Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.7
3.0
Journals
Diagnostics
Special Issues
Novel Imaging Techniques in Infection and Inflammation
share announcement

Novel Imaging Techniques in Infection and Inflammation

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 6845

Special Issue Editors

Dr. Maria Ricci

E-Mail Website
Guest Editor
Nuclear Medicine Unit, Cardarelli Hospital, Campobasso, Italy
Interests: nuclear medicine; oncology neurology; theranostic; positron emission tomography
Special Issues, Collections and Topics in MDPI journals
Dr. Andrea Cimini

E-Mail Website
Guest Editor
Nuclear Medicine Unit, St. Salvatore Hospital, 67100 L'Aquila, Italy
Interests: nuclear medicine; molecular imaging; positron emission tomography
Prof. Dr. Ennio Lubrano

E-Mail Website
Guest Editor
Academic Rheumatology Unit, Dipartimento di Medicina e Scienze della Salute “Vincenzo Tiberio”, University of Molise, 86100 Campobasso, Italy
Interests: psoriasis; psoriatic arthritis; rheumatic diseases; rheumatoid arthritis; rheumatology; dermatology; inflammation; systemic lupus erythematosus; autoimmunity; spondyloarthritis

Special Issue Information

Dear Colleagues,

We are the Guest Editors of the Special Issue “Novel Imaging Techniques in Infection and Inflammation”, published in the open access journal Diagnostics (https://www.mdpi.com/journal/diagnostics). I am proud to announce that the IF of Diagnostics has increased to 3.992 (2021).

The diagnosis, severity and extent of an infection or sterile inflammation could be challenging since there is not a single, clearly defined test that allows an accurate diagnosis and therapy monitoring. In the last decades, novel imaging techniques have been investigated with heterogeneous results in infection and inflammation diseases, including autoimmune diseases, both in research and in clinical practice settings. Moreover, the growing interest in patients’ tailored approach suggests that precision therapy can be performed according to the possible responsiveness and needs of patients. It has become quite evident that novel imaging techniques can play a major role in the management of patients with suspected infection and inflammation diseases, by providing potential advantages over existing imaging techniques. Novel imaging biomarkers for inflammation and infection, either alone or in combination with further diagnostic biomarkers, may provide a novel insight in the infection and inflammation fields.

We would like to invite you to publish your next paper in this Special Issue. Both long review papers and original research articles are welcome.

We look forward to receiving your contributions.

Dr. Maria Ricci
Dr. Andrea Cimini
Prof. Dr. Ennio Lubrano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammation
  • infection
  • imaging biomarkers
  • autoimmune diseases
  • novel diagnostic biomarkers

Published Papers (4 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review, Other

13 pages, 618 KiB  
Article
The Diagnostic Yield of [18F]FDG-PET/CT in a Heterogeneous In-Patient Population with Suspected Infection or Inflammation Is Comparable to Findings in Patients with Classic Fever of Unknown Origin
by Kristian Kimer Becker, Jacob Søholm and Søren Hess
Diagnostics 2024, 14(13), 1420; https://doi.org/10.3390/diagnostics14131420 - 3 Jul 2024
Viewed by 507
Abstract
Introduction: Suspected infection or inflammation of unknown origin in in-patients remains challenging. Literature on [18F]FDG-PET/CT is abundant in classic fever of unknown origin (FUO), but evidence is complex and may not always reflect clinical reality. This study explores the application of [...] Read more.
Introduction: Suspected infection or inflammation of unknown origin in in-patients remains challenging. Literature on [18F]FDG-PET/CT is abundant in classic fever of unknown origin (FUO), but evidence is complex and may not always reflect clinical reality. This study explores the application of [18F]FDG-PET/CT in a diverse clinical population of in-patients with suspected infection not defined by stringent FUO-criteria. Methods: Retrospective chart review of consecutive in-patients who underwent [18F]FDG-PET/CT in the workup of suspected infection or inflammation from 1 July 2022 to 31 December 2022 was conducted. We evaluated indications, diagnostic yield, and clinical impact of [18F]FDG-PET/CT, and compared the findings of [18F]FDG-PET/CT and stand-alone CT. Univariate logistic regression assessed associations between [18F]FDG-PET/CT outcome and clinical parameters. Receiver operating characteristic curve (ROC) analysis evaluated diagnostic performance. Results: 77 patients met the inclusion criteria. [18F]FDG-PET/CT established a diagnosis in 35% of cases, ruled out focal infection in 26%, and thus was helpful in 61% of patients. It prompted 72 additional examinations resulting in seven incidental diagnoses, including two cancers. Antibiotic treatment was changed in 26% of cases. Regression analysis found white blood cell counts (WBC) associated with true positive outcomes. [18F]FDG-PET/CT was compared to stand-alone CT findings, and was concordant in 69% of cases. Conclusions: Results were comparable to findings in more classic FUO. [18F]FDG-PET/CT was clinically helpful in 61% of cases but also prompted many additional examinations with relatively few clinically important findings. WBC count was a predictor of true positive outcome. CT and [18F]FDG-PET/CT were discordant in 31%, of cases, especially in cases of endocarditis and spondylodiscitis. Full article
(This article belongs to the Special Issue Novel Imaging Techniques in Infection and Inflammation)
►▼ Show Figures

Figure 1

10 pages, 1088 KiB  
Communication
Ultrasonographic Evaluation of Entheseal Fibrocartilage in Patients with Psoriatic Arthritis, Athletes and Healthy Controls: A Comparison Study
by Fabio Massimo Perrotta, Mario Ronga, Silvia Scriffignano and Ennio Lubrano
Diagnostics 2023, 13(8), 1446; https://doi.org/10.3390/diagnostics13081446 - 17 Apr 2023
Viewed by 1158
Abstract
The aims of this study were as follows: (1) To evaluate the entheseal fibrocartilage (EF) during Achilles tendon insertion in patients with Psoriatic Arthritis (PsA) by using power Doppler ultrasound (PDUS), (2) to assess the intra and inter-reader reliability of the evaluation of [...] Read more.
The aims of this study were as follows: (1) To evaluate the entheseal fibrocartilage (EF) during Achilles tendon insertion in patients with Psoriatic Arthritis (PsA) by using power Doppler ultrasound (PDUS), (2) to assess the intra and inter-reader reliability of the evaluation of EF thickness, (3) to compare the EF thickness of PsA patients, athletes and healthy controls (HCs), and (4) to evaluate the correlations between EF abnormalities, disease activity and functional indices in PsA. Methods: Consecutive PsA patients attending our unit were asked to participate. HCs and agonist athletes were enrolled as a control group. A bilateral PDUS evaluation of Achilles tendons was performed in order to evaluate the EF in all patients and controls. Results: In total, 30 PsA patients, 40 athletes and 20 HCs were enrolled. The median (IQR) EF thickness among the PsA patients, athletes and HCs was 0.035 cm (0.028–0.04) cm, 0.036 (0.025–0.043) cm and 0.030 (0.020–0.038) cm, respectively (p = 0.05 between PsA patients and HCs). The intra-reader reliability was excellent [ICC (95% CI) of 0.91 (0.88–0.95)] and the inter-reader reliability was good (0.80 (0.71–0.86). The assessment of EF was feasible, with a mean time of 2 min. No correlations were found with disease activity indices in PsA patients. Conclusion: The assessment of EF is a feasible and reproducible test and may be explored as a potential imaging biomarker. Full article
(This article belongs to the Special Issue Novel Imaging Techniques in Infection and Inflammation)
►▼ Show Figures

Figure 1

Review

Jump to: Research, Other

17 pages, 3316 KiB  
Review
Neurological and Psychiatric Manifestations of Long COVID-19 and Their [18F]FDG PET Findings: A Review
by Rizwanullah Hameed, Anuradha Rosario Bahadur, Shashi Bhushan Singh, Juwairah Sher, Maia Todua, Leah (Mahsa) Moradi, Sanjiv Bastakoti, Maeen Arslan, Hanfa Ajmal, Gha Young Lee, Cyrus Ayubcha, Thomas J. Werner, Abass Alavi and Mona-Elisabeth Revheim
Diagnostics 2023, 13(14), 2353; https://doi.org/10.3390/diagnostics13142353 - 12 Jul 2023
Cited by 2 | Viewed by 2318
Abstract
For more than two years, lingering sequalae of COVID-19 have been extensively investigated. Approximately 10% of individuals infected by COVID-19 have been found to experience long-term symptoms termed “long COVID-19”. The neurological and psychiatric manifestations of long COVID-19 are of particular concern. While [...] Read more.
For more than two years, lingering sequalae of COVID-19 have been extensively investigated. Approximately 10% of individuals infected by COVID-19 have been found to experience long-term symptoms termed “long COVID-19”. The neurological and psychiatric manifestations of long COVID-19 are of particular concern. While pathogenesis remains unclear, emerging imaging studies have begun to better elucidate certain pathological manifestation. Of specific interest is imaging with [18F]FDG PET which directly reflects cellular glycolysis often linked to metabolic and inflammatory processes. Seeking to understand the molecular basis of neurological features of long COVID-19, this review encompasses the most recent [18F]FDG PET literature in this area. Full article
(This article belongs to the Special Issue Novel Imaging Techniques in Infection and Inflammation)
►▼ Show Figures

Figure 1

Other

Jump to: Research, Review

10 pages, 358 KiB  
Systematic Review
PET Imaging of Neuro-Inflammation with Tracers Targeting the Translocator Protein (TSPO), a Systematic Review: From Bench to Bedside
by Ferdinando Corica, Maria Silvia De Feo, Joana Gorica, Marko Magdi Abdou Sidrak, Miriam Conte, Luca Filippi, Orazio Schillaci, Giuseppe De Vincentis and Viviana Frantellizzi
Diagnostics 2023, 13(6), 1029; https://doi.org/10.3390/diagnostics13061029 - 8 Mar 2023
Cited by 7 | Viewed by 2034
Abstract
Parkinson’s disease is the second most common neurodegenerative disorder, affecting 2–3% of the population of patients >65 years. Although the standard diagnosis of PD is clinical, neuroimaging plays a key role in the evaluation of patients who present symptoms related to neurodegenerative disorders. [...] Read more.
Parkinson’s disease is the second most common neurodegenerative disorder, affecting 2–3% of the population of patients >65 years. Although the standard diagnosis of PD is clinical, neuroimaging plays a key role in the evaluation of patients who present symptoms related to neurodegenerative disorders. MRI, DAT-SPECT, and PET with [18F]-FDG are routinely used in the diagnosis and focus on the investigation of morphological changes, nigrostriatal degeneration or shifts in glucose metabolism in patients with parkinsonian syndromes. The aim of this study is to review the current PET radiotracers targeting TSPO, a transmembrane protein that is overexpressed by microglia in another pathophysiological process associated with neurodegenerative disorders known as neuroinflammation. To the best of our knowledge, neuroinflammation is present not only in PD but in many other neurodegenerative disorders, including AD, DLB, and MSA, as well as atypical parkinsonian syndromes. Therefore, in this study, specific patterns of microglial activation in PD and the differences in distribution volumes of these radiotracers in patients with PD as compared to other neurodegenerative disorders are reviewed. Full article
(This article belongs to the Special Issue Novel Imaging Techniques in Infection and Inflammation)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-4
Back to TopTop