diseases
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 31 October 2024 | Viewed by 996
Special Issue Editors
Interests: ageing; Alzheimer’s disease; bioinformatics; RNA-Seq; Parkinson’s disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Ageing is a complex process influenced by genetic and epigenetic regulation, post-translational regulation, metabolic regulation, lifestyle, and many other elements. New research methods, drugs, and clinical treatments are emerging, offering opportunities to reveal the mechanisms of ageing and the prevention or treatment of ageing-related diseases.
We have previously studied ageing gene expression changes in the human brain via analyses of exon microarrays from 1234 post mortem brains of individuals who passed away between the ages of 16 and over 100 (UK Brain Bank). We found cell-type-specific gene expression changes and, in particular, a decrease in neuronal gene expression and an increase in microglial genes. We also quantified neurons and oligodendrocytes through machine learning and image analyses and detected an increase in the number of large neurons and a decrease in oligodendrocytes in old brain samples compared to young ones. RNA-Seq allows for the detailed analysis of patients compared to control post mortem brain samples using statistical/bioinformatic analyses. Ageing is a major risk factor for Alzheimer’s disease, the second most frequent neurodegenerative disease worldwide. Future statistical/bioinformatic analyses may focus on specific brain cell types (such as neurons, endothelial cells, oligodendrocytes microglia, and astrocytes).
The proposed topics include, but are not limited to, the following:
- Neurodegenerative diseases;
- The role of neuroinflammation in the development of ageing;
- Ageing gene expression;
- Molecular biomarkers of ageing;
- Experimental models of ageing.
Dr. Lilach Soreq
Prof. Dr. John Hardy
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- ageing
- bioinformatics
- Alzheimer’s disease
- Parkinson’s disease
- RNA-Seq
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
