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Bioactive Natural and Synthetic Saccharides against Human Diseases

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 780

Special Issue Editor


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Guest Editor
1. Department of Pharmacology & Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
2. AyuVis Research, Fort Worth, TX 76107, USA
Interests: anti-inflammation/anti-oxidant pathways; novel therapeutic molecules; synthetic saccharides; drug delivery

Special Issue Information

Dear Colleagues,

Bioactive oligosaccharides are oligosaccharide molecules with specific structures and functions, synthesized or derived from natural sources. Due to their natural occurrence, non-toxic nature and biodegradability, low-molecular-weight natural oligosaccharides (e.g., chitosan and its derivatives from chitosan and chitin polymers) have attracted much attention as therapeutic candidates for a variety of diseases. Many studies have demonstrated their potential benefits in the prevention and treatment of a variety of diseases in terms of intestinal health, anti-microbial activity, immunomodulation, antioxidant, metabolic regulation and bone density protection. They also provide directions for future research and clinical practice.

In this Special Issue, we would like to emphasize the importance of natural and synthetic oligosaccharides in the prevention and treatment of human diseases. Therefore, we strongly encourage researchers to present their significant research/clinical findings to demonstrate the great biological potential of this class of natural products.

Dr. Suchismita Acharya
Guest Editor

Manuscript Submission Information

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Keywords

  • naturally and synthetically occurring saccharides
  • intestinal health
  • anti-microbial activity
  • immunomodulation
  • antioxidant
  • metabolic regulation
  • neuroprotection
  • lung injury

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Published Papers (1 paper)

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Research

21 pages, 4060 KiB  
Article
Lonicera japonica Thunb. Ethanol Extract Exerts a Protective Effect on Normal Human Gastric Epithelial Cells by Modulating the Activity of Tumor-Necrosis-Factor-α-Induced Inflammatory Cyclooxygenase 2/Prostaglandin E2 and Matrix Metalloproteinase 9
by Hsi-Lung Hsieh, Ming-Chin Yu, Yu-Chia Chang, Yi-Hsuan Wu, Kuo-Hsiung Huang and Ming-Ming Tsai
Curr. Issues Mol. Biol. 2024, 46(7), 7303-7323; https://doi.org/10.3390/cimb46070433 - 9 Jul 2024
Viewed by 596
Abstract
Gastric inflammation-related disorders are commonly observed digestive system illnesses characterized by the activation of proinflammatory cytokines, particularly tumor necrosis factor-α (TNF-α). This results in the induction of cyclooxygenase-2 (COX-2)/prostaglandin E2 (PEG2) and matrix metallopeptidase-9 (MMP-9). These factors contribute to the [...] Read more.
Gastric inflammation-related disorders are commonly observed digestive system illnesses characterized by the activation of proinflammatory cytokines, particularly tumor necrosis factor-α (TNF-α). This results in the induction of cyclooxygenase-2 (COX-2)/prostaglandin E2 (PEG2) and matrix metallopeptidase-9 (MMP-9). These factors contribute to the pathogenesis of gastric inflammation disorders. We examined the preventive effects of Lonicera japonica Thunb. ethanol extract (Lj-EtOH) on gastric inflammation induced by TNF-α in normal human gastric mucosa epithelial cells (GES-1). The GES-1 cell line was used to establish a model that simulated the overexpression of COX-2/PGE2 and MMP-9 proteins induced by TNF-α to examine the anti-inflammatory properties of Lj extracts. The results indicated that Lj-EtOH exhibits significant inhibitory effects on COX-2/PEG2 and MMP-9 activity, attenuates cell migration, and provides protection against TNF-α-induced gastric inflammation. The protective effects of Lj-EtOH are associated with the modulation of COX-2/PEG2 and MMP-9 through the activation of TNFR–ERK 1/2 signaling pathways as well as the involvement of c-Fos and nuclear factor kappa B (NF-κB) signaling pathways. Based on our findings, Lj-EtOH exhibits a preventive effect on human gastric epithelial cells. Consequently, it may represent a novel treatment for the management of gastric inflammation. Full article
(This article belongs to the Special Issue Bioactive Natural and Synthetic Saccharides against Human Diseases)
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