RNA-Seq in Human Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Informatics".
Deadline for manuscript submissions: closed (30 May 2024) | Viewed by 1073
Special Issue Editor
Interests: ageing; Alzheimer’s disease; bioinformatics; RNA-Seq; Parkinson’s disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In total, 6.3 billion people around the world have Alzheimer’s disease (AD), which is the second most prevalent neurodegenerative disease. RNA-Seq data facilitate a detailed analysis of human patient’s genomics data in high resolution, including an analysis of alternative splicing, molecular pathways, and specific cell-type marker genes. Single-cell RNA-Seq facilitates the accurate analysis of such data. The immune system, inflammation and cellular toxicity, and propagation in neurons were previously found to be altered in AD and aging post-mortem brain samples. Specific genes, including such encoding RNA-binding proteins (RBPs) (e.g., Apoe, Tau, Trem, Mapt, A-beta, and glial and neuronal cell-type marker genes), were also found to be involved. We still do not have a complete picture of disease-involved genes and pathways, or the clearance of Tau seeds and toxic oligomers effects. A comparison of AD cases to control brain samples may help to gain a better insight into disease-underlying molecular processes. RNA-Seq data analysis on Parkinson’s disease (PD) patients’ blood leukocytes previously showed changes in long non-coding RNAs, micro-RNAs, and alternative splicing. Exon array analysis on aging compared to young and middle-aged sample changes showed significant changes in microglial, oligodendrocyte, and neuronal cell marker genes. Mice model RNA-Seq produced genomics data which can serve as additional control data and human data.
Dr. Wael Mohamed ([email protected]) is a senior scientist (Reviewer Board member in IJMS), who will assist Dr. Lilach Soreq in managing this Special Issue.
Dr. Lilach Soreq
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- aging
- bioinformatics
- single-cell RNA-Seq
- RNA-Seq
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.